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Claudia Gragnoli
Title Assistant Professor
Institution College of Medicine
Department Medicine
Division Endocrinology
Address 500 University Drive Hershey PA 17033
Email
Background
PREFERRED TITLE/ROLE:

Physician, Assistant Professor

EDUCATION:

Fellowship, Endocrinology, Diabetes, & Metabolism, Massachusetts General Hospital-Harvard Medical School (2005)
Residency, Endocrinology, University of Studies of Rome Italy (1998)
Internship, Internal Medicine, University of Studies of Rome Italy (1993)
M.D., University of Studies of Rome Italy (1992)

Publications
1. Gragnoli C. Overweight condition and waist circumference and a candidate gene within the 12q24 locus. Cardiovasc Diabetol. 2013; 12:2.
  View in: PubMed
 
2. Gragnoli C. Proteasome modulator 9 and depression in type 2 diabetes. Curr Med Chem. 2012 Oct 1; 19(30):5178-80.
  View in: PubMed
 
3. Gragnoli C. Proteasome modulator 9 is linked to microvascular pathology of T2D. J Cell Physiol. 2012 Aug; 227(8):3116-8.
  View in: PubMed
 
4. Oberweis B, Gragnoli C. Potential role of prolactin in antipsychotic-mediated association of schizophrenia and type 2 diabetes. J Cell Physiol. 2012 Aug; 227(8):3001-6.
  View in: PubMed
 
5. Gragnoli C. Depression and type 2 diabetes: cortisol pathway implication and investigational needs. J Cell Physiol. 2012 Jun; 227(6):2318-22.
  View in: PubMed
 
6. Gragnoli C. Proteasome modulator 9 and carpal tunnel syndrome. Diabetes Res Clin Pract. 2011 Nov; 94(2):e47-9.
  View in: PubMed
 
7. Gragnoli C. Proteasome modulator 9 SNPs are linked to hypertension in type 2 diabetes families. Cardiovasc Diabetol. 2011; 10:77.
  View in: PubMed
 
8. Gragnoli C. PSMD9 is linked to type 2 diabetes neuropathy. J Diabetes Complications. 2011 Sep-Oct; 25(5):329-31.
  View in: PubMed
 
9. Gragnoli C. Proteasome modulator 9 gene is linked to diabetic and non-diabetic retinopathy in T2D. Ophthalmic Genet. 2011 Nov; 32(4):228-30.
  View in: PubMed
 
10. Gragnoli C. Hypercholesterolemia and a candidate gene within the 12q24 locus. Cardiovasc Diabetol. 2011; 10:38.
  View in: PubMed
 
11. Gragnoli C. Proteasome modulator 9 and macrovascular pathology of T2D. Cardiovasc Diabetol. 2011; 10:32.
  View in: PubMed
 
12. Gragnoli C. T2D-nephropathy linkage within 12q24 locus. Diabetes Res Clin Pract. 2011 Jun; 92(3):e73-5.
  View in: PubMed
 
13. Gragnoli C. PSMD9 is linked to MODY3. J Cell Physiol. 2010 Apr; 223(1):1-5.
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14. Gragnoli C. PSMD9 gene in the NIDDM2 locus is linked to type 2 diabetes in Italians. J Cell Physiol. 2010 Feb; 222(2):265-7.
  View in: PubMed
 
15. Meenakshisundaram R, Gragnoli C. CDK4 IVS4-nt40G-->A and T2D-associated obesity in Italians. J Cell Physiol. 2009 Nov; 221(2):273-5.
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16. Meenakshisundaram R, Piumelli N, Pierpaoli L, Gragnoli C. CDK4 IVS4-nt40G-->A SNP and type 2 diabetes in Italians. Diabetes Res Clin Pract. 2009 Nov; 86(2):e28-30.
  View in: PubMed
 
17. Meenakshisundaram R, Piumelli N, Pierpaoli L, Gragnoli C. CHOP 5'UTR-c.279T>C and +nt30C>T variants are not associated with overweight condition or with tumors/cancer in Italians - a case-control study. J Exp Clin Cancer Res. 2009; 28:90.
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18. Spanakis E, Gragnoli C. Successful medical management of status post-Roux-en-Y-gastric-bypass hyperinsulinemic hypoglycemia. Obes Surg. 2009 Sep; 19(9):1333-4.
  View in: PubMed
 
19. Meenakshisundaram R, Gragnoli C. CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - a case-control study. J Exp Clin Cancer Res. 2009; 28:42.
  View in: PubMed
 
