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Neil Sharkey
Institution College of Health and Human Development
Department Kinesiology
Address 201 Henderson Bldg
University Park, PA 16802
Telephone 8148631766
Email
Other Positions
Institution Huck Institutes of the Life Sciences
Background
PREFERRED TITLE/ROLE:

Professor of Kinesiology, Orthopaedics and Rehabilitation
Associate Dean for Research and Graduate Education, College of Health and Human Development

EDUCATION:

Ph.D., 1994, Pathology/Physiology, University of California at Davis

NARRATIVE:

Dr. Sharkey's research focuses on the musculoskeletal system (including normal, pathologic, and reconstructed function of bones and joints), mechanisms of injury, internal biomechanical behavior of the foot and ankle, and genetic determinants of bone health over the lifespan.
Publications
1. Shlisky JD, Hartman TJ, Kris-Etherton PM, Rogers CJ, Sharkey NA, Nickols-Richardson SM. Partial sleep deprivation and energy balance in adults: an emerging issue for consideration by dietetics practitioners. J Acad Nutr Diet. 2012 Nov; 112(11):1785-97.
  View in: PubMed
 
2. Zhang Y, Paul EM, Sathyendra V, Davison A, Sharkey N, Bronson S, Srinivasan S, Gross TS, Donahue HJ. Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. PLoS One. 2011; 6(8):e23516.
  View in: PubMed
 
3. Kirane YM, Lewis GS, Sharkey NA, Armstrong AD. Mechanical characteristics of a novel posterior-step prosthesis for biconcave glenoid defects. J Shoulder Elbow Surg. 2012 Jan; 21(1):105-15.
  View in: PubMed
 
4. Bryce CD, Davison AC, Okita N, Lewis GS, Sharkey NA, Armstrong AD. A biomechanical study of posterior glenoid bone loss and humeral head translation. J Shoulder Elbow Surg. 2010 Oct; 19(7):994-1002.
  View in: PubMed
 
5. Bussard KM, Okita N, Sharkey N, Neuberger T, Webb A, Mastro AM. Localization of osteoblast inflammatory cytokines MCP-1 and VEGF to the matrix of the trabecula of the femur, a target area for metastatic breast cancer cell colonization. Clin Exp Metastasis. 2010 May; 27(5):331-40.
  View in: PubMed
 
6. Saunders MM, Simmerman LA, Reed GL, Sharkey NA, Taylor AF. Biomimetic bone mechanotransduction modeling in neonatal rat femur organ cultures: structural verification of proof of concept. Biomech Model Mechanobiol. 2010 Oct; 9(5):539-50.
  View in: PubMed
 
7. Lang DH, Conroy DE, Lionikas A, Mack HA, Larsson L, Vogler GP, Vandenbergh DJ, Blizard DA, McClearn GE, Sharkey NA. Bone, muscle, and physical activity: structural equation modeling of relationships and genetic influence with age. J Bone Miner Res. 2009 Sep; 24(9):1608-17.
  View in: PubMed
 
8. Foreman JE, Lionikas A, Lang DH, Gyekis JP, Krishnan M, Sharkey NA, Gerhard GS, Grant MD, Vogler GP, Mack HA, Stout JT, Griffith JW, Lakoski JM, Hofer SM, McClearn GE, Vandenbergh DJ, Blizard DA. Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice. Genes Brain Behav. 2009 Oct; 8(7):714-27.
  View in: PubMed
 
9. McBrier NM, Neuberger T, Okita N, Webb A, Sharkey N. Reliability and validity of a novel muscle contusion device. J Athl Train. 2009 May-Jun; 44(3):275-8.
  View in: PubMed
 
10. Heller MF, Challis JH, Sharkey NA. Changes in postural sway as a consequence of wearing a military backpack. Gait Posture. 2009 Jul; 30(1):115-7.
  View in: PubMed
 
11. Okita N, Meyers SA, Challis JH, Sharkey NA. An objective evaluation of a segmented foot model. Gait Posture. 2009 Jul; 30(1):27-34.
  View in: PubMed
 
12. McBrier NM, Neuberger T, Denegar CR, Sharkey NA, Webb AG. Magnetic resonance imaging of acute injury in rats and the effects of buprenorphine on limb volume. J Am Assoc Lab Anim Sci. 2009 Mar; 48(2):147-51.
  View in: PubMed
 
