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Timothy Cooper
Title Assistant Professor
Institution College of Medicine
Department Comparative Medicine
Address 500 University Drive Hershey PA 17033
Mailbox: H054
Telephone 7175318460
Email
Background
PREFERRED TITLE/ROLE:

Assistant Professor of Comparative Medicine

GRADUATE PROGRAM AFFILIATIONS:

Lab Animal Medicine

EDUCATION:

PhD, Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, 2011
Diplomate, American College of Veterinary Pathologists, 2007
Post-Doctoral Training, Johns Hopkins University School of Medicine, 2002-2007
DVM, University of Illinois Urbana-Champaign, 1999

NARRATIVE:

Dr. Cooper received his DVM from University of Illinois Urbana-Champaign in 1999. Following three years in private clinical practice as an ambulatory food animal veterinarian, he began a combined pathology residency/PhD program in the Department of Molecular and Comparative Pathobiology at the Johns Hopkins University School of Medicine. Training in comparative pathology of laboratory animals, with a focus on rodents and non-human primates, was augmented by zoo pathology and human autopsy and surgical pathology experience. This culminated in board certification by the American College of Veterinary Pathologists in 2007. Dr. Cooper was also accepted into the Cellular and Molecular Medicine graduate training program at JHUSOM and did his thesis research on the pathogenesis of Marfan syndrome and vascular Ehlers-Danlos syndrome (type IV) in the laboratory of Dr. Hal Dietz. Dr. Cooper was granted his PhD in 2011. Since 2007 he has been an assistant professor in the Department of Comparative Medicine with an adjunct appointment in the Department of Pathology.

As a veterinary and comparative pathologist, Dr. Cooper provides diagnostic and experimental pathology support for the animal based research mission at HMC. Diagnostic necropsies are performed free of charge to researchers to investigate unexpected morbidity and/or mortality in research animals related to infectious or non-infectious disease or experimental manipulations. Dr. Cooper has extensive experience in a number of rodent and non-rodent models of human diseases, including background pathology and infectious disease co-morbidities. Current research collaborations include mouse and rat models of diabetes mellitus and cancer of the breast, liver, skin, pancreas, prostate, colon, and hemolymphatic system; zebrafish models of human disease [http://zfatlas.psu.edu/]; and large animal models of blood pumps, extracorporeal life support, and other medical devices. Present research investigations include antibiotic associated arteritis in cattle, urinary biomarkers of renal ischemia, and a novel viral agent of pneumonia in rabbits. As evidenced below, Dr. Cooper has demonstrated expertise in a number of animal models and organ systems.
Publications
1. Chen KM, Guttenplan JB, Zhang SM, Aliaga C, Cooper TK, Sun YW, Deltondo J, Kosinska W, Sharma AK, Jiang K, Bruggeman R, Ahn K, Amin S, El-Bayoumy K. Mechanisms of oral carcinogenesis induced by dibenzo[a,l]pyrene: An environmental pollutant and a tobacco smoke constituent. Int J Cancer. 2013 Mar 9.
  View in: PubMed
 
2. Sun YW, Guttenplan JB, Cooper T, Krzeminski J, Aliaga C, Boyiri T, Kosinska W, Zhao ZL, Chen KM, Berg A, Amin SG, El-Bayoumy K. Mechanisms underlying the varied mammary carcinogenicity of the environmental pollutant 6-nitrochrysene and its metabolites (-)-[R,R]- and (+)-[S,S] -1,2-dihydroxy-1,2-dihydro-6-nitrochrysene in the rat. Chem Res Toxicol. 2013 Mar 5.
  View in: PubMed
 
3. Tiwari A, Hadley JA, Hendricks GL, Elkin RG, Cooper T, Ramachandran R. Characterization of ascites-derived ovarian tumor cells from spontaneously occurring ovarian tumors of the chicken: evidence for e-cadherin upregulation. PLoS One. 2013; 8(2):e57582.
  View in: PubMed
 
4. Takahashi Y, Hori T, Cooper TK, Liao J, Desai N, Serfass JM, Young MM, Park S, Izu Y, Wang HG. Bif-1 haploinsufficiency promotes chromosomal instability and accelerates Myc-driven lymphomagenesis via suppression of mitophagy. Blood. 2013 Feb 28; 121(9):1622-32.
  View in: PubMed
 
5. Villano JS, Cooper TK. Mandibular fracture and necrotizing sialometaplasia in a rabbit. Comp Med. 2013; 63(1):67-70.
  View in: PubMed
 
6. Cooper TK, Griffith JW, Reibson J, Peterson R, Roush EP, Zhong Q, Weiss WJ, Rosenberg G. Antibiotic-associated eosinophilic and occlusive arteritis in calves complicating preclinical studies of left ventricular assist devices. Toxicol Pathol. 2013; 41(3):519-27.
  View in: PubMed
 
