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Zissis Chroneos
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Title Associate Professor
Institution College of Medicine
Department Pediatrics
Address 500 University Drive, Hershey, PA 17033
 Mailbox: H085
Telephone 7175310003
Email
Background
PREFERRED TITLE/ROLE:

Associate Proffesor of Pediatrics

EDUCATION:

1988, B.S.(honors), Biochemical and Biophysical Sciences, University of Houston Honors College, Houston, TX
1992, Ph.D., Chemistry, University of South Carolina, Columbia, SC
1992-1994, Post-Doctoral Fellowship in Biochemistry, Vanderbilt University School of Medicine, Nashville, TN
1994-1997, Post-doctoral Fellowship in Pulmonary Biology and Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

NARRATIVE:

The long-term goal of my research is to elucidate the role of pulmonary surfactant in perinatal development of the pulmonary immune system, lung host defense, inflammation, and injury. Alveolar type II epithelial cells produce surfactant, a complex of lipids and proteins lining the alveolar surface. Surfactant is critical for both respiratory gas exchange and the immunological integrity of the lower respiratory tract. Surfactant dysfunction thwarts the ability of alveolar macrophages to fight infection and, furthermore, to properly initiate, develop, and cease inflammatory reactions to infectious organisms and endogenous insults. Fundamental research on lung surfactant is an urgently needed and largely untapped resource in understanding, diagnosis, and treatment of chronic inflammation, acute lung injury, neonatal and adult respiratory distress syndromes, and pneumonia caused by pathogenic and drug-resistant organisms.

Surfactant modifies the ability of alveolar macrophages and type II epithelial cells to maintain immunological homeostasis avoiding inappropriate inflammatory reactions by innocuous antigens in the air we breathe. Surfactant contains the microbial binding proteins SP-A and SP-D which recognize and mediate clearance of pathogenic microorganisms by alveolar macrophages. During infection, SP-A and SP-D regulate the timing, magnitude, and resolution of inflammation. In the absence of infection, SP-A and SP-D suppress unnecessary activation of antigen-experienced lymphocytes and other immune cells in the lower respiratory tract. My research over the last 15 years has defined receptor-mediated mechanisms through which surfactant components modulate inflammatory, immune, and metabolic functions of alveolar macrophages and type II epithelial cells.
Publications
1. Sever-Chroneos Z, Tvinnereim A, Hunter RL, Chroneos ZC. Prolonged survival of scavenger receptor class A-deficient mice from pulmonary Mycobacterium tuberculosis infection. Tuberculosis (Edinb). 2011 Dec; 91 Suppl 1:S69-74.
  View in: PubMed
 
2. Sever-Chroneos Z, Murthy A, Davis J, Florence JM, Kurdowska A, Krupa A, Tichelaar JW, White MR, Hartshorn KL, Kobzik L, Whitsett JA, Chroneos ZC. GM-CSF modulates pulmonary resistance to influenza A infection. Antiviral Res. 2011 Nov; 92(2):319-28.
  View in: PubMed
 
3. Midde KK, Batchinsky AI, Cancio LC, Shetty S, Komissarov AA, Florova G, Walker KP, Koenig K, Chroneos ZC, Allen T, Chung K, Dubick M, Idell S. Wood bark smoke induces lung and pleural plasminogen activator inhibitor 1 and stabilizes its mRNA in porcine lung cells. Shock. 2011 Aug; 36(2):128-37.
  View in: PubMed
 
4. Huang FF, Barnes PF, Feng Y, Donis R, Chroneos ZC, Idell S, Allen T, Perez DR, Whitsett JA, Dunussi-Joannopoulos K, Shams H. GM-CSF in the lung protects against lethal influenza infection. Am J Respir Crit Care Med. 2011 Jul 15; 184(2):259-68.
  View in: PubMed
 
5. Sever-Chroneos Z, Krupa A, Davis J, Hasan M, Yang CH, Szeliga J, Herrmann M, Hussain M, Geisbrecht BV, Kobzik L, Chroneos ZC. Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A. J Biol Chem. 2011 Feb 11; 286(6):4854-70.
  View in: PubMed
 
6. Chroneos ZC, Sever-Chroneos Z, Shepherd VL. Pulmonary surfactant: an immunological perspective. Cell Physiol Biochem. 2010; 25(1):13-26.
  View in: PubMed
 
7. Chroneos ZC, Midde K, Sever-Chroneos Z, Jagannath C. Pulmonary surfactant and tuberculosis. Tuberculosis (Edinb). 2009 Dec; 89 Suppl 1:S10-4.
  View in: PubMed
 
8. Samten B, Townsend JC, Sever-Chroneos Z, Pasquinelli V, Barnes PF, Chroneos ZC. An antibody against the surfactant protein A (SP-A)-binding domain of the SP-A receptor inhibits T cell-mediated immune responses to Mycobacterium tuberculosis. J Leukoc Biol. 2008 Jul; 84(1):115-23.
  View in: PubMed
 
9. Szeliga J, Daniel DS, Yang CH, Sever-Chroneos Z, Jagannath C, Chroneos ZC. Granulocyte-macrophage colony stimulating factor-mediated innate responses in tuberculosis. Tuberculosis (Edinb). 2008 Jan; 88(1):7-20.
  View in: PubMed
 
