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Nelson Shu-Sang Yee
Title Assistant Professor
Institution College of Medicine
Department Hematology
Division Oncology
Address 500 University Drive, Hershey, PA 17033
Mailbox: CH46
Telephone 7175310003 x280677
Fax 7175315076
Email
Publications
1. Welsh JL, Wagner BA, Van't Erve TJ, Zehr PS, Berg DJ, Halfdanarson TR, Yee NS, Bodeker KL, Du J, Roberts LJ, Drisko J, Levine M, Buettner GR, Cullen JJ. Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial. Cancer Chemother Pharmacol. 2013 Mar; 71(3):765-75.
  View in: PubMed
 
2. Yee NS. Toward the goal of personalized therapy in pancreatic cancer by targeting the molecular phenotype. Adv Exp Med Biol. 2013; 779:91-143.
  View in: PubMed
 
3. Yee NS. Toward the goal of personalized therapy in pancreatic cancer by targeting the molecular phenotype. Adv Exp Med Biol. 2013; 779:91-143.
 
4. Yee NS, Brown RD, Lee MS, Zhou W, Jensen C, Gerke H, Yee RK. TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target. Cancer Biol Ther. 2012 Jun; 13(8):592-9.
  View in: PubMed
 
5. Yee NS, Zhou W, Chun SG, Liang IC, Yee RK. . Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biol Open. 2012; 1(4):295-307.
 
6. Yee NS, Zhou W, Chun SG, Liang IC, Yee RK. Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biol Open. 2012 Apr 15; 1(4):295-307.
  View in: PubMed
 
7. Yee NS, Zhou W, Lee M, Yee RK. Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma. Cancer Lett. 2012 May 1; 318(1):99-105.
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8. Yee NS. Brca2 deficiency and Trp53 deregulation in pancreatic cancer: implications for therapeutic targeting. Cancer Biol Ther. 2011 Jun 1; 11(11):969-73.
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9. Zhou W, Liang IC, Yee NS. Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer. Cancer Biol Ther. 2011 Apr 1; 11(7):659-70.
  View in: PubMed
 
10. Chun SG, Yee NS, Holland JM, Shohet RV, Palalay MP, Bryant-Greenwood PK. Pancreatic Adenocarcinoma Associated With Werner's Syndrome (Adult-Onset Progeria). Gastrointest Cancer Res. 2011 Jan; 4(1):24-8.
  View in: PubMed
 
11. Yee NS, Zhou W, Liang IC. Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Dis Model Mech. 2011 Mar; 4(2):240-54.
  View in: PubMed
 
12. Chun SG, Yee NS. Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy. Cancer Biol Ther. 2010 Sep; 10(5):430-7.
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13. Yee NS, Zhou W, Lee M. Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma. Cancer Lett. 2010 Nov 1; 297(1):49-55.
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14. Chun SG, Zhou W, Yee NS. Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. Cancer Biol Ther. 2009 Jul; 8(14):1328-39.
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15. Yee NS, Gong W, Huang Y, Lorent K, Dolan AC, Maraia RJ, Pack M. Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. PLoS Biol. 2007 Nov; 5(11):e312.
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16. Yee NS, Schuster SJ. Clinical remission of acquired thrombasthenia with low-dose methotrexate in a patient with systemic lupus erythematosus. Mayo Clin Proc. 2006 Apr; 81(4):566-7.
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17. Yee NS, Lorent K, Pack M. Exocrine pancreas development in zebrafish. Dev Biol. 2005 Aug 1; 284(1):84-101.
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18. Yee NS, Pack M. Zebrafish as a model for pancreatic cancer research. Methods Mol Med. 2005; 103:273-98.
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19. Lin JW, Biankin AV, Horb ME, Ghosh B, Prasad NB, Yee NS, Pack MA, Leach SD. Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Dev Biol. 2004 Oct 15; 274(2):491-503.
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20. Lin JW, Biankin AV, Horb ME, Ghosh B, Prasad NB, Yee NS, Pack MA, Leach SD. Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Dev Biol. 2004 Jun 15; 270(2):474-86.
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21. Yee NS, Furth EE, Pack M. Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome. Cancer Biol Ther. 2003 Jan-Feb; 2(1):38-47.
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22. Yee NS, Schuster SJ, Lichtenstein GR. Ischemic colitis associated with anti-beta2 glycoprotein-I antibody. Ann Intern Med. 2002 Aug 20; 137(4):299.
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23. Yee NS, Yusuff S, Pack M. Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell. Genesis. 2001 Jul; 30(3):137-40.
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24. Lichtenstein GR, Yee NS. Ischemic colitis associated with decongestant use. Ann Intern Med. 2000 Apr 18; 132(8):682.
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25. Yee NS, Guerry D, Lichtenstein GR. Ischemic colitis associated with factor V Leiden mutation. Ann Intern Med. 2000 Apr 4; 132(7):595-6.
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26. Vosseller K, Stella G, Yee NS, Besmer P. c-kit receptor signaling through its phosphatidylinositide-3'-kinase-binding site and protein kinase C: role in mast cell enhancement of degranulation, adhesion, and membrane ruffling. Mol Biol Cell. 1997 May; 8(5):909-22.
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27. Serve H, Yee NS, Stella G, Sepp-Lorenzino L, Tan JC, Besmer P. Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J. 1995 Feb 1; 14(3):473-83.
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28. Yee NS, Hsiau CW, Serve H, Vosseller K, Besmer P. Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C. J Biol Chem. 1994 Dec 16; 269(50):31991-8.
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29. Durand B, Migliaccio G, Yee NS, Eddleman K, Huima-Byron T, Migliaccio AR, Adamson JW. Long-term generation of human mast cells in serum-free cultures of CD34+ cord blood cells stimulated with stem cell factor and interleukin-3. Blood. 1994 Dec 1; 84(11):3667-74.
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30. Yee NS, Paek I, Besmer P. Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice. J Exp Med. 1994 Jun 1; 179(6):1777-87.
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31. Yee NS, Langen H, Besmer P. Mechanism of kit ligand, phorbol ester, and calcium-induced down-regulation of c-kit receptors in mast cells. J Biol Chem. 1993 Jul 5; 268(19):14189-201.
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32. Ray P, Higgins KM, Tan JC, Chu TY, Yee NS, Nguyen H, Lacy E, Besmer P. Ectopic expression of a c-kitW42 minigene in transgenic mice: recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors. Genes Dev. 1991 Dec; 5(12A):2265-73.
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33. Yee NS, Shargel L. Effect of cimetidine or ranitidine pretreatment on hepatic mixed function oxidase activity in the rat. Drug Metab Dispos. 1986 Sep-Oct; 14(5):580-4.
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Pancreatic Neoplasms
Adenocarcinoma
Zebrafish
Pancreas, Exocrine
TRPM Cation Channels
See all (226) keywords
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