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Patricia Silveyra
Title Assistant Professor
Institution College of Medicine
Department Pediatrics
Address 500 University Drive, Hershey, PA 17033
Mailbox: H085
Telephone 7175316973
Email
Background
Dr. Silveyra's current research focuses on gender differences in pulmonary miRNA expression, and in response to environmental oxidative stress. Sex differences in lung function and in the risk and severity of various lung diseases have been identified, and in general, women are less likely to develop most types of respiratory infection than men. However, increasing evidence suggests that environmental factors reverse these patterns. The goal of this study is to determine whether sex differences in the expression of lung miRNAs play a role in the differential susceptibility to lung infection and/or disease. Our hypothesis is that sex differences in the miRNome in response to ozone-induced oxidative stress account for differential expression of molecules that affect the immune response to infection. This project is funded by an Penn State K12 BIRCWH award from NIH.

Dr. Silveyra studies the role of miRNAs in the development and resolution of lung disease, infection, and injury caused by environmental stressors, and in the individual and/or gender-related susceptibility to lung disease. She is currently working in a collaborative project aimed to identify miRNA biomarkers for inflammatory lung disease in tracheal aspirates and bronchoalveolar lavage fluid of newborns and infants.

Finally, as a member of the Floros lab, Dr. Silveyra performs research on role of miRNAs in the differential translation of surfactant protein A (SP-A) genetic variants. Human SP-A is an innate immune system collectin encoded by two genes. A number of genetic variants of these two genes have been identified and characterized, and some of these associate with lung disease susceptibility. MiRNAs negatively affect translation by sequence-specific interactions with the 3’ untranslated regions (3’UTRs). The goal of this study is to determine the effects of specific miRNAs in the expression of SP-A variants with sequence polymorphisms at the 3’UTR. This project is currently funded by grants from Children's Miracle Network and a Graduate Women in Science (GWIS) fellowship.

Publications
1. Noutsios GT, Silveyra P, Bhatti F, Floros J. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences interacts with 14-3-3; role of cis elements and secondary structure. Am J Physiol Lung Cell Mol Physiol. 2013 Mar 22.
  View in: PubMed
 
2. Yang W, Ni L, Silveyra P, Wang G, Noutsios GT, Singh A, DiAngelo SL, Sanusi O, Raval M, Floros J. Motifs within the CA-repeat-rich region of Surfactant Protein B (SFTPB) intron 4 differentially affect mRNA splicing. 2013; 2(1):40-55.
  View in: External Web Site
 
3. Silveyra P, Floros J. Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2. Gene. 2012 Oct 12.
  View in: PubMed
 
4. Silveyra P, Floros J. Air pollution and epigenetics: effects on SP-A and innate host defence in the lung. Swiss Med Wkly. 2012; 142:w13579.
  View in: PubMed
 
5. Durrani F, Phelps DS, Weisz J, Silveyra P, Hu S, Mikerov AN, Floros J. Gonadal hormones and oxidative stress interaction differentially affects survival of male and female mice after lung Klebsiella pneumoniae infection. Exp Lung Res. 2012 May; 38(4):165-72.
  View in: PubMed
 
6. Silveyra P, Floros J. Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury. Front Biosci. 2012; 17:407-29.
  View in: PubMed
 
7. Floros J, Londono D, Gordon D, Silveyra P, Diangelo SL, Viscardi RM, Worthen GS, Shenberger J, Wang G, Lin Z, Thomas NJ. IL-18R1 and IL-18RAP SNPs may be associated with bronchopulmonary dysplasia in African-American infants. Pediatr Res. 2012 Jan; 71(1):107-14.
  View in: PubMed
 
8. Silveyra P, Raval M, Simmons B, Diangelo S, Wang G, Floros J. The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L795-803.
  View in: PubMed
 
9. Silveyra P, Wang G, Floros J. Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene. Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L523-34.
  View in: PubMed
 
10. Silveyra P, Cataldi NI, Lux-Lantos VA, Libertun C. Role of orexins in the hypothalamic-pituitary-ovarian relationships. Acta Physiol (Oxf). 2010 Mar; 198(3):355-60.
  View in: PubMed
 
11. Silveyra P, Cataldi NI, Lux-Lantos V, Libertun C. Gonadal steroids modulated hypocretin/orexin type-1 receptor expression in a brain region, sex and daytime specific manner. Regul Pept. 2009 Nov 27; 158(1-3):121-6.
  View in: PubMed
 
12. García-Tornadú I, Díaz-Torga G, Risso GS, Silveyra P, Cataldi N, Ramirez MC, Low MJ, Libertun C, Becu-Villalobos D. Hypothalamic orexin, OX1, alphaMSH, NPY and MCRs expression in dopaminergic D2R knockout mice. Neuropeptides. 2009 Aug; 43(4):267-74.
  View in: PubMed
 
13. Wang G, Guo X, Silveyra P, Kimball SR, Floros J. Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution. Am J Physiol Lung Cell Mol Physiol. 2009 Apr; 296(4):L635-47.
  View in: PubMed
 
14. Silveyra P, Lux-Lantos V, Libertun C. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab. 2007 Oct; 293(4):E977-85.
  View in: PubMed
 
15. Silveyra P, Catalano PN, Lux-Lantos V, Libertun C. Impact of proestrous milieu on expression of orexin receptors and prepro-orexin in rat hypothalamus and hypophysis: actions of Cetrorelix and Nembutal. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E820-8.
  View in: PubMed
 
16. Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos VA. GABA(B1) knockout mice reveal alterations in prolactin levels, gonadotropic axis, and reproductive function. Neuroendocrinology. 2005; 82(5-6):294-305.
  View in: PubMed
 
17. Bianchi MS, Catalano PN, Bonaventura MM, Silveyra P, Bettler B, Libertun C, Lux-Lantos VA. Effect of androgens on sexual differentiation of pituitary gamma-aminobutyric acid receptor subunit GABA(B) expression. Neuroendocrinology. 2004; 80(3):129-42.
  View in: PubMed
 
 
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Co-Authors  
Floros, Joanna
Kimball, Scot
Lin, Zhenwu
Thomas, Neal
Weisz, Judith
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