Search Edit My Profile Login to Profiles FAQs / About
Sang Lee
Back
Title Assistant Professor
Institution College of Medicine
Department Neurosurgery
Address 500 University Drive Hershey PA 17033
 Mailbox: H110
Telephone 7175310003 x285546
Email
Background
PREFERRED TITLE/ROLE:

Assistant Professor of Neurosurgery

EDUCATION:

Ph.D., Kyungpook University (Korea), 1997

NARRATIVE:

We are investigating the cellular mechanisms of neurodegenerative disorders and brain tumors mediated by oxidative stress and iron mismanagement. Iron is tightly regulated for normal function. When iron imbalance occurs by dysfunction of iron regulatory mechanisms, cells are subjected to a pro-oxidative stress and a pro-inflammatory environment. HFE is one of several iron regulatory proteins and polymorphisms in the HFE gene are prevalent in Caucasians. HFE gene variants have been traditionally associated with the iron overload disorder known as Hereditary Hemochromatosis. Recently, it has become clear that the two most common variants in the HFE gene, H63D and C282Y, may be risk modifiers for neurodegenerative disorders (Alzheimer's disease, Amyotrophic Lateral Sclerosis) and cancer, respectively. The following lists are my research interests. First, understand the cellular consequences of carrying variant forms of HFE in brain tumors and neurodegenerative disorders. Second, determine the frequency of HFE polymorphisms in brain tumor patients and neurodegenerative disorders. Third, determine the chemotherapy resistance mechanism in the C282Y-expressing tumor cells. Fourth, develop a new chemotherapeutic agent to treat brain tumors, especially Temodar-resistant brain tumors, and neurodegenerative disorders that express HFE gene variants. For these studies, we utilize both cell culture and animal models. We are using stably-transfected human neuroblastoma cell lines that express different forms of HFE, and human astrocytoma cell lines expressing different HFE variants to determine the cellular consequences of the variants forms of HFE. We are also using H63D and C282Y knock-in mice to determine the consequence of HFE variants in in vivo.
Publications
1. Zhang Y, Cheng Y, Zhang L, Ren X, Huber-Keener KJ, Lee S, Yun J, Wang HG, Yang JM. Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression. Biochem Biophys Res Commun. 2011 Oct 14; 414(1):129-34.
  View in: PubMed
 
2. Lee SY, Liu S, Mitchell RM, Slagle-Webb B, Hong YS, Sheehan JM, Connor JR. HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4A. Int J Cancer. 2011 Nov 1; 129(9):2104-14.
  View in: PubMed
 
3. Liu Y, Lee SY, Neely E, Nandar W, Moyo M, Simmons Z, Connor JR. Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability. J Biol Chem. 2011 Apr 15; 286(15):13161-70.
  View in: PubMed
 
4. Mairuae N, Hall Ii EC, Cheepsunthorn P, Lee SY, Connor JR. The H63D HFE gene variant promotes activation of the intrinsic apoptotic pathway via mitochondria dysfunction following ß-amyloid peptide exposure. J Neurosci Res. 2010 Nov 1; 88(14):3079-89.
  View in: PubMed
 
5. Hall EC, Lee SY, Simmons Z, Neely EB, Nandar W, Connor JR. Prolyl-peptidyl isomerase, Pin1, phosphorylation is compromised in association with the expression of the HFE polymorphic allele, H63D. Biochim Biophys Acta. 2010 Apr; 1802(4):389-95.
  View in: PubMed
 
6. Hall EC, Lee SY, Mairuae N, Simmons Z, Connor JR. Expression of the HFE allelic variant H63D in SH-SY5Y cells affects tau phosphorylation at serine residues. Neurobiol Aging. 2011 Aug; 32(8):1409-19.
  View in: PubMed
 
7. Mitchell RM, Lee SY, Simmons Z, Connor JR. HFE polymorphisms affect cellular glutamate regulation. Neurobiol Aging. 2011 Jun; 32(6):1114-23.
  View in: PubMed
 
8. Mitchell RM, Lee SY, Randazzo WT, Simmons Z, Connor JR. Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1. J Neuroinflammation. 2009; 6:6.
  View in: PubMed
 
9. Lee SY, Patton SM, Henderson RJ, Connor JR. Consequences of expressing mutants of the hemochromatosis gene (HFE) into a human neuronal cell line lacking endogenous HFE. FASEB J. 2007 Feb; 21(2):564-76.
  View in: PubMed
 
10. Connor JR, Lee SY. HFE mutations and Alzheimer's disease. J Alzheimers Dis. 2006 Nov; 10(2-3):267-76.
  View in: PubMed
 
11. Lee SY, Connor JR. Regulation of Hfe by stress factors in BV-2 cells. Neurobiol Aging. 2005 Jun; 26(6):803-12.
  View in: PubMed
 
12. Wang XS, Lee S, Simmons Z, Boyer P, Scott K, Liu W, Connor J. Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences. J Neurol Sci. 2004 Dec 15; 227(1):27-33.
  View in: PubMed
 
13. Lee SY, Andoh T, Murphy DL, Chiueh CC. 17beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection. FASEB J. 2003 May; 17(8):947-8.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Co-Authors  
Connor, James
Ren, Xingcong
Scott, Kevin
Simmons, Zachary
Wang, Hong-gang
See all (7) people
Site Index | Privacy and Legal Statements | Copyright Information | The Pennsylvania State University © 2011