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Qing Yang
Title Professor
Institution College of Medicine
Department Radiology
Address 500 University Drive Hershey PA 17033
Mailbox: H066
Telephone 7175315858
Email
Background
PREFERRED TITLE/ROLE:

Professor of Radiology, Bioengineering, Engineering Sciences and Neurosurgery

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Center for NMR Research and MRI Core Facility

GRADUATE PROGRAM AFFILIATIONS:

Bioengineering and Neural and Behavioral Sciences

EDUCATION:

Ph.D., Georgia Institute of Technology

NARRATIVE:

My research focuses on two fundamental problems that become increasingly important in high field MRI. The problems include magnetic susceptibility effects on the static magnetic and the dielectric effects on the radio-frequency (RF) field. The current is focused on three areas. These three areas of research are closely related to one another and all relate to high field MRI technology.

T2* contrast imaging and its applications.
T2* contrast techniques have become increasingly useful for their unique tissue contrast. T2* image contrast is sensitive to variation in tissue bulk magnetic susceptibility. The T2* contrast provide a useful tool for brain research. One important application is the assessment of relative brain iron concentration. Brain iron dysregulation and resultant deposition have been implicated in many common degenerative diseases such as Alzheimer?s disease (AD), Parkinson?s disease (PD) and multiple sclerosis (MS). Unfortunately, T2* contrast for research and clinical investigations is limited by two major problems in existing techniques:
i. Severe artifact and loss of signal due to magnetic field inhomogeneity,
ii. Low contrast to noise ratio (CNR).

The research objective is to exploit the full potential of T2* contrast by developing reliable T2* contrast-enhanced imaging methods for brain research and clinical examinations.

Olfactory deficit in AD and olfactory functional MRI The behavioral and neuropathological findings of preferential involvement of the central olfactory pathways in the early stages of AD makes olfaction an important system for investigation of AD with fMRI. The purpose of this project is to develop a reliable olfactory fMRI technique for clinical research on olfactory deficits occurring in early AD patients. This study can be correlated with the iron deposition using T2* contrast as mentioned above. This project involves rapid MRI methodology development as well as medical application of fMRI.

Radio frequency field and dielectric materials in high field MRI It is desirable to increase the static magnetic field strength because MR image quality and sensitivity are expected to improve at higher field strength. The RF field becomes significantly inhomogeneous at high fields due to the strong wave behavior of the RF field. The understanding and eventual utilization of the wave behavior are fundamentally important for the development of high field NMR. Computer modeling is used to study the interaction between RF field and dielectric materials including tissues. Dielectric materials can be used in various ways to manipulate the RF field and their potential applications are enormous.
Publications
1. Du G, Lewis MM, Sen S, Wang J, Shaffer ML, Styner M, Yang QX, Huang X. Imaging nigral pathology and clinical progression in Parkinson's disease. Mov Disord. 2012 Nov; 27(13):1636-43.
  View in: PubMed
 
2. Luo W, Lanagan MT, Sica CT, Ryu Y, Oh S, Ketterman M, Yang QX, Collins CM. Permittivity and performance of dielectric pads with sintered ceramic beads in MRI: early experiments and simulations at 3 T. Magn Reson Med. 2012 Aug 13.
  View in: PubMed
 
3. Du G, Lewis MM, Shaffer ML, Chen H, Yang QX, Mailman RB, Huang X. Serum cholesterol and nigrostriatal R2* values in Parkinson's disease. PLoS One. 2012; 7(4):e35397.
  View in: PubMed
 
4. Liu W, Kao CP, Collins CM, Smith MB, Yang QX. On consideration of radiated power in RF field simulations for MRI. Magn Reson Med. 2013 Jan; 69(1):290-4.
  View in: PubMed
 
5. Wang J, Shaffer ML, Eslinger PJ, Sun X, Weitekamp CW, Patel MM, Dossick D, Gill DJ, Connor JR, Yang QX. Maturational and aging effects on human brain apparent transverse relaxation. PLoS One. 2012; 7(2):e31907.
  View in: PubMed
 
