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Blaise Peterson
Title Associate Professor
Institution College of Medicine
Department Cellular and Molecular Physiology
Address 500 University Drive Hershey PA 17033
Mailbox: H166
Telephone 7175318569
Email
Background
PREFERRED TITLE/ROLE:

Associate Professor of Cellular and Molecular Physiology

GRADUATE PROGRAM AFFILIATIONS:

Cell and Molecular Biology, Integrative Biosciences, Physiology

EDUCATION:

Ph.D., Department of Pharmacology, University of Washington
Postdoctoral Training, Department of Biomedical Engineering, The Johns Hopkins University, 1996-1999

NARRATIVE:

Dr. Peterson is interested in understanding how ionic gradients across membranes are associated with disease states such as heart failure and malaria. His group hopes to develop novel therapeutic approaches to treat these diseases by discovering new ways to modulate voltage-gated ion channels with drugs that alter the gating behavior of the channel.
Publications
1. Li Z, Huang H, Yang B, Jiang H, Gao GF, Peterson BZ, Huang CX. Amino acid substitutions in the pore affect the anomalous mole fraction effect of CaV1.2 channels. Mol Med Report. 2013 Feb; 7(2):571-6.
  View in: PubMed
 
2. Yarotskyy V, Gao G, Peterson BZ, Elmslie KS. Domain III regulates N-type (CaV2.2) calcium channel closing kinetics. J Neurophysiol. 2012 Apr; 107(7):1942-51.
  View in: PubMed
 
3. Song J, Gao E, Wang J, Zhang XQ, Chan TO, Koch WJ, Shang X, Joseph JI, Peterson BZ, Feldman AM, Cheung JY. Constitutive overexpression of phosphomimetic phospholemman S68E mutant results in arrhythmias, early mortality, and heart failure: potential involvement of Na+/Ca2+ exchanger. Am J Physiol Heart Circ Physiol. 2012 Feb 1; 302(3):H770-81.
  View in: PubMed
 
4. Lin Z, John G, Hegarty JP, Berg A, Yu W, Wang Y, Kelly AA, Peterson BZ, Poritz LS, Floros J, Koltun WA. Genetic variants and monoallelic expression of surfactant protein-D in inflammatory bowel disease. Ann Hum Genet. 2011 Sep; 75(5):559-68.
  View in: PubMed
 
5. Guo K, Wang X, Gao G, Huang C, Elmslie KS, Peterson BZ. Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels. Am J Physiol Cell Physiol. 2010 Nov; 299(5):C1203-11.
  View in: PubMed
 
6. Wang X, Gao G, Guo K, Yarotskyy V, Huang C, Elmslie KS, Peterson BZ. Phospholemman modulates the gating of cardiac L-type calcium channels. Biophys J. 2010 Apr 7; 98(7):1149-59.
  View in: PubMed
 
7. Li Z, Wang X, Gao G, Qu D, Yu B, Huang C, Elmslie KS, Peterson BZ. A single amino acid change in Ca(v)1.2 channels eliminates the permeation and gating differences between Ca(2+) and Ba(2+). J Membr Biol. 2010 Feb; 233(1-3):23-33.
  View in: PubMed
 
8. Yarotskyy V, Gao G, Du L, Ganapathi SB, Peterson BZ, Elmslie KS. Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation. J Biol Chem. 2010 Jan 1; 285(1):43-53.
  View in: PubMed
 
9. Yu S, Gao G, Peterson BZ, Ouyang A. TRPA1 in mast cell activation-induced long-lasting mechanical hypersensitivity of vagal afferent C-fibers in guinea pig esophagus. Am J Physiol Gastrointest Liver Physiol. 2009 Jul; 297(1):G34-42.
  View in: PubMed
 
10. Yarotskyy V, Gao G, Peterson BZ, Elmslie KS. The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation. J Physiol. 2009 Feb 1; 587(Pt 3):551-65.
  View in: PubMed
 
11. Wang X, Du L, Peterson BZ. Calcicludine binding to the outer pore of L-type calcium channels is allosterically coupled to dihydropyridine binding. Biochemistry. 2007 Jun 26; 46(25):7590-8.
  View in: PubMed
 
12. Peterson BZ, Catterall WA. Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore. Mol Pharmacol. 2006 Aug; 70(2):667-75.
  View in: PubMed
 
13. Tong Q, Zhang W, Conrad K, Mostoller K, Cheung JY, Peterson BZ, Miller BA. Regulation of the transient receptor potential channel TRPM2 by the Ca2+ sensor calmodulin. J Biol Chem. 2006 Apr 7; 281(14):9076-85.
  View in: PubMed
 
14. Wang X, Ponoran TA, Rasmusson RL, Ragsdale DS, Peterson BZ. Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currents. Biophys J. 2005 Sep; 89(3):1731-43.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Calcium Channels, L-Type
Ion Channel Gating
Calcium
Phosphoproteins
Barium
See all (125) keywords
Co-Authors  
Berg, Arthur
Floros, Joanna
Gao, Guofeng
Koltun, Walter
Poritz, Lisa
See all (7) people
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