Search Edit My Profile Login to Profiles FAQs / About
William Kovacs
Title Professor
Institution College of Medicine
Department Medicine
Division Endocrinology
Address 500 University Drive Hershey PA 17033
Email
Background
PREFERRED TITLE/ROLE:

Physician, Professor

EDUCATION:

Fellowship, Endocrinology, University of Texas Southwestern Medical Center (Dallas) (1983)
Residency, Internal Medicine, Medical College of Virginia/Virginia Commonwealth University (Richmond) (1980)
Internship, Internal Medicine, Medical College of Virginia/Virginia Commonwealth University (Richmond) (1978)
M.D., University of Chicago-Pritzker School of Medicine (Illinois) (1977)
Publications
1. Sakiani S, Olsen NJ, Kovacs WJ. Gonadal steroids and humoral immunity. Nat Rev Endocrinol. 2012 Nov 27; 9(1):56-62.
  View in: PubMed
 
2. Benko AL, Olsen NJ, Kovacs WJ. Estrogen and telomerase in human peripheral blood mononuclear cells. Mol Cell Endocrinol. 2012 Nov 25; 364(1-2):83-8.
  View in: PubMed
 
3. Tessnow AH, Olsen NJ, Kovacs WJ. Expression of humoral autoimmunity is related to androgen receptor CAG repeat length in men with systemic lupus erythematosus. J Clin Immunol. 2011 Aug; 31(4):567-73.
  View in: PubMed
 
4. Kovacs WJ, Olsen NJ. Sexual dimorphism of RA manifestations: genes, hormones and behavior. Nat Rev Rheumatol. 2011 May; 7(5):307-10.
  View in: PubMed
 
5. Mathew RP, Kovacs WJ. Short stature in a patient with familial glucocorticoid deficiency. J Pediatr Endocrinol Metab. 2011; 24(7-8):569-71.
  View in: PubMed
 
6. Olsen NJ, Kovacs WJ. Evidence that androgens modulate human thymic T cell output. J Investig Med. 2011 Jan; 59(1):32-5.
  View in: PubMed
 
7. Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF. Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2007 Sep 18; 116(12):1404-12.
  View in: PubMed
 
8. Nuotio-Antar AM, Hasty AH, Kovacs WJ. Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus. J Steroid Biochem Mol Biol. 2006 May; 99(2-3):93-9.
  View in: PubMed
 
9. Kovacs WJ. Editorial: Toward understanding variation in responsiveness to hormones. J Clin Endocrinol Metab. 2004 Jul; 89(7):3129-30.
  View in: PubMed
 
10. Turney MK, Nicholson WE, Kovacs WJ. Gene expression phenotyping of an ACTH-producing small cell lung cancer line. Mol Cell Endocrinol. 2004 Apr 30; 219(1-2):105-13.
  View in: PubMed
 
11. Wahlstrom JT, Fowler MJ, Nicholson WE, Kovacs WJ. A novel mutation in the preprovasopressin gene identified in a kindred with autosomal dominant neurohypophyseal diabetes insipidus. J Clin Endocrinol Metab. 2004 Apr; 89(4):1963-8.
  View in: PubMed
 
12. Feltus FA, Kovacs WJ, Nicholson W, Silva CM, Nagdas SK, Ducharme NA, Melner MH. Epidermal growth factor increases cortisol production and type II 3 beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4)-isomerase expression in human adrenocortical carcinoma cells: evidence for a Stat5-dependent mechanism. Endocrinology. 2003 May; 144(5):1847-53.
  View in: PubMed
 
13. Feltus FA, Cote S, Simard J, Gingras S, Kovacs WJ, Nicholson WE, Clark BJ, Melner MH. Glucocorticoids enhance activation of the human type II 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase gene. J Steroid Biochem Mol Biol. 2002 Sep; 82(1):55-63.
  View in: PubMed
 
14. Olsen NJ, Kovacs WJ. Hormones, pregnancy, and rheumatoid arthritis. J Gend Specif Med. 2002 Jul-Aug; 5(4):28-37.
  View in: PubMed
 
15. Olsen NJ, Gu X, Kovacs WJ. Bone marrow stromal cells mediate androgenic suppression of B lymphocyte development. J Clin Invest. 2001 Dec; 108(11):1697-704.
  View in: PubMed
 
