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1.
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Zhang S, Chen H, Webster J, Gerhard GS. Targeting heme for the identification of cytotoxic agents. Anticancer Agents Med Chem. 2013 Mar 1; 13(3):515-22.
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2.
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Kumashiro N, Yoshimura T, Cantley JL, Majumdar SK, Guebre-Egziabher F, Kursawe R, Vatner DF, Fat I, Kahn M, Erion DM, Zhang XM, Zhang D, Manchem VP, Bhanot S, Gerhard GS, Petersen KF, Cline GW, Samuel VT, Shulman GI. Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats. Hepatology. 2013 May; 57(5):1763-72.
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3.
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Cotarlan V, Brofferio A, Gerhard GS, Chu X, Shirani J. Impact of ß(1)- and ß(2)-Adrenergic Receptor Gene Single Nucleotide Polymorphisms on Heart Rate Response to Metoprolol Prior to Coronary Computed Tomographic Angiography. Am J Cardiol. 2013 Mar 1; 111(5):661-6.
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4.
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Zechner JF, Mirshahi UL, Satapati S, Berglund ED, Rossi J, Scott MM, Still CD, Gerhard GS, Burgess SC, Mirshahi T, Aguirre V. Weight-Independent Effects of Roux-en-Y Gastric Bypass on Glucose Homeostasis via Melanocortin-4 Receptors in Mice and Humans. Gastroenterology. 2013 Mar; 144(3):580-590.e7.
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5.
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Liu H, Shi J, Anandan V, Wang HL, Diehl D, Blansfield J, Gerhard G, Lin F. Reevaluation and identification of the best immunohistochemical panel (pVHL, Maspin, S100P, IMP-3) for ductal adenocarcinoma of the pancreas. Arch Pathol Lab Med. 2012 Jun; 136(6):601-9.
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6.
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Wood GC, Chu X, Manney C, Strodel W, Petrick A, Gabrielsen J, Seiler J, Carey D, Argyropoulos G, Benotti P, Still CD, Gerhard GS. An electronic health record-enabled obesity database. BMC Med Inform Decis Mak. 2012; 12:45.
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7.
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Matzko ME, Argyropoulos G, Wood GC, Chu X, McCarter RJ, Still CD, Gerhard GS. Association of ghrelin receptor promoter polymorphisms with weight loss following Roux-en-Y gastric bypass surgery. Obes Surg. 2012 May; 22(5):783-90.
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8.
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Gattu AK, Birkenfeld AL, Jornayvaz F, Dziura J, Li F, Crawford SE, Chu X, Still CD, Gerhard GS, Chung C, Samuel V. Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients. Acta Diabetol. 2012 Dec; 49 Suppl 1:161-9.
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9.
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Liu Z, Lanford R, Mueller S, Gerhard GS, Luscieti S, Sanchez M, Devireddy L. Siderophore-mediated iron trafficking in humans is regulated by iron. J Mol Med (Berl). 2012 Oct; 90(10):1209-21.
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10.
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Mirshahi UL, Still CD, Masker KK, Gerhard GS, Carey DJ, Mirshahi T. The MC4R(I251L) allele is associated with better metabolic status and more weight loss after gastric bypass surgery. J Clin Endocrinol Metab. 2011 Dec; 96(12):E2088-96.
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11.
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Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16381-5.
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12.
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Boscarino JA, Rukstalis MR, Hoffman SN, Han JJ, Erlich PM, Ross S, Gerhard GS, Stewart WF. Prevalence of prescription opioid-use disorder among chronic pain patients: comparison of the DSM-5 vs. DSM-4 diagnostic criteria. J Addict Dis. 2011 Jul-Sep; 30(3):185-94.
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13.
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Hinterseher I, Erdman R, Donoso LA, Vrabec TR, Schworer CM, Lillvis JH, Boddy AM, Derr K, Golden A, Bowen WD, Gatalica Z, Tapinos N, Elmore JR, Franklin DP, Gray JL, Garvin RP, Gerhard GS, Carey DJ, Tromp G, Kuivaniemi H. Role of complement cascade in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2011 Jul; 31(7):1653-60.
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14.