13. Kirane YM, Michelson JD, Sharkey NA. Evidence of isometric function of the flexor hallucis longus muscle in normal gait. J Biomech. 2008; 41(9):1919-28.
  View in: PubMed
 
14. Kirane YM, Michelson JD, Sharkey NA. Contribution of the flexor hallucis longus to loading of the first metatarsal and first metatarsophalangeal joint. Foot Ankle Int. 2008 Apr; 29(4):367-77.
  View in: PubMed
 
15. Sharkey NA, Lang DH. Genes in context: probing the genetics of fracture resistance. Exerc Sport Sci Rev. 2007 Jul; 35(3):86-96.
  View in: PubMed
 
16. Shahnazari M, Lang DH, Fosmire GJ, Sharkey NA, Mitchell AD, Leach RM. Strontium administration in young chickens improves bone volume and architecture but does not enhance bone structural and material strength. Calcif Tissue Int. 2007 Mar; 80(3):160-6.
  View in: PubMed
 
17. Shahnazari M, Sharkey NA, Fosmire GJ, Leach RM. Effects of strontium on bone strength, density, volume, and microarchitecture in laying hens. J Bone Miner Res. 2006 Nov; 21(11):1696-703.
  View in: PubMed
 
18. Bower AL, Lang DH, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, McClearn GE, Sharkey NA. QTL analysis of trabecular bone in BXD F2 and RI mice. J Bone Miner Res. 2006 Aug; 21(8):1267-75.
  View in: PubMed
 
19. Lang DH, Sharkey NA, Lionikas A, Mack HA, Larsson L, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, Stitt JP, McClearn GE. Adjusting data to body size: a comparison of methods as applied to quantitative trait loci analysis of musculoskeletal phenotypes. J Bone Miner Res. 2005 May; 20(5):748-57.
  View in: PubMed
 
20. Lang DH, Sharkey NA, Mack HA, Vogler GP, Vandenbergh DJ, Blizard DA, Stout JT, McClearn GE. Quantitative trait loci analysis of structural and material skeletal phenotypes in C57BL/6J and DBA/2 second-generation and recombinant inbred mice. J Bone Miner Res. 2005 Jan; 20(1):88-99.
  View in: PubMed
 
21. Hamel AJ, Sharkey NA, Buczek FL, Michelson J. Relative motions of the tibia, talus, and calcaneus during the stance phase of gait: a cadaver study. Gait Posture. 2004 Oct; 20(2):147-53.
  View in: PubMed
 
22. Whipple TJ, Le BH, Demers LM, Chinchilli VM, Petit MA, Sharkey N, Williams NI. Acute effects of moderate intensity resistance exercise on bone cell activity. Int J Sports Med. 2004 Oct; 25(7):496-501.
  View in: PubMed
 
23. Sharkey NA. One step at a time: lessons learned from cadaver simulations of locomotion. J Orthop Sports Phys Ther. 2004 Sep; 34(9):A7-9.
  View in: PubMed
 
24. Michelson J, Hamel A, Buczek F, Sharkey N. The effect of ankle injury on subtalar motion. Foot Ankle Int. 2004 Sep; 25(9):639-46.
  View in: PubMed
 
25. Milgrom C, Finestone A, Hamel A, Mandes V, Burr D, Sharkey N. A comparison of bone strain measurements at anatomically relevant sites using surface gauges versus strain gauged bone staples. J Biomech. 2004 Jun; 37(6):947-52.
  View in: PubMed
 
26. Olson SA, Connolly EA, Smith S, Hamel AJ, Sharkey NA, Bay BK. Development of an animal model of acetabular fractures. Clin Orthop Relat Res. 2004 Jun; (423):64-73.
  View in: PubMed
 
27. Moran MF, Sanders JO, Sharkey NA, Piazza SJ. Effect of attachment site and routing variations in split tendon transfer of tibialis posterior. J Pediatr Orthop. 2004 May-Jun; 24(3):298-303.
  View in: PubMed
 
