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Colin Barnstable
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Title Professor
Institution College of Medicine
Department Neural and Behavioral Sciences
Division Neural & Behavioral Science
Address 500 University Drive Hershey PA 17033
 Mailbox: H109
Telephone 7175318652
Email
Background
PREFERRED TITLE/ROLE:

Professor and Chair of Neural and Behavioral Sciences
Professor of Psychiatry
Research Director of Penn State Hershey Eye Center,

GRADUATE PROGRAM AFFILIATIONS:

Anatomy: http://med.psu.edu/web/anatomy/programs
Bioinformatics and Genomics: http://www.huck.psu.edu/education/bioinformatics-and-genomics
Biomedical Sciences: http://www2.med.psu.edu/
Neuroscience: http://www.huck.psu.edu/education/neuroscience

EDUCATION:

B.A., University College, Oxford, UK
M.A., Wolfson College, Oxford, UK
D. Phil., Wolfson College, Oxford, UK
M.A., Yale University, New Haven, CT, USA
Post-doctoral, Harvard Medical School

NARRATIVE:

We are studying the ways in which interacting networks of transcription factors and signal transduction molecules guide the development of precursor/stem cells into mature neurons of the mammalian nervous system. We also study the role of the same networks in neurodegenerative diseases and factors that can act therapeutically as neuroprotective agents.

Using monoclonal antibodies, cDNA probes and controlled tissue culture systems, we have mapped out events that lead to the formation of the separate lineages of retina and retinal pigment epithelium from a homogeneous neuroepithelial sheet during optic cup formation. Subsequent development of the retinal epithelium and the formation of retinal cell types occurs through an interplay of extrinsic and intrinsic factors. We have used genes encoding proteins of the visual transduction system to study the ways in which these factors act to regulate photoreceptor development. The onset of transcription of these genes delineates distinct phases of development that are under different regulatory mechanisms. We have identified important promoter elements in some of these genes using both biochemical methods and analysis in transgenic mice, and have purified the transcription factors with which they interact. Current studies are aimed at understanding how some of these transcription factors themselves are regulated. Through these experiments we are addressing the fundamental question of how the fate of a progenitor cell is directed to the production of specific neural cell types. We have shown that, under specific conditions, activation of STAT3 can block the formation of rod photoreceptors and promote the formation of Mller glial cells - two cell types derived from the late retinal progenitors (Zhang et al. IOVS 45:2407-12, 2004). We have also shown that STAT3 is expressed in neuroepithelial cells and is not found in the photoreceptor layer follow rod generation, suggesting that STAT3 withdrawal is key for rod differentiation (Zhang et al. Exp. Eye Res. 76:421-31, 2003; Zhang et al. Exp. Eye Res. 81:103-15, 2005). We have recently mapped a signaling pathway involving specific protein kinase C isozymes that inactivate STAT3 and promote rod photoreceptor differentiation.

In collaboration with Dr. Samuel Shao-Min Zhang, we are using modern molecular methods to study retinal development at a systems level. In 2001 we initiated and generated a set of expressed sequence tags (ESTs) from a series of mouse retina libraries. About 30,000 clones were sequenced and 12,000 clones collected as a non-redundant EST set. From this we generated a comprehensive mouse retina transcriptome based on 81,000 murine retina transcripts from whole mouse ESTs. About 33,000 sequence-unique retina transcript clusters (RTCs) have been identified and the highest-grade retina-enriched pool covered almost all the known genes in phototransduction processes that are involved in human retinal diseases, suggesting the potential of gene discoveries for human retina disorders (Zhang et al., BMC Genomics 6:40, 2005). We also generated mouse retina specific cDNA microarrays that represent about 10,000 UniGene clusters for studying the biological process of retina development. These arrays have been used to generate a complete developmental expression profile of the 10,000 genes. Looking at shared gene expression profiles and promoter elements of these genes is allowing us to define patterns of regulation that help explain the development of the retina.

Many forms of neurodegeneration involve oxidative stress. Reactive oxygen species are a natural by product of oxidative phosphorylation and this endogenous production by mitochondria lessens the ability of cells to withstand exogenous reactive oxygen species induced by stress or injury. One group of proteins that can regulate reactive oxygen species generation are the mitochondrial uncoupling proteins. We are studying ways in which mitochondrial uncoupling proteins alter developmental cell death and provide protection in both neurons and glia from a variety of neurotoxic insults. Using cells from mice engineered to overexpress or lack uncoupling proteins we have tested how these proteins prevent apoptotic cell death following treatment with various excitotoxins.. We have also tested the range of protection given by enhanced uncoupling protein expression in primate models of Parkinson's disease. (Horvath et al., Endocrinology 144:2757, 2003)

In collaboration with Dr. Joyce Tombran-Tink, we study the mechanisms by which neurotrophic factors protect cells from excitotoxic, oxidative and other insults. Specifically we are examining the transduction pathways activated by PEDF and comparing them with other protective factors such as CNTF, BDNF and GDNF. Rotation students would define active fragments of PEDF that mediate its potent neuroprotective and anti-angiogenic functions and will develop the best of these into new therapeutic agents. (see Tombran-Tink & Barnstable, Nature Reviews Neuroscience 4:628, 2003). PEDF is unique among these factors in that it is also one of the most potent antiangiogenic factors so far identified and we have recently defined the molecular basis of these actions (Barnstable & Tombran-Tink, Prog Ret Eye Res. 23: 561, 2004). We are developing novel therapeutics based on PEDF and are testing their efficacy in animal models of retinal and neurological disease.