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Still CD, Wood GC, Chu X, Erdman R, Manney CH, Benotti PN, Petrick AT, Strodel WE, Mirshahi UL, Mirshahi T, Carey DJ, Gerhard GS. High allelic burden of four obesity SNPs is associated with poorer weight loss outcomes following gastric bypass surgery. Obesity (Silver Spring). 2011 Aug; 19(8):1676-83.
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15.
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Gerhard GS, Chokshi R, Still CD, Benotti P, Wood GC, Freedman-Weiss M, Rider C, Petrick AT. The influence of iron status and genetic polymorphisms in the HFE gene on the risk for postoperative complications after bariatric surgery: a prospective cohort study in 1,064 patients. Patient Saf Surg. 2011; 5(1):1.
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16.
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Sloane LB, Stout JT, Vandenbergh DJ, Vogler GP, Gerhard GS, McClearn GE. Quantitative trait loci analysis of tail tendon break time in mice of C57BL/6J and DBA/2J lineage. J Gerontol A Biol Sci Med Sci. 2011 Feb; 66(2):170-8.
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17.
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Skelding KA, Gerhard GS, Vlachos H, Selzer F, Kelsey SF, Chu X, Erdman R, Williams DO, Kip KE. Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent. BMC Cardiovasc Disord. 2010; 10:46.
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18.
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Erlich PM, Hoffman SN, Rukstalis M, Han JJ, Chu X, Linda Kao WH, Gerhard GS, Stewart WF, Boscarino JA. Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity. Hum Genet. 2010 Nov; 128(5):491-9.
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19.
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Boscarino JA, Rukstalis M, Hoffman SN, Han JJ, Erlich PM, Gerhard GS, Stewart WF. Risk factors for drug dependence among out-patients on opioid therapy in a large US health-care system. Addiction. 2010 Oct; 105(10):1776-82.
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20.
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Zhang S, Chen H, Gerhard GS. Heme synthesis increases artemisinin-induced radical formation and cytotoxicity that can be suppressed by superoxide scavengers. Chem Biol Interact. 2010 Jun 7; 186(1):30-5.
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21.
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Seaman V, Dearwent SM, Gable D, Lewis B, Metcalf S, Orloff K, Tierney B, Zhu J, Logue J, Marchetto D, Ostroff S, Hoffman R, Xu M, Carey D, Erlich P, Gerhard G, Roda P, Iannuzzo J, Lewis R, Mellow J, Mulvihill L, Myles Z, Wu M, Frank A, Gross-Davis CA, Klotz J, Lynch A, Weissfeld J, Weinberg R, Cole H. A multidisciplinary investigation of a polycythemia vera cancer cluster of unknown origin. Int J Environ Res Public Health. 2010 Mar; 7(3):1139-52.
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22.
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Lang DH, Gerhard GS, Griffith JW, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, Lakoski JM, McClearn GE. Quantitative trait loci (QTL) analysis of longevity in C57BL/6J by DBA/2J (BXD) recombinant inbred mice. Aging Clin Exp Res. 2010 Feb; 22(1):8-19.
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23.
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Benotti PN, Still CD, Wood GC, Akmal Y, King H, El Arousy H, Dancea H, Gerhard GS, Petrick A, Strodel W. Preoperative weight loss before bariatric surgery. Arch Surg. 2009 Dec; 144(12):1150-5.
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24.
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Zhang S, Gerhard GS. Heme mediates cytotoxicity from artemisinin and serves as a general anti-proliferation target. PLoS One. 2009; 4(10):e7472.
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25.
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Samuel VT, Beddow SA, Iwasaki T, Zhang XM, Chu X, Still CD, Gerhard GS, Shulman GI. Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12121-6.
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26.
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Foreman JE, Lionikas A, Lang DH, Gyekis JP, Krishnan M, Sharkey NA, Gerhard GS, Grant MD, Vogler GP, Mack HA, Stout JT, Griffith JW, Lakoski JM, Hofer SM, McClearn GE, Vandenbergh DJ, Blizard DA. Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice. Genes Brain Behav. 2009 Oct; 8(7):714-27.
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27.
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Elmore JR, Obmann MA, Kuivaniemi H, Tromp G, Gerhard GS, Franklin DP, Boddy AM, Carey DJ. Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association. J Vasc Surg. 2009 Jun; 49(6):1525-31.
