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1.
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Steinway SN, Loughran TP. Targeting IL-15 in large granular lymphocyte leukemia. Expert Rev Clin Immunol. 2013 May; 9(5):405-8.
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2.
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Leblanc FR, Hasanali ZS, Loughran TP. Does IL-15 have a causative role in large granular lymphocyte leukemia? Immunotherapy. 2013 Mar; 5(3):231-4.
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3.
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Shah MV, Barochia A, Loughran TP. Impact of genetic targets on cancer therapy in acute myelogenous leukemia. Adv Exp Med Biol. 2013; 779:405-37.
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4.
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Watters RJ, Loughran TP. Diagnosing large granular lymphocyte leukemia is bloody difficult. Leuk Lymphoma. 2013 Feb; 54(2):438-9.
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5.
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Yang L, Mailloux A, Rollison DE, Painter JS, Maciejewski J, Paquette RL, Loughran TP, McGraw K, Makishima H, Radhakrishnan R, Wei S, Ren X, Komrokji R, List AF, Epling-Burnette PK. Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency. Leukemia. 2013 Apr; 27(4):897-906.
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6.
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Ren T, Dong W, Takahashi Y, Xiang D, Yuan Y, Liu X, Loughran TP, Sun SC, Wang HG, Cheng H. HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy. J Biol Chem. 2012 Oct 5; 287(41):34683-93.
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7.
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Mailloux AW, Sugimori C, Komrokji RS, Yang L, Maciejewski JP, Sekeres MA, Paquette R, Loughran TP, List AF, Epling-Burnette PK. Expansion of effector memory regulatory T cells represents a novel prognostic factor in lower risk myelodysplastic syndrome. J Immunol. 2012 Sep 15; 189(6):3198-208.
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8.
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Jerez A, Clemente MJ, Makishima H, Koskela H, Leblanc F, Peng Ng K, Olson T, Przychodzen B, Afable M, Gomez-Segui I, Guinta K, Durkin L, Hsi ED, McGraw K, Zhang D, Wlodarski MW, Porkka K, Sekeres MA, List A, Mustjoki S, Loughran TP, Maciejewski JP. STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia. Blood. 2012 Oct 11; 120(15):3048-57.
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9.
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Leblanc F, Zhang D, Liu X, Loughran TP. Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets. Future Oncol. 2012 Jul; 8(7):787-801.
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10.
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Koskela HL, Eldfors S, Ellonen P, van Adrichem AJ, Kuusanmäki H, Andersson EI, Lagström S, Clemente MJ, Olson T, Jalkanen SE, Majumder MM, Almusa H, Edgren H, Lepistö M, Mattila P, Guinta K, Koistinen P, Kuittinen T, Penttinen K, Parsons A, Knowles J, Saarela J, Wennerberg K, Kallioniemi O, Porkka K, Loughran TP, Heckman CA, Maciejewski JP, Mustjoki S. Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med. 2012 May 17; 366(20):1905-13.
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11.
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Nyland SB, Krissinger DJ, Clemente MJ, Irby RB, Baab KT, Jarbadan NR, Sokol L, Schaefer E, Liao J, Cuthbertson D, Epling-Burnette P, Paquette R, List AF, Maciejewski JP, Loughran TP. Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: results of a bone marrow failure consortium study. Leuk Res. 2012 May; 36(5):581-7.
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12.
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Doi K, Li R, Sung SS, Wu H, Liu Y, Manieri W, Krishnegowda G, Awwad A, Dewey A, Liu X, Amin S, Cheng C, Qin Y, Schonbrunn E, Daughdrill G, Loughran TP, Sebti S, Wang HG. Discovery of marinopyrrole A (maritoclax) as a selective Mcl-1 antagonist that overcomes ABT-737 resistance by binding to and targeting Mcl-1 for proteasomal degradation. J Biol Chem. 2012 Mar 23; 287(13):10224-35.
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13.
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Watters RJ, Kester M, Tran MA, Loughran TP, Liu X. Development and use of ceramide nanoliposomes in cancer. Methods Enzymol. 2012; 508:89-108.
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14.
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Zhang D, Loughran TP. Large granular lymphocytic leukemia: molecular pathogenesis, clinical manifestations, and treatment. Hematology Am Soc Hematol Educ Program. 2012; 2012:652-9.
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15.
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Saadatpour A, Wang RS, Liao A, Liu X, Loughran TP, Albert I, Albert R. Dynamical and structural analysis of a T cell survival network identifies novel candidate therapeutic targets for large granular lymphocyte leukemia. PLoS Comput Biol. 2011 Nov; 7(11):e1002267.
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16.
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Watters RJ, Wang HG, Sung SS, Loughran TP, Liu X. Targeting sphingosine-1-phosphate receptors in cancer. Anticancer Agents Med Chem. 2011 Nov; 11(9):810-7.
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17.
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Loughran TP, Wang HG. Editorial [hot topic: Therapeutic targeting of the sphingolipid "biostat" in hematologic malignancies (guest editors: Thomas P. Loughran and Hong-Gang Wang)]. Anticancer Agents Med Chem. 2011 Nov; 11(9):780-1.
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18.
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El-Bayoumy K, Das A, Russell S, Wolfe S, Jordan R, Renganathan K, Loughran TP, Somiari R. The effect of selenium enrichment on baker's yeast proteome. J Proteomics. 2012 Jan 4; 75(3):1018-30.