The hallmark of glaucoma is death of retinal ganglion cells. We have used a preparation of isolated and purified ganglion cells to study death by excitotoxins such as glutamate and the effects of other molecules, such as arachidonic acid, on glutamate induced cell death. This cell preparation is also being used to test the efficacy of a variety of neuroprotective agents.

The range of causes of the cone photoreceptor loss in Macular Degeneration is not yet known. We recently participated in the study that identified complement Factor H as a major factor in causing this retinal degeneration. Factor H is an important negative regulator of the complement cascade and reduced function might represent excessive activation of the inflammatory system.
Publications
1. Liu Y, Leo LF, McGregor C, Grivitishvili A, Barnstable CJ, Tombran-Tink J. Pigment Epithelium-Derived Factor (PEDF) Peptide Eye Drops Reduce Inflammation, Cell Death and Vascular Leakage in Diabetic Retinopathy in Ins2(Akita) Mice. Mol Med. 2012; 18:1387-401.
  View in: PubMed
 
2. Popova EY, Xu X, Dewan AT, Salzberg AC, Berg A, Hoh J, Zhang SS, Barnstable CJ. Stage and Gene Specific Signatures Defined by Histones H3K4me2 and H3K27me3 Accompany Mammalian Retina Maturation In Vivo. PLoS One. 2012; 7(10):e46867.
  View in: PubMed
 
3. Pinzon-Guzman C, Zhang SS, Barnstable CJ. Specific protein kinase C isoforms are required for rod photoreceptor differentiation. J Neurosci. 2011 Dec 14; 31(50):18606-17.
  View in: PubMed
 
4. Zhang SS, Li H, Huang P, Lou LX, Fu XY, Barnstable CJ. MAPK signaling during Müller glial cell development in retina explant cultures. J Ocul Biol Dis Infor. 2010 Dec; 3(4):129-33.
  View in: PubMed
 
5. Huang P, Zhang C, Wang W, Zhang SM, Barnstable CJ. [Purified mouse retinal ganglion cell culture]. Zhonghua Yan Ke Za Zhi. 2011 Feb; 47(2):129-33.
  View in: PubMed
 
6. Pinzon-Guzman C, Shaomin Zhang S, Barnstable CJ. Protein kinase C regulates rod photoreceptor differentiation through modulation of STAT3 signaling. Adv Exp Med Biol. 2010; 664:21-8.
  View in: PubMed
 
7. Volpert KN, Tombran-Tink J, Barnstable C, Layer PG. PEDF and GDNF are key regulators of photoreceptor development and retinal neurogenesis in reaggregates from chick embryonic retina. J Ocul Biol Dis Infor. 2009; 2(1):1-11.
  View in: PubMed
 
8. Leung KW, Barnstable CJ, Tombran-Tink J. Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling. Mol Immunol. 2009 Apr; 46(7):1374-86.
  View in: PubMed
 
9. Liu MG, Li H, Xu X, Barnstable CJ, Zhang SS. Comparison of gene expression during in vivo and in vitro postnatal retina development. J Ocul Biol Dis Infor. 2008 Dec; 1(2-4):59-72.
  View in: PubMed
 
10. Zhang C, Li H, Liu MG, Kawasaki A, Fu XY, Barnstable CJ, Shao-Min Zhang S. STAT3 activation protects retinal ganglion cell layer neurons in response to stress. Exp Eye Res. 2008 Jun; 86(6):991-7.
  View in: PubMed
 
11. Leung KW, Liu M, Xu X, Seiler MJ, Barnstable CJ, Tombran-Tink J. Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1221-31.
  View in: PubMed
 
12. Dewan A, Liu M, Hartman S, Zhang SS, Liu DT, Zhao C, Tam PO, Chan WM, Lam DS, Snyder M, Barnstable C, Pang CP, Hoh J. HTRA1 promoter polymorphism in wet age-related macular degeneration. Science. 2006 Nov 10; 314(5801):989-92.
  View in: PubMed
 
13. Zhang SS, Xu X, Liu MG, Zhao H, Soares MB, Barnstable CJ, Fu XY. A biphasic pattern of gene expression during mouse retina development. BMC Dev Biol. 2006; 6:48.
  View in: PubMed
 
14. Xu X, Zhang SS, Barnstable CJ, Tombran-Tink J. Molecular phylogeny of the antiangiogenic and neurotrophic serpin, pigment epithelium derived factor in vertebrates. BMC Genomics. 2006; 7:248.
  View in: PubMed
 
15. Chen L, Zhang SS, Barnstable CJ, Tombran-Tink J. PEDF induces apoptosis in human endothelial cells by activating p38 MAP kinase dependent cleavage of multiple caspases. Biochem Biophys Res Commun. 2006 Oct 6; 348(4):1288-95.
  View in: PubMed
 
16. Li H, Tran VV, Hu Y, Mark Saltzman W, Barnstable CJ, Tombran-Tink J. A PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres. Exp Eye Res. 2006 Oct; 83(4):824-33.
  View in: PubMed
 
17. Barnstable CJ, Tombran-Tink J. Molecular mechanisms of neuroprotection in the eye. Adv Exp Med Biol. 2006; 572:291-5.
  View in: PubMed
 
18. Tombran-Tink J, Barnstable CJ. Space flight environment induces degeneration in the retina of rat neonates. Adv Exp Med Biol. 2006; 572:417-24.
  View in: PubMed
 
