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Pengxiang She
Title Assistant Professor
Institution College of Medicine
Department Cellular and Molecular Physiology
Address 500 University Drive Hershey PA 17033
Mailbox: H166
Telephone 7175315344
Email
Background
PREFERRED TITLE/ROLE:

Assistant Professor of Cellular and Molecular Physiology

GRADUATE PROGRAM AFFILIATIONS:

Physiology

EDUCATION:

Ph.D., Iowa State University, 1997
Postdoctoral training, Vanderbilt University School of Medicine, 1997-2001
Postdoctoral training, Johnson & Johnson PRD, 2002-2005

NARRATIVE:

I am interested in the regulation of insulin action, insulin secretion and ß cell mass by leucine, KIC, and mTOR. Over-nutrition due to an abundant food supply significantly contributes to the obesity and diabetes epidemics in humans. Nutrients acting as direct signals and stimulators of insulin secretion activate the mTOR signaling pathway. mTOR is a master regulator of cell growth, protein synthesis, and energy metabolism, thereby playing important roles in diabetes, obesity, cancer, and aging. Over-activation of mTOR signaling leads to insulin resistance through a negative feedback mechanism of down-regulating insulin signaling. Leucine is the most potent nutrient signal activating mTOR. My research lies on determining the effects of mTOR activation interacted with leucine and insulin on insulin actions in muscle, liver, and is ß cells. We are currently working on four projects. Project 1 is to determine the metabolic and molecular mechanisms by which insulin sensitivity and glucose tolerance is markedly improved in mice lacking mitochondrial branched-chain aminotransferase ßBCATm), which catalyzes the first step of leucine catabolism. Project 2 is to determine the mechanisms underlying ? -ketoisocaproate ßKIC) stimulated insulin secretion. Project 3 studies glucose metabolism and insulin secretion in a mouse model of MSUD ßmaple syrup urine disease), E2 knockout mice in which the second step of BCAA metabolism is blocked and branched-chain keto-acids are accumulated. Project 4 is about skeletal muscle wasting, protein metabolism and related signaling pathways in the R6/2 mouse model of Huntington's disease. These studies use transgenic mouse models, in vivo physiology, in vitro biochemical and cell signaling approaches. The research will provide better understanding of pathogenesis and therapeutic strategies of type 2 diabetes.
Publications
1. She P, Olson KC, Kadota Y, Inukai A, Shimomura Y, Hoppel CL, Adams SH, Kawamata Y, Matsumoto H, Sakai R, Lang CH, Lynch CJ. Leucine and protein metabolism in obese zucker rats. PLoS One. 2013; 8(3):e59443.
  View in: PubMed
 
2. Kong FZ, Zheng D, Su ZL, She P, Xu XX, Tian SS, Zhang P, Chen JG, Xu HX. [Construction of eukaryotic co-expression vector of Porphyromonas gingivalis outer membrane protein ragB and glucocorticoid-induced tumor necrosis factor receptor ligand (GITRL) and its immunogenic analysis]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Jun; 28(6):588-91.
  View in: PubMed
 
3. She P, Zhang Z, Marchionini D, Diaz WC, Jetton TJ, Kimball SR, Vary TC, Lang CH, Lynch CJ. Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease. Am J Physiol Endocrinol Metab. 2011 Jul; 301(1):E49-61.
  View in: PubMed
 
4. Zhou Y, Jetton TL, Goshorn S, Lynch CJ, She P. Transamination is required for {alpha}-ketoisocaproate but not leucine to stimulate insulin secretion. J Biol Chem. 2010 Oct 29; 285(44):33718-26.
  View in: PubMed
 
5. Albaugh VL, Judson JG, She P, Lang CH, Maresca KP, Joyal JL, Lynch CJ. Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis. Mol Psychiatry. 2011 May; 16(5):569-81.
  View in: PubMed
 
6. She P, Zhou Y, Zhang Z, Griffin K, Gowda K, Lynch CJ. Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance. J Appl Physiol. 2010 Apr; 108(4):941-9.
  View in: PubMed
 
7. Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem. 2010 Apr 9; 285(15):11348-56.
  View in: PubMed
 
8. Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. J Clin Invest. 2009 Jun; 119(6):1678-87.
  View in: PubMed
 
9. Nairizi A, She P, Vary TC, Lynch CJ. Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice. J Nutr. 2009 Apr; 139(4):715-9.
  View in: PubMed
 
10. Bobe G, Hippen AR, She P, Lindberg GL, Young JW, Beitz DC. Effects of glucagon infusions on protein and amino acid composition of milk from dairy cows. J Dairy Sci. 2009 Jan; 92(1):130-8.
  View in: PubMed
 
