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Zachary Simmons
Title Professor
Institution College of Medicine
Department Neurology
Address 500 University Drive Hershey PA 17033
Telephone 7175311802
Email
Background
PREFERRED TITLE/ROLE:

Physician, Professor of Neurology

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Orthopaedics

GRADUATE PROGRAM AFFILIATIONS:

Neuroscience

EDUCATION:

Fellowship, Neuromuscular Diseases, University of Michigan Hospitals & Health Centers (1992)
Residency, Neurology, University of Iowa Hospitals and Clinics (1986)
Internship, Internal Medicine, University of Iowa Hospitals and Clinics (1983)
M.D., University of Florida, College of Medicine (1982)

NARRATIVE:

We currently have a multidisciplinary team studying Quality of Life issues in patients with ALS and their care givers. We also have a number of other clinical studies involving ALS: 1) religiosity and spirituality; 2) injections of botulinum toxin into the parotid glands to decrease sialorrhea; 3) evaluation of cognition; 4) evaluation of emotional processing; 5) the use of high-frequency chest wall oscillation. In the more basic sciences, collaborative work is being done with Dr. James Connor of the Department of Neural and Behavioral Sciences to study the role of the iron in ALS, and to explore the gene chip (microarray) as a means of understanding ALS. We have an ongoing ALS autopsy/tissue donation program through which our patients can choose to provide tissue for research after death.
In fields other than ALS, we have access to 3,4-diaminopyridine for the treatment of Lambert-Eaton myasthenic syndrome and congenital disorders of neuromuscular transmission.
Publications
1. Houseman G, Walsh S, Brothers A, Lyter J, Simmons Z, Klapper J. Frontotemporal degeneration in the patient with amyotrophic lateral sclerosis: helping the caregiver cope. J Neurosci Nurs. 2013 Apr; 45(2):96-100.
  View in: PubMed
 