19. Gehlbach P, Hose S, Lei B, Zhang C, Cano M, Arora M, Neal R, Barnstable C, Goldberg MF, Zigler JS, Sinha D. Developmental abnormalities in the Nuc1 rat retina: a spontaneous mutation that affects neuronal and vascular remodeling and retinal function. Neuroscience. 2006; 137(2):447-61.
  View in: PubMed
 
20. Tombran-Tink J, Aparicio S, Xu X, Tink AR, Lara N, Sawant S, Barnstable CJ, Zhang SS. PEDF and the serpins: phylogeny, sequence conservation, and functional domains. J Struct Biol. 2005 Aug; 151(2):130-50.
  View in: PubMed
 
21. Zhang SS, Liu MG, Kano A, Zhang C, Fu XY, Barnstable CJ. STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferation. Exp Eye Res. 2005 Jul; 81(1):103-15.
  View in: PubMed
 
22. Tombran-Tink J, Barnstable CJ. Space shuttle flight environment induces degeneration in the retina of rat neonates. Gravit Space Biol Bull. 2005 Jun; 18(2):97-8.
  View in: PubMed
 
23. Zhang SS, Xu X, Li J, Liu MG, Zhao H, Soares MB, Barnstable CJ, Fu XY. Comprehensive in silico functional specification of mouse retina transcripts. BMC Genomics. 2005; 6:40.
  View in: PubMed
 
24. Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, SanGiovanni JP, Mane SM, Mayne ST, Bracken MB, Ferris FL, Ott J, Barnstable C, Hoh J. Complement factor H polymorphism in age-related macular degeneration. Science. 2005 Apr 15; 308(5720):385-9.
  View in: PubMed
 
25. Aparicio S, Sawant S, Lara N, Barnstable CJ, Tombran-Tink J. Expression of angiogenesis factors in human umbilical vein endothelial cells and their regulation by PEDF. Biochem Biophys Res Commun. 2005 Jan 14; 326(2):387-94.
  View in: PubMed
 
26. Andrews ZB, Horvath B, Barnstable CJ, Elsworth J, Elseworth J, Yang L, Beal MF, Roth RH, Matthews RT, Horvath TL. Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J Neurosci. 2005 Jan 5; 25(1):184-91.
  View in: PubMed
 
27. Sawant S, Aparicio S, Tink AR, Lara N, Barnstable CJ, Tombran-Tink J. Regulation of factors controlling angiogenesis in liver development: a role for PEDF in the formation and maintenance of normal vasculature. Biochem Biophys Res Commun. 2004 Dec 10; 325(2):408-13.
  View in: PubMed
 
28. Barnstable CJ, Wei JY, Han MH. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochem Int. 2004 Nov; 45(6):875-84.
  View in: PubMed
 
29. Barnstable CJ, Tombran-Tink J. Neuroprotective and antiangiogenic actions of PEDF in the eye: molecular targets and therapeutic potential. Prog Retin Eye Res. 2004 Sep; 23(5):561-77.
  View in: PubMed
 
30. Zhang SS, Wei J, Qin H, Zhang L, Xie B, Hui P, Deisseroth A, Barnstable CJ, Fu XY. STAT3-mediated signaling in the determination of rod photoreceptor cell fate in mouse retina. Invest Ophthalmol Vis Sci. 2004 Jul; 45(7):2407-12.
  View in: PubMed
 
31. Tombran-Tink J, Lara N, Apricio SE, Potluri P, Gee S, Ma JX, Chader G, Barnstable CJ. Retinoic acid and dexamethasone regulate the expression of PEDF in retinal and endothelial cells. Exp Eye Res. 2004 May; 78(5):945-55.
  View in: PubMed
 
32. Tombran-Tink J, Barnstable CJ. Osteoblasts and osteoclasts express PEDF, VEGF-A isoforms, and VEGF receptors: possible mediators of angiogenesis and matrix remodeling in the bone. Biochem Biophys Res Commun. 2004 Apr 2; 316(2):573-9.
  View in: PubMed
 
33. Diano S, Matthews RT, Patrylo P, Yang L, Beal MF, Barnstable CJ, Horvath TL. Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology. 2003 Nov; 144(11):5014-21.
  View in: PubMed
 
34. Tombran-Tink J, Barnstable CJ. PEDF: a multifaceted neurotrophic factor. Nat Rev Neurosci. 2003 Aug; 4(8):628-36.
  View in: PubMed
 
35. Li M, Zhang SS, Barnstable CJ. Developmental and tissue expression patterns of mouse Mpp4 gene. Biochem Biophys Res Commun. 2003 Jul 25; 307(2):229-35.
  View in: PubMed
 
36. Horvath TL, Diano S, Leranth C, Garcia-Segura LM, Cowley MA, Shanabrough M, Elsworth JD, Sotonyi P, Roth RH, Dietrich EH, Matthews RT, Barnstable CJ, Redmond DE. Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology. 2003 Jul; 144(7):2757-60.
  View in: PubMed
 
37. Horvath TL, Diano S, Barnstable C. Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. Biochem Pharmacol. 2003 Jun 15; 65(12):1917-21.
  View in: PubMed
 
38. Tombran-Tink J, Barnstable CJ. Therapeutic prospects for PEDF: more than a promising angiogenesis inhibitor. Trends Mol Med. 2003 Jun; 9(6):244-50.
  View in: PubMed
 