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19.
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Bai F, Villagra AV, Zou J, Painter JS, Connolly K, Blaskovich MA, Sokol L, Sebti S, Djeu JY, Loughran TP, Wei S, Sotomayor E, Epling-Burnette P. Tipifarnib-mediated suppression of T-bet-dependent signaling pathways. Cancer Immunol Immunother. 2012 Apr; 61(4):523-33.
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20.
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Clemente MJ, Wlodarski MW, Makishima H, Viny AD, Bretschneider I, Shaik M, Bejanyan N, Lichtin AE, His ED, Paquette RL, Loughran TP, Maciejewski JP. Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia. Blood. 2011 Oct 20; 118(16):4384-93.
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21.
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Liao A, Broeg K, Fox T, Tan SF, Watters R, Shah MV, Zhang LQ, Li Y, Ryland L, Yang J, Aliaga C, Dewey A, Rogers A, Loughran K, Hirsch L, Jarbadan NR, Baab KT, Liao J, Wang HG, Kester M, Desai D, Amin S, Loughran TP, Liu X. Therapeutic efficacy of FTY720 in a rat model of NK-cell leukemia. Blood. 2011 Sep 8; 118(10):2793-800.
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22.
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Watters RJ, Liu X, Loughran TP. T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias. Leuk Lymphoma. 2011 Dec; 52(12):2217-25.
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23.
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Campbell C, Zhang R, Haley JS, Liu X, Loughran T, Schell TD, Albert R, Thakar J. Why Do CD8+ T Cells become Indifferent to Tumors: A Dynamic Modeling Approach. Front Physiol. 2011; 2:32.
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24.
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Barth BM, I Altinoglu E, Shanmugavelandy SS, Kaiser JM, Crespo-Gonzalez D, DiVittore NA, McGovern C, Goff TM, Keasey NR, Adair JH, Loughran TP, Claxton DF, Kester M. Targeted indocyanine-green-loaded calcium phosphosilicate nanoparticles for in vivo photodynamic therapy of leukemia. ACS Nano. 2011 Jul 26; 5(7):5325-37.
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25.
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Liu X, Loughran TP. The spectrum of large granular lymphocyte leukemia and Felty's syndrome. Curr Opin Hematol. 2011 Jul; 18(4):254-9.
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26.
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Yang J, Loughran TP. Potential clinical application of imatinib mesylate in patients with leukemic large granular lymphocytes. Leuk Lymphoma. 2011 Oct; 52(10):1834-5.
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27.
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Yu J, Mitsui T, Wei M, Mao H, Butchar JP, Shah MV, Zhang J, Mishra A, Alvarez-Breckenridge C, Liu X, Liu S, Yokohama A, Trotta R, Marcucci G, Benson DM, Loughran TP, Tridandapani S, Caligiuri MA. NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human. J Clin Invest. 2011 Apr; 121(4):1456-70.
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28.
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Zhang R, Loughran TP. Off-target effects of tyrosine kinase inhibitors: Beauty or the Beast? Leuk Lymphoma. 2011 Apr; 52(4):556-7.
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29.
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Ryland LK, Fox TE, Liu X, Loughran TP, Kester M. Dysregulation of sphingolipid metabolism in cancer. Cancer Biol Ther. 2011 Jan 15; 11(2):138-49.
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30.
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Takahashi Y, Meyerkord CL, Hori T, Runkle K, Fox TE, Kester M, Loughran TP, Wang HG. Bif-1 regulates Atg9 trafficking by mediating the fission of Golgi membranes during autophagy. Autophagy. 2011 Jan; 7(1):61-73.
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31.
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Lamy T, Loughran TP. How I treat LGL leukemia. Blood. 2011 Mar 10; 117(10):2764-74.
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32.
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Talamo G, Farooq U, Zangari M, Liao J, Dolloff NG, Loughran TP, Epner E. Beyond the CRAB symptoms: a study of presenting clinical manifestations of multiple myeloma. Clin Lymphoma Myeloma Leuk. 2010 Dec; 10(6):464-8.
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33.
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Iqbal J, Weisenburger DD, Chowdhury A, Tsai MY, Srivastava G, Greiner TC, Kucuk C, Deffenbacher K, Vose J, Smith L, Au WY, Nakamura S, Seto M, Delabie J, Berger F, Loong F, Ko YH, Sng I, Liu X, Loughran TP, Armitage J, Chan WC. Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic ?d T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro. Leukemia. 2011 Feb; 25(2):348-58.
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34.
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Zhang R, Shah MV, Loughran TP. The root of many evils: indolent large granular lymphocyte leukaemia and associated disorders. Hematol Oncol. 2010 Sep; 28(3):105-17.
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35.
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Liu X, Ryland L, Yang J, Liao A, Aliaga C, Watts R, Tan SF, Kaiser J, Shanmugavelandy SS, Rogers A, Loughran K, Petersen B, Yuen J, Meng F, Baab KT, Jarbadan NR, Broeg K, Zhang R, Liao J, Sayers TJ, Kester M, Loughran TP. Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia. Blood. 2010 Nov 18; 116(20):4192-201.
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36.