7. Shi C, Cooper TK, McCloskey DE, Glick AB, Shantz LM, Feith DJ. S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion. Carcinogenesis. 2012 Jul; 33(7):1310-8.
  View in: PubMed
 
8. Cooper TK, Zhong Q, Nabity M, Rosenberg G, Weiss WJ. Use of urinary biomarkers of renal ischemia in a lamb preclinical left ventricular assist device model. Artif Organs. 2012 Sep; 36(9):820-4.
  View in: PubMed
 
9. Koya V, Campbell AM, McLaughlin PJ, Tewari D, Wilson RP, Cooper TK. Outbreak of abdominal distension and obstipation in a C57BL/6J experimental autoimmune encephalomyelitis study. Vet Pathol. 2012 May; 49(3):528-31.
  View in: PubMed
 
10. Chen KM, Zhang SM, Aliaga C, Sun YW, Cooper T, Gowdahalli K, Zhu J, Amin S, El-Bayoumy K. Induction of ovarian cancer and DNA adducts by Dibenzo[a,l]pyrene in the mouse. Chem Res Toxicol. 2012 Feb 20; 25(2):374-80.
  View in: PubMed
 
11. Weiss WJ, Carney EL, Clark JB, Peterson R, Cooper TK, Nifong TP, Siedlecki CA, Hicks D, Doxtater B, Lukic B, Yeager E, Reibson J, Cysyk J, Rosenberg G, Pierce WS. Chronic in vivo testing of the Penn State infant ventricular assist device. ASAIO J. 2012 Jan-Feb; 58(1):65-72.
  View in: PubMed
 
12. Villano JS, Boehm CA, Carney EL, Cooper TK. Complications of elastase-induced arterial saccular aneurysm in rabbits: case reports and literature review. Comp Med. 2012; 62(6):480-6.
  View in: PubMed
 
13. Guttenplan JB, Kosinska W, Zhao ZL, Chen KM, Aliaga C, DelTondo J, Cooper T, Sun YW, Zhang SM, Jiang K, Bruggeman R, Sharma AK, Amin S, Ahn K, El-Bayoumy K. Mutagenesis and carcinogenesis induced by dibenzo[a,l]pyrene in the mouse oral cavity: a potential new model for oral cancer. Int J Cancer. 2012 Jun 15; 130(12):2783-90.
  View in: PubMed
 
14. Morris SM, Gao T, Cooper TK, Kepka-Lenhart D, Awad AS. Arginase-2 mediates diabetic renal injury. Diabetes. 2011 Nov; 60(11):3015-22.
  View in: PubMed
 
15. Mikerov AN, Cooper TK, Wang G, Hu S, Umstead TM, Phelps DS, Floros J. Histopathologic evaluation of lung and extrapulmonary tissues show sex differences in Klebsiella pneumoniae - infected mice under different exposure conditions. Int J Physiol Pathophysiol Pharmacol. 2011 Sep 30; 3(3):176-90.
  View in: PubMed
 
16. Manni A, Xu H, Washington S, Aliaga C, Das A, Cooper T, Richie JP, Prokopczyk B, Calcagnotto A, Trushin N, Van den Heuvel JP, Hamilton C, Demers LM, Liao J, Verderame MF, El-Bayoumy K. The effects of Tamoxifen and fish oil on mammary carcinogenesis in polyoma middle T transgenic mice. Horm Cancer. 2011 Aug; 2(4):249-59.
  View in: PubMed
 
17. Manni A, Richie JP, Xu H, Washington S, Aliaga C, Cooper TK, Bruggeman R, Das A, Prokopczyk B, Calcagnotto A, Trushin N, Dickinson R, Liao J, Verderame MF, El-Bayoumy K. Effects of fish oil and Tamoxifen on preneoplastic lesion development and biomarkers of oxidative stress in the early stages of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Int J Oncol. 2011 Nov; 39(5):1153-64.
  View in: PubMed
 
18. Leocadio DE, Kunselman AR, Cooper T, Barrantes JH, Trussell JC. Anatomical and histological equivalence of the human, canine, and bull vas deferens. Can J Urol. 2011 Jun; 18(3):5699-704.
  View in: PubMed
 
19. Pandey MK, Liu G, Cooper TK, Mulder KM. Knockdown of c-Fos suppresses the growth of human colon carcinoma cells in athymic mice. Int J Cancer. 2012 Jan 1; 130(1):213-22.
  View in: PubMed
 
20. Briest W, Cooper TK, Tae HJ, Krawczyk M, McDonnell NB, Talan MI. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun; 337(3):621-7.
  View in: PubMed
 
