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1.
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Zhang Z, Zheng Y, Petukh M, Pegg A, Ikeguchi Y, Alexov E. Enhancing human spermine synthase activity by engineered mutations. PLoS Comput Biol. 2013 Feb; 9(2):e1002924.
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2.
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Koomoa DL, Geerts D, Lange I, Koster J, Pegg AE, Feith DJ, Bachmann AS. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. Int J Oncol. 2013 Apr; 42(4):1219-28.
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3.
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Feith DJ, Pegg AE, Fong LY. Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. Carcinogenesis. 2013 Mar; 34(3):570-6.
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4.
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Yamazaki K, Ikeguchi Y, Niwa T, Hayashi K, Iwaki T, Ishii I, Niitsu M, Pegg AE, Shirahata A. Determination of cellular aminopropyltransferase activity using precolumn fluorescent etheno-derivatization with high-performance liquid chromatography. Anal Sci. 2012; 28(6):621-4.
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5.
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Kotandeniya D, Murphy D, Seneviratne U, Guza R, Pegg A, Kanugula S, Tretyakova N. Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. Chem Res Toxicol. 2011 Nov 21; 24(11):1966-75.
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6.
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Seckute J, McCloskey DE, Thomas HJ, Secrist JA, Pegg AE, Ealick SE. Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine. Protein Sci. 2011 Nov; 20(11):1836-44.
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7.
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Giordano E, Hillary RA, Vary TC, Pegg AE, Sumner AD, Caldarera CM, Zhang XQ, Song J, Wang J, Cheung JY, Shantz LM. Overexpression of ornithine decarboxylase decreases ventricular systolic function during induction of cardiac hypertrophy. Amino Acids. 2012 Feb; 42(2-3):507-18.
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8.
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Ishii I, Ikeguchi Y, Mano H, Wada M, Pegg AE, Shirahata A. Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino Acids. 2012 Feb; 42(2-3):619-26.
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9.
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Shi C, Welsh PA, Sass-Kuhn S, Wang X, McCloskey DE, Pegg AE, Feith DJ. Characterization of transgenic mice with overexpression of spermidine synthase. Amino Acids. 2012 Feb; 42(2-3):495-505.
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10.
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Green R, Hanfrey CC, Elliott KA, McCloskey DE, Wang X, Kanugula S, Pegg AE, Michael AJ. Independent evolutionary origins of functional polyamine biosynthetic enzyme fusions catalysing de novo diamine to triamine formation. Mol Microbiol. 2011 Aug; 81(4):1109-24.
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11.
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Pegg AE. Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools. Chem Res Toxicol. 2011 May 16; 24(5):618-39.
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12.
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Lee SB, Park JH, Folk JE, Deck JA, Pegg AE, Sokabe M, Fraser CS, Park MH. Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1). Biochem J. 2011 Jan 1; 433(1):205-13.
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13.
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Pegg AE, Wang X, Schwartz CE, McCloskey DE. Spermine synthase activity affects the content of decarboxylated S-adenosylmethionine. Biochem J. 2011 Jan 1; 433(1):139-44.
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14.
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Pegg AE, Casero RA. Current status of the polyamine research field. Methods Mol Biol. 2011; 720:3-35.
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15.
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Wang X, Pegg AE. Use of (Gyro) Gy and spermine synthase transgenic mice to study functions of spermine. Methods Mol Biol. 2011; 720:159-70.
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16.
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Schwartz CE, Wang X, Stevenson RE, Pegg AE. Spermine synthase deficiency resulting in X-linked intellectual disability (Snyder-Robinson syndrome). Methods Mol Biol. 2011; 720:437-45.
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17.
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Saiki R, Park H, Ishii I, Yoshida M, Nishimura K, Toida T, Tatsukawa H, Kojima S, Ikeguchi Y, Pegg AE, Kashiwagi K, Igarashi K. Brain infarction correlates more closely with acrolein than with reactive oxygen species. Biochem Biophys Res Commun. 2011 Jan 28; 404(4):1044-9.
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18.
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Chuk MK, Cole DE, McCully C, Loktionova NA, Pegg AE, Parker RJ, Pauly G, Widemann BC, Balis FM, Fox E. Plasma and CNS pharmacokinetics of O4-benzylfolic acid (O4BF) and metabolite in a non-human primate model. Cancer Chemother Pharmacol. 2011 Jun; 67(6):1291-7.
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19.
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McManus FP, Fang Q, Booth JD, Noronha AM, Pegg AE, Wilds CJ. Synthesis and characterization of an O(6)-2'-deoxyguanosine-alkyl-O(6)-2'-deoxyguanosine interstrand cross-link in a 5'-GNC motif and repair by human O(6)-alkylguanine-DNA alkyltransferase. Org Biomol Chem. 2010 Oct 7; 8(19):4414-26.
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20.
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Geerts D, Koster J, Albert D, Koomoa DL, Feith DJ, Pegg AE, Volckmann R, Caron H, Versteeg R, Bachmann AS. The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. Int J Cancer. 2010 May 1; 126(9):2012-24.
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21.
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Aramini JM, Tubbs JL, Kanugula S, Rossi P, Ertekin A, Maglaqui M, Hamilton K, Ciccosanti CT, Jiang M, Xiao R, Soong TT, Rost B, Acton TB, Everett JK, Pegg AE, Tainer JA, Montelione GT. Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein. J Biol Chem. 2010 Apr 30; 285(18):13736-41.
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22.
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Bale S, Baba K, McCloskey DE, Pegg AE, Ealick SE. Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity. Acta Crystallogr D Biol Crystallogr. 2010 Feb; 66(Pt 2):181-9.
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23.
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Fang Q, Kanugula S, Tubbs JL, Tainer JA, Pegg AE. Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases. J Biol Chem. 2010 Mar 12; 285(11):8185-95.
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24.
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Kalapila AG, Pegg AE. Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells. Mutat Res. 2010 Feb 3; 684(1-2):35-42.
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25.
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Pegg AE. S-Adenosylmethionine decarboxylase. Essays Biochem. 2009; 46:25-45.
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26.
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Pegg AE, Michael AJ. Spermine synthase. Cell Mol Life Sci. 2010 Jan; 67(1):113-21.
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27.
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Pegg AE. Mammalian polyamine metabolism and function. IUBMB Life. 2009 Sep; 61(9):880-94.
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28.
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Li L, Perdigao J, Pegg AE, Lao Y, Hecht SS, Lindgren BR, Reardon JT, Sancar A, Wattenberg EV, Peterson LA. The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines. Chem Res Toxicol. 2009 Aug; 22(8):1464-72.
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29.
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Casero RA, Pegg AE. Polyamine catabolism and disease. Biochem J. 2009 Aug 1; 421(3):323-38.
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30.
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Koomoa DL, Borsics T, Feith DJ, Coleman CC, Wallick CJ, Gamper I, Pegg AE, Bachmann AS. Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma. Mol Cancer Ther. 2009 Jul; 8(7):2067-75.
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31.
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Kalapila AG, Loktionova NA, Pegg AE. Effect of O6-alkylguanine-DNA alkyltransferase on genotoxicity of epihalohydrins. Environ Mol Mutagen. 2009 Jul; 50(6):502-14.
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32.
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Guza R, Ma L, Fang Q, Pegg AE, Tretyakova N. Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides. J Biol Chem. 2009 Aug 21; 284(34):22601-10.
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33.
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Tubbs JL, Latypov V, Kanugula S, Butt A, Melikishvili M, Kraehenbuehl R, Fleck O, Marriott A, Watson AJ, Verbeek B, McGown G, Thorncroft M, Santibanez-Koref MF, Millington C, Arvai AS, Kroeger MD, Peterson LA, Williams DM, Fried MG, Margison GP, Pegg AE, Tainer JA. Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature. 2009 Jun 11; 459(7248):808-13.
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34.
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Pegg AE, Wang X. Mouse models to investigate the function of spermine. Commun Integr Biol. 2009 May; 2(3):271-4.
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35.
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Adams CA, Melikishvili M, Rodgers DW, Rasimas JJ, Pegg AE, Fried MG. Topologies of complexes containing O6-alkylguanine-DNA alkyltransferase and DNA. J Mol Biol. 2009 Jun 5; 389(2):248-63.
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36.
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McCloskey DE, Bale S, Secrist JA, Tiwari A, Moss TH, Valiyaveettil J, Brooks WH, Guida WC, Pegg AE, Ealick SE. New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine. J Med Chem. 2009 Mar 12; 52(5):1388-407.
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37.
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Becerra-Solano LE, Butler J, Castañeda-Cisneros G, McCloskey DE, Wang X, Pegg AE, Schwartz CE, Sánchez-Corona J, GarcÃa-Ortiz JE. A missense mutation, p.V132G, in the X-linked spermine synthase gene (SMS) causes Snyder-Robinson syndrome. Am J Med Genet A. 2009 Mar; 149A(3):328-35.
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38.
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Melikishvili M, Rasimas JJ, Pegg AE, Fried MG. Interactions of human O(6)-alkylguanine-DNA alkyltransferase (AGT) with short double-stranded DNAs. Biochemistry. 2008 Dec 30; 47(52):13754-63.
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39.
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Bale S, Lopez MM, Makhatadze GI, Fang Q, Pegg AE, Ealick SE. Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase. Biochemistry. 2008 Dec 16; 47(50):13404-17.
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40.
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Philip S, Swaminathan S, Kuznetsov SG, Kanugula S, Biswas K, Chang S, Loktionova NA, Haines DC, Kaldis P, Pegg AE, Sharan SK. Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. Cancer Res. 2008 Dec 1; 68(23):9973-81.
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41.
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Pauly GT, Loktionova NA, Fang Q, Vankayala SL, Guida WC, Pegg AE. Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. J Med Chem. 2008 Nov 27; 51(22):7144-53.
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42.
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Wang X, Levic S, Gratton MA, Doyle KJ, Yamoah EN, Pegg AE. Spermine synthase deficiency leads to deafness and a profound sensitivity to alpha-difluoromethylornithine. J Biol Chem. 2009 Jan 9; 284(2):930-7.
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43.
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Fang Q, Noronha AM, Murphy SP, Wilds CJ, Tubbs JL, Tainer JA, Chowdhury G, Guengerich FP, Pegg AE. Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 2008 Oct 14; 47(41):10892-903.
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44.
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Kalapila AG, Loktionova NA, Pegg AE. Alkyltransferase-mediated toxicity of 1,3-butadiene diepoxide. Chem Res Toxicol. 2008 Sep; 21(9):1851-61.
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45.
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de Alencastro G, McCloskey DE, Kliemann SE, Maranduba CM, Pegg AE, Wang X, Bertola DR, Schwartz CE, Passos-Bueno MR, Sertié AL. New SMS mutation leads to a striking reduction in spermine synthase protein function and a severe form of Snyder-Robinson X-linked recessive mental retardation syndrome. J Med Genet. 2008 Aug; 45(8):539-43.
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46.
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deHart GW, Jin T, McCloskey DE, Pegg AE, Sheppard D. The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel. Proc Natl Acad Sci U S A. 2008 May 20; 105(20):7188-93.
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47.
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Wu H, Min J, Zeng H, McCloskey DE, Ikeguchi Y, Loppnau P, Michael AJ, Pegg AE, Plotnikov AN. Crystal structure of human spermine synthase: implications of substrate binding and catalytic mechanism. J Biol Chem. 2008 Jun 6; 283(23):16135-46.
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48.