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Epling-Burnette PK, Loughran TP. Suppression of farnesyltransferase activity in acute myeloid leukemia and myelodysplastic syndrome: current understanding and recommended use of tipifarnib. Expert Opin Investig Drugs. 2010 May; 19(5):689-98.
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37.
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Wozney JL, Damluji AA, Ahmed F, Zangari M, Loughran TP, Talamo G. Estimation of daily proteinuria in patients with multiple myeloma by using the protein-to-creatinine ratio in random urine samples. Acta Haematol. 2010; 123(4):226-9.
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38.
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Abbi KK, Rizvi SM, Sivik J, Thyagarajan S, Loughran T, Drabick JJ. Guillain-Barré syndrome after use of alemtuzumab (Campath) in a patient with T-cell prolymphocytic leukemia: a case report and review of the literature. Leuk Res. 2010 Jul; 34(7):e154-6.
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39.
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Talamo G, Barochia A, Zangari M, Loughran TP. Multiple myeloma presenting as CEA-producing rectal cancer. Rare Tumors. 2010; 2(1):e4.
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40.
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Sekeres MA, List AF, Cuthbertson D, Paquette R, Ganetzky R, Ganetsky R, Latham D, Paulic K, Afable M, Saba HI, Loughran TP, Maciejewski JP. Phase I combination trial of lenalidomide and azacitidine in patients with higher-risk myelodysplastic syndromes. J Clin Oncol. 2010 May 1; 28(13):2253-8.
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41.
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Pastor DM, Eggers AD, Drabick JJ, Loughran TP, Bayerl MG, Shope TR. Retroperitoneal diffuse large B-cell lymphoma presenting as pseudoachalasia. J Clin Oncol. 2010 Apr 20; 28(12):e184-7.
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42.
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Thomas A, Perzova R, Abbott L, Benz P, Poiesz MJ, Dube S, Loughran T, Ferrer J, Sheremata W, Glaser J, Leon-Ponte M, Poiesz BJ. LGL leukemia and HTLV. AIDS Res Hum Retroviruses. 2010 Jan; 26(1):33-40.
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43.
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Yang J, Liu X, Nyland SB, Zhang R, Ryland LK, Broeg K, Baab KT, Jarbadan NR, Irby R, Loughran TP. Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway. Blood. 2010 Jan 7; 115(1):51-60.
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44.
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Hodge DL, Yang J, Buschman MD, Schaughency PM, Dang H, Bere W, Yang Y, Savan R, Subleski JJ, Yin XM, Loughran TP, Young HA. Interleukin-15 enhances proteasomal degradation of bid in normal lymphocytes: implications for large granular lymphocyte leukemias. Cancer Res. 2009 May 1; 69(9):3986-94.
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45.
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Nyland SB, Loughran TP. Putting HIV-1 apoptosis mediators to work against cancer: a killer job, with benefits. Cancer Biol Ther. 2009 Jan; 8(2):188-91.
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46.
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Shah MV, Zhang R, Loughran TP. Never say die: survival signaling in large granular lymphocyte leukemia. Clin Lymphoma Myeloma. 2009; 9 Suppl 3:S244-53.
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47.
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Chen X, Bai F, Sokol L, Zhou J, Ren A, Painter JS, Liu J, Sallman DA, Chen YA, Yoder JA, Djeu JY, Loughran TP, Epling-Burnette PK, Wei S. A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. Blood. 2009 Apr 2; 113(14):3226-34.
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48.
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Zhang R, Shah MV, Yang J, Nyland SB, Liu X, Yun JK, Albert R, Loughran TP. Network model of survival signaling in large granular lymphocyte leukemia. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16308-13.
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49.
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Epling-Burnette PK, Sokol L, Chen X, Bai F, Zhou J, Blaskovich MA, Zou J, Painter JS, Edwards TD, Moscinski L, Yoder JA, Djeu JY, Sebti S, Loughran TP, Wei S. Clinical improvement by farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling. Blood. 2008 Dec 1; 112(12):4694-8.
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50.
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Shah MV, Zhang R, Irby R, Kothapalli R, Liu X, Arrington T, Frank B, Lee NH, Loughran TP. Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes. Blood. 2008 Aug 1; 112(3):770-81.
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51.
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Viny AD, Lichtin A, Pohlman B, Loughran T, Maciejewski J. Chronic B-cell dyscrasias are an important clinical feature of T-LGL leukemia. Leuk Lymphoma. 2008 May; 49(5):932-8.
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52.
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Yang J, Epling-Burnette PK, Painter JS, Zou J, Bai F, Wei S, Loughran TP. Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia. Blood. 2008 Feb 1; 111(3):1610-6.
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53.
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Lai DW, Loughran TP, Maciejewski JP, Sasu S, Song SX, Epling-Burnette PK, Paquette RL. Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia. Leuk Res. 2008 May; 32(5):823-7.
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54.
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Sokol L, Loughran TP. Large granular lymphocyte leukemia. Curr Hematol Malig Rep. 2007 Oct; 2(4):278-82.
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55.
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Bourgault-Rouxel AS, Loughran TP, Zambello R, Epling-Burnette PK, Semenzato G, Donadieu J, Amiot L, Fest T, Lamy T. Clinical spectrum of gammadelta+ T cell LGL leukemia: analysis of 20 cases. Leuk Res. 2008 Jan; 32(1):45-8.