21. Cooper TK, Zhong Q, Krawczyk M, Tae HJ, Müller GA, Schubert R, Myers LA, Dietz HC, Talan MI, Briest W. The haploinsufficient Col3a1 mouse as a model for vascular Ehlers-Danlos syndrome. Vet Pathol. 2010 Nov; 47(6):1028-39.
  View in: PubMed
 
22. Manni A, Xu H, Washington S, Aliaga C, Cooper T, Richie JP, Bruggeman R, Prokopczyk B, Calcagnotto A, Trushin N, Mauger D, Verderame MF, El-Bayoumy K. The impact of fish oil on the chemopreventive efficacy of tamoxifen against development of N-methyl-N-nitrosourea-induced rat mammary carcinogenesis. Cancer Prev Res (Phila). 2010 Mar; 3(3):322-30.
  View in: PubMed
 
23. Spitsbergen JM, Blazer VS, Bowser PR, Cheng KC, Cooper KR, Cooper TK, Frasca S, Groman DB, Harper CM, Law JM, Marty GD, Smolowitz RM, St Leger J, Wolf DC, Wolf JC. Finfish and aquatic invertebrate pathology resources for now and the future. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Mar; 149(2):249-57.
  View in: PubMed
 
24. Xie J, Bessling SL, Cooper TK, Dietz HC, McCallion AS, Fisher S. Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Genetics. 2007 Jun; 176(2):1339-42.
  View in: PubMed
 
25. Cooper TK, Gabrielson KL. Spontaneous lesions in the reproductive tract and mammary gland of female non-human primates. Birth Defects Res B Dev Reprod Toxicol. 2007 Apr; 80(2):149-70.
  View in: PubMed
 
26. Helke KL, Cooper TK, Mankowski JL, Poynton SL. Disseminated visceral coccidiosis in Indo-gangetic flap-shelled turtles, Lissemys punctata andersonii. J Wildl Dis. 2006 Oct; 42(4):788-96.
  View in: PubMed
 
27. Cooper TK, Ronnett BM, Ruben DS, Zink MC. Uterine myxoid leiomyosarcoma with widespread metastases in a cat. Vet Pathol. 2006 Jul; 43(4):552-6.
  View in: PubMed
 
28. Cooper TK, Adelsohn D, Gilbertson SR. Spontaneous deciduosarcoma in a domestic rabbit (Oryctolagus cuniculus). Vet Pathol. 2006 May; 43(3):377-80.
  View in: PubMed
 
29. Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, Rifkin DB, Carta L, Ramirez F, Huso DL, Dietz HC. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science. 2006 Apr 7; 312(5770):117-21.
  View in: PubMed
 
30. Cooper TK, Shih IM, Gabrielson KL. Uterine epithelioid trophoblastic tumour in a red-tailed guenon (Cercopithecus ascanius). J Comp Pathol. 2005 Aug-Oct; 133(2-3):218-22.
  View in: PubMed
 
31. Pisharath HR, Cooper TK, Brice AK, Cianciolo RE, Pistorio AL, Wachtman LM, Mankowski JL, Newcomer CE. Septicemia and peritonitis in a colony of common marmosets (Callithrix jacchus) secondary to Klebsiella pneumoniae infection. Contemp Top Lab Anim Sci. 2005 Jan; 44(1):35-7.
  View in: PubMed
 
32. Chen W, Cooper TK, Zahnow CA, Overholtzer M, Zhao Z, Ladanyi M, Karp JE, Gokgoz N, Wunder JS, Andrulis IL, Levine AJ, Mankowski JL, Baylin SB. Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell. 2004 Oct; 6(4):387-98.
  View in: PubMed
 
33. Whittem T, Hogan D, Sisson D, Cooper T. The population pharmacokinetics of digoxin in dogs with heart disease. J Vet Pharmacol Ther. 2000 Aug; 23(4):261-3.
  View in: PubMed
 
34. Whittem TL, Johnson AL, Smith CW, Schaeffer DJ, Coolman BR, Averill SM, Cooper TK, Merkin GR. Effect of perioperative prophylactic antimicrobial treatment in dogs undergoing elective orthopedic surgery. J Am Vet Med Assoc. 1999 Jul 15; 215(2):212-6.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Uterine Neoplasms
Ehlers-Danlos Syndrome
Disease Outbreaks
Disease Models, Animal
Constipation
See all (235) keywords
Co-Authors  
Aliaga, Cesar
Chen, Kun-Ming
El bayoumy, Karam
Verderame, Michael
Weiss, William
See all (40) people
Same Department  
Griffith, James
Lang, Carol
Peng, Xuwen
Wilson, Ronald
Whitcomb, Tiffany
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