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Soriano EV, McCloskey DE, Kinsland C, Pegg AE, Ealick SE. Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii. Acta Crystallogr D Biol Crystallogr. 2008 Apr; 64(Pt 4):377-82.
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49.
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Pegg AE. Spermidine/spermine-N(1)-acetyltransferase: a key metabolic regulator. Am J Physiol Endocrinol Metab. 2008 Jun; 294(6):E995-1010.
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50.
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Loeber R, Michaelson E, Fang Q, Campbell C, Pegg AE, Tretyakova N. Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. Chem Res Toxicol. 2008 Apr; 21(4):787-95.
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51.
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Mumenthaler SM, Yu H, Tze S, Cederbaum SD, Pegg AE, Seligson DB, Grody WW. Expression of arginase II in prostate cancer. Int J Oncol. 2008 Feb; 32(2):357-65.
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52.
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Coulter R, Blandino M, Tomlinson JM, Pauly GT, Krajewska M, Moschel RC, Peterson LA, Pegg AE, Spratt TE. Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase. Chem Res Toxicol. 2007 Dec; 20(12):1966-71.
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53.
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Fang Q, Loktionova NA, Moschel RC, Javanmard S, Pauly GT, Pegg AE. Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase. Biochem Pharmacol. 2008 Feb 1; 75(3):618-26.
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54.
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Javanmard S, Loktionova NA, Fang Q, Pauly GT, Pegg AE, Moschel RC. Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine. J Med Chem. 2007 Oct 18; 50(21):5193-201.
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55.
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Deignan JL, Livesay JC, Shantz LM, Pegg AE, O'Brien WE, Iyer RK, Cederbaum SD, Grody WW. Polyamine homeostasis in arginase knockout mice. Am J Physiol Cell Physiol. 2007 Oct; 293(4):C1296-301.
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56.
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Brooks WH, McCloskey DE, Daniel KG, Ealick SE, Secrist JA, Waud WR, Pegg AE, Guida WC. In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase. J Chem Inf Model. 2007 Sep-Oct; 47(5):1897-905.
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57.
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Wang X, Feith DJ, Welsh P, Coleman CS, Lopez C, Woster PM, O'Brien TG, Pegg AE. Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis. Carcinogenesis. 2007 Nov; 28(11):2404-11.
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58.
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Wu H, Min J, Ikeguchi Y, Zeng H, Dong A, Loppnau P, Pegg AE, Plotnikov AN. Structure and mechanism of spermidine synthases. Biochemistry. 2007 Jul 17; 46(28):8331-9.
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59.
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Feith DJ, Shantz LM, Shoop PL, Keefer KA, Prakashagowda C, Pegg AE. Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds. Mol Carcinog. 2007 Jun; 46(6):453-65.
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60.
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Pegg AE, Fang Q, Loktionova NA. Human variants of O6-alkylguanine-DNA alkyltransferase. DNA Repair (Amst). 2007 Aug 1; 6(8):1071-8.
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61.
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Hansen RJ, Ludeman SM, Paikoff SJ, Pegg AE, Dolan ME. Role of MGMT in protecting against cyclophosphamide-induced toxicity in cells and animals. DNA Repair (Amst). 2007 Aug 1; 6(8):1145-54.
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62.
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Tubbs JL, Pegg AE, Tainer JA. DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy. DNA Repair (Amst). 2007 Aug 1; 6(8):1100-15.
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63.
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Pegg AE, Feith DJ. Polyamines and neoplastic growth. Biochem Soc Trans. 2007 Apr; 35(Pt 2):295-9.
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64.
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Rider JE, Hacker A, Mackintosh CA, Pegg AE, Woster PM, Casero RA. Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide. Amino Acids. 2007 Aug; 33(2):231-40.
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65.
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Liu L, Watanabe K, Fang Q, Williams KM, Guengerich FP, Pegg AE. Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane. Chem Res Toxicol. 2007 Jan; 20(1):155-63.
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66.
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Rasimas JJ, Kar SR, Pegg AE, Fried MG. Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short single-stranded DNAs. J Biol Chem. 2007 Feb 2; 282(5):3357-66.
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67.
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Mijal RS, Kanugula S, Vu CC, Fang Q, Pegg AE, Peterson LA. DNA sequence context affects repair of the tobacco-specific adduct O(6)-[4-Oxo-4-(3-pyridyl)butyl]guanine by human O(6)-alkylguanine-DNA alkyltransferases. Cancer Res. 2006 May 1; 66(9):4968-74.
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68.
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Loeber R, Rajesh M, Fang Q, Pegg AE, Tretyakova N. Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane. Chem Res Toxicol. 2006 May; 19(5):645-54.
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69.
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Guza R, Rajesh M, Fang Q, Pegg AE, Tretyakova N. Kinetics of O(6)-methyl-2'-deoxyguanosine repair by O(6)-alkylguanine DNA alkyltransferase within K-ras gene-derived DNA sequences. Chem Res Toxicol. 2006 Apr; 19(4):531-8.
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70.
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Pegg AE. Regulation of ornithine decarboxylase. J Biol Chem. 2006 May 26; 281(21):14529-32.
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71.
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Bewley MC, Graziano V, Jiang J, Matz E, Studier FW, Pegg AE, Coleman CS, Flanagan JM. Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2063-8.
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72.
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Nisenberg O, Pegg AE, Welsh PA, Keefer K, Shantz LM. Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice. Biochem J. 2006 Jan 1; 393(Pt 1):295-302.
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73.
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Ikeguchi Y, Bewley MC, Pegg AE. Aminopropyltransferases: function, structure and genetics. J Biochem. 2006 Jan; 139(1):1-9.
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74.
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Fontes AM, Davis BM, Encell LP, Lingas K, Covas DT, Zago MA, Loeb LA, Pegg AE, Gerson SL. Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol Cancer Ther. 2006 Jan; 5(1):121-8.
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75.
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Fang Q, Kanugula S, Pegg AE. Function of domains of human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 2005 Nov 22; 44(46):15396-405.
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76.
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Quinn JA, Desjardins A, Weingart J, Brem H, Dolan ME, Delaney SM, Vredenburgh J, Rich J, Friedman AH, Reardon DA, Sampson JH, Pegg AE, Moschel RC, Birch R, McLendon RE, Provenzale JM, Gururangan S, Dancey JE, Maxwell J, Tourt-Uhlig S, Herndon JE, Bigner DD, Friedman HS. Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol. 2005 Oct 1; 23(28):7178-87.
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77.
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Mijal RS, Loktionova NA, Vu CC, Pegg AE, Peterson LA. O6-pyridyloxobutylguanine adducts contribute to the mutagenic properties of pyridyloxobutylating agents. Chem Res Toxicol. 2005 Oct; 18(10):1619-25.
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78.
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Wallick CJ, Gamper I, Thorne M, Feith DJ, Takasaki KY, Wilson SM, Seki JA, Pegg AE, Byus CV, Bachmann AS. Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells. Oncogene. 2005 Aug 25; 24(36):5606-18.
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79.
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Zang H, Fang Q, Pegg AE, Guengerich FP. Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase. J Biol Chem. 2005 Sep 2; 280(35):30873-81.
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80.
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Marverti G, Giuseppina Monti M, Pegg AE, McCloskey DE, Bettuzzi S, Ligabue A, Caporali A, D'Arca D, Moruzzi MS. Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin. Carcinogenesis. 2005 Oct; 26(10):1677-86.
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81.
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Kanugula S, Pauly GT, Moschel RC, Pegg AE. A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities. Proc Natl Acad Sci U S A. 2005 Mar 8; 102(10):3617-22.
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82.
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Ackermann JM, Kanugula S, Pegg AE. DNAzyme-mediated silencing of ornithine decarboxylase. Biochemistry. 2005 Feb 15; 44(6):2143-52.
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83.
|
Wei G, Loktionova NA, Pegg AE, Moschel RC. Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine. J Med Chem. 2005 Jan 13; 48(1):256-61.
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84.
|
Thomson NM, Mijal RS, Ziegel R, Fleischer NL, Pegg AE, Tretyakova NY, Peterson LA. Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]-2'-deoxyguanosine. Chem Res Toxicol. 2004 Dec; 17(12):1600-6.
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85.
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Coleman CS, Stanley BA, Jones AD, Pegg AE. Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. Biochem J. 2004 Nov 15; 384(Pt 1):139-48.
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86.
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Levin VA, Jochec JL, Shantz LM, Koch PE, Pegg AE. Tissue-based assay for ornithine decarboxylase to identify patients likely to respond to difluoromethylornithine. J Histochem Cytochem. 2004 Nov; 52(11):1467-74.
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87.
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Chen C, Young BA, Coleman CS, Pegg AE, Sheppard D. Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. J Cell Biol. 2004 Oct 11; 167(1):161-70.
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88.
|
Wang X, Ikeguchi Y, McCloskey DE, Nelson P, Pegg AE. Spermine synthesis is required for normal viability, growth, and fertility in the mouse. J Biol Chem. 2004 Dec 3; 279(49):51370-5.
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|
|
|
|
89.
|
Tantini B, Pignatti C, Fattori M, Fiumana E, Facchini A, Stefanelli C, Caldarera CM, Pegg AE, Flamigni F. Polyamine depletion inhibits etoposide-induced NF-kappaB activation in transformed mouse fibroblasts. Amino Acids. 2004 Oct; 27(2):207-14.
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|
|
|
|
90.
|
Bacolod MD, Johnson SP, Pegg AE, Dolan ME, Moschel RC, Bullock NS, Fang Q, Colvin OM, Modrich P, Bigner DD, Friedman HS. Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations. Mol Cancer Ther. 2004 Sep; 3(9):1127-35.
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|
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|
|
91.
|
Choi U, DeRavin SS, Yamashita K, Whiting-Theobald N, Linton GF, Loktionova NA, Pegg AE, Malech HL. Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker. Exp Hematol. 2004 Aug; 32(8):709-19.
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|
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|
|
92.
|
Ikeguchi Y, Wang X, McCloskey DE, Coleman CS, Nelson P, Hu G, Shantz LM, Pegg AE. Characterization of transgenic mice with widespread overexpression of spermine synthase. Biochem J. 2004 Aug 1; 381(Pt 3):701-7.
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|
|
|
|
93.
|
Nelson ME, Loktionova NA, Pegg AE, Moschel RC. 2-amino-O4-benzylpteridine derivatives: potent inactivators of O6-alkylguanine-DNA alkyltransferase. J Med Chem. 2004 Jul 15; 47(15):3887-91.
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|
|
|
|
94.
|
Valadez JG, Liu L, Loktionova NA, Pegg AE, Guengerich FP. Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase. Chem Res Toxicol. 2004 Jul; 17(7):972-82.
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|
|
|
|
95.
|
Daniels DS, Woo TT, Luu KX, Noll DM, Clarke ND, Pegg AE, Tainer JA. DNA binding and nucleotide flipping by the human DNA repair protein AGT. Nat Struct Mol Biol. 2004 Aug; 11(8):714-20.
|
|
|
|
|
96.
|
Shah R, Coleman CS, Mir K, Baldwin J, Van Etten JL, Grishin NV, Pegg AE, Stanley BA, Phillips MA. Paramecium bursaria chlorella virus-1 encodes an unusual arginine decarboxylase that is a close homolog of eukaryotic ornithine decarboxylases. J Biol Chem. 2004 Aug 20; 279(34):35760-7.