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56.
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Thomas J, Haseman JK, Goodman JI, Ward JM, Loughran TP, Spencer PJ. A review of large granular lymphocytic leukemia in Fischer 344 rats as an initial step toward evaluating the implication of the endpoint to human cancer risk assessment. Toxicol Sci. 2007 Sep; 99(1):3-19.
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57.
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Burks EJ, Loughran TP. Pathogenesis of neutropenia in large granular lymphocyte leukemia and Felty syndrome. Blood Rev. 2006 Sep; 20(5):245-66.
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58.
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Sokol L, Loughran TP. Large granular lymphocyte leukemia. Oncologist. 2006 Mar; 11(3):263-73.
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59.
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Hellmich B, Pinals RS, Loughran TP, Sullivan KE. New clues to accrue on neutropenia in rheumatoid arthritis. Clin Immunol. 2005 Oct; 117(1):1-5.
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60.
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Wlodarski MW, O'Keefe C, Howe EC, Risitano AM, Rodriguez A, Warshawsky I, Loughran TP, Maciejewski JP. Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia. Blood. 2005 Oct 15; 106(8):2769-80.
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61.
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Burks EJ, Loughran TP. Perspectives in the treatment of LGL leukemia. Leuk Res. 2005 Feb; 29(2):123-5.
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62.
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Kothapalli R, Nyland SB, Kusmartseva I, Bailey RD, McKeown TM, Loughran TP. Constitutive production of proinflammatory cytokines RANTES, MIP-1beta and IL-18 characterizes LGL leukemia. Int J Oncol. 2005 Feb; 26(2):529-35.
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63.
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Epling-Burnette PK, Bai F, Wei S, Chaurasia P, Painter JS, Olashaw N, Hamilton A, Sebti S, Djeu JY, Loughran TP. ERK couples chronic survival of NK cells to constitutively activated Ras in lymphoproliferative disease of granular lymphocytes (LDGL). Oncogene. 2004 Dec 9; 23(57):9220-9.
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64.
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Sokol L, Agrawal D, Loughran TP. Characterization of HTLV envelope seroreactivity in large granular lymphocyte leukemia. Leuk Res. 2005 Apr; 29(4):381-7.
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65.
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Epling-Burnette PK, Painter JS, Chaurasia P, Bai F, Wei S, Djeu JY, Loughran TP. Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes. Blood. 2004 May 1; 103(9):3431-9.
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66.
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Berliner N, Horwitz M, Loughran TP. Congenital and acquired neutropenia. Hematology Am Soc Hematol Educ Program. 2004; 63-79.
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67.
|
Mohapatra S, Chu B, Wei S, Djeu J, Epling-Burnette PK, Loughran T, Jove R, Pledger WJ. Roscovitine inhibits STAT5 activity and induces apoptosis in the human leukemia virus type 1-transformed cell line MT-2. Cancer Res. 2003 Dec 1; 63(23):8523-30.
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68.
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Kothapalli R, Yoder SJ, Kusmartseva I, Loughran TP. Characterization of a variant of PAC-1 in large granular lymphocyte leukemia. Protein Expr Purif. 2003 Nov; 32(1):52-60.
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69.
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Sokol L, Loughran TP. Large granular lymphocyte leukemia and natural killer cell leukemia/lymphomas. Curr Treat Options Oncol. 2003 Aug; 4(4):289-96.
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70.
|
Lamy T, Loughran TP. Clinical features of large granular lymphocyte leukemia. Semin Hematol. 2003 Jul; 40(3):185-95.
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71.
|
Epling-Burnette PK, Loughran TP. Survival signals in leukemic large granular lymphocytes. Semin Hematol. 2003 Jul; 40(3):213-20.
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72.
|
Kothapalli R, Danyluck GM, Bailey RD, Loughran TP. Problems associated with product enhancement reverse transcriptase assay using bacteriophage MS2 RNA as a template. J Virol Methods. 2003 May; 109(2):203-7.
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73.
|
Nyland SB, Cao C, Bai Y, Loughran TP, Ugen KE. Modulation of infection and type 1 cytokine expression parameters by morphine during in vitro coinfection with human T-cell leukemia virus type I and HIV-1. J Acquir Immune Defic Syndr. 2003 Apr 1; 32(4):406-16.
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74.
|
Kanchan K, Loughran TP. Antigen-driven clonal T cell expansion in disorders of hematopoiesis. Leuk Res. 2003 Apr; 27(4):291-2.
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75.
|
Yang J, Fier A, Carter Y, Liu G, Epling-Burnette PK, Bai F, Loughran TP, Mastorides S, Norman JG, Murr MM. Liver injury during acute pancreatitis: the role of pancreatitis-associated ascitic fluid (PAAF), p38-MAPK, and caspase-3 in inducing hepatocyte apoptosis. J Gastrointest Surg. 2003 Feb; 7(2):200-7; discussion 208.
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76.
|
Kothapalli R, Bailey RD, Kusmartseva I, Mane S, Epling-Burnette PK, Loughran TP. Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia. Int J Oncol. 2003 Jan; 22(1):33-9.
