Search Edit My Profile Login to Profiles FAQs / About
Xuwen Peng
Title Associate Professor
Institution College of Medicine
Department Comparative Medicine
Address 500 University Drive Hershey PA 17033
Mailbox: H054
Telephone 7175318460
Email
Background
PREFERRED TITLE/ROLE:

Associate Professor of Comparative Medicine

GRADUATE PROGRAM AFFILIATIONS:

Lab Animal Medicine

EDUCATION:

D.V.M., Huazhong Agricultural University
M.S. in Lab Animal Medicine, Pennsylvania State University
Ph.D. in Genetics, Pennsylvania State University

NARRATIVE:

Dr. Peng is a laboratory animal veterinarian and faculty of basic sciences. His primary research interest is the development and use of genetically modified animals, especially transgenic rabbits, as models for studies of human diseases. His research has been focused on studying the mechanisms of the tissue specificity of papillomavirus infection and the infection related tumor initiation, regression and progression.

Additionally, due to his expertise in production of transgenic rabbits, he has been actively involved in collaboration with investigators both inside and outside of the institution. In collaboration with Dr. Christensen of Penn State Hershey, transgenic lines of rabbits expressing the human MHC class I gene HLA-A2.1 have been established for studies of host immunity to the specific epitopes of human papillomaviruses. The initial studies indicated that the HLA-A2.1 transgenic rabbits can provide an important preclinical animal model system for studies of virus-host interactions and to assess specific targets for immunoprotection and/or immunotherapy related to infection by several human pathogens with permissiveness or semipermissiveness in rabbits.

In the collaboration with Dr. Koren of Brown University and Dr. Zehender of University of Freiburg in Germany, the first transgenic rabbit models for long QT syndrome, LQT1 and LQT2, have been established. These two transgenic rabbit lines model the human conditions by exhibiting prolonged QT, gender differences in QT intervals, ventricular arrhythmias and a high incidence of sudden death. These transgenic rabbit models have provided a novel system to further study the mechanism of long QT syndrome in humans and develop new approaches for its treatment.
Publications
1. Ziv O, Schofield L, Lau E, Chaves L, Patel D, Jeng P, Peng X, Choi BR, Koren G. A novel, minimally invasive, segmental myocardial infarction with a clear healed infarct borderzone in rabbits. Am J Physiol Heart Circ Physiol. 2012 Jun 1; 302(11):H2321-30.
  View in: PubMed
 
2. Odening KE, Choi BR, Liu GX, Hartmann K, Ziv O, Chaves L, Schofield L, Centracchio J, Zehender M, Peng X, Brunner M, Koren G. Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective. Heart Rhythm. 2012 May; 9(5):823-32.
  View in: PubMed
 
3. Peng X. Transgenic rabbit models for studying human cardiovascular diseases. Comp Med. 2012; 62(6):472-9.
  View in: PubMed
 
4. Christensen ND, Peng X. Rabbit Genetics and Transgenic Models. In: The Laboratory Rabbit, Guinea Pig, Hamster and Other Rodents. Suckow MA, Stevens K, Wilson RP (eds). 2012; 165-193.
 
5. Bentzen BH, Bahrke S, Wu K, Larsen AP, Odening KE, Franke G, Storm vans Gravesande K, Biermann J, Peng X, Koren G, Zehender M, Bode C, Grunnet M, Brunner M. Pharmacological activation of Kv11.1 in transgenic long QT-1 rabbits. J Cardiovasc Pharmacol. 2011 Feb; 57(2):223-30.
  View in: PubMed
 
6. Biermann J, Wu K, Odening KE, Asbach S, Koren G, Peng X, Zehender M, Bode C, Brunner M. Nicorandil normalizes prolonged repolarisation in the first transgenic rabbit model with Long-QT syndrome 1 both in vitro and in vivo. Eur J Pharmacol. 2011 Jan 10; 650(1):309-16.
  View in: PubMed
 
7. Hu J, Schell TD, Peng X, Cladel NM, Balogh KK, Christensen ND. Using HLA-A2.1 Transgenic Rabbit Model to Screen and Characterize New HLA-A2.1 Restricted Epitope DNA Vaccines. J Vaccines Vaccin. 2010 Aug 20; 1(1).
  View in: PubMed
 
8. Odening KE, Kirk M, Brunner M, Ziv O, Lorvidhaya P, Liu GX, Schofield L, Chaves L, Peng X, Zehender M, Choi BR, Koren G. Electrophysiological studies of transgenic long QT type 1 and type 2 rabbits reveal genotype-specific differences in ventricular refractoriness and His conduction. Am J Physiol Heart Circ Physiol. 2010 Sep; 299(3):H643-55.
  View in: PubMed
 
9. Ziv O, Morales E, Song YK, Peng X, Odening KE, Buxton AE, Karma A, Koren G, Choi BR. Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome. J Physiol. 2009 Oct 1; 587(Pt 19):4661-80.
  View in: PubMed
 
10. Hu J, Schell TD, Peng X, Cladel NM, Balogh KK, Christensen ND. Strong and specific protective and therapeutic immunity induced by single HLA-A2.1 restricted epitope DNA vaccine in rabbits. Procedia in Vaccinology. 2009; (1):4-14.
 