11. Pruznak AM, Hong-Brown L, Lantry R, She P, Frost RA, Vary TC, Lang CH. Skeletal and cardiac myopathy in HIV-1 transgenic rats. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E964-73.
  View in: PubMed
 
12. Bobe G, Amin VR, Hippen AR, She P, Young JW, Beitz DC. Non-invasive detection of fatty liver in dairy cows by digital analyses of hepatic ultrasonograms. J Dairy Res. 2008 Feb; 75(1):84-9.
  View in: PubMed
 
13. She P, Van Horn C, Reid T, Hutson SM, Cooney RN, Lynch CJ. Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1552-63.
  View in: PubMed
 
14. She P, Reid TM, Bronson SK, Vary TC, Hajnal A, Lynch CJ, Hutson SM. Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab. 2007 Sep; 6(3):181-94.
  View in: PubMed
 
15. Liang Y, She P, Wang X, Demarest K. The messenger RNA profiles in liver, hypothalamus, white adipose tissue, and skeletal muscle of female Zucker diabetic fatty rats after topiramate treatment. Metabolism. 2006 Oct; 55(10):1411-9.
  View in: PubMed
 
16. Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, Reddy P, Xiang X, Luo Z, Ruderman N. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes. 2005 Dec; 54(12):3458-65.
  View in: PubMed
 
17. Liang Y, Osborne MC, Monia BP, Bhanot S, Watts LM, She P, DeCarlo SO, Chen X, Demarest K. Antisense oligonucleotides targeted against glucocorticoid receptor reduce hepatic glucose production and ameliorate hyperglycemia in diabetic mice. Metabolism. 2005 Jul; 54(7):848-55.
  View in: PubMed
 
18. Liang Y, Osborne MC, Monia BP, Bhanot S, Gaarde WA, Reed C, She P, Jetton TL, Demarest KT. Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice. Diabetes. 2004 Feb; 53(2):410-7.
  View in: PubMed
 
19. Yang JG, Liu X, Yu G, Long T, She P, Liu Z. [The influence on the biodegradation of phenanthrene by nonionic surfactant, Tween20]. Huan Jing Ke Xue. 2004 Jan; 25(1):53-6.
  View in: PubMed
 
20. Yang J, Liu X, Yu G, Long T, She P, Liu Z. [Characterization of polycyclic aromatic hydrocarbons dissolved in nonionic surfactants]. Huan Jing Ke Xue. 2003 Nov; 24(6):79-82.
  View in: PubMed
 
21. She P, Burgess SC, Shiota M, Flakoll P, Donahue EP, Malloy CR, Sherry AD, Magnuson MA. Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. Diabetes. 2003 Jul; 52(7):1649-54.
  View in: PubMed
 
22. Magnuson MA, She P, Shiota M. Gene-altered mice and metabolic flux control. J Biol Chem. 2003 Aug 29; 278(35):32485-8.
  View in: PubMed
 
23. She P, Shiota M, Shelton KD, Chalkley R, Postic C, Magnuson MA. Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. Mol Cell Biol. 2000 Sep; 20(17):6508-17.
  View in: PubMed
 
24. She P, Hippen AR, Young JW, Lindberg GL, Beitz DC, Richardson LF, Tucker RW. Metabolic responses of lactating dairy cows to 14-day intravenous infusions of glucagon. J Dairy Sci. 1999 Jun; 82(6):1118-27.
  View in: PubMed
 
25. Hippen AR, She P, Young JW, Beitz DC, Lindberg GL, Richardson LF, Tucker RW. Metabolic responses of dairy cows and heifers to various intravenous dosages of glucagon. J Dairy Sci. 1999 Jun; 82(6):1128-38.
  View in: PubMed
 
26. Hippen AR, She P, Young JW, Beitz DC, Lindberg GL, Richardson LF, Tucker RW. Alleviation of fatty liver in dairy cows with 14-day intravenous infusions of glucagon. J Dairy Sci. 1999 Jun; 82(6):1139-52.
  View in: PubMed
 
27. She P, Lindberg GL, Hippen AR, Beitz DC, Young JW. Regulation of messenger ribonucleic acid expression for gluconeogenic enzymes during glucagon infusions into lactating cows. J Dairy Sci. 1999 Jun; 82(6):1153-63.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Transaminases
Leucine
Amino Acids, Branched-Chain
Phosphoenolpyruvate Carboxykinase (GTP)
Liver
See all (182) keywords
Co-Authors  
Bronson, Sarah
Frost, Robert
Hajnal, Andras
Lang, Charles
Lynch, Christopher
See all (6) people
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