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28.
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Blizard DA, Lionikas A, Vandenbergh DJ, Vasilopoulos T, Gerhard GS, Griffith JW, Klein LC, Stout JT, Mack HA, Lakoski JM, Larsson L, Spicer JM, Vogler GP, McClearn GE. Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics. 2009 Feb 2; 36(3):158-66.
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29.
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Wood GC, Still CD, Chu X, Susek M, Erdman R, Hartman C, Yeager S, Blosky MA, Krum W, Carey DJ, Skelding KA, Benotti P, Stewart WF, Gerhard GS. Association of chromosome 9p21 SNPs with cardiovascular phenotypes in morbid obesity using electronic health record data. Genomic Med. 2008 Jan; 2(1-2):33-43.
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30.
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Zhang WJ, Li BH, Yang XZ, Li PD, Yuan Q, Liu XH, Xu SB, Zhang Y, Yuan J, Gerhard GS, Masker KK, Dong C, Koltun WA, Chorney MJ. IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells. Cytokine. 2008 Apr; 42(1):39-47.
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31.
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Chu X, Erdman R, Susek M, Gerst H, Derr K, Al-Agha M, Wood GC, Hartman C, Yeager S, Blosky MA, Krum W, Stewart WF, Carey D, Benotti P, Still CD, Gerhard GS. Association of morbid obesity with FTO and INSIG2 allelic variants. Arch Surg. 2008 Mar; 143(3):235-40; discussion 241.
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32.
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Zhang S, Gerhard GS. Heme activates artemisinin more efficiently than hemin, inorganic iron, or hemoglobin. Bioorg Med Chem. 2008 Aug 15; 16(16):7853-61.
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33.
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Kalyanasundaram A, Gerhard GS, Skelding KA. Genomics, haplotypes and cardiovascular disease. Future Cardiol. 2007 Nov; 3(6):601-10.
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34.
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Still CD, Benotti P, Wood GC, Gerhard GS, Petrick A, Reed M, Strodel W. Outcomes of preoperative weight loss in high-risk patients undergoing gastric bypass surgery. Arch Surg. 2007 Oct; 142(10):994-8; discussion 999.
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35.
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Gorman N, Trask HS, Robinson SW, Sinclair JF, Gerhard GS, Smith AG, Sinclair PR. Hexachlorobenzene stimulates uroporphyria in low affinity AHR mice without increasing CYP1A2. Toxicol Appl Pharmacol. 2007 Jun 1; 221(2):235-42.
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36.
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Gerhard GS. Small laboratory fish as models for aging research. Ageing Res Rev. 2007 May; 6(1):64-72.
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37.
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Skelding KA, Gerhard GS, Simari RD, Holmes DR. The effect of HapMap on cardiovascular research and clinical practice. Nat Clin Pract Cardiovasc Med. 2007 Mar; 4(3):136-42.
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38.
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Foreman JE, Blizard DA, Gerhard G, Mack HA, Lang DH, Van Nimwegen KL, Vogler GP, Stout JT, Shihabi ZK, Griffith JW, Lakoski JM, McClearn GE, Vandenbergh DJ. Serum alkaline phosphatase activity is regulated by a chromosomal region containing the alkaline phosphatase 2 gene (Akp2) in C57BL/6J and DBA/2J mice. Physiol Genomics. 2005 Nov 17; 23(3):295-303.
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39.
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Lionikas A, Blizard DA, Gerhard GS, Vandenbergh DJ, Stout JT, Vogler GP, McClearn GE, Larsson L. Genetic determinants of weight of fast- and slow-twitch skeletal muscle in 500-day-old mice of the C57BL/6J and DBA/2J lineage. Physiol Genomics. 2005 Apr 14; 21(2):184-92.
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40.
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Gerhard GS, Chorney MJ. Genes for gestational iron loading? Gastroenterology. 2004 Dec; 127(6):1861; author reply 1861-2.
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41.
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Gorman N, Trask HW, Bement WJ, Szakacs JG, Elder GH, Balestra D, Jacobs NJ, Jacobs JM, Sinclair JF, Gerhard GS, Sinclair PR. Genetic factors influence ethanol-induced uroporphyria in Hfe(-/-) mice. Hepatology. 2004 Oct; 40(4):942-50.
