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Christopher Herzog
Title Assistant Professor
Institution College of Medicine
Department Pharmacology
Address 500 University Drive Hershey PA 17033
Mailbox: R130
Telephone 7175315986
Email
Background
PREFERRED TITLE/ROLE:

Assistant Professor of Pharmacology and Pathology

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Pathology, The Huck Institute of the Life Sciences

GRADUATE PROGRAM AFFILIATIONS:

Pharmacology, Biomedical Sciences; Translational Therapeutics, Integrative Biosciences: Molecular Toxicology, Molecular Medicine

EDUCATION:

M.S., Genetics, University of Toledo, 1989
Ph.D., Cancer Genetics, Medical College of Ohio, 1995

NARRATIVE:

My research interests broadly encompass the genetic basis of carcinogenesis. My current work focuses on the role of genotoxic carcinogens in the genetic selection occurring during the development of lung cancer. This includes the identification of carcinogen-induced genetic alterations and the characterization of their role in lung cancer. My lab also studies the mechanisms of genomic instability in cancer. Of particular interest are the mechanisms by which carcinogens induce genomic instability in lung cancer. This work seeks to identify specific genetic changes that might serve as targets for lung cancer prevention and treatment.
Publications
1. Mikse OR, Blake DC, Jones NR, Sun YW, Amin S, Gallagher CJ, Lazarus P, Weisz J, Herzog CR. FOXO3 encodes a carcinogen-activated transcription factor frequently deleted in early-stage lung adenocarcinoma. Cancer Res. 2010 Aug 1; 70(15):6205-15.
  View in: PubMed
 
2. Blake DC, Mikse OR, Freeman WM, Herzog CR. FOXO3a elicits a pro-apoptotic transcription program and cellular response to human lung carcinogen nicotine-derived nitrosaminoketone (NNK). Lung Cancer. 2010 Jan; 67(1):37-47.
  View in: PubMed
 
3. Miller JC, Blake DC, Herzog CR. Adenylosuccinate synthetase 1 gene is a novel target of deletion in lung adenocarcinoma. Mol Carcinog. 2009 Dec; 48(12):1116-22.
  View in: PubMed
 
4. Herzog CR, Blake DC, Mikse OR, Grigoryeva LS, Gundermann EL. FoxO3a gene is a target of deletion in mouse lung adenocarcinoma. Oncol Rep. 2009 Oct; 22(4):837-43.
  View in: PubMed
 
5. Sun YW, Herzog CR, Krzeminski J, Amin S, Perdew G, El-Bayoumy K. Effects of the environmental mammary carcinogen 6-nitrochrysene on p53 and p21(Cip1) protein expression and cell cycle regulation in MCF-7 and MCF-10A cells. Chem Biol Interact. 2007 Oct 20; 170(1):31-9.
  View in: PubMed
 
6. Herzog CR, Desai D, Amin S. Array CGH analysis reveals chromosomal aberrations in mouse lung adenocarcinomas induced by the human lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Biochem Biophys Res Commun. 2006 Mar 17; 341(3):856-63.
  View in: PubMed
 
7. Herzog CR, Bodon N, Pittman B, Maronpot RR, Massey TE, Anderson MW, You M, Devereux TR. Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: implications for chromosome instability and tumor progression. Oncogene. 2004 Apr 15; 23(17):3033-9.
  View in: PubMed
 
8. Chung FL, Schwartz J, Herzog CR, Yang YM. Tea and cancer prevention: studies in animals and humans. J Nutr. 2003 Oct; 133(10):3268S-3274S.
  View in: PubMed
 
9. Swamy MV, Herzog CR, Rao CV. Inhibition of COX-2 in colon cancer cell lines by celecoxib increases the nuclear localization of active p53. Cancer Res. 2003 Sep 1; 63(17):5239-42.
  View in: PubMed
 
10. Herzog CR, Devereux TR, Pittman B, You M. Carcinogenic induction directs the selection of allelic losses in mouse lung tumorigenesis. Cancer Res. 2002 Nov 15; 62(22):6424-9.
  View in: PubMed
 