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77.
|
Huang M, Dorsey JF, Epling-Burnette PK, Nimmanapalli R, Landowski TH, Mora LB, Niu G, Sinibaldi D, Bai F, Kraker A, Yu H, Moscinski L, Wei S, Djeu J, Dalton WS, Bhalla K, Loughran TP, Wu J, Jove R. Inhibition of Bcr-Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells. Oncogene. 2002 Dec 12; 21(57):8804-16.
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78.
|
Kothapalli R, Kusmartseva I, Loughran TP. Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia. Biochim Biophys Acta. 2002 Dec 12; 1579(2-3):117-23.
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79.
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Nimmanapalli R, O'Bryan E, Huang M, Bali P, Burnette PK, Loughran T, Tepperberg J, Jove R, Bhalla K. Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin. Cancer Res. 2002 Oct 15; 62(20):5761-9.
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80.
|
Kothapalli R, Yoder SJ, Mane S, Loughran TP. Microarray results: how accurate are they? BMC Bioinformatics. 2002 Aug 23; 3:22.
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81.
|
Liu JH, Wei S, Lamy T, Li Y, Epling-Burnette PK, Djeu JY, Loughran TP. Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia. Blood. 2002 Aug 15; 100(4):1449-53.
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82.
|
Seiter K, Liu D, Loughran T, Siddiqui A, Baskind P, Ahmed T. Phase I study of temozolomide in relapsed/refractory acute leukemia. J Clin Oncol. 2002 Aug 1; 20(15):3249-53.
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83.
|
Epling-Burnette PK, Garcia R, Bai F, Ismail S, Loughran TP, Djeu JY, Jove R, Wei S. Carboxy-terminal truncated STAT5 is induced by interleukin-2 and GM-CSF in human neutrophils. Cell Immunol. 2002 May-Jun; 217(1-2):1-11.
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84.
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Kantarjian H, Sawyers C, Hochhaus A, Guilhot F, Schiffer C, Gambacorti-Passerini C, Niederwieser D, Resta D, Capdeville R, Zoellner U, Talpaz M, Druker B, Goldman J, O'Brien SG, Russell N, Fischer T, Ottmann O, Cony-Makhoul P, Facon T, Stone R, Miller C, Tallman M, Brown R, Schuster M, Loughran T, Gratwohl A, Mandelli F, Saglio G, Lazzarino M, Russo D, Baccarani M, Morra E. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med. 2002 Feb 28; 346(9):645-52.
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85.
|
Epling-Burnette PK, Zhong B, Bai F, Jiang K, Bailey RD, Garcia R, Jove R, Djeu JY, Loughran TP, Wei S. Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils. J Immunol. 2001 Jun 15; 166(12):7486-95.
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86.
|
Epling-Burnette PK, Liu JH, Catlett-Falcone R, Turkson J, Oshiro M, Kothapalli R, Li Y, Wang JM, Yang-Yen HF, Karras J, Jove R, Loughran TP. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest. 2001 Feb; 107(3):351-62.
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87.
|
Greer JP, Kinney MC, Loughran TP. T cell and NK cell lymphoproliferative disorders. Hematology Am Soc Hematol Educ Program. 2001; 259-81.
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|
88.
|
Liu JH, Wei S, Lamy T, Epling-Burnette PK, Starkebaum G, Djeu JY, Loughran TP. Chronic neutropenia mediated by fas ligand. Blood. 2000 May 15; 95(10):3219-22.
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89.
|
Coakley G, Brooks D, Iqbal M, Kondeatis E, Vaughan R, Loughran TP, Panayi GS, Lanchbury JS. Major histocompatility complex haplotypic associations in Felty's syndrome and large granular lymphocyte syndrome are secondary to allelic association with HLA-DRB1 *0401. Rheumatology (Oxford). 2000 Apr; 39(4):393-8.
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90.
|
Perzova RN, Loughran TP, Dube S, Ferrer J, Esteban E, Poiesz BJ. Lack of BLV and PTLV DNA sequences in the majority of patients with large granular lymphocyte leukaemia. Br J Haematol. 2000 Apr; 109(1):64-70.
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91.
|
Lesesve JF, Feugier P, Lamy T, Béné MC, Grégoire MJ, Lenormand B, Loughran T. Association of B-chronic lymphocytic leukaemia and T-large granular lymphocyte leukaemia. Clin Lab Haematol. 2000 Apr; 22(2):121-2.
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92.
|
Lamy T, Bauer FA, Liu JH, Li YX, Pillemer E, Shahidi H, Gregory SA, Zambello R, Marcolongo R, Semenzato G, Loughran TP. Clinicopathological features of aggressive large granular lymphocyte leukaemia resemble Fas ligand transgenic mice. Br J Haematol. 2000 Mar; 108(4):717-23.
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93.
|
Hall MA, McGlinn E, Coakley G, Fisher SA, Boki K, Middleton D, Kaklamani E, Moutsopoulos H, Loughran TP, Ollier WE, Panayi GS, Lanchbury JS. Genetic polymorphism of IL-12 p40 gene in immune-mediated disease. Genes Immun. 2000 Feb; 1(3):219-24.
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94.
|
Lamy T, Loughran TP. Current concepts: large granular lymphocyte leukemia. Blood Rev. 1999 Dec; 13(4):230-40.
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95.
|
Coakley G, Manolios N, Loughran TP, Panayi GS, Lanchbury JS. A Fas promoter polymorphism at position -670 in the enhancer region does not confer susceptibility to Felty's and large granular lymphocyte syndromes. Rheumatology (Oxford). 1999 Sep; 38(9):883-6.