2. Roney JR, Simmons ZL. Hormonal predictors of sexual motivation in natural menstrual cycles. Horm Behav. 2013 Apr; 63(4):636-45.
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3. Simmons Z. Rehabilitation of motor neuron disease. Handb Clin Neurol. 2013; 110:483-98.
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4. Simmons Z. Electrodiagnosis of brachial plexopathies and proximal upper extremity neuropathies. Phys Med Rehabil Clin N Am. 2013 Feb; 24(1):13-32.
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5. Roney JR, Simmons ZL. Men smelling women: null effects of exposure to ovulatory sweat on men's testosterone. Evol Psychol. 2012; 10(4):703-13.
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6. Burns TM, Graham CD, Rose MR, Simmons Z. Quality of life and measures of quality of life in patients with neuromuscular disorders. Muscle Nerve. 2012 Jul; 46(1):9-25.
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7. Simmons Z. What's in the literature? J Clin Neuromuscul Dis. 2012 Mar; 13(3):162-7.
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8. Pagnini F, Simmons Z, Corbo M, Molinari E. Amyotrophic lateral sclerosis: time for research on psychological intervention? Amyotroph Lateral Scler. 2012 Sep; 13(5):416-7.
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9. Zamietra K, Lehman EB, Felgoise SH, Walsh SM, Stephens HE, Simmons Z. Non-invasive ventilation and gastrostomy may not impact overall quality of life in patients with ALS. Amyotroph Lateral Scler. 2012 Jan; 13(1):55-8.
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10. Isackson PJ, Ochs-Balcom HM, Ma C, Harley JB, Peltier W, Tarnopolsky M, Sripathi N, Wortmann RL, Simmons Z, Wilson JD, Smith SA, Barboi A, Fine E, Baer A, Baker S, Kaufman K, Cobb B, Kilpatrick JR, Vladutiu GD. Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS. Muscle Nerve. 2011 Oct; 44(4):531-8.
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11. Simmons ZL, Roney JR. Variation in CAG repeat length of the androgen receptor gene predicts variables associated with intrasexual competitiveness in human males. Horm Behav. 2011 Aug; 60(3):306-12.
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12. McAllister MW, Hsi RS, Torrey RR, Simmons Z, Baldwin BD, Baldwin DD. In vitro comparison of changes in effective patient weight between purely laparoscopic and hand-assisted laparoscopic surgery. J Endourol. 2011 Apr; 25(4):651-5.
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13. Flaherty-Craig CV, Brothers A, Yang C, Svoboda R, Simmons Z. Declines in problem solving and anosognosia in amyotrophic lateral sclerosis: application of Guilford's structure of intellect theory. Cogn Behav Neurol. 2011 Mar; 24(1):26-34.
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14. Liu Y, Lee SY, Neely E, Nandar W, Moyo M, Simmons Z, Connor JR. Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability. J Biol Chem. 2011 Apr 15; 286(15):13161-70.
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15. Cupp J, Simmons Z, Berg A, Felgoise SH, Walsh SM, Stephens HE. Psychological health in patients with ALS is maintained as physical function declines. Amyotroph Lateral Scler. 2011 Jul; 12(4):290-6.
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16. Bede P, Oliver D, Stodart J, van den Berg L, Simmons Z, O Brannagáin D, Borasio GD, Hardiman O. Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives. J Neurol Neurosurg Psychiatry. 2011 Apr; 82(4):413-8.
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17. Roney JR, Simmons ZL, Gray PB. Changes in estradiol predict within-women shifts in attraction to facial cues of men's testosterone. Psychoneuroendocrinology. 2011 Jun; 36(5):742-9.
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18. Hossler C, Levi BH, Simmons Z, Green MJ. Advance care planning for patients with ALS: feasibility of an interactive computer program. Amyotroph Lateral Scler. 2011 May; 12(3):172-7.
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19. Felgoise SH, Chakraborty BH, Bond E, Rodriguez J, Bremer BA, Walsh SM, Lai EC, McCluskey L, Simmons Z. Psychological morbidity in ALS: the importance of psychological assessment beyond depression alone. Amyotroph Lateral Scler. 2010 Aug; 11(4):351-8.
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20. Mitchell RM, Simmons Z, Beard JL, Stephens HE, Connor JR. Plasma biomarkers associated with ALS and their relationship to iron homeostasis. Muscle Nerve. 2010 Jul; 42(1):95-103.
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21. Sundaram AN, Simmons Z, Towfighi J, Sheehan J, Reichwein R. Contralateral cranial polyneuropathy due to perineural invasion by a cutaneous squamous cell carcinoma. J Clin Neuromuscul Dis. 2010 Mar; 11(3):132-6.