28. Erdemir A, Hamel AJ, Fauth AR, Piazza SJ, Sharkey NA. Dynamic loading of the plantar aponeurosis in walking. J Bone Joint Surg Am. 2004 Mar; 86-A(3):546-52.
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29. Piazza SJ, Adamson RL, Moran MF, Sanders JO, Sharkey NA. Effects of tensioning errors in split transfers of tibialis anterior and posterior tendons. J Bone Joint Surg Am. 2003 May; 85-A(5):858-65.
  View in: PubMed
 
30. Erdemir A, Hamel AJ, Piazza SJ, Sharkey NA. Fiberoptic measurement of tendon forces is influenced by skin movement artifact. J Biomech. 2003 Mar; 36(3):449-55.
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31. Whipple T, Sharkey N, Demers L, Williams N. Leptin and the skeleton. Clin Endocrinol (Oxf). 2002 Dec; 57(6):701-11.
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32. Michelson JD, Hamel AJ, Buczek FL, Sharkey NA. Kinematic behavior of the ankle following malleolar fracture repair in a high-fidelity cadaver model. J Bone Joint Surg Am. 2002 Nov; 84-A(11):2029-38.
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33. Erdemir A, Piazza SJ, Sharkey NA. Influence of loading rate and cable migration on fiberoptic measurement of tendon force. J Biomech. 2002 Jun; 35(6):857-62.
  View in: PubMed
 
34. Goodwin KJ, Sharkey NA. Material properties of interstitial lamellae reflect local strain environments. J Orthop Res. 2002 May; 20(3):600-6.
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35. Milgrom C, Finestone A, Sharkey N, Hamel A, Mandes V, Burr D, Arndt A, Ekenman I. Metatarsal strains are sufficient to cause fatigue fracture during cyclic overloading. Foot Ankle Int. 2002 Mar; 23(3):230-5.
  View in: PubMed
 
36. Piazza SJ, Adamson RL, Sanders JO, Sharkey NA. Changes in muscle moment arms following split tendon transfer of tibialis anterior and tibialis posterior. Gait Posture. 2001 Dec; 14(3):271-8.
  View in: PubMed
 
37. Hamel AJ, Donahue SW, Sharkey NA. Contributions of active and passive toe flexion to forefoot loading. Clin Orthop Relat Res. 2001 Dec; (393):326-34.
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38. Hertel J, Denegar CR, Buckley WE, Sharkey NA, Stokes WL. Effect of rearfoot orthotics on postural sway after lateral ankle sprain. Arch Phys Med Rehabil. 2001 Jul; 82(7):1000-3.
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39. Peterman MM, Hamel AJ, Cavanagh PR, Piazza SJ, Sharkey NA. In vitro modeling of human tibial strains during exercise in micro-gravity. J Biomech. 2001 May; 34(5):693-8.
  View in: PubMed
 
40. Donahue SW, Sharkey NA, Modanlou KA, Sequeira LN, Martin RB. Bone strain and microcracks at stress fracture sites in human metatarsals. Bone. 2000 Dec; 27(6):827-33.
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41. Sharkey NA, Williams NI, Guerin JB. The role of exercise in the prevention and treatment of osteoporosis and osteoarthritis. Nurs Clin North Am. 2000 Mar; 35(1):209-21.
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42. Donahue SW, Sharkey NA. Strains in the metatarsals during the stance phase of gait: implications for stress fractures. J Bone Joint Surg Am. 1999 Sep; 81(9):1236-44.
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43. Konrath GA, Hamel AJ, Guerin J, Olson SA, Bay B, Sharkey NA. Biomechanical evaluation of impaction fractures of the femoral head. J Orthop Trauma. 1999 Aug; 13(6):407-13.
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44. Forster RI, Sharkey NA, Szabo RM. Forearm interosseous ligament isometry. J Hand Surg Am. 1999 May; 24(3):538-45.
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45. Sharkey NA, Donahue SW, Ferris L. Biomechanical consequences of plantar fascial release or rupture during gait. Part II: alterations in forefoot loading. Foot Ankle Int. 1999 Feb; 20(2):86-96.
  View in: PubMed
 
