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Sinisa Dovat
Title Associate Professor
Institution College of Medicine
Department Pediatrics
Division Pediatrics Hematology Oncology
Address 500 University Drive Hershey PA 17033
Telephone 7175310003 x280286
Email
Background
PREFERRED TITLE/ROLE:

Physician, Associate Professor, M.D., Ph.D.

EDUCATION:

Fellowship, Pediatric Hematology/Oncology, University of California - Los Angeles (1999) Residency, Pediatrics, Penn State Milton S. Hershey Medical Center (1996) Residency, Pediatrics, Institute for Health Care of Mother & Child (1993) M.D., University of Novi Sad Medical School, Serbia (1988)
Publications
1. Gowda C, Dovat S. Genetic targets in pediatric acute lymphoblastic leukemia. Adv Exp Med Biol. 2013; 779:327-40.
  View in: PubMed
 
2. Uckun FM, Ma H, Zhang J, Ozer Z, Dovat S, Mao C, Ishkhanian R, Goodman P, Qazi S. Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):18072-7.
  View in: PubMed
 
3. Savic A, Cemerikic-Martinovic V, Dovat S, Rajic N, Urosevic I, Sekulic B, Kvrgic V, Popovic S. Angiogenesis and survival in patients with myelodysplastic syndrome. Pathol Oncol Res. 2012 Jul; 18(3):681-90.
  View in: PubMed
 
4. Li Z, Song C, Ouyang H, Lai L, Payne KJ, Dovat S. Cell cycle-specific function of Ikaros in human leukemia. Pediatr Blood Cancer. 2012 Jul 15; 59(1):69-76.
  View in: PubMed
 
5. Nahar R, Ramezani-Rad P, Mossner M, Duy C, Cerchietti L, Geng H, Dovat S, Jumaa H, Ye BH, Melnick A, Müschen M. Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. Blood. 2011 Oct 13; 118(15):4174-8.
  View in: PubMed
 
6. Dovat S, Song C, Payne KJ, Li Z. Ikaros, CK2 kinase, and the road to leukemia. Mol Cell Biochem. 2011 Oct; 356(1-2):201-7.
  View in: PubMed
 
7. Dovat S. Ikaros in hematopoiesis and leukemia. World J Biol Chem. 2011 Jun 26; 2(6):105-7.
  View in: PubMed
 
8. Song C, Li Z, Erbe AK, Savic A, Dovat S. Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1. World J Biol Chem. 2011 Jun 26; 2(6):126-31.
  View in: PubMed
 
9. Li Z, Perez-Casellas LA, Savic A, Song C, Dovat S. Ikaros isoforms: The saga continues. World J Biol Chem. 2011 Jun 26; 2(6):140-5.
  View in: PubMed
 
10. Goldman FD, Gurel Z, Al-Zubeidi D, Fried AJ, Icardi M, Song C, Dovat S. Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene. Pediatr Blood Cancer. 2012 Apr; 58(4):591-7.
  View in: PubMed
 
11. Yang D, Yaguchi T, Nagata T, Gotoh A, Dovat S, Song C, Nishizaki T. AMID mediates adenosine-induced caspase-independent HuH-7 cell apoptosis. Cell Physiol Biochem. 2011; 27(1):37-44.
  View in: PubMed
 
12. Payne KJ, Dovat S. Ikaros and tumor suppression in acute lymphoblastic leukemia. Crit Rev Oncog. 2011; 16(1-2):3-12.
  View in: PubMed
 
13. Dovat S, Payne KJ. Tumor suppression in T cell leukemia--the role of Ikaros. Leuk Res. 2010 Apr; 34(4):416-7.
  View in: PubMed
 
14. Benton KD, Hermann RJ, Vomhof-DeKrey EE, Haring JS, Van der Steen T, Smith J, Dovat S, Dorsam GP. A transcriptionally permissive epigenetic landscape at the vasoactive intestinal peptide receptor-1 promoter suggests a euchromatin nuclear position in murine CD4 T cells. Regul Pept. 2009 Nov 27; 158(1-3):68-76.
  View in: PubMed
 
