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Kun-Ming Chen
Title Assistant Professor
Institution College of Medicine
Department Biochemistry and Molecular Biology
Address 500 University Drive, Hershey, PA 17033
Mailbox: CH76
Telephone 7175311011
Email
Background
B.S.: Taipei Medical University, School of Pharmacy, 1989
M.S.: Pharmaceutical Sciences, St. John's University, 1996
Ph. D.: Pharmaceutical Sciences, St. John's University, 2001
Publications
1. Chen KM, Guttenplan JB, Zhang SM, Aliaga C, Cooper TK, Sun YW, Deltondo J, Kosinska W, Sharma AK, Jiang K, Bruggeman R, Ahn K, Amin S, El-Bayoumy K. Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: An environmental pollutant and a tobacco smoke constituent. Int J Cancer. 2013 Mar 9.
  View in: PubMed
 
2. Sun YW, Guttenplan JB, Cooper T, Krzeminski J, Aliaga C, Boyiri T, Kosinska W, Zhao ZL, Chen KM, Berg A, Amin SG, El-Bayoumy K. Mechanisms underlying the varied mammary carcinogenicity of the environmental pollutant 6-nitrochrysene and its metabolites (-)-[R,R]- and (+)-[S,S] -1,2-dihydroxy-1,2-dihydro-6-nitrochrysene in the rat. Chem Res Toxicol. 2013 Mar 5.
  View in: PubMed
 
3. Chen KM, Zhang SM, Aliaga C, Sun YW, Cooper T, Gowdahalli K, Zhu J, Amin S, El-Bayoumy K. Induction of ovarian cancer and DNA adducts by Dibenzo[a,l]pyrene in the mouse. Chem Res Toxicol. 2012 Feb 20; 25(2):374-80.
  View in: PubMed
 
4. Guttenplan JB, Kosinska W, Zhao ZL, Chen KM, Aliaga C, DelTondo J, Cooper T, Sun YW, Zhang SM, Jiang K, Bruggeman R, Sharma AK, Amin S, Ahn K, El-Bayoumy K. Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer. Int J Cancer. 2012 Jun 15; 130(12):2783-90.
  View in: PubMed
 
5. Zhang SM, Chen KM, Aliaga C, Sun YW, Lin JM, Sharma AK, Amin S, El-Bayoumy K. Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[a,l]pyrene by HPLC-MS/MS. Chem Res Toxicol. 2011 Aug 15; 24(8):1297-303.
  View in: PubMed
 
6. Sun YW, Niu TK, Yang JM, Kwon CH, Chen KY, Chen KM. Potentiation of the growth inhibition activity of 2-({4-[4-(acridin-9-ylamino)phenylthio]phenyl}(2-hydroxyethyl)amino)ethan-1-ol (CK0402) by Herceptin in SKBR-3 human breast cancer cells. Exp Ther Med. 2010 5; 1(3):513-518.
  View in: PubMed
 
7. Chen KM, Sacks PG, Spratt TE, Lin JM, Boyiri T, Schwartz J, Richie JP, Calcagnotto A, Das A, Bortner J, Zhao Z, Amin S, Guttenplan J, El-Bayoumy K. Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate. Biochem Biophys Res Commun. 2009 May 22; 383(1):151-5.
  View in: PubMed
 
8. Melikian AA, Chen KM, Li H, Sodum R, Fiala E, El-Bayoumy K. The role of nitric oxide on DNA damage induced by benzene metabolites. Oncol Rep. 2008 May; 19(5):1331-7.
  View in: PubMed
 
9. Chen KM, Spratt TE, Stanley BA, De Cotiis DA, Bewley MC, Flanagan JM, Desai D, Das A, Fiala ES, Amin S, El-Bayoumy K. Inhibition of nuclear factor-kappaB DNA binding by organoselenocyanates through covalent modification of the p50 subunit. Cancer Res. 2007 Nov 1; 67(21):10475-83.
  View in: PubMed
 
10. Guttenplan J, Chen KM, Khmelnitsky M, Kosinska W, Hennessy J, Bruggeman R, Desai D, Amin S, Sun YW, Spratt TE, El-Bayoumy K. Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide. Mutat Res. 2007 Dec 1; 634(1-2):146-55.
  View in: PubMed
 
11. Sun YW, Chen KM, Kwon CH. Sulfonyl-containing nucleoside phosphotriesters and phosphoramidates as novel anticancer prodrugs of 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP). Mol Pharm. 2006 Mar-Apr; 3(2):161-73.
  View in: PubMed
 
12. Chen KM, El-Bayoumy K, Hosey J, Cunningham J, Aliaga C, Melikian AA. Benzene increases protein-bound 3-nitrotyrosine in bone marrow of B6C3F1 mice. Chem Biol Interact. 2005 Oct 20; 156(2-3):81-91.
  View in: PubMed
 
13. Chen KM, Sun YW, Tang YW, Sun ZY, Kwon CH. Synthesis and antitumor activity of sulfur-containing 9-anilinoacridines. Mol Pharm. 2005 Mar-Apr; 2(2):118-28.
  View in: PubMed
 
14. Chen KM, El-Bayoumy K, Cunningham J, Aliaga C, Li H, Melikian AA. Detection of nitrated benzene metabolites in bone marrow of B6C3F1 mice treated with benzene. Chem Res Toxicol. 2004 Mar; 17(3):370-7.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Carcinogens
Anticarcinogenic Agents
Organoselenium Compounds
Benzopyrenes
Benzene
See all (96) keywords
Co-Authors  
Aliaga, Cesar
Amin, Shantu
Cooper, Timothy
El bayoumy, Karam
Sun, Yuan-wan
See all (16) people
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