46. Nagy SM, Szabo RM, Sharkey NA. Unilateral elbow arthrodesis: the preferred position. J South Orthop Assoc. 1999; 8(2):80-5.
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47. McKinley TO, McLain RF, Yerby SA, Sharkey NA, Sarigul-Klijn N, Smith TS. Characteristics of pedicle screw loading. Effect of surgical technique on intravertebral and intrapedicular bending moments. Spine (Phila Pa 1976). 1999 Jan 1; 24(1):18-24, discussion 25.
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48. Sharkey NA, Ferris L, Donahue SW. Biomechanical consequences of plantar fascial release or rupture during gait: part I--disruptions in longitudinal arch conformation. Foot Ankle Int. 1998 Dec; 19(12):812-20.
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49. Konrath GA, Hamel AJ, Olson SA, Bay B, Sharkey NA. The role of the acetabular labrum and the transverse acetabular ligament in load transmission in the hip. J Bone Joint Surg Am. 1998 Dec; 80(12):1781-8.
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50. Konrath GA, Hamel AJ, Sharkey NA, Bay BK, Olson SA. Biomechanical consequences of anterior column fracture of the acetabulum. J Orthop Trauma. 1998 Nov-Dec; 12(8):547-52.
  View in: PubMed
 
51. Sharkey NA, Hamel AJ. A dynamic cadaver model of the stance phase of gait: performance characteristics and kinetic validation. Clin Biomech (Bristol, Avon). 1998 Sep; 13(6):420-433.
  View in: PubMed
 
52. Marco RA, Sharkey NA, Smith TS, Zissimos AG. Pathomechanics of closed rupture of the flexor tendon pulleys in rock climbers. J Bone Joint Surg Am. 1998 Jul; 80(7):1012-9.
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53. Konrath GA, Hamel AJ, Sharkey NA, Bay B, Olson SA. Biomechanical evaluation of a low anterior wall fracture: correlation with the CT subchondral arc. J Orthop Trauma. 1998 Mar-Apr; 12(3):152-8.
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54. Hak DJ, Hamel AJ, Bay BK, Sharkey NA, Olson SA. Consequences of transverse acetabular fracture malreduction on load transmission across the hip joint. J Orthop Trauma. 1998 Feb; 12(2):90-100.
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55. Bay BK, Sharkey NA, Szabo RM. Displacement and strain of the median nerve at the wrist. J Hand Surg Am. 1997 Jul; 22(4):621-7.
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56. Ziran BH, Sharkey NA, Smith TS, Wang G, Chapman MW. Modified transverse locking nail fixation of proximal femoral fractures. Clin Orthop Relat Res. 1997 Jun; (339):82-91.
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57. Vogelsang RL, Vasseur PB, Peauroi JR, Kass PH, Sharkey N. Structural, material, and anatomic characteristics of the collateral ligaments of the canine cubital joint. Am J Vet Res. 1997 May; 58(5):461-6.
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58. Sharkey NA, Donahue SW, Smith TS, Bay BK, Marder RA. Patellar strain and patellofemoral contact after bone-patellar tendon-bone harvest for anterior cruciate ligament reconstruction. Arch Phys Med Rehabil. 1997 Mar; 78(3):256-63.
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59. Bay BK, Hamel AJ, Olson SA, Sharkey NA. Statically equivalent load and support conditions produce different hip joint contact pressures and periacetabular strains. J Biomech. 1997 Feb; 30(2):193-6.
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60. Pinkowski JL, Rodrigo JJ, Sharkey NA, Vasseur PB. Immune response to nonspecific and altered tissue antigens in soft tissue allografts. Clin Orthop Relat Res. 1996 May; (326):80-5.
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61. Rodrigo JJ, Heiden E, Hegyes M, Sharkey NA. Immune response inhibition by irrigating subchondral bone with cytotoxic agents. Clin Orthop Relat Res. 1996 May; (326):96-106.
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62. Donald PJ, Deckard-Janatpour K, Sharkey N, Lagunas-Solar M. The effects of irradiation dose on the stiffness of cartilage grafts. Ann Plast Surg. 1996 Mar; 36(3):297-303.
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63. Olson SA, Bay BK, Pollak AN, Sharkey NA, Lee T. The effect of variable size posterior wall acetabular fractures on contact characteristics of the hip joint. J Orthop Trauma. 1996; 10(6):395-402.
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64. Gillis C, Sharkey N, Stover SM, Pool RR, Meagher DM, Willits N. Ultrasonography as a method to determine tendon cross-sectional area. Am J Vet Res. 1995 Oct; 56(10):1270-4.
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65. Gillis C, Sharkey N, Stover SM, Pool RR, Meagher DM, Willits N. Effect of maturation and aging on material and ultrasonographic properties of equine superficial digital flexor tendon. Am J Vet Res. 1995 Oct; 56(10):1345-50.
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66. Olson SA, Bay BK, Chapman MW, Sharkey NA. Biomechanical consequences of fracture and repair of the posterior wall of the acetabulum. J Bone Joint Surg Am. 1995 Aug; 77(8):1184-92.
  View in: PubMed
 