16. Holla VR, Adas F, Imig JD, Zhao X, Price E, Olsen N, Kovacs WJ, Magnuson MA, Keeney DS, Breyer MD, Falck JR, Waterman MR, Capdevila JH. Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A. 2001 Apr 24; 98(9):5211-6.
  View in: PubMed
 
17. Olsen NJ, Olson G, Viselli SM, Gu X, Kovacs WJ. Androgen receptors in thymic epithelium modulate thymus size and thymocyte development. Endocrinology. 2001 Mar; 142(3):1278-83.
  View in: PubMed
 
18. Turney MK, Kovacs WJ. Function of a truncated glucocorticoid receptor form at a negative glucocorticoid response element in the proopiomelanocortin gene. J Mol Endocrinol. 2001 Feb; 26(1):43-9.
  View in: PubMed
 
19. Olsen NJ, Kovacs WJ. Effects of androgens on T and B lymphocyte development. Immunol Res. 2001; 23(2-3):281-8.
  View in: PubMed
 
20. Parks LL, Turney MK, Gaitan D, Kovacs WJ. Expression of 11beta-hydroxysteroid dehydrogenase type 2 in an ACTH-producing small cell lung cancer. J Steroid Biochem Mol Biol. 1998 Nov; 67(4):341-6.
  View in: PubMed
 
21. Parks LL, Turney MK, Detera-Wadleigh S, Kovacs WJ. An ACTH-producing small cell lung cancer expresses aberrant glucocorticoid receptor transcripts from a normal gene. Mol Cell Endocrinol. 1998 Jul 25; 142(1-2):175-81.
  View in: PubMed
 
22. Olsen NJ, Viselli SM, Fan J, Kovacs WJ. Androgens accelerate thymocyte apoptosis. Endocrinology. 1998 Feb; 139(2):748-52.
  View in: PubMed
 
23. Viselli SM, Reese KR, Fan J, Kovacs WJ, Olsen NJ. Androgens alter B cell development in normal male mice. Cell Immunol. 1997 Dec 15; 182(2):99-104.
  View in: PubMed
 
24. Nakazawa M, Fantappie MR, Freeman GL, Eloi-Santos S, Olsen NJ, Kovacs WJ, Secor WE, Colley DG. Schistosoma mansoni: susceptibility differences between male and female mice can be mediated by testosterone during early infection. Exp Parasitol. 1997 Mar; 85(3):233-40.
  View in: PubMed
 
25. Olsen NJ, Kovacs WJ. Gonadal steroids and immunity. Endocr Rev. 1996 Aug; 17(4):369-84.
  View in: PubMed
 
26. Olsen NJ, Kovacs WJ. Case report: testosterone treatment of systemic lupus erythematosus in a patient with Klinefelter's syndrome. Am J Med Sci. 1995 Oct; 310(4):158-60.
  View in: PubMed
 
27. Gaitan D, DeBold CR, Turney MK, Zhou P, Orth DN, Kovacs WJ. Glucocorticoid receptor structure and function in an adrenocorticotropin-secreting small cell lung cancer. Mol Endocrinol. 1995 Sep; 9(9):1193-201.
  View in: PubMed
 
28. Viselli SM, Olsen NJ, Shults K, Steizer G, Kovacs WJ. Immunochemical and flow cytometric analysis of androgen receptor expression in thymocytes. Mol Cell Endocrinol. 1995 Mar; 109(1):19-26.
  View in: PubMed
 
29. Viselli SM, Stanziale S, Shults K, Kovacs WJ, Olsen NJ. Castration alters peripheral immune function in normal male mice. Immunology. 1995 Feb; 84(2):337-42.
  View in: PubMed
 
30. Olsen NJ, Viselli SM, Shults K, Stelzer G, Kovacs WJ. Induction of immature thymocyte proliferation after castration of normal male mice. Endocrinology. 1994 Jan; 134(1):107-13.
  View in: PubMed
 
31. Maciunas RJ, Mericle RA, Sneed CL, Hefner DJ, Commers PA, Kovacs WJ. Determination of the lethal dose of dexamethasone for early passage in vitro human glioblastoma cell cultures. Neurosurgery. 1993 Sep; 33(3):485-8; discussion 488.
  View in: PubMed
 