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42.
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Gerhard GS, Malek RL, Keller E, Murtha J, Cheng KC. Zebrafish, killifish, neither fish, both fish? J Gerontol A Biol Sci Med Sci. 2004 Sep; 59(9):B873-5.
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43.
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Malek RL, Sajadi H, Abraham J, Grundy MA, Gerhard GS. The effects of temperature reduction on gene expression and oxidative stress in skeletal muscle from adult zebrafish. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Jul; 138(3):363-73.
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44.
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Grundy MA, Gorman N, Sinclair PR, Chorney MJ, Gerhard GS. High-throughput non-heme iron assay for animal tissues. J Biochem Biophys Methods. 2004 May 31; 59(2):195-200.
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45.
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Gerhard GS, Kasales CJ. Aging and kyphosis. J Gerontol A Biol Sci Med Sci. 2003 Nov; 58(11):968.
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46.
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Gerhard GS. Comparative aspects of zebrafish (Danio rerio) as a model for aging research. Exp Gerontol. 2003 Nov-Dec; 38(11-12):1333-41.
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47.
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Chorney MJ, Yoshida Y, Meyer PN, Yoshida M, Gerhard GS. The enigmatic role of the hemochromatosis protein (HFE) in iron absorption. Trends Mol Med. 2003 Mar; 9(3):118-25.
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48.
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Sinclair PR, Gorman N, Trask HW, Bement WJ, Szakacs JG, Elder GH, Balestra D, Sinclair JF, Gerhard GS. Uroporphyria caused by ethanol in Hfe(-/-) mice as a model for porphyria cutanea tarda. Hepatology. 2003 Feb; 37(2):351-8.
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49.
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Zacharski LR, Gerhard GS. Atherosclerosis: a manifestation of chronic iron toxicity? Vasc Med. 2003; 8(3):153-5.
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50.
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Gerhard GS, Cheng KC. A call to fins! Zebrafish as a gerontological model. Aging Cell. 2002 Dec; 1(2):104-11.
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51.
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Nifong TP, Gerhard GS. Separation of IgG and IgM from albumin in citrated human plasma using electrodialysis and metal ion affinity precipitation. ASAIO J. 2002 Nov-Dec; 48(6):645-9.
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52.
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Meyer PN, Gerhard GS, Yoshida Y, Yoshida M, Chorney KA, Beard J, Kauffman EJ, Weiss G, Chorney MJ. Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway? Blood Cells Mol Dis. 2002 Nov-Dec; 29(3):274-85.
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53.
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Gerhard GS, Kauffman EJ, Wang X, Stewart R, Moore JL, Kasales CJ, Demidenko E, Cheng KC. Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio). Exp Gerontol. 2002 Aug-Sep; 37(8-9):1055-68.
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54.
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Gorman N, Ross KL, Walton HS, Bement WJ, Szakacs JG, Gerhard GS, Dalton TP, Nebert DW, Eisenstein RS, Sinclair JF, Sinclair PR. Uroporphyria in mice: thresholds for hepatic CYP1A2 and iron. Hepatology. 2002 Apr; 35(4):912-21.
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55.
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Gerhard GS, Benko FA, Allen RG, Tresini M, Kalbach A, Cristofalo VJ, Gocke CD. Mitochondrial DNA mutation analysis in human skin fibroblasts from fetal, young, and old donors. Mech Ageing Dev. 2002 Jan; 123(2-3):155-66.
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56.
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Gerhard GS, Kaufmann EJ, Wang X, Erikson KM, Abraham J, Grundy M, Beard JL, Chorney MJ. Genetic differences in hepatic lipid peroxidation potential and iron levels in mice. Mech Ageing Dev. 2002 Jan; 123(2-3):167-76.
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57.
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Gerhard GS, Levin KA, Price Goldstein J, Wojnar MM, Chorney MJ, Belchis DA. Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation. Arch Pathol Lab Med. 2001 Aug; 125(8):1107-9.
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58.
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Sinclair PR, Gorman N, Walton HS, Bement WJ, Sinclair JF, Gerhard GS, Szakacs JG, Andrews NC, Levy JE. Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda. Hepatology. 2001 Feb; 33(2):406-12.