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96.
|
Loughran TP. CD56+ hematologic malignancies. Leuk Res. 1999 Jul; 23(7):675-6.
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97.
|
Lamy T, Liu JH, Landowski TH, Dalton WS, Loughran TP. Dysregulation of CD95/CD95 ligand-apoptotic pathway in CD3(+) large granular lymphocyte leukemia. Blood. 1998 Dec 15; 92(12):4771-7.
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98.
|
Gentile TC, Hadlock KG, Uner AH, Delal B, Squiers E, Crowley S, Woodman RC, Foung SK, Poiesz BJ, Loughran TP. Large granular lymphocyte leukaemia occurring after renal transplantation. Br J Haematol. 1998 Jun; 101(3):507-12.
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99.
|
Love JL, Marchioli CC, Dube S, Bryz-Gornia V, Loughran TP, Glaser JB, Esteban E, Feldman L, Ferrer JF, Poiesz BJ. Expansion of clonotypic T-cell populations in the peripheral blood of asymptomatic Gran Chaco Amerindians infected with HTLV-IIB. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jun 1; 18(2):178-85.
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100.
|
Loughran TP. Large granular lymphocytic leukemia: an overview. Hosp Pract (Minneap). 1998 May 15; 33(5):133-8.
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|
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|
|
101.
|
Loughran TP, Hadlock KG, Perzova R, Gentile TC, Yang Q, Foung SK, Poiesz BJ. Epitope mapping of HTLV envelope seroreactivity in LGL leukaemia. Br J Haematol. 1998 May; 101(2):318-24.
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102.
|
Lamy T, Drenou B, Fardel O, Amiot L, Grulois I, Le Prise PY, Loughran TP, Fauchet R. Multidrug resistance analysis in lymphoproliferative disease of large granular lymphocytes. Br J Haematol. 1998 Mar; 100(3):509-15.
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103.
|
Loughran TP, Hadlock KG, Yang Q, Perzova R, Zambello R, Semenzato G, Foung SK, Poiesz BJ. Seroreactivity to an envelope protein of human T-cell leukemia/lymphoma virus in patients with CD3- (natural killer) lymphoproliferative disease of granular lymphocytes. Blood. 1997 Sep 1; 90(5):1977-81.
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104.
|
Loughran TP, Abbott L, Gentile TC, Love J, Cunningham C, Friedman-Kien A, Huang YQ, Poiesz BJ. Absence of human herpes virus 8 DNA sequences in large granular lymphocyte (LGL) leukemia. Leuk Lymphoma. 1997 Jun; 26(1-2):177-80.
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105.
|
Starkebaum G, Loughran TP, Gaur LK, Davis P, Nepom BS. Immunogenetic similarities between patients with Felty's syndrome and those with clonal expansions of large granular lymphocytes in rheumatoid arthritis. Arthritis Rheum. 1997 Apr; 40(4):624-6.
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106.
|
Perzova R, Loughran TP. Constitutive expression of Fas ligand in large granular lymphocyte leukaemia. Br J Haematol. 1997 Apr; 97(1):123-6.
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|
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|
107.
|
Semenzato G, Zambello R, Starkebaum G, Oshimi K, Loughran TP. The lymphoproliferative disease of granular lymphocytes: updated criteria for diagnosis. Blood. 1997 Jan 1; 89(1):256-60.
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|
108.
|
Gentile TC, Wener MH, Starkebaum G, Loughran TP. Humoral immune abnormalities in T-cell large granular lymphocyte leukemia. Leuk Lymphoma. 1996 Oct; 23(3-4):365-70.
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109.
|
Pellenz M, Zambello R, Semenzato G, Loughran TP. Detection of Epstein-Barr virus by PCR analyses in lymphoproliferative disease of granular lymphocytes. Leuk Lymphoma. 1996 Oct; 23(3-4):371-4.
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|
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|
110.
|
Gentile TC, Loughran TP. Resolution of autoimmune hemolytic anemia following splenectomy in CD3+ large granular lymphocyte leukemia. Leuk Lymphoma. 1996 Oct; 23(3-4):405-8.
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|
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|
|
111.
|
Loughran TP. HTLV infection and hematologic malignancies. Leuk Res. 1996 Jun; 20(6):457-8.
|
|
|
|
|
112.
|
Starkebaum G, Shasteen NM, Fleming-Jones RM, Loughran TP, Mannik M. Sera of patients with rheumatoid arthritis contain antibodies to recombinant human T-lymphotrophic virus type I/II envelope glycoprotein p21. Clin Immunol Immunopathol. 1996 May; 79(2):182-8.
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113.
|
Kingreen D, Dalal BI, Heyman M, Phillips GL, Horsman D, Kidd P, Loughran TP. Lymphocytosis of large granular lymphocytes in patients with Hodgkin's disease. Am J Hematol. 1995 Dec; 50(4):234-6.
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114.
|
Gentile TC, Loughran TP. Interleukin-12 is a costimulatory cytokine for leukemic CD3+ large granular lymphocytes. Cell Immunol. 1995 Nov; 166(1):158-61.