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|
|
|
|
97.
|
Liu L, Williams KM, Guengerich FP, Pegg AE. O6-alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate. Chem Res Toxicol. 2004 Jun; 17(6):742-52.
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|
|
|
|
98.
|
Toms AV, Kinsland C, McCloskey DE, Pegg AE, Ealick SE. Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase. J Biol Chem. 2004 Aug 6; 279(32):33837-46.
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|
|
|
|
99.
|
Gabrielson E, Tully E, Hacker A, Pegg AE, Davidson NE, Casero RA. Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine. Cancer Chemother Pharmacol. 2004 Aug; 54(2):122-6.
|
|
|
|
|
100.
|
Coleman CS, Hu G, Pegg AE. Putrescine biosynthesis in mammalian tissues. Biochem J. 2004 May 1; 379(Pt 3):849-55.
|
|
|
|
|
101.
|
Mijal RS, Thomson NM, Fleischer NL, Pauly GT, Moschel RC, Kanugula S, Fang Q, Pegg AE, Peterson LA. The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants. Chem Res Toxicol. 2004 Mar; 17(3):424-34.
|
|
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|
|
102.
|
Tang X, Kim AL, Feith DJ, Pegg AE, Russo J, Zhang H, Aszterbaum M, Kopelovich L, Epstein EH, Bickers DR, Athar M. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. J Clin Invest. 2004 Mar; 113(6):867-75.
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|
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|
|
103.
|
Rasimas JJ, Dalessio PA, Ropson IJ, Pegg AE, Fried MG. Active-site alkylation destabilizes human O6-alkylguanine DNA alkyltransferase. Protein Sci. 2004 Jan; 13(1):301-5.
|
|
|
|
|
104.
|
Cason AL, Ikeguchi Y, Skinner C, Wood TC, Holden KR, Lubs HA, Martinez F, Simensen RJ, Stevenson RE, Pegg AE, Schwartz CE. X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet. 2003 Dec; 11(12):937-44.
|
|
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|
|
105.
|
Liu L, Hachey DL, Valadez G, Williams KM, Guengerich FP, Loktionova NA, Kanugula S, Pegg AE. Characterization of a mutagenic DNA adduct formed from 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. J Biol Chem. 2004 Feb 6; 279(6):4250-9.
|
|
|
|
|
106.
|
Meyer AS, McCain MD, Fang Q, Pegg AE, Spratt TE. O6-alkylguanine-DNA alkyltransferases repair O6-methylguanine in DNA with Michaelis-Menten-like kinetics. Chem Res Toxicol. 2003 Nov; 16(11):1405-9.
|
|
|
|
|
107.
|
Kanugula S, Pegg AE. Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus. Biochem J. 2003 Oct 15; 375(Pt 2):449-55.
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|
|
|
|
108.
|
Guengerich FP, Fang Q, Liu L, Hachey DL, Pegg AE. O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145. Biochemistry. 2003 Sep 23; 42(37):10965-70.
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|
|
|
|
109.
|
Kokkinakis DM, Ahmed MM, Chendil D, Moschel RC, Pegg AE. Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine. Clin Cancer Res. 2003 Sep 1; 9(10 Pt 1):3801-7.
|
|
|
|
|
110.
|
Ikeguchi Y, Mackintosh CA, McCloskey DE, Pegg AE. Effect of spermine synthase on the sensitivity of cells to anti-tumour agents. Biochem J. 2003 Aug 1; 373(Pt 3):885-92.
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|
|
|
|
111.
|
Fong LY, Feith DJ, Pegg AE. Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. Cancer Res. 2003 Jul 15; 63(14):3945-54.
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|
|
|
|
112.
|
Hillary RA, Pegg AE. Decarboxylases involved in polyamine biosynthesis and their inactivation by nitric oxide. Biochim Biophys Acta. 2003 Apr 11; 1647(1-2):161-6.
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|
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|
|
113.
|
Pegg AE, Feith DJ, Fong LY, Coleman CS, O'Brien TG, Shantz LM. Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth. Biochem Soc Trans. 2003 Apr; 31(2):356-60.
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|
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|
|
114.
|
Tolbert WD, Zhang Y, Cottet SE, Bennett EM, Ekstrom JL, Pegg AE, Ealick SE. Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant. Biochemistry. 2003 Mar 4; 42(8):2386-95.
|
|
|
|
|
115.
|
McCloskey DE, Pegg AE. Properties of the spermidine/spermine N1-acetyltransferase mutant L156F that decreases cellular sensitivity to the polyamine analogue N1, N11-bis(ethyl)norspermine. J Biol Chem. 2003 Apr 18; 278(16):13881-7.
|
|
|
|
|
116.
|
Rasimas JJ, Kanugula S, Dalessio PM, Ropson IJ, Fried MG, Pegg AE. Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 2003 Feb 4; 42(4):980-90.
|
|
|
|
|
117.
|
Ackermann JM, Pegg AE, McCloskey DE. Drugs affecting the cell cycle via actions on the polyamine metabolic pathway. Prog Cell Cycle Res. 2003; 5:461-8.
|
|
|
|
|
118.
|
Rasimas JJ, Pegg AE, Fried MG. DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase. Effects of protein and DNA alkylation on complex stability. J Biol Chem. 2003 Mar 7; 278(10):7973-80.
|
|
|
|
|
119.
|
Bennett EM, Ekstrom JL, Pegg AE, Ealick SE. Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation. Biochemistry. 2002 Dec 10; 41(49):14509-17.
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|
|
|
|
120.
|
Stefanelli C, Tantini B, Fattori M, Stanic' I, Pignatti C, Clo C, Guarnieri C, Caldarera CM, Mackintosh CA, Pegg AE, Flamigni F. Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion. FEBS Lett. 2002 Sep 11; 527(1-3):223-28.
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|
|
|
|
121.
|
Friedman HS, Keir S, Pegg AE, Houghton PJ, Colvin OM, Moschel RC, Bigner DD, Dolan ME. O6-benzylguanine-mediated enhancement of chemotherapy. Mol Cancer Ther. 2002 Sep; 1(11):943-8.
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|
|
|
|
122.
|
Liu L, Pegg AE, Williams KM, Guengerich FP. Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase. J Biol Chem. 2002 Oct 4; 277(40):37920-8.
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|
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|
|
123.
|
Luu KX, Kanugula S, Pegg AE, Pauly GT, Moschel RC. Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase. Biochemistry. 2002 Jul 9; 41(27):8689-97.
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|
|
|
|
124.
|
Liu L, Xu-Welliver M, Kanugula S, Pegg AE. Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide. Cancer Res. 2002 Jun 1; 62(11):3037-43.
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|
|
|
|
125.
|
Xu-Welliver M, Pegg AE. Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase. Carcinogenesis. 2002 May; 23(5):823-30.
|
|
|
|
|
126.
|
Quinn JA, Pluda J, Dolan ME, Delaney S, Kaplan R, Rich JN, Friedman AH, Reardon DA, Sampson JH, Colvin OM, Haglund MM, Pegg AE, Moschel RC, McLendon RE, Provenzale JM, Gururangan S, Tourt-Uhlig S, Herndon JE, Bigner DD, Friedman HS. Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. J Clin Oncol. 2002 May 1; 20(9):2277-83.
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|
|
|
|
127.
|
Loktionova NA, Pegg AE. Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine. Biochem Pharmacol. 2002 Apr 15; 63(8):1431-42.
|
|
|
|
|
128.
|
Shantz LM, Guo Y, Sawicki JA, Pegg AE, O'Brien TG. Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation. Carcinogenesis. 2002 Apr; 23(4):657-64.
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|
|
|
|
129.
|
Coleman CS, Pegg AE, Megosh LC, Guo Y, Sawicki JA, O'Brien TG. Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis. Carcinogenesis. 2002 Feb; 23(2):359-64.
|
|
|
|
|
130.
|
Korolev S, Ikeguchi Y, Skarina T, Beasley S, Arrowsmith C, Edwards A, Joachimiak A, Pegg AE, Savchenko A. The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor. Nat Struct Biol. 2002 Jan; 9(1):27-31.
|
|
|
|
|
131.
|
Shantz LM, Feith DJ, Pegg AE. Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy. Biochem J. 2001 Aug 15; 358(Pt 1):25-32.
|
|
|
|
|
132.
|
Coleman CS, Pegg AE. Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation. Biochem J. 2001 Aug 15; 358(Pt 1):137-45.
|
|
|
|
|
133.
|
Feith DJ, Shantz LM, Pegg AE. Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. Cancer Res. 2001 Aug 15; 61(16):6073-81.
|
|
|
|
|
134.
|
Tolbert WD, Ekstrom JL, Mathews II, Secrist JA, Kapoor P, Pegg AE, Ealick SE. The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase. Biochemistry. 2001 Aug 14; 40(32):9484-94.
|
|
|
|
|
135.
|
Ekstrom JL, Tolbert WD, Xiong H, Pegg AE, Ealick SE. Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant. Biochemistry. 2001 Aug 14; 40(32):9495-504.
|
|
|
|
|
136.
|
Bauer PM, Buga GM, Fukuto JM, Pegg AE, Ignarro LJ. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. J Biol Chem. 2001 Sep 14; 276(37):34458-64.
|
|
|
|
|
137.
|
Stefanelli C, Pignatti C, Tantini B, Fattori M, Stanic I, Mackintosh CA, Flamigni F, Guarnieri C, Caldarera CM, Pegg AE. Effect of polyamine depletion on caspase activation: a study with spermine synthase-deficient cells. Biochem J. 2001 Apr 1; 355(Pt 1):199-206.
|
|
|
|
|
138.
|
Fong LY, Nguyen VT, Pegg AE, Magee PN. Alpha-difluoromethylornithine induction of apoptosis: a mechanism which reverses pre-established cell proliferation and cancer initiation in esophageal carcinogenesis in zinc-deficient rats. Cancer Epidemiol Biomarkers Prev. 2001 Mar; 10(3):191-9.
|
|
|
|
|
139.
|
Pegg AE, Goodtzova K, Loktionova NA, Kanugula S, Pauly GT, Moschel RC. Inactivation of human O(6)-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O(6)-benzylguanine. J Pharmacol Exp Ther. 2001 Mar; 296(3):958-65.
|
|
|
|
|
140.
|
Kokkinakis DM, Bocangel DB, Schold SC, Moschel RC, Pegg AE. Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide. Clin Cancer Res. 2001 Feb; 7(2):421-8.
|
|
|
|
|
141.
|
Pourquier P, Waltman JL, Urasaki Y, Loktionova NA, Pegg AE, Nitiss JL, Pommier Y. Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine. Cancer Res. 2001 Jan 1; 61(1):53-8.