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59.
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Nifong TP, Bongiovanni MB, Gerhard GS. Mathematical modeling and computer simulation of erythrocytapheresis for SCD. Transfusion. 2001 Feb; 41(2):256-63.
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60.
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Gerhard GS, Kauffman EJ, Grundy MA. Molecular cloning and sequence analysis of the Danio rerio catalase gene. Comp Biochem Physiol B Biochem Mol Biol. 2000 Dec; 127(4):447-57.
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61.
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Gerhard GS. Cutting back the calories. Science. 1999 Nov 26; 286(5445):1679-80.
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62.
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Gerhard GS. Inter-strain variation in murine models of leukemia. Blood. 1999 Aug 1; 94(3):1142.
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63.
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Nifong TP, Gerhard GS. Physical determinants of line pressures during apheresis. Transfus Sci. 1999 Jun; 20(3):167-73.
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64.
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Ten Elshof AE, Brittenham GM, Chorney KA, Page MJ, Gerhard G, Cable EE, Chorney MJ. Gamma delta intraepithelial lymphocytes drive tumor necrosis factor-alpha responsiveness to intestinal iron challenge: relevance to hemochromatosis. Immunol Rev. 1999 Feb; 167:223-32.
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65.
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Gerhard GS, Hoffman SM, Williams EC. Coagulation parameters of ABO group-specific cryosupernatant. Am J Clin Pathol. 1998 Apr; 109(4):379-86.
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66.
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Gerhard GS, Ten Elshof AE, Chorney MJ. Hereditary haemochromatosis as an immunological disease. Br J Haematol. 1998 Feb; 100(2):247-55.
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67.
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Allen RG, Keogh BP, Tresini M, Gerhard GS, Volker C, Pignolo RJ, Horton J, Cristofalo VJ. Development and age-associated differences in electron transport potential and consequences for oxidant generation. J Biol Chem. 1997 Oct 3; 272(40):24805-12.
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68.
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Bears L, Gerhard GS, Bongiovanni MB. Loss of red cells from the use of blood warmers during apheresis procedures. J Clin Apher. 1997; 12(3):122-5.
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69.
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Venditti CP, Seese NK, Gerhard GS, Ten Elshof AE, Chorney KA, Mowrey PN, Lacey PG, Knoll JH, Chorney MJ. 46,XX, inv(6)(p21.1p23) in a pedigree with hereditary haemochromatosis. J Med Genet. 1997 Jan; 34(1):24-7.
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70.
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Seese NK, Venditti CP, Chorney KA, Gerhard GS, Ma J, Hudson TJ, Phatak PD, Chorney MJ. Localization of the hemochromatosis disease gene: linkage disequilibrium analysis using an American patient collection. Blood Cells Mol Dis. 1996; 22(1):36-46; discussion 47-8.
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71.
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Beutler E, Gelbart T, West C, Lee P, Adams M, Blackstone R, Pockros P, Kosty M, Venditti CP, Phatak PD, Seese NK, Chorney KA, Ten Elshof AE, Gerhard GS, Chorney M. Mutation analysis in hereditary hemochromatosis. Blood Cells Mol Dis. 1996; 22(2):187-94; discussion 194a-194b.
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72.
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Allen RG, Keogh BP, Gerhard GS, Pignolo R, Horton J, Cristofalo VJ. Expression and regulation of superoxide dismutase activity in human skin fibroblasts from donors of different ages. J Cell Physiol. 1995 Dec; 165(3):576-87.
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73.
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Cristofalo VJ, Gerhard GS, Pignolo RJ. Molecular biology of aging. Surg Clin North Am. 1994 Feb; 74(1):1-21.
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74.
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Gerhard GS, Phillips PD, Cristofalo VJ. EGF- and PDGF-stimulated phosphorylation in young and senescent WI-38 cells. Exp Cell Res. 1991 Mar; 193(1):87-92.
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75.
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Cristofalo VJ, Phillips PD, Sorger T, Gerhard G. Alterations in the responsiveness of senescent cells to growth factors. J Gerontol. 1989 Nov; 44(6):55-62.
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