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Neil Trushin
Title Senior Research Associate
Institution College of Medicine
Department Pharmacology
Address 500 University Drive Hershey PA 17033
Mailbox: CH74
Telephone 7175317937
Email
Background
PREFERRED TITLE/ROLE:

Senior Research Associate

EDUCATION:

B.A., State University of New York at Purchase, 1983
M.S., New York Medical College, 2003

NARRATIVE:

Working in Dr. Prokopczyk’s lab, we use a variety of methods, including HPLC with UV, fluorescence, and radioflow detectors as well as UPLC/MS and GC/MS to determine the metabolic pathways and DNA binding capabilities of tobacco carcinogens. We also employ GC/FID to determine fatty acid levels in animal diets and tissues as well as in animal and human plasma samples. We are currently collaborating with the core facility in an LC/MS/MS assay to study the relationship between dietary fatty acids and levels of ethenoguanine DNA adducts in rat mammary fat pad and human lymphocyte samples.
Publications
1. Trushin N, Alam S, El-Bayoumy K, Krzeminski J, Amin SG, Gullett J, Meyers C, Prokopczyk B. Comparative metabolism of benzo[a]pyrene by human keratinocytes infected with high-risk human papillomavirus types 16 and 18 as episomal or integrated genomes. J Carcinog. 2012; 11:1.
  View in: PubMed
 
2. Prokopczyk B, Sinha I, Trushin N, Freeman WM, El-Bayoumy K. Gene expression profiles in HPV-immortalized human cervical cells treated with the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Chem Biol Interact. 2009 Feb 12; 177(3):173-80.
  View in: PubMed
 
3. Trushin N, Leder G, El-Bayoumy K, Hoffmann D, Beger HG, Henne-Bruns D, Ramadani M, Prokopczyk B. The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols. Langenbecks Arch Surg. 2008 Jul; 393(4):571-9.
  View in: PubMed
 
4. Chang SI, El-Bayoumy K, Sinha I, Trushin N, Stanley B, Pittman B, Prokopczyk B. 4-(Methylnitrosamino)-I-(3-pyridyl)-1-butanone enhances the expression of apolipoprotein A-I and Clara cell 17-kDa protein in the lung proteomes of rats fed a corn oil diet but not a fish oil diet. Cancer Epidemiol Biomarkers Prev. 2007 Feb; 16(2):228-35.
  View in: PubMed
 
5. Prokopczyk B, Leder G, Trushin N, Cunningham AJ, Akerkar S, Pittman B, Ramadani M, Straeter J, Beger HG, Henne-Bruns D, El-Bayoumy K. 4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue. Cancer Epidemiol Biomarkers Prev. 2005 Feb; 14(2):540-1.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Nitrosamines
Pancreas
Carcinogens
Microsomes
Cytosol
See all (44) keywords
Co-Authors  
Alam, Samina
Amin, Shantu
Krzeminski, Jacek
Prokopczyk, Bogdan
Sinha, Indu
See all (8) people
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