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|
|
|
|
142.
|
Kanugula S, Pegg AE. Novel DNA repair alkyltransferase from Caenorhabditis elegans. Environ Mol Mutagen. 2001; 38(2-3):235-43.
|
|
|
|
|
143.
|
Griffin RJ, Arris CE, Bleasdale C, Boyle FT, Calvert AH, Curtin NJ, Dalby C, Kanugula S, Lembicz NK, Newell DR, Pegg AE, Golding BT. Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine. J Med Chem. 2000 Nov 2; 43(22):4071-83.
|
|
|
|
|
144.
|
Lopatin AN, Shantz LM, Mackintosh CA, Nichols CG, Pegg AE. Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis. J Mol Cell Cardiol. 2000 Nov; 32(11):2007-24.
|
|
|
|
|
145.
|
Mackintosh CA, Pegg AE. Effect of spermine synthase deficiency on polyamine biosynthesis and content in mice and embryonic fibroblasts, and the sensitivity of fibroblasts to 1,3-bis-(2-chloroethyl)-N-nitrosourea. Biochem J. 2000 Oct 15; 351 Pt 2:439-47.
|
|
|
|
|
146.
|
Friedman HS, Pluda J, Quinn JA, Ewesuedo RB, Long L, Friedman AH, Cokgor I, Colvin OM, Haglund MM, Ashley DM, Rich JN, Sampson J, Pegg AE, Moschel RC, McLendon RE, Provenzale JM, Stewart ES, Tourt-Uhlig S, Garcia-Turner AM, Herndon JE, Bigner DD, Dolan ME. Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol. 2000 Oct 15; 18(20):3522-8.
|
|
|
|
|
147.
|
Cai Y, Wu MH, Xu-Welliver M, Pegg AE, Ludeman SM, Dolan ME. Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases. Cancer Res. 2000 Oct 1; 60(19):5464-9.
|
|
|
|
|
148.
|
Patel VJ, Elion GB, Houghton PJ, Keir S, Pegg AE, Johnson SP, Dolan ME, Bigner DD, Friedman HS. Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft. Clin Cancer Res. 2000 Oct; 6(10):4154-7.
|
|
|
|
|
149.
|
McCloskey DE, Pegg AE. Altered spermidine/spermine N1-acetyltransferase activity as a mechanism of cellular resistance to bis(ethyl)polyamine analogues. J Biol Chem. 2000 Sep 15; 275(37):28708-14.
|
|
|
|
|
150.
|
Mackintosh CA, Feith DJ, Shantz LM, Pegg AE. Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy. Biochem J. 2000 Sep 15; 350 Pt 3:645-53.
|
|
|
|
|
151.
|
Ragg S, Xu-Welliver M, Bailey J, D'Souza M, Cooper R, Chandra S, Seshadri R, Pegg AE, Williams DA. Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells. Cancer Res. 2000 Sep 15; 60(18):5187-95.
|
|
|
|
|
152.
|
Liu H, Xu-Welliver M, Pegg AE. The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli. Mutat Res. 2000 Jul 20; 452(1):1-10.
|
|
|
|
|
153.
|
Williams DA, Maze R, Kurpad C, Pegg A, Erickson LC. Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase. Bone Marrow Transplant. 2000 May; 25 Suppl 2:S105-9.
|
|
|
|
|
154.
|
Xu-Welliver M, Pegg AE. Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine. Biochem J. 2000 Apr 15; 347(Pt 2):519-26.
|
|
|
|
|
155.
|
Xu-Welliver M, Kanugula S, Loktionova NA, Crone TM, Pegg AE. Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine. Biochem J. 2000 Apr 15; 347(Pt 2):527-34.
|
|
|
|
|
156.
|
Daniels DS, Mol CD, Arvai AS, Kanugula S, Pegg AE, Tainer JA. Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding. EMBO J. 2000 Apr 3; 19(7):1719-30.
|
|
|
|
|
157.
|
Pegg AE. Repair of O(6)-alkylguanine by alkyltransferases. Mutat Res. 2000 Apr; 462(2-3):83-100.
|
|
|
|
|
158.
|
Olmo MT, Urdiales JL, Pegg AE, Medina MA, Sánchez-Jiménez F. In vitro study of proteolytic degradation of rat histidine decarboxylase. Eur J Biochem. 2000 Mar; 267(5):1527-31.
|
|
|
|
|
159.
|
Wibley JE, Pegg AE, Moody PC. Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase. Nucleic Acids Res. 2000 Jan 15; 28(2):393-401.
|
|
|
|
|
160.
|
Kokkinakis DM, Moschel RC, Pegg AE, Schold SC. Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism. Cancer Chemother Pharmacol. 2000; 45(1):69-77.
|
|
|
|
|
161.
|
Keir ST, Dolan ME, Pegg AE, Lawless A, Moschel RC, Bigner DD, Friedman HS. O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials. Cancer Chemother Pharmacol. 2000; 45(6):437-40.
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|
|
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|
162.
|
Xiong H, Pegg AE. Mechanistic studies of the processing of human S-adenosylmethionine decarboxylase proenzyme. Isolation of an ester intermediate. J Biol Chem. 1999 Dec 3; 274(49):35059-66.
|
|
|
|
|
163.
|
Nutt CL, Loktionova NA, Pegg AE, Chambers AF, Cairncross JG. O(6)-methylguanine-DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes. Carcinogenesis. 1999 Dec; 20(12):2361-5.
|
|
|
|
|
164.
|
Davis BM, Roth JC, Liu L, Xu-Welliver M, Pegg AE, Gerson SL. Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy. Hum Gene Ther. 1999 Nov 20; 10(17):2769-78.
|
|
|
|
|
165.
|
Kokkinakis DM, Moschel RC, Pegg AE, Schold SC. Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea. Clin Cancer Res. 1999 Nov; 5(11):3676-81.
|
|
|
|
|
166.
|
Xu-Welliver M, Leitão J, Kanugula S, Meehan WJ, Pegg AE. Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine. Biochem Pharmacol. 1999 Oct 15; 58(8):1279-85.
|
|
|
|
|
167.
|
Wada M, Amano D, Hosoda H, Shirahata A, Samejima K, Pegg AE. Primary structure of rat spermidine synthase: an example of refining the cDNA-derived amino acid sequence. Biol Pharm Bull. 1999 Sep; 22(9):889-95.
|
|
|
|
|
168.
|
Maze R, Kurpad C, Pegg AE, Erickson LC, Williams DA. Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment. J Pharmacol Exp Ther. 1999 Sep; 290(3):1467-74.
|
|
|
|
|
169.
|
Bauer PM, Fukuto JM, Buga GM, Pegg AE, Ignarro LJ. Nitric oxide inhibits ornithine decarboxylase by S-nitrosylation. Biochem Biophys Res Commun. 1999 Aug 27; 262(2):355-8.
|
|
|
|
|
170.
|
Loktionova NA, Xu-Welliver M, Crone TM, Kanugula S, Pegg AE. Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine. Biochem Pharmacol. 1999 Jul 15; 58(2):237-44.
|
|
|
|
|
171.
|
Gabrielson EW, Pegg AE, Casero RA. The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine. Clin Cancer Res. 1999 Jul; 5(7):1638-41.
|
|
|
|
|
172.
|
Spratt TE, Wu JD, Levy DE, Kanugula S, Pegg AE. Reaction and binding of oligodeoxynucleotides containing analogues of O6-methylguanine with wild-type and mutant human O6-alkylguanine-DNA alkyltransferase. Biochemistry. 1999 May 25; 38(21):6801-6.
|
|
|
|
|
173.
|
Ekstrom JL, Mathews II, Stanley BA, Pegg AE, Ealick SE. The crystal structure of human S-adenosylmethionine decarboxylase at 2.25 A resolution reveals a novel fold. Structure. 1999 May; 7(5):583-95.
|
|
|
|
|
174.
|
Xu-Welliver M, Leitão J, Kanugula S, Pegg AE. Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine. Cancer Res. 1999 Apr 1; 59(7):1514-9.
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175.
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McCloskey DE, Coleman CS, Pegg AE. Properties and regulation of human spermidine/spermine N1-acetyltransferase stably expressed in Chinese hamster ovary cells. J Biol Chem. 1999 Mar 5; 274(10):6175-82.
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176.
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Gerson SL, Schupp J, Liu L, Pegg AE, Srinivasen S. Leukocyte O6-alkylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O6-benzylguanine. Clin Cancer Res. 1999 Mar; 5(3):521-4.
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177.
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Xiong H, Stanley BA, Pegg AE. Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase. Biochemistry. 1999 Feb 23; 38(8):2462-70.
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178.
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Wang L, Spratt TE, Pegg AE, Peterson LA. Synthesis of DNA oligonucleotides containing site-specifically incorporated O6-[4-oxo-4-(3-pyridyl)butyl]guanine and their reaction with O6-alkylguanine-DNA alkyltransferase. Chem Res Toxicol. 1999 Feb; 12(2):127-31.
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179.
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Shantz LM, Pegg AE. Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway. Int J Biochem Cell Biol. 1999 Jan; 31(1):107-22.
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180.
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Friedman HS, Pegg AE, Johnson SP, Loktionova NA, Dolan ME, Modrich P, Moschel RC, Struck R, Brent TP, Ludeman S, Bullock N, Kilborn C, Keir S, Dong Q, Bigner DD, Colvin OM. Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase. Cancer Chemother Pharmacol. 1999; 43(1):80-5.
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181.
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Edara S, Kanugula S, Pegg AE. Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis. 1999 Jan; 20(1):103-8.
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182.
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Pegg AE. DNA repair pathways and cancer prevention. Adv Exp Med Biol. 1999; 472:253-67.
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183.
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Fong LY, Pegg AE, Magee PN. Alpha-difluoromethylornithine inhibits N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in zinc-deficient rats: effects on esophageal cell proliferation and apoptosis. Cancer Res. 1998 Dec 1; 58(23):5380-8.
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184.
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Pegg AE, Xiong H, Feith DJ, Shantz LM. S-adenosylmethionine decarboxylase: structure, function and regulation by polyamines. Biochem Soc Trans. 1998 Nov; 26(4):580-6.
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185.
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Friedman HS, Kokkinakis DM, Pluda J, Friedman AH, Cokgor I, Haglund MM, Ashley DM, Rich J, Dolan ME, Pegg AE, Moschel RC, McLendon RE, Kerby T, Herndon JE, Bigner DD, Schold SC. Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma. J Clin Oncol. 1998 Nov; 16(11):3570-5.
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186.
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Goodtzova K, Kanugula S, Edara S, Pegg AE. Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase. Biochemistry. 1998 Sep 8; 37(36):12489-95.
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187.
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Matés JM, del Valle AE, Urdiales JL, Coleman CS, Feith D, Olmo MT, Pegg AE, Sánchez-Jiménez F. Structure/function relationship studies on the T/S residues 173-177 of rat ODC. Biochim Biophys Acta. 1998 Jul 28; 1386(1):113-20.
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188.
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Shantz LM, Pegg AE. Ornithine decarboxylase induction in transformation by H-Ras and RhoA. Cancer Res. 1998 Jul 1; 58(13):2748-53.
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189.
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Vora RA, Pegg AE, Ealick SE. A new model for how O6-methylguanine-DNA methyltransferase binds DNA. Proteins. 1998 Jul 1; 32(1):3-6.
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190.
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Dolan ME, Roy SK, Garbiras BJ, Helft P, Paras P, Chae MY, Moschel RC, Pegg AE. O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases. Biochem Pharmacol. 1998 May 15; 55(10):1701-9.
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191.
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Pegg AE, Kanugula S, Edara S, Pauly GT, Moschel RC, Goodtzova K. Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides. J Biol Chem. 1998 May 1; 273(18):10863-7.
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192.
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Xu-Welliver M, Kanugula S, Pegg AE. Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine. Cancer Res. 1998 May 1; 58(9):1936-45.
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193.
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Kanugula S, Goodtzova K, Pegg AE. Probing of conformational changes in human O6-alkylguanine-DNA alkyl transferase protein in its alkylated and DNA-bound states by limited proteolysis. Biochem J. 1998 Feb 1; 329 ( Pt 3):545-50.
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194.