39. Zhang SS, Wei JY, Li C, Barnstable CJ, Fu XY. Expression and activation of STAT proteins during mouse retina development. Exp Eye Res. 2003 Apr; 76(4):421-31.
  View in: PubMed
 
40. Barnstable CJ, Li M, Reddy R, Horvath TL. Mitochondrial uncoupling proteins: regulators of retinal cell death. Adv Exp Med Biol. 2003; 533:269-75.
  View in: PubMed
 
41. Zhang SS, Fu XY, Barnstable CJ. Tissue culture studies of retinal development. Methods. 2002 Dec; 28(4):439-47.
  View in: PubMed
 
42. Zhang SS, Fu XY, Barnstable CJ. Molecular aspects of vertebrate retinal development. Mol Neurobiol. 2002 Oct-Dec; 26(2-3):137-52.
  View in: PubMed
 
43. Kawasaki A, Han MH, Wei JY, Hirata K, Otori Y, Barnstable CJ. Protective effect of arachidonic acid on glutamate neurotoxicity in rat retinal ganglion cells. Invest Ophthalmol Vis Sci. 2002 Jun; 43(6):1835-42.
  View in: PubMed
 
44. Wei JY, Jin X, Cohen ED, Daw NW, Barnstable CJ. cGMP-induced presynaptic depression and postsynaptic facilitation at glutamatergic synapses in visual cortex. Brain Res. 2002 Feb 8; 927(1):42-54.
  View in: PubMed
 
45. Bumsted KM, Rizzolo LJ, Barnstable CJ. Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation. Exp Eye Res. 2001 Sep; 73(3):383-92.
  View in: PubMed
 
46. Han MH, Kawasaki A, Wei JY, Barnstable CJ. Miniature postsynaptic currents depend on Ca2+ released from internal stores via PLC/IP3 pathway. Neuroreport. 2001 Jul 20; 12(10):2203-7.
  View in: PubMed
 
47. Roy DR, Barnstable CJ. Developmental expression of intracellular targets of cGMP in rat visual cortex and alteration with dark rearing. Vis Neurosci. 2001 Jan-Feb; 18(1):109-18.
  View in: PubMed
 
48. Kawasaki A, Otori Y, Barnstable CJ. Müller cell protection of rat retinal ganglion cells from glutamate and nitric oxide neurotoxicity. Invest Ophthalmol Vis Sci. 2000 Oct; 41(11):3444-50.
  View in: PubMed
 
49. Baas D, Bumsted KM, Martinez JA, Vaccarino FM, Wikler KC, Barnstable CJ. The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina. Brain Res Mol Brain Res. 2000 May 31; 78(1-2):26-37.
  View in: PubMed
 
50. Bumsted KM, Barnstable CJ. Dorsal retinal pigment epithelium differentiates as neural retina in the microphthalmia (mi/mi) mouse. Invest Ophthalmol Vis Sci. 2000 Mar; 41(3):903-8.
  View in: PubMed
 
51. Leconte L, Barnstable CJ. Impairment of rod cGMP-gated channel alpha-subunit expression leads to photoreceptor and bipolar cell degeneration. Invest Ophthalmol Vis Sci. 2000 Mar; 41(3):917-26.
  View in: PubMed
 
52. Samanta Roy DR, Barnstable CJ. Temporal and spatial pattern of expression of cyclic nucleotide-gated channels in developing rat visual cortex. Cereb Cortex. 1999 Jun; 9(4):340-7.
  View in: PubMed
 
53. Kingston PA, Zufall F, Barnstable CJ. Widespread expression of olfactory cyclic nucleotide-gated channel genes in rat brain: implications for neuronal signalling. Synapse. 1999 Apr; 32(1):1-12.
  View in: PubMed
 
54. Wei JY, Roy DS, Leconte L, Barnstable CJ. Molecular and pharmacological analysis of cyclic nucleotide-gated channel function in the central nervous system. Prog Neurobiol. 1998 Oct; 56(1):37-64.
  View in: PubMed
 
55. Martinez JA, Barnstable CJ. Erx, a novel retina-specific homeodomain transcription factor, can interact with Ret 1/PCEI sites. Biochem Biophys Res Commun. 1998 Sep 8; 250(1):175-80.
  View in: PubMed
 
56. Chiang RK, Barnstable CJ. Developmental expression of the rat rod photoreceptor cGMP-gated cation channel. Vis Neurosci. 1998 Sep-Oct; 15(5):823-9.
  View in: PubMed
 
57. Baas D, Barnstable CJ. HPC-7: a novel oligodendrocyte lineage protein which appears prior to galactocerebroside. Glia. 1998 Jun; 23(2):169-79.
  View in: PubMed
 
58. Otori Y, Wei JY, Barnstable CJ. Neurotoxic effects of low doses of glutamate on purified rat retinal ganglion cells. Invest Ophthalmol Vis Sci. 1998 May; 39(6):972-81.
  View in: PubMed
 
59. Barnstable CJ. Yoav Citri. J Mol Neurosci. 1998 Apr; 10(2):71-3.
  View in: PubMed
 
60. Wei JY, Cohen ED, Genieser HG, Barnstable CJ. Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel. J Mol Neurosci. 1998 Feb; 10(1):53-64.
  View in: PubMed
 
61. Wei JY, Cohen ED, Barnstable CJ. Direct blockade of both cloned rat rod photoreceptor cyclic nucleotide-gated non-selective cation (CNG) channel alpha-subunit and native CNG channels from Xenopus rod outer segments by H-8, a non-specific cyclic nucleotide-dependent protein kinase inhibitor. Neurosci Lett. 1997 Sep 12; 233(1):37-40.
  View in: PubMed
 