15. Parrish YK, Baez I, Milford TA, Benitez A, Galloway N, Rogerio JW, Sahakian E, Kagoda M, Huang G, Hao QL, Sevilla Y, Barsky LW, Zielinska E, Price MA, Wall NR, Dovat S, Payne KJ. IL-7 Dependence in human B lymphopoiesis increases during progression of ontogeny from cord blood to bone marrow. J Immunol. 2009 Apr 1; 182(7):4255-66.
  View in: PubMed
 
16. Popescu M, Gurel Z, Ronni T, Song C, Hung KY, Payne KJ, Dovat S. Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1. J Biol Chem. 2009 May 15; 284(20):13869-80.
  View in: PubMed
 
17. Kim JH, Ebersole T, Kouprina N, Noskov VN, Ohzeki J, Masumoto H, Mravinac B, Sullivan BA, Pavlicek A, Dovat S, Pack SD, Kwon YW, Flanagan PT, Loukinov D, Lobanenkov V, Larionov V. Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. Genome Res. 2009 Apr; 19(4):533-44.
  View in: PubMed
 
18. Tcheng WY, Dovat S, Gurel Z, Donkin J, Wong WY. Severe congenital protein C deficiency: description of a new mutation and prophylactic protein C therapy and in vivo pharmacokinetics. J Pediatr Hematol Oncol. 2008 Feb; 30(2):166-71.
  View in: PubMed
 
19. Gurel Z, Ronni T, Ho S, Kuchar J, Payne KJ, Turk CW, Dovat S. Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation. J Biol Chem. 2008 Mar 28; 283(13):8291-300.
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20. Ronni T, Payne KJ, Ho S, Bradley MN, Dorsam G, Dovat S. Human Ikaros function in activated T cells is regulated by coordinated expression of its largest isoforms. J Biol Chem. 2007 Jan 26; 282(4):2538-47.
  View in: PubMed
 
21. Yamamoto E, Ito T, Abe A, Sido F, Ino K, Itakura A, Mizutani S, Dovat S, Nomura S, Kikkawa F. Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion. Mol Hum Reprod. 2005 Nov; 11(11):825-31.
  View in: PubMed
 
22. Dovat S, Montecino-Rodriguez E, Schuman V, Teitell MA, Dorshkind K, Smale ST. Transgenic expression of Helios in B lineage cells alters B cell properties and promotes lymphomagenesis. J Immunol. 2005 Sep 15; 175(6):3508-15.
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23. Dovat S, Ronni T, Russell D, Ferrini R, Cobb BS, Smale ST. A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains. Genes Dev. 2002 Dec 1; 16(23):2985-90.
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24. Ziegner UH, Ochs HD, Schanen C, Feig SA, Seyama K, Futatani T, Gross T, Wakim M, Roberts RL, Rawlings DJ, Dovat S, Fraser JK, Stiehm ER. Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies. J Pediatr. 2001 Apr; 138(4):570-3.
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25. Dovat S, Roberts RL, Wakim M, Stiehm ER, Feig SA. Immune thrombocytopenia after umbilical cord progenitor cell transplant: response to vincristine. Bone Marrow Transplant. 1999 Aug; 24(3):321-3.
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26. Dovat S, Gilbert KA, Petrovic-Dovat L, Rannels DE. Isolation, cloning, and characterization of a novel rat lung zinc finger gene, RLZF-Y. Biochim Biophys Acta. 1998 Nov 8; 1442(2-3):380-8.
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27. Dovat S, Gilbert KA, Petrovic-Dovat L, Rannels DE. Targeted identification of zinc finger genes expressed in rat lungs. Am J Physiol. 1998 Jul; 275(1 Pt 1):L30-7.
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28. Dovat S, Feig SA. The use of umbilical cord blood stem cells for hematopoietic reconstitution. West J Med. 1997 May; 166(5):342-3.
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29. Dovat S, Nikolic-Dovat V, Stevanovic V, Malesevic S, Varga J, Protic S, Vukadinovic I. [Supplementary feeding--additional food in daily infant nutrition]. Med Pregl. 1992; 45(5-6):179-83.
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30. Stevanovic V, Dovat S, Nikolic-Dovat V, Stevanovic S. [Hematologic parameter of red blood cells in children up to 2 years of age]. Med Pregl. 1991; 44(11-12):478-81.
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