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22. Simmons Z, Specht CS. The neuromuscular manifestations of amyloidosis. J Clin Neuromuscul Dis. 2010 Mar; 11(3):145-57.
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23. Hall EC, Lee SY, Simmons Z, Neely EB, Nandar W, Connor JR. Prolyl-peptidyl isomerase, Pin1, phosphorylation is compromised in association with the expression of the HFE polymorphic allele, H63D. Biochim Biophys Acta. 2010 Apr; 1802(4):389-95.
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24. Felgoise SH, Stewart JL, Bremer BA, Walsh SM, Bromberg MB, Simmons Z. The SEIQoL-DW for assessing quality of life in ALS: strengths and limitations. Amyotroph Lateral Scler. 2009 Oct-Dec; 10(5-6):456-62.
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25. Roney JR, Simmons ZL, Lukaszewski AW. Androgen receptor gene sequence and basal cortisol concentrations predict men's hormonal responses to potential mates. Proc Biol Sci. 2010 Jan 7; 277(1678):57-63.
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26. Hall EC, Lee SY, Mairuae N, Simmons Z, Connor JR. Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues. Neurobiol Aging. 2011 Aug; 32(8):1409-19.
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27. Ahmed A, Simmons Z. Electrodiagnostic findings in a patient with Waardenburg syndrome. J Clin Neuromuscul Dis. 2009 Sep; 11(1):54-6.
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28. Mitchell RM, Lee SY, Simmons Z, Connor JR. HFE polymorphisms affect cellular glutamate regulation. Neurobiol Aging. 2011 Jun; 32(6):1114-23.
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29. Simmons Z. Can we eliminate placebo in ALS clinical Trials? Muscle Nerve. 2009 Jun; 39(6):861-5.
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30. Simmons Z. What's in the Literature? J Clin Neuromuscul Dis. 2009 Jun; 10(4):202-7.
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31. Murphy V, Felgoise SH, Walsh SM, Simmons Z. Problem solving skills predict quality of life and psychological morbidity in ALS caregivers. Amyotroph Lateral Scler. 2009 Jun; 10(3):147-53.
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32. Flaherty-Craig C, Brothers A, Dearman B, Eslinger P, Simmons Z. Penn State screen exam for the detection of frontal and temporal dysfunction syndromes: application to ALS. Amyotroph Lateral Scler. 2009 Apr; 10(2):107-12.
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33. Mitchell RM, Lee SY, Randazzo WT, Simmons Z, Connor JR. Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1. J Neuroinflammation. 2009; 6:6.
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34. Chiò A, Schymick JC, Restagno G, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, Ding J, Crews C, Rafferty I, Washecka N, Hernandez D, Ferrucci L, Bandinelli S, Guralnik J, Macciardi F, Torri F, Lupoli S, Chanock SJ, Thomas G, Hunter DJ, Gieger C, Wichmann HE, Calvo A, Mutani R, Battistini S, Giannini F, Caponnetto C, Mancardi GL, La Bella V, Valentino F, Monsurrò MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Siciliano G, Carlesi C, Orrell RW, Talbot K, Simmons Z, Connor J, Pioro EP, Dunkley T, Stephan DA, Kasperaviciute D, Fisher EM, Jabonka S, Sendtner M, Beck M, Bruijn L, Rothstein J, Schmidt S, Singleton A, Hardy J, Traynor BJ. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum Mol Genet. 2009 Apr 15; 18(8):1524-32.
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35. Landsverk ML, Ruzzo EK, Mefford HC, Buysse K, Buchan JG, Eichler EE, Petty EM, Peterson EA, Knutzen DM, Barnett K, Farlow MR, Caress J, Parry GJ, Quan D, Gardner KL, Hong M, Simmons Z, Bird TD, Chance PF, Hannibal MC. Duplication within the SEPT9 gene associated with a founder effect in North American families with hereditary neuralgic amyotrophy. Hum Mol Genet. 2009 Apr 1; 18(7):1200-8.
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36. Simmons ZL, Roney JR. Androgens and energy allocation: quasi-experimental evidence for effects of influenza vaccination on men's testosterone. Am J Hum Biol. 2009 Jan-Feb; 21(1):133-5.
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37. Mitchell RM, Freeman WM, Randazzo WT, Stephens HE, Beard JL, Simmons Z, Connor JR. A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis. Neurology. 2009 Jan 6; 72(1):14-9.
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38. Groh WJ, Groh MR, Saha C, Kincaid JC, Simmons Z, Ciafaloni E, Pourmand R, Otten RF, Bhakta D, Nair GV, Marashdeh MM, Zipes DP, Pascuzzi RM. Electrocardiographic abnormalities and sudden death in myotonic dystrophy type 1. N Engl J Med. 2008 Jun 19; 358(25):2688-97.
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39. Roney JR, Simmons ZL. Women's estradiol predicts preference for facial cues of men's testosterone. Horm Behav. 2008 Jan; 53(1):14-9.
  View in: PubMed
 