10. Yang CH, Szeliga J, Jordan J, Faske S, Sever-Chroneos Z, Dorsett B, Christian RE, Settlage RE, Shabanowitz J, Hunt DF, Whitsett JA, Chroneos ZC. Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A. J Biol Chem. 2005 Oct 14; 280(41):34447-57.
  View in: PubMed
 
11. Szeliga J, Jordan J, Yang CH, Sever-Chroneos Z, Chroneos ZC. Bacterial expression of recombinant MyoXVIIIA domains. Anal Biochem. 2005 Nov 1; 346(1):179-81.
  View in: PubMed
 
12. Wizel B, Starcher BC, Samten B, Chroneos Z, Barnes PF, Dzuris J, Higashimoto Y, Appella E, Sette A. Multiple Chlamydia pneumoniae antigens prime CD8+ Tc1 responses that inhibit intracellular growth of this vacuolar pathogen. J Immunol. 2002 Sep 1; 169(5):2524-35.
  View in: PubMed
 
13. Shibata Y, Berclaz PY, Chroneos ZC, Yoshida M, Whitsett JA, Trapnell BC. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity. 2001 Oct; 15(4):557-67.
  View in: PubMed
 
14. Gurel O, Ikegami M, Chroneos ZC, Jobe AH. Macrophage and type II cell catabolism of SP-A and saturated phosphatidylcholine in mouse lungs. Am J Physiol Lung Cell Mol Physiol. 2001 Jun; 280(6):L1266-72.
  View in: PubMed
 
15. Yoshida M, Ikegami M, Reed JA, Chroneos ZC, Whitsett JA. GM-CSF regulates protein and lipid catabolism by alveolar macrophages. Am J Physiol Lung Cell Mol Physiol. 2001 Mar; 280(3):L379-86.
  View in: PubMed
 
16. Chroneos ZC, Wert SE, Livingston JL, Hassett DJ, Whitsett JA. Role of cystic fibrosis transmembrane conductance regulator in pulmonary clearance of Pseudomonas aeruginosa in vivo. J Immunol. 2000 Oct 1; 165(7):3941-50.
  View in: PubMed
 
17. Weikert LF, Lopez JP, Abdolrasulnia R, Chroneos ZC, Shepherd VL. Surfactant protein A enhances mycobacterial killing by rat macrophages through a nitric oxide-dependent pathway. Am J Physiol Lung Cell Mol Physiol. 2000 Aug; 279(2):L216-23.
  View in: PubMed
 
18. Ikegami M, Whitsett JA, Chroneos ZC, Ross GF, Reed JA, Bachurski CJ, Jobe AH. IL-4 increases surfactant and regulates metabolism in vivo. Am J Physiol Lung Cell Mol Physiol. 2000 Jan; 278(1):L75-80.
  View in: PubMed
 
19. Borron P, McCormack FX, Elhalwagi BM, Chroneos ZC, Lewis JF, Zhu S, Wright JR, Shepherd VL, Possmayer F, Inchley K, Fraher LJ. Surfactant protein A inhibits T cell proliferation via its collagen-like tail and a 210-kDa receptor. Am J Physiol. 1998 Oct; 275(4 Pt 1):L679-86.
  View in: PubMed
 
20. Jain-Vora S, LeVine AM, Chroneos Z, Ross GF, Hull WM, Whitsett JA. Interleukin-4 enhances pulmonary clearance of Pseudomonas aeruginosa. Infect Immun. 1998 Sep; 66(9):4229-36.
  View in: PubMed
 
21. Weikert LF, Edwards K, Chroneos ZC, Hager C, Hoffman L, Shepherd VL. SP-A enhances uptake of bacillus Calmette-Guérin by macrophages through a specific SP-A receptor. Am J Physiol. 1997 May; 272(5 Pt 1):L989-95.
  View in: PubMed
 
22. Chroneos ZC, Abdolrasulnia R, Whitsett JA, Rice WR, Shepherd VL. Purification of a cell-surface receptor for surfactant protein A. J Biol Chem. 1996 Jul 5; 271(27):16375-83.
  View in: PubMed
 
23. Chroneos Z, Shepherd VL. Differential regulation of the mannose and SP-A receptors on macrophages. Am J Physiol. 1995 Dec; 269(6 Pt 1):L721-6.
  View in: PubMed
 
24. Chroneos ZC, Baynes JW, Thorpe SR. Identification of liver endothelial cells as the primary site of IgM catabolism in the rat. Arch Biochem Biophys. 1995 May 10; 319(1):63-73.
  View in: PubMed
 
25. Thorpe SR, Baynes JW, Chroneos ZC. The design and application of residualizing labels for studies of protein catabolism. FASEB J. 1993 Mar; 7(5):399-405.
  View in: PubMed
 
26. Potter D, Chroneos ZC, Baynes JW, Sinclair PR, Gorman N, Liem HH, Muller-Eberhard U, Thorpe SR. In vivo fate of hemopexin and heme-hemopexin complexes in the rat. Arch Biochem Biophys. 1993 Jan; 300(1):98-104.
  View in: PubMed
 
27. Vu QA, Zhang DE, Chroneos ZC, Nelson DA. Polyamines inhibit the yeast histone deacetylase. FEBS Lett. 1987 Aug 10; 220(1):79-83.
  View in: PubMed
 
 
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