6. Roopnariane CA, Ryu YC, Tofighi MR, Miller PA, Oh S, Wang J, Park BS, Ansel L, Lieu CA, Subramanian T, Yang QX, Collins CM. Quadrature RF Coil for In Vivo Brain MRI of a Macaque Monkey in a Stereotaxic Head Frame. Concepts Magn Reson Part B Magn Reson Eng. 2012 Feb; 41B(1):22-27.
  View in: PubMed
 
7. Aksu Y, Miller DJ, Kesidis G, Bigler DC, Yang QX. An MRI-derived definition of MCI-to-AD conversion for long-term, automatic prognosis of MCI patients. PLoS One. 2011; 6(10):e25074.
  View in: PubMed
 
8. Du G, Lewis MM, Styner M, Shaffer ML, Sen S, Yang QX, Huang X. Combined R2* and diffusion tensor imaging changes in the substantia nigra in Parkinson's disease. Mov Disord. 2011 Aug 1; 26(9):1627-32.
  View in: PubMed
 
9. Connor JR, Ponnuru P, Lee BY, Podskalny GD, Alam S, Allen RP, Earley CJ, Yang QX. Postmortem and imaging based analyses reveal CNS decreased myelination in restless legs syndrome. Sleep Med. 2011 Jun; 12(6):614-9.
  View in: PubMed
 
10. Yang QX, Wang J, Wang J, Collins CM, Wang C, Smith MB. Reducing SAR and enhancing cerebral signal-to-noise ratio with high permittivity padding at 3 T. Magn Reson Med. 2011 Feb; 65(2):358-62.
  View in: PubMed
 
11. Wang J, Eslinger PJ, Doty RL, Zimmerman EK, Grunfeld R, Sun X, Meadowcroft MD, Connor JR, Price JL, Smith MB, Yang QX. Olfactory deficit detected by fMRI in early Alzheimer's disease. Brain Res. 2010 Oct 21; 1357:184-94.
  View in: PubMed
 
12. Aksu Y, Miller DJ, Kesidis G, Yang QX. Margin-maximizing feature elimination methods for linear and nonlinear kernel-based discriminant functions. IEEE Trans Neural Netw. 2010 May; 21(5):701-17.
  View in: PubMed
 
13. Robinson-Long M, Eslinger PJ, Wang J, Meadowcroft M, Yang QX. Functional MRI evidence for distinctive binding and consolidation pathways for face-name associations: analysis of activation maps and BOLD response amplitudes. Top Magn Reson Imaging. 2009 Oct; 20(5):271-8.
  View in: PubMed
 
14. Meadowcroft MD, Connor JR, Smith MB, Yang QX. MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice. J Magn Reson Imaging. 2009 May; 29(5):997-1007.
  View in: PubMed
 
15. Bigler DC, Aksu Y, Miller DJ, Yang QX. STAMPS: Software Tool for Automated MRI Post-processing on a supercomputer. Comput Methods Programs Biomed. 2009 Aug; 95(2):146-57.
  View in: PubMed
 
16. Madhankumar AB, Slagle-Webb B, Wang X, Yang QX, Antonetti DA, Miller PA, Sheehan JM, Connor JR. Efficacy of interleukin-13 receptor-targeted liposomal doxorubicin in the intracranial brain tumor model. Mol Cancer Ther. 2009 Mar; 8(3):648-54.
  View in: PubMed
 
17. Thompson K, Biddle KR, Robinson-Long M, Poger J, Wang J, Yang QX, Eslinger PJ. Cerebral plasticity and recovery of function after childhood prefrontal cortex damage. Dev Neurorehabil. 2009; 12(5):298-312.
  View in: PubMed
 
18. Eslinger PJ, Robinson-Long M, Realmuto J, Moll J, deOliveira-Souza R, Tovar-Moll F, Wang J, Yang QX. Developmental frontal lobe imaging in moral judgment: Arthur Benton's enduring influence 60 years later. J Clin Exp Neuropsychol. 2009 Feb; 31(2):158-69.
  View in: PubMed
 
19. Eslinger PJ, Blair C, Wang J, Lipovsky B, Realmuto J, Baker D, Thorne S, Gamson D, Zimmerman E, Rohrer L, Yang QX. Developmental shifts in fMRI activations during visuospatial relational reasoning. Brain Cogn. 2009 Feb; 69(1):1-10.
  View in: PubMed
 