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|
115.
|
Zambello R, Loughran TP, Trentin L, Pontisso P, Battistella L, Raimondi R, Facco M, Sancetta R, Agostini C, Pizzolo G, et al. Serologic and molecular evidence for a possible pathogenetic role of viral infection in CD3-negative natural killer-type lymphoproliferative disease of granular lymphocytes. Leukemia. 1995 Jul; 9(7):1207-11.
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|
116.
|
Brody JP, Allen S, Schulman P, Sun T, Chan WC, Friedman HD, Teichberg S, Koduru P, Cone RW, Loughran TP. Acute agranular CD4-positive natural killer cell leukemia. Comprehensive clinicopathologic studies including virologic and in vitro culture with inducing agents. Cancer. 1995 May 15; 75(10):2474-83.
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|
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117.
|
Litam PP, Loughran TP. Recurrent infection in a patient with chronic neutropenia. Hosp Pract (Off Ed). 1995 Feb 15; 30(2):117-8.
|
|
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|
|
118.
|
Davey MP, Starkebaum G, Loughran TP. CD3+ leukemic large granular lymphocytes utilize diverse T-cell receptor V beta genes. Blood. 1995 Jan 1; 85(1):146-50.
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|
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119.
|
Litam PP, Loughran TP. Clostridium septicum bacteremia in a patient with large granular lymphocyte leukemia. Cancer Invest. 1995; 13(5):492-4.
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|
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|
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120.
|
Loughran TP, Kidd PG, Starkebaum G. Treatment of large granular lymphocyte leukemia with oral low-dose methotrexate. Blood. 1994 Oct 1; 84(7):2164-70.
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|
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|
|
121.
|
Gentile TC, Uner AH, Hutchison RE, Wright J, Ben-Ezra J, Russell EC, Loughran TP. CD3+, CD56+ aggressive variant of large granular lymphocyte leukemia. Blood. 1994 Oct 1; 84(7):2315-21.
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122.
|
Loughran TP, Sherman MP, Ruscetti FW, Frey S, Coyle T, Montagna RA, Jones B, Starkebaum G, Poiesz BJ. Prototypical HTLV-I/II infection is rare in LGL leukemia. Leuk Res. 1994 Jun; 18(6):423-9.
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|
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123.
|
Loughran TP. Clonal diseases of large granular lymphocytes. Blood. 1993 Jul 1; 82(1):1-14.
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|
|
124.
|
Loughran TP, Zambello R, Ashley R, Guderian J, Pellenz M, Semenzato G, Starkebaum G. Failure to detect Epstein-Barr virus DNA in peripheral blood mononuclear cells of most patients with large granular lymphocyte leukemia. Blood. 1993 May 15; 81(10):2723-7.
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|
125.
|
Nash R, McSweeney P, Zambello R, Semenzato G, Loughran TP. Clonal studies of CD3- lymphoproliferative disease of granular lymphocytes. Blood. 1993 May 1; 81(9):2363-8.
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126.
|
Loughran TP, Coyle T, Sherman MP, Starkebaum G, Ehrlich GD, Ruscetti FW, Poiesz BJ. Detection of human T-cell leukemia/lymphoma virus, type II, in a patient with large granular lymphocyte leukemia. Blood. 1992 Sep 1; 80(5):1116-9.
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127.
|
Riddell SR, Greenberg PD, Overell RW, Loughran TP, Gilbert MJ, Lupton SD, Agosti J, Scheeler S, Coombs RW, Corey L. Phase I study of cellular adoptive immunotherapy using genetically modified CD8+ HIV-specific T cells for HIV seropositive patients undergoing allogeneic bone marrow transplant. The Fred Hutchinson Cancer Research Center and the University of Washington School of Medicine, Department of Medicine, Division of Oncology. Hum Gene Ther. 1992 Jun; 3(3):319-38.
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128.
|
Aprile JA, Russo M, Pepe MS, Loughran TP. Activation signals leading to proliferation of normal and leukemic CD3+ large granular lymphocytes. Blood. 1991 Sep 1; 78(5):1282-5.
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129.
|
Storb R, Anasetti C, Appelbaum F, Bensinger W, Buckner CD, Clift R, Deeg HJ, Doney K, Hansen J, Loughran T, et al. Marrow transplantation for severe aplastic anemia and thalassemia major. Semin Hematol. 1991 Jul; 28(3):235-9.
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130.
|
Yoon HJ, Aprile JA, Loughran TP. Interleukin-2 receptor monoclonal antibodies have no effect on anti-CD3 monoclonal antibody-mediated cytotoxicity in CD3+ leukemic large granular lymphocytes. Cell Immunol. 1990 Dec; 131(2):404-8.
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131.
|
Yoon HJ, Sugamura K, Loughran TP. Activation of leukemic large granular lymphocytes by interleukin-2 via the p75 interleukin-2 receptor. Leukemia. 1990 Dec; 4(12):848-50.
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132.
|
Loughran TP, Sullivan K, Morton T, Beckham C, Schubert M, Witherspoon R, Sale G, Sanders J, Fisher L, Shulman H, et al. Value of day 100 screening studies for predicting the development of chronic graft-versus-host disease after allogeneic bone marrow transplantation. Blood. 1990 Jul 1; 76(1):228-34.
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|
|
133.
|
Loughran TP, Aprile JA, Ruscetti FW. Anti-CD3 monoclonal antibody-mediated cytotoxicity occurs through an interleukin-2-independent pathway in CD3+ large granular lymphocytes. Blood. 1990 Feb 15; 75(4):935-40.