40. Zimmerman EK, Eslinger PJ, Simmons Z, Barrett AM. Emotional perception deficits in amyotrophic lateral sclerosis. Cogn Behav Neurol. 2007 Jun; 20(2):79-82.
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41. Roney JR, Lukaszewski AW, Simmons ZL. Rapid endocrine responses of young men to social interactions with young women. Horm Behav. 2007 Sep; 52(3):326-33.
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42. Vender RL, Mauger D, Walsh S, Alam S, Simmons Z. Respiratory systems abnormalities and clinical milestones for patients with amyotrophic lateral sclerosis with emphasis upon survival. Amyotroph Lateral Scler. 2007 Feb; 8(1):36-41.
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43. Flaherty-Craig C, Eslinger P, Stephens B, Simmons Z. A rapid screening battery to identify frontal dysfunction in patients with ALS. Neurology. 2006 Dec 12; 67(11):2070-2.
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44. Wang XS, Simmons Z, Liu W, Boyer PJ, Connor JR. Differential expression of genes in amyotrophic lateral sclerosis revealed by profiling the post mortem cortex. Amyotroph Lateral Scler. 2006 Dec; 7(4):201-10.
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45. Simmons Z, Felgoise SH, Bremer BA, Walsh SM, Hufford DJ, Bromberg MB, David W, Forshew DA, Heiman-Patterson TD, Lai EC, McCluskey L. The ALSSQOL: balancing physical and nonphysical factors in assessing quality of life in ALS. Neurology. 2006 Nov 14; 67(9):1659-64.
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46. Vladutiu GD, Simmons Z, Isackson PJ, Tarnopolsky M, Peltier WL, Barboi AC, Sripathi N, Wortmann RL, Phillips PS. Genetic risk factors associated with lipid-lowering drug-induced myopathies. Muscle Nerve. 2006 Aug; 34(2):153-62.
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47. Chaisson KM, Walsh S, Simmons Z, Vender RL. A clinical pilot study: high frequency chest wall oscillation airway clearance in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2006 Jun; 7(2):107-11.
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48. Fisher J, Towfighi J, Darvish D, Simmons Z. A case of hereditary inclusion body myopathy: 1 patient, 2 novel mutations. J Clin Neuromuscul Dis. 2006 Jun; 7(4):179-84.
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49. Scott KR, Kothari MJ, Venkatesh YS, Murphy T, Simmons Z. Parotid gland injections of botulinum toxin a are effective in treating sialorrhea in amyotrophic lateral sclerosis. J Clin Neuromuscul Dis. 2005 Dec; 7(2):62-5.
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50. Simmons Z. Management strategies for patients with amyotrophic lateral sclerosis from diagnosis through death. Neurologist. 2005 Sep; 11(5):257-70.
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51. Groh WJ, Lowe MR, Simmons Z, Bhakta D, Pascuzzi RM. Familial clustering of muscular and cardiac involvement in myotonic dystrophy type 1. Muscle Nerve. 2005 Jun; 31(6):719-24.
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52. Wang XS, Lee S, Simmons Z, Boyer P, Scott K, Liu W, Connor J. Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences. J Neurol Sci. 2004 Dec 15; 227(1):27-33.
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53. Bremer BA, Simone AL, Walsh S, Simmons Z, Felgoise SH. Factors supporting quality of life over time for individuals with amyotrophic lateral sclerosis: the role of positive self-perception and religiosity. Ann Behav Med. 2004 Oct; 28(2):119-25.
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54. You H, Simmons Z, Freivalds A, Kothari M, Naidu S, Young R. The development of risk assessment models for carpal tunnel syndrome: a case-referent study. Ergonomics. 2004 May 15; 47(6):688-709.
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55. Walsh SM, Bremer BA, Felgoise SH, Simmons Z. Religiousness is related to quality of life in patients with ALS. Neurology. 2003 May 13; 60(9):1527-9.
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56. Scott K, Simmons Z, Kothari MJ. A comparison of quantitative sensory testing with skin biopsy in small fiber neuropathy. J Clin Neuromuscul Dis. 2003 Mar; 4(3):129-32.
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57. Simmons Z, Peterlin BL, Boyer PJ, Towfighi J. Muscle biopsy in the evaluation of patients with modestly elevated creatine kinase levels. Muscle Nerve. 2003 Feb; 27(2):242-4.