20. Meadowcroft MD, Zhang S, Liu W, Park BS, Connor JR, Collins CM, Smith MB, Yang QX. Direct magnetic resonance imaging of histological tissue samples at 3.0T. Magn Reson Med. 2007 May; 57(5):835-41.
  View in: PubMed
 
21. Yang Q, Sumner AD, Puhl HL, Ruiz-Velasco V. M(1) and M(2) muscarinic acetylcholine receptor subtypes mediate Ca(2+) channel current inhibition in rat sympathetic stellate ganglion neurons. J Neurophysiol. 2006 Nov; 96(5):2479-87.
  View in: PubMed
 
22. Lindquist MA, Zhang CH, Glover G, Shepp L, Yang QX. A generalization of the two-dimensional prolate spheroidal wave function method for nonrectilinear MRI data acquisition methods. IEEE Trans Image Process. 2006 Sep; 15(9):2792-804.
  View in: PubMed
 
23. Yang QX, Mao W, Wang J, Smith MB, Lei H, Zhang X, Ugurbil K, Chen W. Manipulation of image intensity distribution at 7.0 T: passive RF shimming and focusing with dielectric materials. J Magn Reson Imaging. 2006 Jul; 24(1):197-202.
  View in: PubMed
 
24. Lazovic J, Wrzos HF, Yang QX, Collins CM, Smith MB, Norgren R, Matyas K, Ouyang A. Regional activation in the rat brain during visceral stimulation detected by c-fos expression and fMRI. Neurogastroenterol Motil. 2005 Aug; 17(4):548-56.
  View in: PubMed
 
25. Yang QX, Shao CK, Feng ZY, Huang BQ, Han AJ, Xiong M, Zhao WL, Wu TT. [Detection of cytokeratin 19 and thyroperoxidase expressions in the diagnosis of thyroid diseases]. Di Yi Jun Yi Da Xue Xue Bao. 2005 Jun; 25(6):678-81.
  View in: PubMed
 
26. Lazovic J, Stojkovic DS, Collins CM, Yang QX, Vaughan JT, Smith MB. Hexagonal zero mode TEM coil: a single-channel coil design for imaging multiple small animals. Magn Reson Med. 2005 May; 53(5):1150-7.
  View in: PubMed
 
27. Wang J, Eslinger PJ, Smith MB, Yang QX. Functional magnetic resonance imaging study of human olfaction and normal aging. J Gerontol A Biol Sci Med Sci. 2005 Apr; 60(4):510-4.
  View in: PubMed
 
28. Collins CM, Liu W, Schreiber W, Yang QX, Smith MB. Central brightening due to constructive interference with, without, and despite dielectric resonance. J Magn Reson Imaging. 2005 Feb; 21(2):192-6.
  View in: PubMed
 
29. Wang J, Qiu M, Yang QX, Smith MB, Constable RT. Measurement and correction of transmitter and receiver induced nonuniformities in vivo. Magn Reson Med. 2005 Feb; 53(2):408-17.
  View in: PubMed
 
30. Yang QX, Wang J, Smith MB, Meadowcroft M, Sun X, Eslinger PJ, Golay X. Reduction of magnetic field inhomogeneity artifacts in echo planar imaging with SENSE and GESEPI at high field. Magn Reson Med. 2004 Dec; 52(6):1418-23.
  View in: PubMed
 
31. Yang QX, Wang J, Collins CM, Smith MB, Zhang X, Ugurbil K, Chen W. Phantom design method for high-field MRI human systems. Magn Reson Med. 2004 Nov; 52(5):1016-20.
  View in: PubMed
 
32. Mosher TJ, Liu Y, Yang QX, Yao J, Smith R, Dardzinski BJ, Smith MB. Age dependency of cartilage magnetic resonance imaging T2 relaxation times in asymptomatic women. Arthritis Rheum. 2004 Sep; 50(9):2820-8.
  View in: PubMed
 
33. Lazovic-Stojkovic J, Mosher TJ, Smith HE, Yang QX, Dardzinski BJ, Smith MB. Interphalangeal joint cartilage: high-spatial-resolution in vivo MR T2 mapping--a feasibility study. Radiology. 2004 Oct; 233(1):292-6.
  View in: PubMed
 