11. Odening KE, Hyder O, Chaves L, Schofield L, Brunner M, Kirk M, Zehender M, Peng X, Koren G. Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2264-72.
  View in: PubMed
 
12. Brunner M, Peng X, Liu GX, Ren XQ, Ziv O, Choi BR, Mathur R, Hajjiri M, Odening KE, Steinberg E, Folco EJ, Pringa E, Centracchio J, Macharzina RR, Donahay T, Schofield L, Rana N, Kirk M, Mitchell GF, Poppas A, Zehender M, Koren G. Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome. J Clin Invest. 2008 Jun; 118(6):2246-59.
  View in: PubMed
 
13. Hu J, Cladel N, Peng X, Balogh K, Christensen ND. Protective immunity with an E1 multivalent epitope DNA vaccine against cottontail rabbit papillomavirus (CRPV) infection in an HLA-A2.1 transgenic rabbit model. Vaccine. 2008 Feb 6; 26(6):809-16.
  View in: PubMed
 
14. Hu J, Peng X, Budgeon LR, Cladel NM, Balogh KK, Christensen ND. Establishment of a cottontail rabbit papillomavirus/HLA-A2.1 transgenic rabbit model. J Virol. 2007 Jul; 81(13):7171-7.
  View in: PubMed
 
15. Hu J, Peng X, Schell TD, Budgeon LR, Cladel NM, Christensen ND. An HLA-A2.1-transgenic rabbit model to study immunity to papillomavirus infection. J Immunol. 2006 Dec 1; 177(11):8037-45.
  View in: PubMed
 
16. Guan Z, Vgontzas AN, Omori T, Peng X, Bixler EO, Fang J. Interleukin-6 levels fluctuate with the light-dark cycle in the brain and peripheral tissues in rats. Brain Behav Immun. 2005 Nov; 19(6):526-9.
  View in: PubMed
 
17. Hu J, Peng X, Cladel NM, Pickel MD, Christensen ND. Large cutaneous rabbit papillomas that persist during cyclosporin A treatment can regress spontaneously after cessation of immunosuppression. J Gen Virol. 2005 Jan; 86(Pt 1):55-63.
  View in: PubMed
 
18. Guan Z, Peng X, Fang J. Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus. Brain Res. 2004 Aug 20; 1018(1):38-47.
  View in: PubMed
 
19. Han R, Peng X, Reed CA, Cladel NM, Budgeon LR, Pickel MD, Christensen ND. Gene gun-mediated intracutaneous vaccination with papillomavirus E7 gene delays cancer development of papillomavirus-induced skin papillomas on rabbits. Cancer Detect Prev. 2002; 26(6):458-67.
  View in: PubMed
 
20. Peng X, Griffith JW, Lang CM. Reinitiated expression of EJras transgene in targeted epidermal cells of transgenic rabbits by cottontail rabbit papillomavirus infection. Cancer Lett. 2001 Oct 10; 171(2):193-200.
  View in: PubMed
 
21. Han R, Cladel NM, Reed CA, Peng X, Budgeon LR, Pickel M, Christensen ND. DNA vaccination prevents and/or delays carcinoma development of papillomavirus-induced skin papillomas on rabbits. J Virol. 2000 Oct; 74(20):9712-6.
  View in: PubMed
 
22. Han R, Cladel NM, Reed CA, Peng X, Christensen ND. Protection of rabbits from viral challenge by gene gun-based intracutaneous vaccination with a combination of cottontail rabbit papillomavirus E1, E2, E6, and E7 genes. J Virol. 1999 Aug; 73(8):7039-43.
  View in: PubMed
 
23. Peng X, Griffith JW, Han R, Lang CM, Kreider JW. Development of keratoacanthomas and squamous cell carcinomas in transgenic rabbits with targeted expression of EJras oncogene in epidermis. Am J Pathol. 1999 Jul; 155(1):315-24.
  View in: PubMed
 
24. Peng X, Lang CM, Kreider JW. Immortalization of inbred rabbit keratinocytes from a Shope papilloma and tumorigenic transformation of the cells by EJ-ras. Cancer Lett. 1996 Nov 12; 108(1):101-9.
  View in: PubMed
 
25. Peng X, Lang CM, Kreider JW. Methylation of cottontail rabbit papillomavirus DNA and tissue-specific expression in transgenic rabbits. Virus Res. 1995 Jan; 35(1):101-8.
  View in: PubMed
 
26. Peng X, Olson RO, Christian CB, Lang CM, Kreider JW. Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA. J Virol. 1993 Mar; 67(3):1698-701.
  View in: PubMed
 
27. Peng X, Griffith JW, Lang CM. Cystitis, urolithiasis and cystic calculi in ageing guineapigs. Lab Anim. 1990 Apr; 24(2):159-63.
  View in: PubMed
 
28. Peng X, Lang CM, Drozdowicz CK, Ohlsson-Wilhelm BM. Effect of cage population density on plasma corticosterone and peripheral lymphocyte populations of laboratory mice. Lab Anim. 1989 Oct; 23(4):302-6.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Co-Authors  
Christensen, Neil
Griffith, James
Hu, Jiafen
Lang, Carol
Schell, Todd
See all (7) people
Same Department  
Griffith, James
Lang, Carol
Cooper, Timothy
Wilson, Ronald
Whitcomb, Tiffany
Search for (30) people
Site Index | Privacy and Legal Statements | Copyright Information | The Pennsylvania State University © 2011