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Prasanna Karunanayaka
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Title Assistant Professor
Institution College of Medicine
Department Radiology
Address 500 University Drive Hershey PA 17033
 Mailbox: H066
Telephone 7175315400
Email
Background
PREFERRED TITLE/ROLE:

Assistant Professor

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Center for NMR Research

EDUCATION:

Ph.D.

NARRATIVE:

My research in Brain Imaging is highly applied in nature and involves computational as well as numerical techniques. The current emphasis of my research is to investigate the reading ability in children using fMRI, Diffusion Tensor Imaging (DTI) and magnetoencephalography (MEG) data in appropriate brain function networks. To be more specific, my goal is to apply the knowledge I have gained in machine learning techniques to study the information flow in the reading substrate. I am fully convinced that this approach: combining neuroimaging and computational modeling will be able to decipher the causal structure (or the interactions) sub-serving the reading substrate. In the longer term, I intend to extend my prior work on narrative comprehension in normally developing (ND) children to reading disabled (RD) children seizing the tantalizing opportunity to investigate how reading comprehension is affected in RD.
The long-term goal of my research is to bridge the disciplines of Computer Science, Imaging, and Neuroscience. The methods I propose to develop for neuroimaging may offer significant benefits in providing insight into a wide range of disorders such as auditory and language, which manifest as early markers for the presence of developmental or acquired neurological disorders. I am fully convinced that the applications serve as the measure of worth of applied biomedical research.
Publications
1. Lin X, Meng X, Karunanayaka P, Holland SK. A spectral graphical model approach for learning brain connectivity network of children's narrative comprehension. Brain Connect. 2011; 1(5):389-400.
  View in: PubMed
 
2. Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A linear structural equation model for covert verb generation based on independent component analysis of FMRI data from children and adolescents. Front Syst Neurosci. 2011; 5:29.
  View in: PubMed
 
3. Kim KK, Karunanayaka P, Privitera MD, Holland SK, Szaflarski JP. Semantic association investigated with functional MRI and independent component analysis. Epilepsy Behav. 2011 Apr; 20(4):613-22.
  View in: PubMed
 
4. Karunanayaka P, Kim KK, Holland SK, Szaflarski JP. The effects of left or right hemispheric epilepsy on language networks investigated with semantic decision fMRI task and independent component analysis. Epilepsy Behav. 2011 Apr; 20(4):623-32.
  View in: PubMed
 
5. Vannest J, Rasmussen J, Eaton KP, Patel K, Schmithorst V, Karunanayaka P, Plante E, Byars A, Holland S. FMRI activation in language areas correlates with verb generation performance in children. Neuropediatrics. 2010 Oct; 41(5):235-9.
  View in: PubMed
 
6. Karunanayaka P, Schmithorst VJ, Vannest J, Szaflarski JP, Plante E, Holland SK. A group independent component analysis of covert verb generation in children: a functional magnetic resonance imaging study. Neuroimage. 2010 May 15; 51(1):472-87.
  View in: PubMed
 
7. Vannest J, Karunanayaka PR, Schmithorst VJ, Szaflarski JP, Holland SK. Language networks in children: evidence from functional MRI studies. AJR Am J Roentgenol. 2009 May; 192(5):1190-6.
  View in: PubMed
 
8. Vannest JJ, Karunanayaka PR, Altaye M, Schmithorst VJ, Plante EM, Eaton KJ, Rasmussen JM, Holland SK. Comparison of fMRI data from passive listening and active-response story processing tasks in children. J Magn Reson Imaging. 2009 Apr; 29(4):971-6.
  View in: PubMed
 
9. Kramer ME, Chiu CY, Walz NC, Holland SK, Yuan W, Karunanayaka P, Wade SL. Long-term neural processing of attention following early childhood traumatic brain injury: fMRI and neurobehavioral outcomes. J Int Neuropsychol Soc. 2008 May; 14(3):424-35.
  View in: PubMed
 
10. Yuan W, Holland SK, Schmithorst VJ, Walz NC, Cecil KM, Jones BV, Karunanayaka P, Michaud L, Wade SL. Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood. AJNR Am J Neuroradiol. 2007 Nov-Dec; 28(10):1919-25.
  View in: PubMed
 
11. Holland SK, Vannest J, Mecoli M, Jacola LM, Tillema JM, Karunanayaka PR, Schmithorst VJ, Yuan W, Plante E, Byars AW. Functional MRI of language lateralization during development in children. Int J Audiol. 2007 Sep; 46(9):533-51.
  View in: PubMed
 
12. Karunanayaka PR, Holland SK, Yuan W, Altaye M, Jones BV, Michaud LJ, Walz NC, Wade SL. Neural substrate differences in language networks and associated language-related behavioral impairments in children with TBI: a preliminary fMRI investigation. NeuroRehabilitation. 2007; 22(5):355-69.
  View in: PubMed
 
13. Karunanayaka PR, Holland SK, Schmithorst VJ, Solodkin A, Chen EE, Szaflarski JP, Plante E. Age-related connectivity changes in fMRI data from children listening to stories. Neuroimage. 2007 Jan 1; 34(1):349-60.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Magnetic Resonance Imaging
Brain Mapping
Brain
Functional Laterality
Brain Injuries
See all (60) keywords
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