34. Yang QX, Lindquist MA, Shepp L, Zhang CH, Wang J, Smith MB. Two dimensional prolate spheroidal wave functions for MRI. J Magn Reson. 2002 Sep-Oct; 158(1-2):43-51.
  View in: PubMed
 
35. Wang J, Yang QX, Zhang X, Collins CM, Smith MB, Zhu XH, Adriany G, Ugurbil K, Chen W. Polarization of the RF field in a human head at high field: a study with a quadrature surface coil at 7.0 T. Magn Reson Med. 2002 Aug; 48(2):362-9.
  View in: PubMed
 
36. Bus SA, Yang QX, Wang JH, Smith MB, Wunderlich R, Cavanagh PR. Intrinsic muscle atrophy and toe deformity in the diabetic neuropathic foot: a magnetic resonance imaging study. Diabetes Care. 2002 Aug; 25(8):1444-50.
  View in: PubMed
 
37. Collins CM, Yang B, Yang QX, Smith MB. Numerical calculations of the static magnetic field in three-dimensional multi-tissue models of the human head. Magn Reson Imaging. 2002 Jun; 20(5):413-24.
  View in: PubMed
 
38. Demeure RJ, Jordan BF, Yang QX, Beghein N, Smith MB, Grégoire V, Gallez B. Removal of local field gradient artefacts in BOLD contrast imaging of head and neck tumours. Phys Med Biol. 2002 May 21; 47(10):1819-25.
  View in: PubMed
 
39. Yang QX, Wang J, Zhang X, Collins CM, Smith MB, Liu H, Zhu XH, Vaughan JT, Ugurbil K, Chen W. Analysis of wave behavior in lossy dielectric samples at high field. Magn Reson Med. 2002 May; 47(5):982-9.
  View in: PubMed
 
40. Collins CM, Yang QX, Wang JH, Zhang X, Liu H, Michaeli S, Zhu XH, Adriany G, Vaughan JT, Anderson P, Merkle H, Ugurbil K, Smith MB, Chen W. Different excitation and reception distributions with a single-loop transmit-receive surface coil near a head-sized spherical phantom at 300 MHz. Magn Reson Med. 2002 May; 47(5):1026-8.
  View in: PubMed
 
41. Smith HE, Mosher TJ, Dardzinski BJ, Collins BG, Collins CM, Yang QX, Schmithorst VJ, Smith MB. Spatial variation in cartilage T2 of the knee. J Magn Reson Imaging. 2001 Jul; 14(1):50-5.
  View in: PubMed
 
42. Cornett JA, Herr MD, Gray KS, Smith MB, Yang QX, Sinoway LI. Ischemic exercise and the muscle metaboreflex. J Appl Physiol. 2000 Oct; 89(4):1432-6.
  View in: PubMed
 
43. Lee F, Shoemaker JK, McQuillan PM, Kunselman AR, Smith MB, Yang QX, Smith H, Gray K, Sinoway LI. Effects of forearm bier block with bretylium on the hemodynamic and metabolic responses to handgrip. Am J Physiol Heart Circ Physiol. 2000 Aug; 279(2):H586-93.
  View in: PubMed
 
44. Yang QX, Smith MB, Briggs RW, Rycyna RE. Microimaging at 14 tesla using GESEPI for removal of magnetic susceptibility artifacts in T(2)(*)-weighted image contrast. J Magn Reson. 1999 Nov; 141(1):1-6.
  View in: PubMed
 
45. Yang QX, Demeure RJ, Dardzinski BJ, Arnold BW, Smith MB. Multiple echo frequency-domain image contrast: improved signal-to-noise ratio and T2 (T2*) weighting. Magn Reson Med. 1999 Feb; 41(2):423-8.
  View in: PubMed
 
46. Ettinger SM, Silber DH, Gray KS, Smith MB, Yang QX, Kunselman AR, Sinoway LI. Effects of the ovarian cycle on sympathetic neural outflow during static exercise. J Appl Physiol. 1998 Dec; 85(6):2075-81.
  View in: PubMed
 