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Coleman CS, Pegg AE. Assay of mammalian ornithine decarboxylase activity using [14C]ornithine. Methods Mol Biol. 1998; 79:41-4.
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195.
|
Shantz LM, Pegg AE. Assay of mammalian S-adenosylmethionine decarboxylase activity. Methods Mol Biol. 1998; 79:45-9.
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196.
|
Wiest L, Pegg AE. Assay of spermidine and spermine synthases. Methods Mol Biol. 1998; 79:51-7.
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197.
|
Hu RH, Pegg AE. Rapid induction of apoptosis by deregulated uptake of polyamine analogues. Biochem J. 1997 Nov 15; 328 ( Pt 1):307-16.
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198.
|
Xiong H, Stanley BA, Tekwani BL, Pegg AE. Processing of mammalian and plant S-adenosylmethionine decarboxylase proenzymes. J Biol Chem. 1997 Nov 7; 272(45):28342-8.
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199.
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Dolan ME, Pegg AE. O6-benzylguanine and its role in chemotherapy. Clin Cancer Res. 1997 Jun; 3(6):837-47.
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200.
|
Pegg AE, Chung L, Moschel RC. Effect of DNA on the inactivation of O6-alkylguanine-DNA alkyltransferase by 9-substituted O6-benzylguanine derivatives. Biochem Pharmacol. 1997 May 15; 53(10):1559-64.
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201.
|
Hazra TK, Roy R, Biswas T, Grabowski DT, Pegg AE, Mitra S. Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase. Biochemistry. 1997 May 13; 36(19):5769-76.
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202.
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Coleman CS, Pegg AE. Proteasomal degradation of spermidine/spermine N1-acetyltransferase requires the carboxyl-terminal glutamic acid residues. J Biol Chem. 1997 May 2; 272(18):12164-9.
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203.
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Wang L, Spratt TE, Liu XK, Hecht SS, Pegg AE, Peterson LA. Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase. Chem Res Toxicol. 1997 May; 10(5):562-7.
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204.
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Goodtzova K, Kanugula S, Edara S, Pauly GT, Moschel RC, Pegg AE. Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases. J Biol Chem. 1997 Mar 28; 272(13):8332-9.
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205.
|
Nishikawa Y, Kar S, Wiest L, Pegg AE, Carr BI. Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells. Biochem J. 1997 Jan 15; 321 ( Pt 2):537-43.
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206.
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Kurpad SN, Dolan ME, McLendon RE, Archer GE, Moschel RC, Pegg AE, Bigner DD, Friedman HS. Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Chemother Pharmacol. 1997; 39(4):307-16.
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207.
|
Edara S, Kanugula S, Goodtzova K, Pegg AE. Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine. Cancer Res. 1996 Dec 15; 56(24):5571-5.
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208.
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Fried MG, Kanugula S, Bromberg JL, Pegg AE. DNA binding mechanism of O6-alkylguanine-DNA alkyltransferase: stoichiometry and effects of DNA base composition and secondary structure on complex stability. Biochemistry. 1996 Dec 3; 35(48):15295-301.
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209.
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Engel N, Olmo MT, Coleman CS, Medina MA, Pegg AE, Sánchez-Jiménez F. Experimental evidence for structure-activity features in common between mammalian histidine decarboxylase and ornithine decarboxylase. Biochem J. 1996 Dec 1; 320 ( Pt 2):365-8.
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210.
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Ruan H, Shantz LM, Pegg AE, Morris DR. The upstream open reading frame of the mRNA encoding S-adenosylmethionine decarboxylase is a polyamine-responsive translational control element. J Biol Chem. 1996 Nov 22; 271(47):29576-82.
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211.
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Shantz LM, Coleman CS, Pegg AE. Expression of an ornithine decarboxylase dominant-negative mutant reverses eukaryotic initiation factor 4E-induced cell transformation. Cancer Res. 1996 Nov 15; 56(22):5136-40.
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212.
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Shantz LM, Hu RH, Pegg AE. Regulation of ornithine decarboxylase in a transformed cell line that overexpresses translation initiation factor eIF-4E. Cancer Res. 1996 Jul 15; 56(14):3265-9.
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213.
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Coleman CS, Huang H, Pegg AE. Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase. Biochem J. 1996 Jun 15; 316 ( Pt 3):697-701.
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214.
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Wu R, Saab NH, Huang H, Wiest L, Pegg AE, Casero RA, Woster PM. Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase. Bioorg Med Chem. 1996 Jun; 4(6):825-36.
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215.
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Crone TM, Goodtzova K, Pegg AE. Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase. Mutat Res. 1996 May 15; 363(1):15-25.
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216.
|
Schold SC, Kokkinakis DM, Rudy JL, Moschel RC, Pegg AE. Treatment of human brain tumor xenografts with O6-benzyl-2'-deoxyguanosine and BCNU. Cancer Res. 1996 May 1; 56(9):2076-81.
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217.
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Kokkinakis DM, Moschel RC, Vuong TH, Reddy MV, Schold SC, Pegg AE. Mechanism of depletion of O6-methylguanine-DNA methyltransferase activity in rat tissues by O6-Benzyl-2'-deoxyguanosine. Role of metabolism. In Vivo. 1996 May-Jun; 10(3):297-306.
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218.
|
Loktionova NA, Pegg AE. Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea. Cancer Res. 1996 Apr 1; 56(7):1578-83.
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219.
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Poulin R, Pegg AE. Stable intracellular acidification upon polyamine depletion induced by alpha-difluoromethylornithine or N1,N12-bis(ethyl)spermine in L1210 leukaemia cells. Biochem J. 1995 Dec 15; 312 ( Pt 3):749-56.
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220.
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Poulin R, Pelletier G, Pegg AE. Induction of apoptosis by excessive polyamine accumulation in ornithine decarboxylase-overproducing L1210 cells. Biochem J. 1995 Nov 1; 311 ( Pt 3):723-7.
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221.
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Coleman CS, Huang H, Pegg AE. Role of the carboxyl terminal MATEE sequence of spermidine/spermine N1-acetyltransferase in the activity and stabilization by the polyamine analog N1,N12-bis(ethyl)spermine. Biochemistry. 1995 Oct 17; 34(41):13423-30.
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222.
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Pegg AE, Swenn K, Chae MY, Dolan ME, Moschel RC. Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea. Biochem Pharmacol. 1995 Oct 12; 50(8):1141-8.
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223.
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Ciocco GM, Moschel RC, Chae MY, McLaughlin PJ, Zagon IS, Pegg AE. Specific labeling of O6-alkylguanine-DNA alkyltransferase by reaction with O6-(p-hydroxy[3H]methylbenzyl)guanine. Cancer Res. 1995 Sep 15; 55(18):4085-91.
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224.
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Pegg AE, Hu RH. Effect of polyamine analogues and inhibition of polyamine oxidase on spermidine/spermine N1-acetyltransferase activity and cell proliferation. Cancer Lett. 1995 Aug 16; 95(1-2):247-52.
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225.
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Crone TM, Kanugula S, Pegg AE. Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine. Carcinogenesis. 1995 Aug; 16(8):1687-92.
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226.
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Lakanen JR, Pegg AE, Coward JK. Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase. J Med Chem. 1995 Jul 7; 38(14):2714-27.
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227.
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Edara S, Goodtzova K, Pegg AE. The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity. Carcinogenesis. 1995 Jul; 16(7):1637-42.
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228.
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Friedman HS, Dolan ME, Pegg AE, Marcelli S, Keir S, Catino JJ, Bigner DD, Schold SC. Activity of temozolomide in the treatment of central nervous system tumor xenografts. Cancer Res. 1995 Jul 1; 55(13):2853-7.
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229.
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Kanugula S, Goodtzova K, Edara S, Pegg AE. Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine. Biochemistry. 1995 May 30; 34(21):7113-9.
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230.
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Pegg AE, Poulin R, Coward JK. Use of aminopropyltransferase inhibitors and of non-metabolizable analogs to study polyamine regulation and function. Int J Biochem Cell Biol. 1995 May; 27(5):425-42.
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231.
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Parry L, Lopez-Ballester J, Wiest L, Pegg AE. Effect of expression of human spermidine/spermine N1-acetyltransferase in Escherichia coli. Biochemistry. 1995 Feb 28; 34(8):2701-9.
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232.
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Chae MY, Swenn K, Kanugula S, Dolan ME, Pegg AE, Moschel RC. 8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase. J Med Chem. 1995 Jan 20; 38(2):359-65.
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233.
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Parry L, Balaña Fouce R, Pegg AE. Post-transcriptional regulation of the content of spermidine/spermine N1-acetyltransferase by N1N12-bis(ethyl)spermine. Biochem J. 1995 Jan 15; 305 ( Pt 2):451-8.
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234.
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Pegg AE, Dolan ME, Moschel RC. Structure, function, and inhibition of O6-alkylguanine-DNA alkyltransferase. Prog Nucleic Acid Res Mol Biol. 1995; 51:167-223.
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235.
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Marton LJ, Pegg AE. Polyamines as targets for therapeutic intervention. Annu Rev Pharmacol Toxicol. 1995; 35:55-91.
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236.
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Pegg AE, Shantz LM, Coleman CS. Ornithine decarboxylase as a target for chemoprevention. J Cell Biochem Suppl. 1995; 22:132-8.
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237.
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Crone TM, Goodtzova K, Edara S, Pegg AE. Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine. Cancer Res. 1994 Dec 1; 54(23):6221-7.
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238.
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Kokkinakis DM, Moschel RC, Pegg AE, Dolan ME, Schold SC. Metabolism and disposition of O6-benzyl-2'-deoxyguanosine in Sprague-Dawley rats. Chem Res Toxicol. 1994 Nov-Dec; 7(6):762-9.
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239.
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Pegg AE, Shantz LM, Coleman CS. Ornithine decarboxylase: structure, function and translational regulation. Biochem Soc Trans. 1994 Nov; 22(4):846-52.
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240.
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Byers TL, Lakanen JR, Coward JK, Pegg AE. The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine. Biochem J. 1994 Oct 15; 303 ( Pt 2):363-8.
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241.
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Byers TL, Wechter RS, Hu RH, Pegg AE. Effects of the S-adenosylmethionine decarboxylase inhibitor, 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine, on cell growth and polyamine metabolism and transport in Chinese hamster ovary cell cultures. Biochem J. 1994 Oct 1; 303 ( Pt 1):89-96.
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242.
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Dolan ME, Chae MY, Pegg AE, Mullen JH, Friedman HS, Moschel RC. Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase. Cancer Res. 1994 Oct 1; 54(19):5123-30.
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243.
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Shantz LM, Viswanath R, Pegg AE. Role of the 5'-untranslated region of mRNA in the synthesis of S-adenosylmethionine decarboxylase and its regulation by spermine. Biochem J. 1994 Sep 15; 302 ( Pt 3):765-72.
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244.
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Casero RA, Gabrielson EW, Pegg AE. Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues. Cancer Res. 1994 Aug 1; 54(15):3955-8.
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245.
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Goodtzova K, Crone TM, Pegg AE. Activation of human O6-alkylguanine-DNA alkyltransferase by DNA. Biochemistry. 1994 Jul 19; 33(28):8385-90.
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246.
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Shantz LM, Pegg AE. Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation. Cancer Res. 1994 May 1; 54(9):2313-6.
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247.
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Stanley BA, Shantz LM, Pegg AE. Expression of mammalian S-adenosylmethionine decarboxylase in Escherichia coli. Determination of sites for putrescine activation of activity and processing. J Biol Chem. 1994 Mar 18; 269(11):7901-7.