67. Ferris L, Sharkey NA, Smith TS, Matthews DK. Influence of extrinsic plantar flexors on forefoot loading during heel rise. Foot Ankle Int. 1995 Aug; 16(8):464-73.
  View in: PubMed
 
68. Sharkey NA, Ferris L, Smith TS, Matthews DK. Strain and loading of the second metatarsal during heel-lift. J Bone Joint Surg Am. 1995 Jul; 77(7):1050-7.
  View in: PubMed
 
69. Sharkey NA, Marder RA. The rotator cuff opposes superior translation of the humeral head. Am J Sports Med. 1995 May-Jun; 23(3):270-5.
  View in: PubMed
 
70. Sharkey NA, Smith TS, Lundmark DC. Freeze clamping musculo-tendinous junctions for in vitro simulation of joint mechanics. J Biomech. 1995 May; 28(5):631-5.
  View in: PubMed
 
71. McLain RF, Fry MF, Moseley TA, Sharkey NA. Lumbar pedicle screw salvage: pullout testing of three different pedicle screw designs. J Spinal Disord. 1995 Feb; 8(1):62-8.
  View in: PubMed
 
72. Szabo RM, Bay BK, Sharkey NA, Gaut C. Median nerve displacement through the carpal canal. J Hand Surg Am. 1994 Nov; 19(6):901-6.
  View in: PubMed
 
73. Sharkey NA, Marder RA, Hanson PB. The entire rotator cuff contributes to elevation of the arm. J Orthop Res. 1994 Sep; 12(5):699-708.
  View in: PubMed
 
74. Zissimos AG, Szabo RM, Yinger KE, Sharkey NA. Biomechanics of the thumb flexor pulley system. J Hand Surg Am. 1994 May; 19(3):475-9.
  View in: PubMed
 
75. Szabo RM, Sharkey NA. Response of peripheral nerve to cyclic compression in a laboratory rat model. J Orthop Res. 1993 Nov; 11(6):828-33.
  View in: PubMed
 