47. Silber DH, Sutliff G, Yang QX, Smith MB, Sinoway LI, Leuenberger UA. Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure. J Appl Physiol. 1998 May; 84(5):1551-9.
  View in: PubMed
 
48. Yang QX, Williams GD, Demeure RJ, Mosher TJ, Smith MB. Removal of local field gradient artifacts in T2*-weighted images at high fields by gradient-echo slice excitation profile imaging. Magn Reson Med. 1998 Mar; 39(3):402-9.
  View in: PubMed
 
49. Shoemaker JK, Pandey P, Herr MD, Silber DH, Yang QX, Smith MB, Gray K, Sinoway LI. Augmented sympathetic tone alters muscle metabolism with exercise: lack of evidence for functional sympatholysis. J Appl Physiol. 1997 Jun; 82(6):1932-8.
  View in: PubMed
 
50. Yang QX, Dardzinski BJ, Li S, Eslinger PJ, Smith MB. Multi-gradient echo with susceptibility inhomogeneity compensation (MGESIC): demonstration of fMRI in the olfactory cortex at 3.0 T. Magn Reson Med. 1997 Mar; 37(3):331-5.
  View in: PubMed
 
51. Yang QX, Huang FY, Lin TH, Gelbaum L, Howell EE, Huang TH. Dynamics of trimethoprim bound to dihydrofolate reductase--a deuterium NMR study. Solid State Nucl Magn Reson. 1996 Dec; 7(3):193-201.
  View in: PubMed
 
52. Li S, Dardzinski BJ, Collins CM, Yang QX, Smith MB. Three-dimensional mapping of the static magnetic field inside the human head. Magn Reson Med. 1996 Nov; 36(5):705-14.
  View in: PubMed
 
53. Yang QX, Posse S, Le Bihan D, Smith MB. Double-sampled echo-planar imaging at 3 tesla. J Magn Reson B. 1996 Nov; 113(2):145-50.
  View in: PubMed
 
54. Ettinger SM, Silber DH, Collins BG, Gray KS, Sutliff G, Whisler SK, McClain JM, Smith MB, Yang QX, Sinoway LI. Influences of gender on sympathetic nerve responses to static exercise. J Appl Physiol. 1996 Jan; 80(1):245-51.
  View in: PubMed
 
55. Batman BA, Hardy JC, Leuenberger UA, Smith MB, Yang QX, Sinoway LI. Sympathetic nerve activity during prolonged rhythmic forearm exercise. J Appl Physiol. 1994 Mar; 76(3):1077-81.
  View in: PubMed
 
56. Li S, Yang QX, Smith MB. RF coil optimization: evaluation of B1 field homogeneity using field histograms and finite element calculations. Magn Reson Imaging. 1994; 12(7):1079-87.
  View in: PubMed
 
57. Yang QX, Huang FY, Huang TH, Gelbaum L. The effect of hydration on the dynamics of trimethoprim bound to dihydrofolate reductase. A deuterium NMR study. Biophys J. 1993 Apr; 64(4):1361-5.
  View in: PubMed
 
58. Huang FY, Yang QX, Huang TH. 15N NMR studies of the conformation of E. coli dihydrofolate reductase in complex with folate or methotrexate. FEBS Lett. 1991 Sep 9; 289(2):231-4.
  View in: PubMed
 
59. Huang FY, Yang QX, Huang TH, Gelbaum L, Kuyper LF. The conformations of trimethoprim/E. coli dihydrofolate reductase complexes. A 15N and 31P NMR study. FEBS Lett. 1991 May 20; 283(1):44-6.
  View in: PubMed
 
60. Huang TH, DeSiervo AJ, Yang QX. Effect of cholesterol and lanosterol on the structure and dynamics of the cell membrane of Mycoplasma capricolum. Deuterium nuclear magnetic resonance study. Biophys J. 1991 Mar; 59(3):691-702.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Magnetic Resonance Imaging
Brain
Image Enhancement
Alzheimer Disease
Brain Mapping
See all (268) keywords
Co-Authors  
Collins, Christopher
Connor, James
Eslinger, Paul
Sinoway, Lawrence
Smith, Michael
See all (23) people
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