20. Spanakis E, Milord E, Gragnoli C. AVPR2 variants and mutations in nephrogenic diabetes insipidus: review and missense mutation significance. J Cell Physiol. 2008 Dec; 217(3):605-17.
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21. Jonnakuty C, Gragnoli C. What do we know about serotonin? J Cell Physiol. 2008 Nov; 217(2):301-6.
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22. Gragnoli C. CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians. J Cell Physiol. 2008 Nov; 217(2):291-5.
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23. Spanakis E, Gragnoli C. Bariatric surgery, safety and type 2 diabetes. Obes Surg. 2009 Mar; 19(3):363-8.
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24. Gragnoli C. The CM cell line derived from liver metastasis of malignant human insulinoma is not a valid beta cell model for in vitro studies. J Cell Physiol. 2008 Aug; 216(2):569-70.
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25. Jonnakuty C, Gragnoli C. Karyotype of the human insulinoma CM cell line--beta cell model in vitro? J Cell Physiol. 2007 Dec; 213(3):661-2.
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26. Gragnoli C, Pierpaoli L, Piumelli N, Chiaramonte F. Linkage studies for T2D in Chop and C/EBPbeta chromosomal regions in Italians. J Cell Physiol. 2007 Nov; 213(2):552-5.
  View in: PubMed
 
27. Gragnoli C, Cronsell J. PSMD9 gene variants within NIDDM2 may rarely contribute to type 2 diabetes. J Cell Physiol. 2007 Sep; 212(3):568-71.
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28. Gragnoli C, Cronsell J. Meta-analysis of the IPF1 D76N polymorphism in a worldwide type 2 diabetes population. Minerva Med. 2007 Jun; 98(3):163-6.
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29. Milord E, Gragnoli C. NEUROG3 variants and type 2 diabetes in Italians. Minerva Med. 2006 Oct; 97(5):373-8.
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30. Gragnoli C, Stanojevic V, Gorini A, Von Preussenthal GM, Thomas MK, Habener JF. IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes. Metabolism. 2005 Aug; 54(8):983-8.
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31. Gragnoli C, Gragnoli C, Milord E, Habener JF. Linkage study of the glucagon receptor gene with type 2 diabetes mellitus in Italians. Metabolism. 2005 Jun; 54(6):786-7.
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32. Gragnoli C, Menzinger Von Preussenthal G, Habener JF. Triple genetic variation in the HNF-4alpha gene is associated with early-onset type 2 diabetes mellitus in a philippino family. Metabolism. 2004 Aug; 53(8):959-63.
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33. Gragnoli C, Cockburn BN, Chiaramonte F, Gorini A, Marietti G, Marozzi G, Signorini AM. Early-onset Type II diabetes mellitus in Italian families due to mutations in the genes encoding hepatic nuclear factor 1 alpha and glucokinase. Diabetologia. 2001 Oct; 44(10):1326-9.
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34. Godart F, Bellanné-Chantelot C, Clauin S, Gragnoli C, Abderrahmani A, Blanché H, Boutin P, Chèvre JC, Froguel P, Bailleul B. Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients. Hum Mutat. 2000; 15(2):173-80.
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35. Gragnoli C, Lindner T, Cockburn BN, Kaisaki PJ, Gragnoli F, Marozzi G, Bell GI. Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene. Diabetes. 1997 Oct; 46(10):1648-51.
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36. Lindner T, Gragnoli C, Furuta H, Cockburn BN, Petzold C, Rietzsch H, Weiss U, Schulze J, Bell GI. Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene. J Clin Invest. 1997 Sep 15; 100(6):1400-5.
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37. Lindner T, Gragnoli C, Schulze J, Rietzsch H, Petzold C, Schröder HE, Cox NJ, Bell GI. The 31-cM region of chromosome 11 including the obesity gene tubby and ATP-sensitive potassium channel genes, SUR1 and Kir6.2, does not contain a major susceptibility locus for NIDDM in 127 non-Hispanic white affected sibships. Diabetes. 1997 Jul; 46(7):1227-9.
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38. Pozzilli P, Visalli N, Signore A, Baroni MG, Buzzetti R, Cavallo MG, Boccuni ML, Fava D, Gragnoli C, Andreani D, et al. Double blind trial of nicotinamide in recent-onset IDDM (the IMDIAB III study). Diabetologia. 1995 Jul; 38(7):848-52.
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39. Pozzilli P, Buzzetti R, Giovannini C, Gragnoli C, Leslie RD. New and old trends for treating organ-specific autoimmune endocrinopathies. J Endocrinol. 1995 May; 145(2):195-9.
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40. Baroni MG, Alcolado JC, Gragnoli C, Franciosi AM, Cavallo MG, Fiore V, Pozzilli P, Galton DJ. Affected sib-pair analysis of the GLUT1 glucose transporter gene locus in non-insulin-dependent diabetes mellitus (NIDDM): evidence for no linkage. Hum Genet. 1994 Jun; 93(6):675-80.
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