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248.
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Lijinsky W, Pegg AE, Anver MR, Moschel RC. Effects of inhibition of O6-alkylguanine-DNA alkyltransferase in rats on carcinogenesis by methylnitrosourea and ethylnitrosourea. Jpn J Cancer Res. 1994 Mar; 85(3):226-30.
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249.
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Coleman CS, Stanley BA, Viswanath R, Pegg AE. Rapid exchange of subunits of mammalian ornithine decarboxylase. J Biol Chem. 1994 Feb 4; 269(5):3155-8.
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250.
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Chae MY, McDougall MG, Dolan ME, Swenn K, Pegg AE, Moschel RC. Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase. J Med Chem. 1994 Feb 4; 37(3):342-7.
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251.
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Dolan ME, Pegg AE, Moschel RC, Vishnuvajjala BR, Flora KP, Grever MR, Friedman HS. Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL. Cancer Chemother Pharmacol. 1994; 35(2):121-6.
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252.
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Coleman CS, Stanley BA, Pegg AE. Effect of mutations at active site residues on the activity of ornithine decarboxylase and its inhibition by active site-directed irreversible inhibitors. J Biol Chem. 1993 Nov 25; 268(33):24572-9.
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253.
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Pegg AE, Boosalis M, Samson L, Moschel RC, Byers TL, Swenn K, Dolan ME. Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. Biochemistry. 1993 Nov 16; 32(45):11998-2006.
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254.
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Crone TM, Pegg AE. A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine. Cancer Res. 1993 Oct 15; 53(20):4750-3.
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255.
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O'Toole SM, Pegg AE, Swenberg JA. Repair of O6-methylguanine and O4-methylthymidine in F344 rat liver following treatment with 1,2-dimethylhydrazine and O6-benzylguanine. Cancer Res. 1993 Sep 1; 53(17):3895-8.
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256.
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Pegg AE, Coward JK. Effect of N-(n-butyl)-1,3-diaminopropane on polyamine metabolism, cell growth and sensitivity to chloroethylating agents. Biochem Pharmacol. 1993 Aug 17; 46(4):717-24.
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257.
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Dolan ME, Pegg AE, Moschel RC, Grindey GB. Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Biochem Pharmacol. 1993 Jul 20; 46(2):285-90.
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258.
|
Deen DF, Chiarodo A, Grimm EA, Fike JR, Israel MA, Kun LE, Levin VA, Marton LJ, Packer RJ, Pegg AE, et al. Brain Tumor Working Group Report on the 9th International Conference on Brain Tumor Research and Therapy. Organ System Program, National Cancer Institute. J Neurooncol. 1993 Jun; 16(3):243-72.
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259.
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Casero RA, Pegg AE. Spermidine/spermine N1-acetyltransferase--the turning point in polyamine metabolism. FASEB J. 1993 May; 7(8):653-61.
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260.
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Albanese L, Bergeron RJ, Pegg AE. Investigations of the mechanism by which mammalian cell growth is inhibited by N1N12-bis(ethyl)spermine. Biochem J. 1993 Apr 1; 291 ( Pt 1):131-7.
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261.
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Poulin R, Coward JK, Lakanen JR, Pegg AE. Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress. J Biol Chem. 1993 Mar 5; 268(7):4690-8.
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262.
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Byers TL, Wiest L, Wechter RS, Pegg AE. Effects of chronic 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxy- adenosine (AbeAdo) treatment on polyamine and eIF-5A metabolism in AbeAdo-sensitive and -resistant L1210 murine leukaemia cells. Biochem J. 1993 Feb 15; 290 ( Pt 1):115-21.
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263.
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Dolan ME, Pegg AE, Biser ND, Moschel RC, English HF. Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer. Cancer Chemother Pharmacol. 1993; 32(3):221-5.
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264.
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Sarkar A, Dolan ME, Gonzalez GG, Marton LJ, Pegg AE, Deen DF. The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells. Cancer Chemother Pharmacol. 1993; 32(6):477-81.
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265.
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Friedman HS, Dolan ME, Moschel RC, Pegg AE, Felker GM, Rich J, Bigner DD, Schold SC. Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. J Natl Cancer Inst. 1992 Dec 16; 84(24):1926-31.
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266.
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Madhubala R, Pegg AE. Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase synthesis by antisense oligodeoxynucleotides. Mol Cell Biochem. 1992 Dec 16; 118(2):191-5.
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267.
|
Pegg AE, McCann PP. S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec; 56(3):359-77.
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268.
|
Shantz LM, Holm I, Jänne OA, Pegg AE. Regulation of S-adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content. Biochem J. 1992 Dec 1; 288 ( Pt 2):511-8.
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269.
|
Pegg AE, Stanley BA, Wiest L, Casero RA. Nucleotide sequence of hamster spermidine/spermine-N1-acetyltransferase cDNA. Biochim Biophys Acta. 1992 Nov 15; 1171(1):106-8.
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270.
|
Moschel RC, McDougall MG, Dolan ME, Stine L, Pegg AE. Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase. J Med Chem. 1992 Nov 13; 35(23):4486-91.
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271.
|
Tekwani BL, Bacchi CJ, Pegg AE. Putrescine activated S-adenosylmethionine decarboxylase from Trypanosoma brucei brucei. Mol Cell Biochem. 1992 Nov 4; 117(1):53-61.
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272.
|
Byers TL, Ganem B, Pegg AE. Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine may be due to hypusine depletion. Biochem J. 1992 Nov 1; 287 ( Pt 3):717-24.
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273.
|
Tekwani BL, Bacchi CJ, Secrist JA, Pegg AE. Irreversible inhibition of S-adenosylmethionine decarboxylase of Trypanosoma brucei brucei by S-adenosylmethionine analogues. Biochem Pharmacol. 1992 Sep 1; 44(5):905-11.
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274.
|
Graves R, Laval J, Pegg AE. Sequence specificity of DNA repair by Escherichia coli Fpg protein. Carcinogenesis. 1992 Aug; 13(8):1455-9.
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275.
|
Shantz LM, Stanley BA, Secrist JA, Pegg AE. Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine. Biochemistry. 1992 Jul 28; 31(29):6848-55.
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276.
|
Tekwani BL, Stanley BA, Pegg AE. Nucleotide sequence of hamster S-adenosylmethionine decarboxylase cDNA. Biochim Biophys Acta. 1992 Mar 24; 1130(2):221-3.
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277.
|
Pegg AE, Byers TL. Repair of DNA containing O6-alkylguanine. FASEB J. 1992 Mar; 6(6):2302-10.
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278.
|
Lakanen JR, Coward JK, Pegg AE. alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines. J Med Chem. 1992 Feb 21; 35(4):724-34.
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279.
|
Poulin R, Lu L, Ackermann B, Bey P, Pegg AE. Mechanism of the irreversible inactivation of mouse ornithine decarboxylase by alpha-difluoromethylornithine. Characterization of sequences at the inhibitor and coenzyme binding sites. J Biol Chem. 1992 Jan 5; 267(1):150-8.
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280.
|
McCann PP, Pegg AE. Ornithine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992; 54(2):195-215.
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281.
|
Dolan ME, Pegg AE, Dumenco LL, Moschel RC, Gerson SL. Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine. Carcinogenesis. 1991 Dec; 12(12):2305-9.
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282.
|
Stanley BA, Pegg AE. Amino acid residues necessary for putrescine stimulation of human S-adenosylmethionine decarboxylase proenzyme processing and catalytic activity. J Biol Chem. 1991 Oct 5; 266(28):18502-6.
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283.
|
Pegg A, Fitzgerald F, Wise D, Singh BM, Wise PH. A community-based study of diabetes-related skills and knowledge in elderly people with insulin-requiring diabetes. Diabet Med. 1991 Oct; 8(8):778-81.
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284.
|
Lukash LL, Boldt J, Pegg AE, Dolan ME, Maher VM, McCormick JJ. Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts. Mutat Res. 1991 Sep-Oct; 250(1-2):397-409.
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285.
|
Pegg AE, Wiest L, Mummert C, Dolan ME. Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts. Carcinogenesis. 1991 Sep; 12(9):1671-7.
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286.
|
Pegg AE, Wiest L, Mummert C, Stine L, Moschel RC, Dolan ME. Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis. 1991 Sep; 12(9):1679-83.
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287.
|
Xiao L, Celano P, Mank AR, Pegg AE, Casero RA. Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase. Biochem Biophys Res Commun. 1991 Aug 30; 179(1):407-15.
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288.
|
Lu L, Stanley BA, Pegg AE. Identification of residues in ornithine decarboxylase essential for enzymic activity and for rapid protein turnover. Biochem J. 1991 Aug 1; 277 ( Pt 3):671-5.
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289.
|
Dolan ME, Mitchell RB, Mummert C, Moschel RC, Pegg AE. Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. Cancer Res. 1991 Jul 1; 51(13):3367-72.
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290.
|
Poulin R, Wechter RS, Pegg AE. An early enlargement of the putrescine pool is required for growth in L1210 mouse leukemia cells under hypoosmotic stress. J Biol Chem. 1991 Apr 5; 266(10):6142-51.
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291.
|
Pegg AE, Nagarajan S, Naficy S, Ganem B. Role of unsaturated derivatives of spermidine as substrates for spermine synthase and in supporting growth of SV-3T3 cells. Biochem J. 1991 Feb 15; 274 ( Pt 1):167-71.
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292.
|
Casero RA, Celano P, Ervin SJ, Applegren NB, Wiest L, Pegg AE. Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase. J Biol Chem. 1991 Jan 15; 266(2):810-4.
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293.
|
Marton LJ, Pegg AE, Morris DR. Directions for polyamine research. J Cell Biochem. 1991 Jan; 45(1):7-8.
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294.
|
Pegg AE. Factors influencing carcinogenesis by alkylating agents. Recent Results Cancer Res. 1991; 122:22-32.
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295.
|
Pegg A, Fitzgerald F. Elderly patients with IDDM in the community. Nurs Times. 1990 Nov 14-20; 86(46):53.
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296.
|
Pegg AE. Properties of mammalian O6-alkylguanine-DNA transferases. Mutat Res. 1990 Nov-Dec; 233(1-2):165-75.
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|
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297.
|
Pegg AE. Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res. 1990 Oct 1; 50(19):6119-29.
|
|
|
|
|
298.
|
McGarrity TJ, Peiffer LP, Bartholomew MJ, Pegg AE. Colonic polyamine content and ornithine decarboxylase activity as markers for adenomas. Cancer. 1990 Oct 1; 66(7):1539-43.
|
|
|
|
|
299.
|
Casero RA, Celano P, Ervin SJ, Wiest L, Pegg AE. High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. Biochem J. 1990 Sep 15; 270(3):615-20.
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|
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|
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300.
|
Dolan ME, Moschel RC, Pegg AE. Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5368-72.
|
|
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301.
|
Byers TL, Pegg AE. Regulation of polyamine transport in Chinese hamster ovary cells. J Cell Physiol. 1990 Jun; 143(3):460-7.
|
|
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302.
|
Porter CW, Pegg AE, Ganis B, Madhabala R, Bergeron RJ. Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine. Biochem J. 1990 May 15; 268(1):207-12.