11. Herzog CR. Chk2 meets Plk3 in damage control. Cell Cycle. 2002 Nov-Dec; 1(6):408-9.
  View in: PubMed
 
12. Zhang Z, Wang Y, Herzog CR, Liu G, Lee HW, DePinho RA, You M. A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. Oncogene. 2002 Aug 29; 21(38):5960-6.
  View in: PubMed
 
13. McDoniels-Silvers AL, Herzog CR, Tyson FL, Malkinson AM, You M. Inactivation of both Rb and p53 pathways in mouse lung epithelial cell lines. Exp Lung Res. 2001 Apr-May; 27(3):297-318.
  View in: PubMed
 
14. Herzog CR, Crist KA, Sabourin CL, Kelloff GJ, Boone CW, Stoner GD, You M. Chromosome 3p tumor-suppressor gene alterations in cervical carcinomas. Mol Carcinog. 2001 Mar; 30(3):159-68.
  View in: PubMed
 
15. Herzog CR, Noh S, Lantry LE, Guan KL, You M. Cdkn2a encodes functional variation of p16INK4a but not p19ARF, which confers selection in mouse lung tumorigenesis. Mol Carcinog. 1999 Jun; 25(2):92-8.
  View in: PubMed
 
16. Sabourin CL, Wang QS, Ralston SL, Evans J, Coate J, Herzog CR, Jones SL, Weghorst CM, Kelloff GJ, Lubet RA, You M, Stoner GD. Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors. Exp Lung Res. 1998 Jul-Aug; 24(4):499-521.
  View in: PubMed
 
17. Herzog CR, You M. Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene. Mamm Genome. 1997 Jan; 8(1):65-6.
  View in: PubMed
 
18. Herzog CR, Lubet RA, You M. Genetic alterations in mouse lung tumors: implications for cancer chemoprevention. J Cell Biochem Suppl. 1997; 28-29:49-63.
  View in: PubMed
 
19. Soloff EV, Herzog CR, You M. The 5'-flanking region of the E1 alpha form of the murine p16INK4a (MTS1) gene. Gene. 1996 Nov 21; 180(1-2):213-5.
  View in: PubMed
 
20. Herzog CR, Soloff EV, McDoniels AL, Tyson FL, Malkinson AM, Haugen-Strano A, Wiseman RW, Anderson MW, You M. Homozygous codeletion and differential decreased expression of p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor cells. Oncogene. 1996 Nov 7; 13(9):1885-91.
  View in: PubMed
 
21. Herzog CR, Chen B, Wang Y, Schut HA, You M. Loss of heterozygosity on chromosomes 1, 11, 12, and 14 in hybrid mouse lung adenocarcinomas. Mol Carcinog. 1996 Jun; 16(2):83-90.
  View in: PubMed
 
22. Herzog CR, Wang Y, You M. Allelic loss of distal chromosome 4 in mouse lung tumors localize a putative tumor suppressor gene to a region homologous with human chromosome 1p36. Oncogene. 1995 Nov 2; 11(9):1811-5.
  View in: PubMed
 
23. Herzog CR, Wiseman RW, You M. Deletion mapping of a putative tumor suppressor gene on chromosome 4 in mouse lung tumors. Cancer Res. 1994 Aug 1; 54(15):4007-10.
  View in: PubMed
 
24. Herzog CR, Schut HA, Maronpot RR, You M. ras mutations in 2-amino-3-methylimidazo-[4,5-f]quinoline-induced tumors in the CDF1 mouse. Mol Carcinog. 1993; 8(3):202-7.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Adenocarcinoma
Lung Neoplasms
Carcinogens
Forkhead Transcription Factors
Nitrosamines
See all (144) keywords
Co-Authors  
Amin, Shantu
Desai, Dhimant
Freeman, Willard
Gallagher, Carla
Sun, Yuan-wan
See all (8) people
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