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|
134.
|
Pandolfi F, Loughran TP, Starkebaum G, Chisesi T, Barbui T, Chan WC, Brouet JC, De Rossi G, McKenna RW, Salsano F, et al. Clinical course and prognosis of the lymphoproliferative disease of granular lymphocytes. A multicenter study. Cancer. 1990 Jan 15; 65(2):341-8.
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135.
|
Hanks GA, Mathews HH, Routson GW, Loughran TP. Supracondylar fracture of the femur following total knee arthroplasty. J Arthroplasty. 1989 Dec; 4(4):289-92.
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136.
|
Agnarsson BA, Loughran TP, Starkebaum G, Kadin ME. The pathology of large granular lymphocyte leukemia. Hum Pathol. 1989 Jul; 20(7):643-51.
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137.
|
Williams ML, Loughran TP, Kidd PG, Starkebaum GA. Polyclonal proliferation of activated suppressor/cytotoxic T cells with transient depression of natural killer cell function in acute infectious mononucleosis. Clin Exp Immunol. 1989 Jul; 77(1):71-6.
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|
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|
|
138.
|
Loughran TP, Starkebaum G, Ruscetti FW. Similar rearrangements of T-cell receptor beta gene in cell lines and uncultured cells from patients with large granular lymphocyte leukemia. Blood. 1988 Aug; 72(2):613-5.
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|
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|
|
139.
|
Loughran TP, Starkebaum G, Aprile JA. Rearrangement and expression of T-cell receptor genes in large granular lymphocyte leukemia. Blood. 1988 Mar; 71(3):822-4.
|
|
|
|
|
140.
|
Loughran TP, Starkebaum G, Kidd P, Neiman P. Clonal proliferation of large granular lymphocytes in rheumatoid arthritis. Arthritis Rheum. 1988 Jan; 31(1):31-6.
|
|
|
|
|
141.
|
Loughran TP, Starkebaum G, Clark E, Wallace P, Kadin ME. Evaluation of splenectomy in large granular lymphocyte leukaemia. Br J Haematol. 1987 Oct; 67(2):135-40.
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142.
|
Loughran TP, Starkebaum G. Large granular lymphocyte leukemia. Report of 38 cases and review of the literature. Medicine (Baltimore). 1987 Sep; 66(5):397-405.
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|
143.
|
Loughran TP, Starkebaum G. Clinical features in large granular lymphocytic leukemia. Blood. 1987 Jun; 69(6):1786.
|
|
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|
|
144.
|
Starkebaum G, Loughran TP, Kalyanaraman VS, Kadin ME, Kidd PG, Singer JW, Ruscetti FW. Serum reactivity to human T-cell leukaemia/lymphoma virus type I proteins in patients with large granular lymphocytic leukaemia. Lancet. 1987 Mar 14; 1(8533):596-9.
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|
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|
145.
|
Raff RF, Loughran TP, Deeg HJ, Aprile JA, Graham TC, Sale GE, Storb R. Role of radiation-resistant large granular lymphocytes in the rejection of unrelated DLA-nonidentical marrow grafts in dogs. Transplant Proc. 1987 Feb; 19(1 Pt 3):2718-20.
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|
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|
|
146.
|
Loughran TP, Draves KE, Starkebaum G, Kidd P, Clark EA. Induction of NK activity in large granular lymphocyte leukemia: activation with anti-CD3 monoclonal antibody and interleukin 2. Blood. 1987 Jan; 69(1):72-8.
|
|
|
|
|
147.
|
Loughran TP, Hammond WP. Adult-onset cyclic neutropenia is a benign neoplasm associated with clonal proliferation of large granular lymphocytes. J Exp Med. 1986 Dec 1; 164(6):2089-94.
|
|
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|
|
148.
|
Loughran TP, Clark EA, Price TH, Hammond WP. Adult-onset cyclic neutropenia is associated with increased large granular lymphocytes. Blood. 1986 Nov; 68(5):1082-7.
|
|
|
|
|
149.
|
Raff RF, Deeg HJ, Loughran TP, Graham TC, Aprile JA, Sale GE, Storb R. Characterization of host cells involved in resistance to marrow grafts in dogs transplanted from unrelated DLA-nonidentical donors. Blood. 1986 Oct; 68(4):861-8.
|
|
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|
|
150.
|
Loughran TP, Deeg HJ, Storb R. Morphologic and phenotypic analysis of canine natural killer cells: evidence for T-cell lineage. Cell Immunol. 1985 Oct 15; 95(2):207-17.
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|
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|
|
151.
|
Wallis WJ, Loughran TP, Kadin ME, Clark EA, Starkebaum GA. Polyarthritis and neutropenia associated with circulating large granular lymphocytes. Ann Intern Med. 1985 Sep; 103(3):357-62.
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152.
|
Loughran TP, Kadin ME, Starkebaum G, Abkowitz JL, Clark EA, Disteche C, Lum LG, Slichter SJ. Leukemia of large granular lymphocytes: association with clonal chromosomal abnormalities and autoimmune neutropenia, thrombocytopenia, and hemolytic anemia. Ann Intern Med. 1985 Feb; 102(2):169-75.
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