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|
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|
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303.
|
Pegg AE, Pakala R, Bergeron RJ. Induction of spermidine/spermine N1-acetyltransferase activity in Chinese-hamster ovary cells by N1N11-bis(ethyl)norspermine (corrected) and related compounds. Biochem J. 1990 Apr 15; 267(2):331-8.
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|
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304.
|
Poulin R, Pegg AE. Regulation of ornithine decarboxylase expression by anisosmotic shock in alpha-difluoromethylornithine-resistant L1210 cells. J Biol Chem. 1990 Mar 5; 265(7):4025-32.
|
|
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|
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305.
|
Dolan ME, Stine L, Mitchell RB, Moschel RC, Pegg AE. Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. Cancer Commun. 1990; 2(11):371-7.
|
|
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|
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306.
|
Stanley BA, Pegg AE, Holm I. Site of pyruvate formation and processing of mammalian S-adenosylmethionine decarboxylase proenzyme. J Biol Chem. 1989 Dec 15; 264(35):21073-9.
|
|
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|
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307.
|
Rannels DE, Kameji R, Pegg AE, Rannels SR. Spermidine uptake by type II pneumocytes: interactions of amine uptake pathways. Am J Physiol. 1989 Dec; 257(6 Pt 1):L346-53.
|
|
|
|
|
308.
|
Byers TL, Wechter R, Nuttall ME, Pegg AE. Expression of a human gene for polyamine transport in Chinese-hamster ovary cells. Biochem J. 1989 Nov 1; 263(3):745-52.
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|
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|
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309.
|
Pegg AE, Wechter R, Poulin R, Woster PM, Coward JK. Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells. Biochemistry. 1989 Oct 17; 28(21):8446-53.
|
|
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|
|
310.
|
Poulin R, Secrist JA, Pegg AE. Effect of 1-amino-oxy-3-aminopropane on polyamine metabolism and growth of L1210 cells. Biochem J. 1989 Oct 1; 263(1):215-21.
|
|
|
|
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311.
|
Choudhury S, Pegg AE, Kreider JW, Mayo DR, Howett MK. Administration of ethylnitrosourea to neonate hamsters increases growth and frequency of SV40-induced fibrosarcomas. Proc Soc Exp Biol Med. 1989 Oct; 192(1):72-7.
|
|
|
|
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312.
|
Dolan ME, Norbeck L, Clyde C, Hora NK, Erickson LC, Pegg AE. Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents. Carcinogenesis. 1989 Sep; 10(9):1613-9.
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|
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|
313.
|
Byers TL, Pegg AE. Properties and physiological function of the polyamine transport system. Am J Physiol. 1989 Sep; 257(3 Pt 1):C545-53.
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314.
|
Pegg AE, Wechter R, Pakala R, Bergeron RJ. Effect of N1,N12-bis(ethyl)spermine and related compounds on growth and polyamine acetylation, content, and excretion in human colon tumor cells. J Biol Chem. 1989 Jul 15; 264(20):11744-9.
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|
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|
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315.
|
Holm I, Persson L, Pegg AE, Heby O. Effects of S-adenosyl-1,8-diamino-3-thio-octane and S-methyl-5'-methylthioadenosine on polyamine synthesis in Ehrlich ascites-tumour cells. Biochem J. 1989 Jul 1; 261(1):205-10.
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|
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|
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316.
|
Woster PM, Black AY, Duff KJ, Coward JK, Pegg AE. Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase. J Med Chem. 1989 Jun; 32(6):1300-7.
|
|
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|
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317.
|
Pine MJ, Huben RP, Pegg AE. Production of N1-acetyl spermidine by renal cell tumors. J Urol. 1989 Mar; 141(3):651-5.
|
|
|
|
|
318.
|
Kameji R, Rannels SR, Pegg AE, Rannels DE. Spermidine uptake by type II pulmonary epithelial cells in primary culture. Am J Physiol. 1989 Jan; 256(1 Pt 1):C160-7.
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|
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319.
|
Dolan ME, Larkin GL, English HF, Pegg AE. Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine. Cancer Chemother Pharmacol. 1989; 25(2):103-8.
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|
|
|
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320.
|
Weisburger JH, Jones RC, Barnes WS, Pegg AE. Mechanisms of differential strain sensitivity in gastric carcinogenesis. Jpn J Cancer Res. 1988 Dec; 79(12):1304-10.
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|
|
|
|
321.
|
Pajunen A, Crozat A, Jänne OA, Ihalainen R, Laitinen PH, Stanley B, Madhubala R, Pegg AE. Structure and regulation of mammalian S-adenosylmethionine decarboxylase. J Biol Chem. 1988 Nov 15; 263(32):17040-9.
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322.
|
Belinsky SA, Dolan ME, White CM, Maronpot RR, Pegg AE, Anderson MW. Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells. Carcinogenesis. 1988 Nov; 9(11):2053-8.
|
|
|
|
|
323.
|
McGarrity TJ, Peiffer LP, Colony PC, Pegg AE. The effects of chronic ethanol administration on polyamine content during dimethylhydrazine-induced colorectal carcinogenesis in the rat. Carcinogenesis. 1988 Nov; 9(11):2093-8.
|
|
|
|
|
324.
|
Dolan ME, Oplinger M, Pegg AE. Sequence specificity of guanine alkylation and repair. Carcinogenesis. 1988 Nov; 9(11):2139-43.
|
|
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|
|
325.
|
Nagarajan S, Ganem B, Pegg AE. Studies of non-metabolizable polyamines that support growth of SV-3T3 cells depleted of natural polyamines by exposure to alpha-difluoromethylornithine. Biochem J. 1988 Sep 1; 254(2):373-8.
|
|
|
|
|
326.
|
Madhubala R, Secrist JA, Pegg AE. Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells. Biochem J. 1988 Aug 15; 254(1):45-50.
|
|
|
|
|
327.
|
Pegg AE, Madhubala R, Kameji T, Bergeron RJ. Control of ornithine decarboxylase activity in alpha-difluoromethylornithine-resistant L1210 cells by polyamines and synthetic analogues. J Biol Chem. 1988 Aug 5; 263(22):11008-14.
|
|
|
|
|
328.
|
Dolan ME, Pegg AE, Hora NK, Erickson LC. Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate. Cancer Res. 1988 Jul 1; 48(13):3603-6.
|
|
|
|
|
329.
|
Pegg AE, Secrist JA, Madhubala R. Properties of L1210 cells resistant to alpha-difluoromethylornithine. Cancer Res. 1988 May 15; 48(10):2678-82.
|
|
|
|
|
330.
|
Pegg AE, Jones DB, Secrist JA. Effect of inhibitors of S-adenosylmethionine decarboxylase on polyamine content and growth of L1210 cells. Biochemistry. 1988 Mar 8; 27(5):1408-15.
|
|
|
|
|
331.
|
Dolan ME, Scicchitano D, Pegg AE. Use of oligodeoxynucleotides containing O6-alkylguanine for the assay of O6-alkylguanine-DNA-alkyltransferase activity. Cancer Res. 1988 Mar 1; 48(5):1184-8.
|
|
|
|
|
332.
|
Dolan ME, Oplinger M, Pegg AE. Use of a dodecadeoxynucleotide to study repair of the O4-methylthymine lesion. Mutat Res. 1988 Mar; 193(2):131-7.
|
|
|
|
|
333.
|
Brent TP, Dolan ME, Fraenkel-Conrat H, Hall J, Karran P, Laval L, Margison GP, Montesano R, Pegg AE, Potter PM, et al. Repair of O-alkylpyrimidines in mammalian cells: a present consensus. Proc Natl Acad Sci U S A. 1988 Mar; 85(6):1759-62.
|
|
|
|
|
334.
|
Pegg AE. Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res. 1988 Feb 15; 48(4):759-74.
|
|
|
|
|
335.
|
Pegg AE, Wiest L, Pajunen A. Detection of proenzyme form of S-adenosylmethionine decarboxylase in extracts from rat prostate. Biochem Biophys Res Commun. 1988 Jan 29; 150(2):788-93.
|
|
|
|
|
336.
|
Pegg AE, Stanley B, Pajunen A, Crozat A, Jänne OA. Properties of human and rodent S-adenosylmethionine decarboxylase. Adv Exp Med Biol. 1988; 250:101-9.
|
|
|
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|
337.
|
Pegg AE, Kameji T, Shirahata A, Stanley B, Madhubala R, Pajunen A. Regulation of mammalian S-adenosylmethionine decarboxylase. Adv Enzyme Regul. 1988; 27:43-55.
|
|
|
|
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338.
|
Radford DM, Eddy R, Haley L, Henry WM, Pegg AE, Pajunen A, Shows TB. Gene sequences coding for S-adenosylmethionine decarboxylase are present on human chromosome 6 and the X and are not amplified in colon neoplasia. Cytogenet Cell Genet. 1988; 49(4):285-8.
|
|
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|
|
339.
|
Pegg AE, Morimoto K, Dolan ME. Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase. Chem Biol Interact. 1988; 65(3):275-81.
|
|
|
|
|
340.
|
White MW, Kameji T, Pegg AE, Morris DR. Increased efficiency of translation of ornithine decarboxylase mRNA in mitogen-activated lymphocytes. Eur J Biochem. 1987 Dec 30; 170(1-2):87-92.
|
|
|
|
|
341.
|
Scicchitano DA, Pegg AE. Inhibition of O6-alkylguanine-DNA-alkyltransferase by metals. Mutat Res. 1987 Nov; 192(3):207-10.
|
|
|
|
|
342.
|
Sertich GJ, Persson L, Pegg AE. Regulation of ovarian ornithine decarboxylase by human chorionic gonadotrophin. Am J Physiol. 1987 Nov; 253(5 Pt 1):C687-92.
|
|
|
|
|
343.
|
Byers TL, Kameji R, Rannels DE, Pegg AE. Multiple pathways for uptake of paraquat, methylglyoxal bis(guanylhydrazone), and polyamines. Am J Physiol. 1987 Jun; 252(6 Pt 1):C663-9.
|
|
|
|
|
344.
|
Pegg AE, Wechter R, Pajunen A. Increase in S-adenosylmethionine decarboxylase in SV-3T3 cells treated with S-methyl-5'-methylthioadenosine. Biochem J. 1987 May 15; 244(1):49-54.
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|
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|
|
345.
|
Kameji T, Pegg AE. Effect of putrescine on the synthesis of S-adenosylmethionine decarboxylase. Biochem J. 1987 Apr 1; 243(1):285-8.
|
|
|
|
|
346.
|
Sertich GJ, Pegg AE. Polyamine administration reduces ornithine decarboxylase activity without affecting its mRNA content. Biochem Biophys Res Commun. 1987 Mar 13; 143(2):424-30.
|
|
|
|
|
347.
|
Porter CW, Berger FG, Pegg AE, Ganis B, Bergeron RJ. Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine. Biochem J. 1987 Mar 1; 242(2):433-40.
|
|
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348.
|
Kameji T, Pegg AE. Inhibition of translation of mRNAs for ornithine decarboxylase and S-adenosylmethionine decarboxylase by polyamines. J Biol Chem. 1987 Feb 25; 262(6):2427-30.
|
|
|
|
|
349.
|
Coward JK, Pegg AE. Specific multisubstrate adduct inhibitors of aminopropyltransferases and their effect on polyamine biosynthesis in cultured cells. Adv Enzyme Regul. 1987; 26:107-13.
|
|
|
|
|
350.
|
Pegg AE, Scicchitano D, Morimoto K, Dolan ME. Specificity of O6-alkylguanine-DNA alkyltransferase. IARC Sci Publ. 1987; (84):30-4.