76. Jones AA, Dougherty PJ, Sharkey NA, Benson DR. Iliac crest bone graft. Osteotome versus saw. Spine (Phila Pa 1976). 1993 Oct 15; 18(14):2048-52.
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77. Bay BK, Martin RB, Sharkey NA, Chapman MW. Repair of large cortical defects with block coralline hydroxyapatite. Bone. 1993 May-Jun; 14(3):225-30.
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78. Martin RB, Chapman MW, Sharkey NA, Zissimos SL, Bay B, Shors EC. Bone ingrowth and mechanical properties of coralline hydroxyapatite 1 yr after implantation. Biomaterials. 1993 Apr; 14(5):341-8.
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79. Marder RA, Swanson TV, Sharkey NA, Duwelius PJ. Effects of partial patellectomy and reattachment of the patellar tendon on patellofemoral contact areas and pressures. J Bone Joint Surg Am. 1993 Jan; 75(1):35-45.
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80. Hanson PB, Montesano PX, Sharkey NA, Rauschning W. Anatomic and biomechanical assessment of transarticular screw fixation for atlantoaxial instability. Spine (Phila Pa 1976). 1991 Oct; 16(10):1141-5.
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81. Vasseur PB, Stevenson S, Gregory CR, Rodrigo JJ, Pauli S, Heitter D, Sharkey N. Anterior cruciate ligament allograft transplantation in dogs. Clin Orthop Relat Res. 1991 Aug; (269):295-304.
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82. Leighton RK, Waddell JP, Bray TJ, hapman MW, Simpson L, Martin RB, Sharkey NA. Biomechanical testing of new and old fixation devices for vertical shear fractures of the pelvis. J Orthop Trauma. 1991; 5(3):313-7.
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83. Huang CD, Sharkey NA, Szabo RM. Coupled suturing: a new technique for microvascular anastomosis. Microsurgery. 1991; 12(2):72-5.
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84. Rodrigo JJ, Martin RB, Reynolds HB, Sharkey N, Zissimos S. Interlocking femoral components for revision arthroplasty with allografts. J Arthroplasty. 1990; 5 Suppl:S35-41.
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85. Sharkey NA, Hennings H, Yuspa SH, Blumberg PM. Comparison of octahydromezerein and mezerein as protein kinase C activators and as mouse skin tumor promoters. Carcinogenesis. 1989 Oct; 10(10):1937-41.
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86. Thorson E, Rodrigo JJ, Vasseur P, Sharkey N, Heitter D. Replacement of the anterior cruciate ligament. A comparison of autografts and allografts in dogs. Acta Orthop Scand. 1989 Oct; 60(5):555-60.
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87. Stevenson S, Dannucci GA, Sharkey NA, Pool RR. The fate of articular cartilage after transplantation of fresh and cryopreserved tissue-antigen-matched and mismatched osteochondral allografts in dogs. J Bone Joint Surg Am. 1989 Oct; 71(9):1297-307.
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88. Martin RB, Chapman MW, Holmes RE, Sartoris DJ, Shors EC, Gordon JE, Heitter DO, Sharkey NA, Zissimos AG. Effects of bone ingrowth on the strength and non-invasive assessment of a coralline hydroxyapatite material. Biomaterials. 1989 Sep; 10(7):481-8.
  View in: PubMed
 
89. Martin RB, Paul HA, Bargar WL, Dannucci GA, Sharkey NA. Effects of estrogen deficiency on the growth of tissue into porous titanium implants. J Bone Joint Surg Am. 1988 Apr; 70(4):540-7.
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90. Younger EW, Sharkey NA, Szabo RM. An apparatus to measure flexor tendon excursion and angular motion of the distal interphalangeal joint in a rabbit model. J Orthop Res. 1988; 6(3):462-4.
  View in: PubMed
 
91. Vasseur PB, Rodrigo JJ, Stevenson S, Clark G, Sharkey N. Replacement of the anterior cruciate ligament with a bone-ligament-bone anterior cruciate ligament allograft in dogs. Clin Orthop Relat Res. 1987 Jun; (219):268-77.
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92. Martin RB, Butcher RL, Sherwood LL, Buckendahl P, Boyd RD, Farris D, Sharkey N, Dannucci G. Effects of ovariectomy in beagle dogs. Bone. 1987; 8(1):23-31.
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93. Bargar WL, Sharkey NA, Paul HA, Manske DJ. Efficacy of bone staples for fixation. J Orthop Trauma. 1987; 1(4):326-30.
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94. Bargar WL, Paul HA, Merritt K, Sharkey N. The calcar bone graft. Clin Orthop Relat Res. 1986 Jan; (202):269-77.
  View in: PubMed
 
95. Bargar WL, Brown SA, Paul HA, Voegli T, Hseih Y, Sharkey N. In vivo versus in vitro polymerization of acrylic bone cement: effect on material properties. J Orthop Res. 1986; 4(1):86-9.
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96. Merritt K, Brown SA, Sharkey NA. The binding of metal salts and corrosion products to cells and proteins in vitro. J Biomed Mater Res. 1984 Nov-Dec; 18(9):1005-15.
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97. Merritt K, Brown SA, Sharkey NA. Blood distribution of nickel, cobalt, and chromium following intramuscular injection into hamsters. J Biomed Mater Res. 1984 Nov-Dec; 18(9):991-1004.
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Gait
Biomechanics
Foot
Bone and Bones
Models, Biological
See all (381) keywords
Co-Authors  
Blizard, David
Neuberger, Thomas
Piazza, Stephen
Vandenbergh, David
Vogler, George
See all (23) people
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