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58. Simmons Z, Feldman EL. Update on diabetic neuropathy. Curr Opin Neurol. 2002 Oct; 15(5):595-603.
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59. Scott KR, Simmons Z, Boyer PJ. Hypothyroid myopathy with a strikingly elevated serum creatine kinase level. Muscle Nerve. 2002 Jul; 26(1):141-4.
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60. Simmons Z, Towfighi J. Sporadic inclusion body myositis and hereditary inclusion body myopathy. J Clin Neuromuscul Dis. 2002 Mar; 3(3):122-32.
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61. Kovach MJ, Waggoner B, Leal SM, Gelber D, Khardori R, Levenstien MA, Shanks CA, Gregg G, Al-Lozi MT, Miller T, Rakowicz W, Lopate G, Florence J, Glosser G, Simmons Z, Morris JC, Whyte MP, Pestronk A, Kimonis VE. Clinical delineation and localization to chromosome 9p13.3-p12 of a unique dominant disorder in four families: hereditary inclusion body myopathy, Paget disease of bone, and frontotemporal dementia. Mol Genet Metab. 2001 Dec; 74(4):458-75.
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62. Simmons Z, Epstein DK, Borg B, Mauger DT, Kothari MJ, Shefner JM. Reproducibility of motor unit number estimation in individual subjects. Muscle Nerve. 2001 Apr; 24(4):467-73.
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63. Robbins RA, Simmons Z, Bremer BA, Walsh SM, Fischer S. Quality of life in ALS is maintained as physical function declines. Neurology. 2001 Feb 27; 56(4):442-4.
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64. Simmons Z, Bremer BA, Robbins RA, Walsh SM, Fischer S. Quality of life in ALS depends on factors other than strength and physical function. Neurology. 2000 Aug 8; 55(3):388-92.
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65. Zhu X, Raina AK, Boux H, Simmons ZL, Takeda A, Smith MA. Activation of oncogenic pathways in degenerating neurons in Alzheimer disease. Int J Dev Neurosci. 2000 Jul-Aug; 18(4-5):433-7.
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66. Kothari MJ, Heistand M, Simmons Z. Side to side difference of nerve conduction amplitudes. Electromyogr Clin Neurophysiol. 2000 Mar; 40(2):81-2.
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67. Simmons Z. Chronic inflammatory demyelinating polyradiculoneuropathy. J Clin Neuromuscul Dis. 1999 Dec; 1(2):90-8.
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68. Simmons Z. Paraproteinemia and neuropathy. Curr Opin Neurol. 1999 Oct; 12(5):589-95.
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69. You H, Simmons Z, Freivalds A, Kothari MJ, Naidu SH. Relationships between clinical symptom severity scales and nerve conduction measures in carpal tunnel syndrome. Muscle Nerve. 1999 Apr; 22(4):497-501.
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70. Simmons Z, Mahadeen ZI, Kothari MJ, Powers S, Wise S, Towfighi J. Localized hypertrophic neuropathy: magnetic resonance imaging findings and long-term follow-up. Muscle Nerve. 1999 Jan; 22(1):28-36.
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71. Kothari MJ, Blakeslee MA, Reichwein R, Simmons Z, Logigian EL. Electrodiagnostic studies: are they useful in clinical practice? Arch Phys Med Rehabil. 1998 Dec; 79(12):1510-1.
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72. Simmons Z, Thornton CA, Seltzer WK, Richards CS. Relative stability of a minimal CTG repeat expansion in a large kindred with myotonic dystrophy. Neurology. 1998 May; 50(5):1501-4.
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73. Simmons Z, Wald JJ, Albers JW. Chronic inflammatory demyelinating polyradiculoneuropathy in children: II. Long-term follow-up, with comparison to adults. Muscle Nerve. 1997 Dec; 20(12):1569-75.
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74. Simmons Z, Nicholson T, Wilde C, Manders EK. Variation of calculated ulnar motor conduction velocity across the elbow with body mass index. Muscle Nerve. 1997 Dec; 20(12):1607-8.
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75. Simmons Z, Wald JJ, Albers JW. Chronic inflammatory demyelinating polyradiculoneuropathy in children: I. Presentation, electrodiagnostic studies, and initial clinical course, with comparison to adults. Muscle Nerve. 1997 Aug; 20(8):1008-15.
  View in: PubMed
 