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|
|
|
351.
|
Pegg AE, Dolan ME. Properties and assay of mammalian O6-alkylguanine-DNA alkyltransferase. Pharmacol Ther. 1987; 34(2):167-79.
|
|
|
|
|
352.
|
Pegg AE, McGovern KA, Wiest L. Decarboxylation of alpha-difluoromethylornithine by ornithine decarboxylase. Biochem J. 1987 Jan 1; 241(1):305-7.
|
|
|
|
|
353.
|
Shirahata A, Pegg AE. Increased content of mRNA for a precursor of S-adenosylmethionine decarboxylase in rat prostate after treatment with 2-difluoromethylornithine. J Biol Chem. 1986 Oct 15; 261(29):13833-7.
|
|
|
|
|
354.
|
Dolan ME, Young GS, Pegg AE. Effect of O6-alkylguanine pretreatment on the sensitivity of human colon tumor cells to the cytotoxic effects of chloroethylating agents. Cancer Res. 1986 Sep; 46(9):4500-4.
|
|
|
|
|
355.
|
Erwin BG, Pegg AE. Regulation of spermidine/spermine N1-acetyltransferase in L6 cells by polyamines and related compounds. Biochem J. 1986 Sep 1; 238(2):581-7.
|
|
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|
|
356.
|
Scicchitano D, Jones RA, Kuzmich S, Gaffney B, Lasko DD, Essigmann JM, Pegg AE. Repair of oligodeoxynucleotides containing O6-methylguanine by O6-alkylguanine-DNA-alkyltransferase. Carcinogenesis. 1986 Aug; 7(8):1383-6.
|
|
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|
|
357.
|
Pegg AE, Coward JK, Talekar RR, Secrist JA. Effects of certain 5'-substituted adenosines on polyamine synthesis: selective inhibitors of spermine synthase. Biochemistry. 1986 Jul 15; 25(14):4091-7.
|
|
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|
|
358.
|
McGovern KA, Clark RS, Pegg AE. Effect of 1,3,6-triaminohexane and 1,4,7-triaminoheptane on growth and polyamine metabolism in SV-3T3 cells treated with 2-difluoromethylornithine. J Cell Physiol. 1986 May; 127(2):311-6.
|
|
|
|
|
359.
|
Pegg AE. Recent advances in the biochemistry of polyamines in eukaryotes. Biochem J. 1986 Mar 1; 234(2):249-62.
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|
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360.
|
Pegg AE, Wechter RS, Clark RS, Wiest L, Erwin BG. Acetylation of decarboxylated S-adenosylmethionine by mammalian cells. Biochemistry. 1986 Jan 28; 25(2):379-84.
|
|
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|
361.
|
Venitt S, Bartsch H, Becking G, Fuchs RP, Hofnung M, Malaveille C, Matsushima T, Pegg AE, Rajewsky MR, Roberfroid M, et al. Short-term assays to predict carcinogenicity. DNA damage and repair. IARC Sci Publ. 1986; (83):129-42.
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362.
|
Venitt S, Bartsch H, Becking G, Fuchs RP, Hofnung M, Malaveille C, Matsushima T, Mendelsohn ML, Pegg AE, Roberfroid M, et al. Short-term assays to predict carcinogenicity. Metabolic activation. IARC Sci Publ. 1986; (83):439-55.
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363.
|
Della Ragione F, Porcelli M, Cartenì-Farina M, Zappia V, Pegg AE. Escherichia coli S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase. Purification, substrate specificity and mechanism of action. Biochem J. 1985 Dec 1; 232(2):335-41.
|
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364.
|
Dolan ME, Morimoto K, Pegg AE. Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines. Cancer Res. 1985 Dec; 45(12 Pt 1):6413-7.
|
|
|
|
|
365.
|
Domoradzki J, Pegg AE, Dolan ME, Maher VM, McCormick JJ. Depletion of O6-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis. 1985 Dec; 6(12):1823-6.
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366.
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Pegg AE, Coward JK. Growth of mammalian cells in the absence of the accumulation of spermine. Biochem Biophys Res Commun. 1985 Nov 27; 133(1):82-9.
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367.
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Dolan ME, Pegg AE. Extent of formation of O4-methylthymidine in calf thymus DNA methylated by N-methyl-N-nitrosourea and lack of repair of this product by rat liver O6-alkylguanine-DNA-alkyltransferase. Carcinogenesis. 1985 Nov; 6(11):1611-4.
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368.
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Rannels DE, Pegg AE, Clark RS, Addison JL. Interaction of paraquat and amine uptake by rat lungs perfused in situ. Am J Physiol. 1985 Nov; 249(5 Pt 1):E506-13.
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369.
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Pegg AE, Erwin BG, Persson L. Induction of spermidine/spermine N1-acetyltransferase by methylglyoxal bis(guanylhydrazone). Biochim Biophys Acta. 1985 Oct 17; 842(2-3):111-8.
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370.
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Pegg AE, Erwin BG. Induction of spermidine/spermine N1-acetyltransferase in rat tissues by polyamines. Biochem J. 1985 Oct 15; 231(2):285-9.
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371.
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Dolan ME, Corsico CD, Pegg AE. Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents. Biochem Biophys Res Commun. 1985 Oct 15; 132(1):178-85.
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372.
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Keller BT, Clark RS, Pegg AE, Borchardt RT. Purification and characterization of some metabolic effects of S-neplanocylmethionine. Mol Pharmacol. 1985 Oct; 28(4):364-70.
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373.
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Pegg AE, Dolan ME, Scicchitano D, Morimoto K. Studies of the repair of O6-alkylguanine and O4-alkylthymine in DNA by alkyltransferases from mammalian cells and bacteria. Environ Health Perspect. 1985 Oct; 62:109-14.
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374.
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Shirahata A, Pegg AE. Regulation of S-adenosylmethionine decarboxylase activity in rat liver and prostate. J Biol Chem. 1985 Aug 15; 260(17):9583-8.
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375.
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Wolf LM, Leitzel KE, Pegg AE, Harvey HA, Lipton A. The in vitro interaction of alpha-difluoromethyl ornithine (DFMO) and several interferons on human cell lines. J Biol Response Mod. 1985 Aug; 4(4):391-5.
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376.
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Shirahata A, Christman KL, Pegg AE. Quantitation of S-adenosylmethionine decarboxylase protein. Biochemistry. 1985 Jul 30; 24(16):4417-23.
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377.
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Morimoto K, Dolan ME, Scicchitano D, Pegg AE. Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli. Carcinogenesis. 1985 Jul; 6(7):1027-31.
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378.
|
Rannels DE, Addison JL, Pegg AE. Carrier-mediated uptake of methylglyoxal bis(guanylhydrazone) by rat lungs perfused in situ. Am J Physiol. 1985 Mar; 248(3 Pt 1):E292-8.
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379.
|
Seely JE, Persson L, Sertich GJ, Pegg AE. Comparison of ornithine decarboxylase from rat liver, rat hepatoma and mouse kidney. Biochem J. 1985 Mar 1; 226(2):577-86.
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380.
|
Domoradzki J, Pegg AE, Dolan ME, Maher VM, McCormick JJ. Correlation between O6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis. 1984 Dec; 5(12):1641-7.
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381.
|
Pegg AE. The role of polyamine depletion and accumulation of decarboxylated S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with alpha-difluoromethylornithine. Biochem J. 1984 Nov 15; 224(1):29-38.
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382.
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Persson L, Pegg AE. Studies of the induction of spermidine/spermine N1-acetyltransferase using a specific antiserum. J Biol Chem. 1984 Oct 25; 259(20):12364-7.
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383.
|
Pegg AE, Lijinsky W. Saturation of repair system for O6-methylguanine in rat liver DNA by pretreatment with cyclic nitrosamines. Chem Biol Interact. 1984 Oct; 51(3):365-70.
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384.
|
Ewton DZ, Erwin BG, Pegg AE, Florini JR. The role of polyamines in somatomedin-stimulated differentiation of L6 myoblasts. J Cell Physiol. 1984 Sep; 120(3):263-70.
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385.
|
Pegg AE, Scicchitano D, Dolan ME. Comparison of the rates of repair of O6-alkylguanines in DNA by rat liver and bacterial O6-alkylguanine-DNA alkyltransferase. Cancer Res. 1984 Sep; 44(9):3806-11.
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386.
|
Dolan ME, Scicchitano D, Singer B, Pegg AE. Comparison of repair of methylated pyrimidines in poly(dT) by extracts from rat liver and Escherichia coli. Biochem Biophys Res Commun. 1984 Aug 30; 123(1):324-30.
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387.
|
Erwin BG, Persson L, Pegg AE. Differential inhibition of histone and polyamine acetylases by multisubstrate analogues. Biochemistry. 1984 Aug 28; 23(18):4250-5.
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388.
|
Persson L, Seely JE, Pegg AE. Investigation of structure and rate of synthesis of ornithine decarboxylase protein in mouse kidney. Biochemistry. 1984 Jul 31; 23(16):3777-83.
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389.
|
Grafstrom RC, Pegg AE, Trump BF, Harris CC. O6-alkylguanine-DNA alkyltransferase activity in normal human tissues and cells. Cancer Res. 1984 Jul; 44(7):2855-7.
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390.
|
Seely JE, Stetler DA, Jacob ST, Pegg AE. Absence of inactivation or phosphorylation of ornithine decarboxylase by nuclear protein kinase NII and of immunological cross-reactivity between RNA polymerase I and ornithine decarboxylase. Biochem Biophys Res Commun. 1984 Apr 16; 120(1):219-25.
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391.
|
Oredsson SM, Pegg AE, Alhonen-Hongisto L, Deen DF, Marton LJ. Possible factors in the potentiation of 1-(2-chloroethyl)-3-trans-4-methylcyclohexyl-1-nitrosourea cytotoxicity by alpha-difluoromethylornithine in 9L rat brain tumor cells. Eur J Cancer Clin Oncol. 1984 Apr; 20(4):535-42.
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392.
|
Erwin BG, Bethell DR, Pegg AE. Role of polyamines in differentiation of 3T3-L1 fibroblasts into adipocytes. Am J Physiol. 1984 Mar; 246(3 Pt 1):C293-300.
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393.
|
Hung DT, Oredsson SM, Pegg AE, Deen DF, Marton LJ. Potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity in 9L rat brain tumor cells by methylglyoxal-bis(guanylhydrazone), an inhibitor of S-adenosyl-L-methionine decarboxylase. Eur J Cancer Clin Oncol. 1984 Mar; 20(3):417-20.
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394.
|
Wiestler O, Kleihues P, Pegg AE. O6-alkylguanine-DNA alkyltransferase activity in human brain and brain tumors. Carcinogenesis. 1984 Jan; 5(1):121-4.
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395.
|
Pegg AE. Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents. Cancer Invest. 1984; 2(3):223-31.
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396.
|
Zagon IS, McLaughlin PJ, Seely JE, Hoeksema GW, Pegg AE. Autoradiographic localization of ornithine decarboxylase in mouse kidney by use of radiolabeled alpha-difluoromethylornithine. Cell Tissue Res. 1984; 235(2):371-7.
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397.
|
Pegg AE, Seely JE, Persson L, Herlyn M, Ponsell K, O'Brien TG. Studies of mammalian ornithine decarboxylase using a monoclonal antibody. Biochem J. 1984 Jan 1; 217(1):123-8.
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