62. Zufall F, Shepherd GM, Barnstable CJ. Cyclic nucleotide gated channels as regulators of CNS development and plasticity. Curr Opin Neurobiol. 1997 Jun; 7(3):404-12.
  View in: PubMed
 
63. Saito Y, Park L, Skolik SA, Alfaro DV, Chaudhry NA, Barnstable CJ, Liggett PE. Experimental preretinal neovascularization by laser-induced venous thrombosis in rats. Curr Eye Res. 1997 Jan; 16(1):26-33.
  View in: PubMed
 
64. Zhao S, Rizzolo LJ, Barnstable CJ. Differentiation and transdifferentiation of the retinal pigment epithelium. Int Rev Cytol. 1997; 171:225-66.
  View in: PubMed
 
65. Wei JY, Cohen ED, Yan YY, Genieser HG, Barnstable CJ. Identification of competitive antagonists of the rod photoreceptor cGMP-gated cation channel: beta-phenyl-1,N2-etheno-substituted cGMP analogues as probes of the cGMP-binding site. Biochemistry. 1996 Dec 24; 35(51):16815-23.
  View in: PubMed
 
66. Kusaka S, Dabin I, Barnstable CJ, Puro DG. cGMP-mediated effects on the physiology of bovine and human retinal Müller (glial) cells. J Physiol. 1996 Dec 15; 497 ( Pt 3):813-24.
  View in: PubMed
 
67. Yu X, Leconte L, Martinez JA, Barnstable CJ. Ret 1, a cis-acting element of the rat opsin promoter, can direct gene expression in rod photoreceptors. J Neurochem. 1996 Dec; 67(6):2494-504.
  View in: PubMed
 
68. Kingston PA, Zufall F, Barnstable CJ. Rat hippocampal neurons express genes for both rod retinal and olfactory cyclic nucleotide-gated channels: novel targets for cAMP/cGMP function. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10440-5.
  View in: PubMed
 
69. Zhao S, Barnstable CJ. Differential effects of bFGF on development of the rat retina. Brain Res. 1996 Jun 3; 723(1-2):169-76.
  View in: PubMed
 
70. Liu CJ, Chaturvedi N, Barnstable CJ, Dreyer EB. Retinal Thy-1 expression during development. Invest Ophthalmol Vis Sci. 1996 Jun; 37(7):1469-73.
  View in: PubMed
 
71. Dreyer EB, Leifer D, Heng JE, McConnell JE, Gorla M, Levin LA, Barnstable CJ, Lipton SA. An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):11195-9.
  View in: PubMed
 
72. Leinders-Zufall T, Rosenboom H, Barnstable CJ, Shepherd GM, Zufall F. A calcium-permeable cGMP-activated cation conductance in hippocampal neurons. Neuroreport. 1995 Sep 11; 6(13):1761-5.
  View in: PubMed
 
73. Dabin I, Barnstable CJ. Rat retinal Müller cells express Thy-1 following neuronal cell death. Glia. 1995 May; 14(1):23-32.
  View in: PubMed
 
74. Zhao S, Thornquist SC, Barnstable CJ. In vitro transdifferentiation of embryonic rat retinal pigment epithelium to neural retina. Brain Res. 1995 Apr 24; 677(2):300-10.
  View in: PubMed
 
75. Christmas NJ, Skolik SA, Howard MA, Saito Y, Barnstable CJ, Liggett PE. Treatment of retinal breaks with autologous serum in an experimental model. Ophthalmology. 1995 Feb; 102(2):263-71.
  View in: PubMed
 
76. Barnstable CJ. Isolation and characterization of the alpha-subunit of the rat rod photoreceptor cGMP-gated cation channel. J Mol Neurosci. 1995; 6(4):289-302.
  View in: PubMed
 
77. Castillo B, del Cerro M, Breakefield XO, Frim DM, Barnstable CJ, Dean DO, Bohn MC. Retinal ganglion cell survival is promoted by genetically modified astrocytes designed to secrete brain-derived neurotrophic factor (BDNF). Brain Res. 1994 May 30; 647(1):30-6.
  View in: PubMed
 
78. Ahmad I, Yu X, Barnstable CJ. A cis-acting element, T alpha-1, in the upstream region of rod alpha-transducin gene that binds a developmentally regulated retina-specific nuclear factor. J Neurochem. 1994 Jan; 62(1):396-9.
  View in: PubMed
 
79. Ahmad I, Leinders-Zufall T, Kocsis JD, Shepherd GM, Zufall F, Barnstable CJ. Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron. 1994 Jan; 12(1):155-65.
  View in: PubMed
 
80. Yu X, Barnstable CJ. Characterization and regulation of the protein binding to a cis-acting element, RET 1, in the rat opsin promoter. J Mol Neurosci. 1994-1995; 5(4):259-71.
  View in: PubMed
 
81. Barnstable CJ, Morabito MA. Isolation and coding sequence of the rat rod opsin gene. J Mol Neurosci. 1994; 5(3):207-9.
  View in: PubMed
 
82. Sheedlo HJ, Li L, Barnstable CJ, Turner JE. Synaptic and photoreceptor components in retinal pigment epithelial cell transplanted retinas of Royal College of Surgeons dystrophic rats. J Neurosci Res. 1993 Nov 1; 36(4):423-31.
  View in: PubMed
 