76. Thornton CA, Wymer JP, Simmons Z, McClain C, Moxley RT. Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene. Nat Genet. 1997 Aug; 16(4):407-9.
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77. Simmons Z, Tivakaran S. Acquired demyelinating polyneuropathy presenting as a pure clinical sensory syndrome. Muscle Nerve. 1996 Sep; 19(9):1174-6.
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78. Kluin KJ, Bromberg MB, Feldman EL, Simmons Z. Dysphagia in elderly men with myasthenia gravis. J Neurol Sci. 1996 Jun; 138(1-2):49-52.
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79. Doherty T, Simmons Z, O'Connell B, Felice KJ, Conwit R, Chan KM, Komori T, Brown T, Stashuk DW, Brown WF. Methods for estimating the numbers of motor units in human muscles. J Clin Neurophysiol. 1995 Nov; 12(6):565-84.
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80. Simmons Z, Albers JW, Bromberg MB, Feldman EL. Long-term follow-up of patients with chronic inflammatory demyelinating polyradiculoneuropathy, without and with monoclonal gammopathy. Brain. 1995 Apr; 118 ( Pt 2):359-68.
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81. Simmons Z, Wald J, Albers JW, Feldman EL. The natural history of a "benign" rib lesion in a patient with a demyelinating polyneuropathy and an unusual variant of POEMS syndrome. Muscle Nerve. 1994 Sep; 17(9):1055-9.
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82. Simmons Z, Blaivas M, Aguilera AJ, Feldman EL, Bromberg MB, Towfighi J. Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis. J Neurol Sci. 1993 Dec 1; 120(1):60-3.
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83. Bromberg MB, Forshew DA, Nau KL, Bromberg J, Simmons Z, Fries TJ. Motor unit number estimation, isometric strength, and electromyographic measures in amyotrophic lateral sclerosis. Muscle Nerve. 1993 Nov; 16(11):1213-9.
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84. Simmons Z, Albers JW, Bromberg MB, Feldman EL. Presentation and initial clinical course in patients with chronic inflammatory demyelinating polyradiculoneuropathy: comparison of patients without and with monoclonal gammopathy. Neurology. 1993 Nov; 43(11):2202-9.
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85. Simmons Z, Bromberg MB, Feldman EL, Blaivas M. Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance. Muscle Nerve. 1993 Jan; 16(1):77-83.
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86. Simmons Z, Albers JW, Sima AA. Case-of-the-month: perineuritis presenting as mononeuritis multiplex. Muscle Nerve. 1992 May; 15(5):630-5.
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87. Simmons Z, Biller J, Beck DW, Keyes W. Painless compressive cervical myelopathy with false localizing sensory findings. Spine (Phila Pa 1976). 1986 Nov; 11(9):869-72.
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88. Biller J, Adams HP, Dunn V, Simmons Z, Jacoby CG. Dichotomy between clinical findings and MR abnormalities in pontine infarction. J Comput Assist Tomogr. 1986 May-Jun; 10(3):379-85.
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89. Simmons Z, Biller J, Adams HP, Dunn V, Jacoby CG. Cerebellar infarction: comparison of computed tomography and magnetic resonance imaging. Ann Neurol. 1986 Mar; 19(3):291-3.
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90. Trumpower BL, Simmons Z. Diminished inhibition of mitochondrial electron transfer from succinate to cytochrome c by thenoyltrifluoroacetone induced by antimycin. J Biol Chem. 1979 Jun 10; 254(11):4608-16.
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91. Lusby AF, Simmons Z, McGuire PM. Variation in mutagenicity of s-triazine compounds tested on four Salmonella strains. Environ Mutagen. 1979; 1(3):287-90.
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Co-Authors  
Connor, James
Kothari, Milind
Lee, Sang
Scott, Kevin
Towfighi, Javad
See all (18) people
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