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C. Bart Rountree
Title Associate Professor
Institution College of Medicine
Department Pediatrics
Division Pediatric Gastroenterology
Address 500 University Drive, Hershey, PA 17033
Mailbox: H085
Telephone 7175315901
Email
Background
EDUCATION

B.A., Dartmouth College, 1995
M.D., University of Texas Health Science Center at San Antonio, 2000
Residency, Pediatrics, Children's Hospital Los Angeles, 2003
Fellowship, Pediatric Gastroenterology, Children's Hospital, Los Angeles 2007


NARRATIVE

Dr. Rountree is currently focused on elucidating the role of liver stem cells in hepatocarcinogenesis. Liver cancer stem cells are proposed to be the cause of metastasis, disease resistance, and tumor re-growth after resection/transplant. He has described novel liver stem cell and cancer stem cell populations using CD133 and CD44 surface expression. His work utilizes both murine models of chronic liver injury and human cirrhosis and liver cancer samples. Current projects include:

1) Understanding epithelial-to-mesenchymal transition in liver cancer metastasis and chemotherapy resistance

2) Targeting receptor tyrosine kinases, which are primary driver of epithelial-to-mesenchymal transition and liver cancer stem cell proliferation

3) Understanding the transcriptional regulators of stem cell genes in liver cancer stem cell populations

4) Utilizing Dynamic Network Modeling to identify key targets of survival in liver cancer stem cell populations
Publications
1. Avella DM, Li G, Schell TD, Liu D, Zhang SS, Lou X, Berg A, Kimchi ET, Tagaram HR, Yang Q, Shereef S, Garcia LS, Kester M, Isom HC, Rountree CB, Staveley-O'Carroll KF. Regression of established hepatocellular carcinoma is induced by chemoimmunotherapy in an orthotopic murine model. Hepatology. 2012 Jan; 55(1):141-52.
  View in: PubMed
 
2. Rountree CB, Mishra L, Willenbring H. Stem cells in liver diseases and cancer: recent advances on the path to new therapies. Hepatology. 2012 Jan; 55(1):298-306.
  View in: PubMed
 
3. Rountree CB, Ding W, Dang H, Vankirk C, Crooks GM. Isolation of CD133+ liver stem cells for clonal expansion. J Vis Exp. 2011; (56).
  View in: PubMed
 
4. Dang H, Ding W, Emerson D, Rountree CB. Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics. BMC Cancer. 2011; 11:396.
  View in: PubMed
 
5. You H, Ding W, Dang H, Jiang Y, Rountree CB. c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma. Hepatology. 2011 Sep 2; 54(3):879-89.
  View in: PubMed
 
6. Rountree CB. Stem cells in drug discovery, regenerative medicine and cancer. Genome Med. 2011; 3(3):15.
  View in: PubMed
 
7. Rountree CB, Van Kirk CA, You H, Ding W, Dang H, VanGuilder HD, Freeman WM. Clinical application for the preservation of phospho-proteins through in-situ tissue stabilization. Proteome Sci. 2010; 8:61.
  View in: PubMed
 
8. Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles BL. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 2010 Dec; 139(6):2170-82.
  View in: PubMed
 
9. Ding W, You H, Dang H, LeBlanc F, Galicia V, Lu SC, Stiles B, Rountree CB. Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology. 2010 Sep; 52(3):945-53.
  View in: PubMed
 
10. Mouzaki M, Nichter C, Qureshi M, Rountree B, Furuya KN. Idiopathic intracranial hypertension in two patients with Alagille syndrome. J Child Neurol. 2010 Aug; 25(8):1006-8.
  View in: PubMed
 
11. You H, Ding W, Rountree CB. Epigenetic regulation of cancer stem cell marker CD133 by transforming growth factor-beta. Hepatology. 2010 May; 51(5):1635-44.
  View in: PubMed
 
12. Ding W, Mouzaki M, You H, Laird JC, Mato J, Lu SC, Rountree CB. CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. Hepatology. 2009 Apr; 49(4):1277-86.
  View in: PubMed
 
13. Rountree CB, Ding W, He L, Stiles B. Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells. 2009 Feb; 27(2):290-9.
  View in: PubMed
 
14. Rountree CB, Senadheera S, Mato JM, Crooks GM, Lu SC. Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice. Hepatology. 2008 Apr; 47(4):1288-97.
  View in: PubMed
 
15. Berg T, Rountree CB, Lee L, Estrada J, Sala FG, Choe A, Veltmaat JM, De Langhe S, Lee R, Tsukamoto H, Crooks GM, Bellusci S, Wang KS. Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology. 2007 Oct; 46(4):1187-97.
  View in: PubMed
 
16. Rountree CB, Barsky L, Ge S, Zhu J, Senadheera S, Crooks GM. A CD133-expressing murine liver oval cell population with bilineage potential. Stem Cells. 2007 Oct; 25(10):2419-29.
  View in: PubMed
 
17. Rountree CB, Wang X, Ge S, Barsky L, Zhu J, Gonzales I, Crooks GM. Bone marrow fails to differentiate into liver epithelium during murine development and regeneration. Hepatology. 2007 May; 45(5):1250-60.
  View in: PubMed
 
18. Wang X, Ge S, Gonzalez I, McNamara G, Rountree CB, Xi KK, Huang G, Bhushan A, Crooks GM. Formation of pancreatic duct epithelium from bone marrow during neonatal development. Stem Cells. 2006 Feb; 24(2):307-14.
  View in: PubMed
 
19. Hemphill RR, Santen SA, Rountree CB, Szmit AR. Patients' understanding of the roles of interns, residents, and attending physicians in the emergency department. Acad Emerg Med. 1999 Apr; 6(4):339-44.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Liver Neoplasms
Neoplastic Stem Cells
Antigens, CD
Glycoproteins
Carcinoma, Hepatocellular
See all (141) keywords
Co-Authors  
Ding, Wei
Kester, Mark
Staveley-O'Carroll, Kevin
You, Hanning
Zhang, Samuel
See all (11) people
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