83. Barnstable CJ. Glutamate and GABA in retinal circuitry. Curr Opin Neurobiol. 1993 Aug; 3(4):520-5.
  View in: PubMed
 
84. Yu X, Chung M, Morabito MA, Barnstable CJ. Shared nuclear protein binding sites in the upstream region of the rat opsin gene. Biochem Biophys Res Commun. 1993 Feb 26; 191(1):76-82.
  View in: PubMed
 
85. Neill JM, Thornquist SC, Raymond MC, Thompson JT, Barnstable CJ. RET-PE10: a 61 kD polypeptide epitope expressed late during vertebrate RPE maturation. Invest Ophthalmol Vis Sci. 1993 Feb; 34(2):453-62.
  View in: PubMed
 
86. Barnstable CJ. Cyclic nucleotide-gated nonselective cation channels: a multifunctional gene family. EXS. 1993; 66:121-33.
  View in: PubMed
 
87. Korbmacher C, Barnstable CJ. Renal epithelial cells show nonselective cation channel activity and express a gene related to the cGMP-gated photoreceptor channel. EXS. 1993; 66:147-64.
  View in: PubMed
 
88. Ahmad I, Barnstable CJ. Differential laminar expression of particulate and soluble guanylate cyclase genes in rat retina. Exp Eye Res. 1993 Jan; 56(1):51-62.
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89. Ahmad I, Korbmacher C, Segal AS, Cheung P, Boulpaep EL, Barnstable CJ. Mouse cortical collecting duct cells show nonselective cation channel activity and express a gene related to the cGMP-gated rod photoreceptor channel. Proc Natl Acad Sci U S A. 1992 Nov 1; 89(21):10262-6.
  View in: PubMed
 
90. Lipton SA, Leifer D, Barnstable CJ. Selectivity of Thy-1 monoclonal antibodies in enhancing neurite outgrowth. Neurosci Lett. 1992 Mar 16; 137(1):75-7.
  View in: PubMed
 
91. Barnstable CJ, Kosaka T, Naegele JR, Arimatsu Y. Molecular properties of GABAergic local-circuit neurons in the mammalian visual cortex. Prog Brain Res. 1992; 90:503-22.
  View in: PubMed
 
92. Naegele JR, Barnstable CJ. A carbohydrate epitope defined by monoclonal antibody VC1.1 is found on N-CAM and other cell adhesion molecules. Brain Res. 1991 Sep 13; 559(1):118-29.
  View in: PubMed
 
93. Morabito MA, Yu X, Barnstable CJ. Characterization of developmentally regulated and retina-specific nuclear protein binding to a site in the upstream region of the rat opsin gene. J Biol Chem. 1991 May 25; 266(15):9667-72.
  View in: PubMed
 
94. Naegele JR, Barnstable CJ, Wahle PR. Expression of a unique 56-kDa polypeptide by neurons in the subplate zone of the developing cerebral cortex. Proc Natl Acad Sci U S A. 1991 Jan 15; 88(2):330-4.
  View in: PubMed
 
95. Ahmad I, Redmond LJ, Barnstable CJ. Developmental and tissue-specific expression of the rod photoreceptor cGMP-gated ion channel gene. Biochem Biophys Res Commun. 1990 Nov 30; 173(1):463-70.
  View in: PubMed
 
96. Neill JM, Barnstable CJ. Expression of the cell surface antigens RET-PE2 and N-CAM by rat retinal pigment epithelial cells during development and in tissue culture. Exp Eye Res. 1990 Nov; 51(5):573-83.
  View in: PubMed
 
97. Zaremba S, Naegele JR, Barnstable CJ, Hockfield S. Neuronal subsets express multiple high-molecular-weight cell-surface glycoconjugates defined by monoclonal antibodies Cat-301 and VC1.1. J Neurosci. 1990 Sep; 10(9):2985-95.
  View in: PubMed
 
98. Sparrow JR, Hicks D, Barnstable CJ. Cell commitment and differentiation in explants of embryonic rat neural retina. Comparison with the developmental potential of dissociated retina. Brain Res Dev Brain Res. 1990 Jan 1; 51(1):69-84.
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99. Kosaka T, Isogai K, Barnstable CJ, Heizmann CW. Monoclonal antibody HNK-1 selectively stains a subpopulation of GABAergic neurons containing the calcium-binding protein parvalbumin in the rat cerebral cortex. Exp Brain Res. 1990; 82(3):566-74.
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100. Devoto SH, Barnstable CJ. Expression of the growth cone specific epitope CDA 1 and the synaptic vesicle protein SVP38 in the developing mammalian cerebral cortex. J Comp Neurol. 1989 Dec 1; 290(1):154-68.
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101. Hicks D, Sparrow J, Barnstable CJ. Immunoelectron microscopical examination of the surface distribution of opsin in rat rod photoreceptor cells. Exp Eye Res. 1989 Jul; 49(1):13-29.
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102. Kosaka T, Heizmann CW, Barnstable CJ. Monoclonal antibody VC1.1 selectively stains a population of GABAergic neurons containing the calcium-binding protein parvalbumin in the rat cerebral cortex. Exp Brain Res. 1989; 78(1):43-50.
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103. Naegele JR, Barnstable CJ. Molecular determinants of GABAergic local-circuit neurons in the visual cortex. Trends Neurosci. 1989 Jan; 12(1):28-34.
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104. Sparrow JR, Barnstable CJ. A gradient molecule in developing rat retina: expression of 9-O-acetyl GD3 in relation to cell type, developmental age, and GD3 ganglioside. J Neurosci Res. 1988 Oct-Dec; 21(2-4):398-409.
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105. Silver R, Witkovsky P, Horvath P, Alones V, Barnstable CJ, Lehman MN. Coexpression of opsin- and VIP-like-immunoreactivity in CSF-contacting neurons of the avian brain. Cell Tissue Res. 1988 Jul; 253(1):189-98.
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106. Treisman JE, Morabito MA, Barnstable CJ. Opsin expression in the rat retina is developmentally regulated by transcriptional activation. Mol Cell Biol. 1988 Apr; 8(4):1570-9.
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107. Mendez-Otero R, Schlosshauer B, Barnstable CJ, Constantine-Paton M. A developmentally regulated antigen associated with neural cell and process migration. J Neurosci. 1988 Feb; 8(2):564-79.
  View in: PubMed
 
108. Schlosshauer B, Blum AS, Mendez-Otero R, Barnstable CJ, Constantine-Paton M. Developmental regulation of ganglioside antigens recognized by the JONES antibody. J Neurosci. 1988 Feb; 8(2):580-92.
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109. Naegele JR, Arimatsu Y, Schwartz P, Barnstable CJ. Selective staining of a subset of GABAergic neurons in cat visual cortex by monoclonal antibody VC1.1. J Neurosci. 1988 Jan; 8(1):79-89.
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110. Barnstable CJ, Blum AS, Devoto SH, Hicks D, Morabito MA, Sparrow JR, Treisman JE. Cell differentiation and pattern formation in the developing mammalian retina. Neurosci Res Suppl. 1988; 8:S27-41.
  View in: PubMed
 
111. Akagawa K, Hicks D, Barnstable CJ. Histiotypic organization and cell differentiation in rat retinal reaggregate cultures. Brain Res. 1987 Dec 29; 437(2):298-308.
  View in: PubMed
 
112. Barnstable CJ. Immunological studies of the diversity and development of the mammalian visual system. Immunol Rev. 1987 Dec; 100:47-78.
  View in: PubMed
 
113. Blum AS, Barnstable CJ. O-acetylation of a cell-surface carbohydrate creates discrete molecular patterns during neural development. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8716-20.
  View in: PubMed
 
114. Hicks D, Barnstable CJ. Different rhodopsin monoclonal antibodies reveal different binding patterns on developing and adult rat retina. J Histochem Cytochem. 1987 Nov; 35(11):1317-28.
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115. Hicks D, Barnstable CJ. A phosphorylation-sensitive anti-rhodopsin monoclonal antibody reveals light-induced phosphorylation of rhodopsin in the photoreceptor cell body. Eur J Cell Biol. 1987 Oct; 44(2):341-7.
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116. Akagawa K, Barnstable CJ. Identification and characterisation of cell types accumulating GABA in rat retinal cultures using cell type specific monoclonal antibodies. Brain Res. 1987 Apr 7; 408(1-2):154-62.
  View in: PubMed
 
117. Barnstable CJ. A molecular view of vertebrate retinal development. Mol Neurobiol. 1987 Spring-Summer; 1(1-2):9-46.
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118. Arimatsu Y, Naegele JR, Barnstable CJ. Molecular markers of neuronal subpopulations in layers 4, 5, and 6 of cat primary visual cortex. J Neurosci. 1987 Apr; 7(4):1250-63.
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119. Akagawa K, Barnstable CJ. Selective localization of glycine-accumulating cells in reaggregate culture of rat retina. Brain Res. 1987 Jan; 428(1):124-8.
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120. Constantine-Paton M, Blum AS, Mendez-Otero R, Barnstable CJ. A cell surface molecule distributed in a dorsoventral gradient in the perinatal rat retina. Nature. 1986 Dec 4-10; 324(6096):459-62.
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121. Akagawa K, Barnstable CJ. Identification and characterization of cell types in monolayer cultures of rat retina using monoclonal antibodies. Brain Res. 1986 Sep 24; 383(1-2):110-20.
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122. Barnstable CJ. Clues about glues in development. Nature. 1986 Jun 19-25; 321(6072):731-2.
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123. Hicks D, Barnstable CJ. Lectin and antibody labelling of developing rat photoreceptor cells: an electron microscope immunocytochemical study. J Neurocytol. 1986 Apr; 15(2):219-30.
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124. Barnstable CJ, Hofstein R, Akagawa K. A marker of early amacrine cell development in rat retina. Brain Res. 1985 Jun; 352(2):286-90.
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125. Dräger UC, Edwards DL, Barnstable CJ. Antibodies against filamentous components in discrete cell types of the mouse retina. J Neurosci. 1984 Aug; 4(8):2025-42.
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126. Leifer D, Lipton SA, Barnstable CJ, Masland RH. Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture. Science. 1984 Apr 20; 224(4646):303-6.
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127. Barnstable CJ, Dräger UC. Thy-1 antigen: a ganglion cell specific marker in rodent retina. Neuroscience. 1984 Apr; 11(4):847-55.
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128. MacLeish PR, Barnstable CJ, Townes-Anderson E. Use of a monoclonal antibody as a substrate for mature neurons in vitro. Proc Natl Acad Sci U S A. 1983 Nov; 80(22):7014-8.
  View in: PubMed
 
129. Barnstable C, Jessell T, Sanes J, Stevens C, Robertson M. How molecular is neurobiology? Nature. 1983 Nov 3-9; 306(5938):14-6.
  View in: PubMed
 
130. Fekete DM, Barnstable CJ. The subcellular localization of rat photoreceptor-specific antigens. J Neurocytol. 1983 Oct; 12(5):785-803.
  View in: PubMed
 
131. Barnstable CJ, Akagawa K, Hofstein R, Horn JP. Monoclonal antibodies that label discrete cell types in the mammalian nervous system. Cold Spring Harb Symp Quant Biol. 1983; 48 Pt 2:863-76.
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132. Barnstable CJ. Molecular heterogeneity and the nervous system. Nature. 1982 Aug 19; 298(5876):708-9.
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133. Gozes I, Barnstable CJ. Monoclonal antibodies that recognize discrete forms of tubulin. Proc Natl Acad Sci U S A. 1982 Apr; 79(8):2579-83.
  View in: PubMed
 
134. Barnstable CJ. A gradient of membrane protein in the retina. Nature. 1981 Jul 2; 292(5818):13-4.
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135. Barnstable CJ. Monoclonal antibodies which recognize different cell types in the rat retina. Nature. 1980 Jul 17; 286(5770):231-5.
  View in: PubMed
 
136. Barnstable CJ, Snary D, Crumpton MJ, Balner H, Bodmer WF. Antisera recognising HLA-A, -B and DRW antigens raised in rhesus monkeys. Tissue Antigens. 1980 May; 15(5):407-18.
  View in: PubMed
 
137. Parham P, Barnstable CJ, Bodmer WF. Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C, antigens. J Immunol. 1979 Jul; 123(1):342-9.
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138. Barnstable CJ, Snary D, Crumpton MJ, Bodmer WF. The structure and evolution of the HLA--Bw4 and Bw6 antigens. Tissue Antigens. 1979 May; 13(5):334-41.
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139. Brodsky FM, Parham P, Barnstable CJ, Crumpton MJ, Bodmer WF. Monoclonal antibodies for analysis of the HLA system. Immunol Rev. 1979; 47:3-61.
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140. Brown G, Joshua DE, Bastin J, Mason DY, Barnstable CJ. Monoclonal antibodies to human cell surface antigens. Haematol Blood Transfus. 1979; 23:365-8.
  View in: PubMed
 
141. Barnstable CJ, Jones EA, Crumpton MJ. Isolation, structure and genetics of HLA-A, -B, -C and -DRw (Ia) antigens. Br Med Bull. 1978 Sep; 34(3):241-6.
  View in: PubMed
 
142. Crumpton MJ, Snary D, Walsh FS, Barnstable CJ, Goodfellow PN, Jones EA, Bodmer WF. Molecular structure of the gene products of the human HLA system: isolation and characterization of HLA-A, -B, -C and Ia antigens. Proc R Soc Lond B Biol Sci. 1978 Jun 5; 202(1146):159-75.
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143. Bodmer WF, Jones EA, Barnstable CJ, Bodmer JG. Genetics HLA: the major human histocompatibility system. Proc R Soc Lond B Biol Sci. 1978 Jun 5; 202(1146):93-116.
  View in: PubMed
 
144. Barnstable CJ, Bodmer WF, Brown G, Galfre G, Milstein C, Williams AF, Ziegler A. Production of monoclonal antibodies to group A erythrocytes, HLA and other human cell surface antigens-new tools for genetic analysis. Cell. 1978 May; 14(1):9-20.
  View in: PubMed
 
145. Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF. The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin. Tissue Antigens. 1978 Feb; 11(2):96-112.
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146. Snary D, Barnstable CJ, Bodmer WF, Crumpton MJ. Molecular structure of human histocompatibility antigens: the HLA-C series. Eur J Immunol. 1977 Aug; 7(8):580-5.
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147. Bodmer J, Young D, Jones E, Barnstable C, Goodfellow P, Bodmer W, Svejgaard A, Thomsen M, Trucco M, Curtoni ES, Festenstein H, Sachs J. Serologic characterization of human Ia antigens using B-cell lymphoid lines. Transplant Proc. 1977 Mar; 9(1 Suppl 1):121-6.
  View in: PubMed
 
148. Snary D, Barnstable CJ, Bodmer WF, Goodfellow PN, Crumpton MJ. Cellular distrubtion, purification, and molecular nature of human Ia antigens. Scand J Immunol. 1977; 6(5):439-52.
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149. Barnstable CJ, Jones EA, Bodmer WF, Bodmer JG, Arce-Gomez B, Snary D, Crumpton MJ. Genetics and serology of HL-A-linked human Ia antigens. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 2:443-55.
  View in: PubMed
 
150. Snary D, Barnstable C, Bodmer WF, Goodfellow P, Crumpton MJ. Human Ia antigens--purification and molecular structure. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 1:379-86.
  View in: PubMed
 
151. Goodfellow PN, Barnstable CJ, Bodmer WF, Snary D, Crumpton MJ. Expression of HLA system antigens on placenta. Transplantation. 1976 Dec; 22(6):595-603.
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152. Goodfellow P, Barnstable C, Jones E, Bodmer WF, Crumpton MJ, Snary D. Production of specific antisera to human B lymphocytes. Tissue Antigens. 1976 Feb; 7(2):105-17.
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Keyword
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Keywords   
Retina
Ion Channels
Eye Proteins
Retinal Rod Photoreceptor Cells
Retinal Ganglion Cells
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Co-Authors  
Berg, Arthur
Popova, Evgenya
Tombran-Tink, Joyce
Zhang, Samuel
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