32. Olsen NJ, Zhou P, Ong H, Kovacs WJ. Testosterone induces expression of transforming growth factor-beta 1 in the murine thymus. J Steroid Biochem Mol Biol. 1993 May; 45(5):327-32.
  View in: PubMed
 
33. McCammon DK, Zhou P, Turney MK, McPhaul MJ, Kovacs WJ. An androgenic affinity ligand covalently binds to cytosolic aldehyde dehydrogenase from human genital skin fibroblasts. Mol Cell Endocrinol. 1993 Feb; 91(1-2):177-83.
  View in: PubMed
 
34. Olsen NJ, Watson MB, Henderson GS, Kovacs WJ. Androgen deprivation induces phenotypic and functional changes in the thymus of adult male mice. Endocrinology. 1991 Nov; 129(5):2471-6.
  View in: PubMed
 
35. Olsen NJ, Watson MB, Kovacs WJ. Studies of immunological function in mice with defective androgen action. Distinction between alterations in immune function due to hormonal insensitivity and alterations due to other genetic factors. Immunology. 1991 May; 73(1):52-7.
  View in: PubMed
 
36. Guerami A, Griffin JE, Kovacs WJ, Grino PB, MacDonald PC, Wilson JD. Estrogen and androgen production rates in two brothers with Reifenstein syndrome. J Clin Endocrinol Metab. 1990 Jul; 71(1):247-51.
  View in: PubMed
 
37. Anthony CT, Kovacs WJ, Skinner MK. Analysis of the androgen receptor in isolated testicular cell types with a microassay that uses an affinity ligand. Endocrinology. 1989 Nov; 125(5):2628-35.
  View in: PubMed
 
38. Belsham DD, Rosenmann E, Pereira FA, Williams SG, Turney MK, Kovacs WJ, Faber LE, Wrogemann K. The 56 kDa protein of human genital skin fibroblasts is identical to that radiolabelled by [3H]dihydrotestosterone 17 beta-bromoacetate. J Steroid Biochem. 1989 Sep; 33(3):389-94.
  View in: PubMed
 
39. Olsen NJ, Kovacs WJ. Increased thymic size and thymocyte interleukin 2 production in androgen-resistant mice. Scand J Immunol. 1989 Jun; 29(6):733-8.
  View in: PubMed
 
40. Kovacs WJ, Turney MK, Skinner MK. Biochemical characterization of the protein affinity labeled by dihydrotestosterone 17 beta-bromoacetate: comparison with the human androgen receptor. Endocrinology. 1989 Mar; 124(3):1270-7.
  View in: PubMed
 
41. Kovacs WJ, Bell BW, Turney MK, Danzo BJ. Monoclonal antibodies to rat androgen-binding protein recognize both of its subunits and cross-react with rabbit and human testosterone-binding globulin. Endocrinology. 1988 Jun; 122(6):2639-47.
  View in: PubMed
 
42. Kovacs WJ, Turney MK. High efficiency covalent radiolabeling of the human androgen receptor. Studies in cultured fibroblasts using dihydrotestosterone 17 beta-bromoacetate. J Clin Invest. 1988 Feb; 81(2):342-8.
  View in: PubMed
 
43. Kovacs WJ, Olsen NJ. Androgen receptors in human thymocytes. J Immunol. 1987 Jul 15; 139(2):490-3.
  View in: PubMed
 
44. Pavlou SN, Interlandi JW, Wakefield G, Island DP, Rivier J, Vale W, Kovacs WJ. Gonadotropins and testosterone escape from suppression during prolonged luteinizing hormone-releasing hormone antagonist administration in normal men. J Clin Endocrinol Metab. 1987 May; 64(5):1070-4.
  View in: PubMed
 
45. Pavlou SN, Wakefield GB, Island DP, Hoffman PG, LePage ME, Chan RL, Nerenberg CA, Kovacs WJ. Suppression of pituitary-gonadal function by a potent new luteinizing hormone-releasing hormone antagonist in normal men. J Clin Endocrinol Metab. 1987 May; 64(5):931-6.
  View in: PubMed
 
46. Dahl KD, Pavlou SN, Kovacs WJ, Hsueh AJ. The changing ratio of serum bioactive to immunoreactive follicle-stimulating hormone in normal men following treatment with a potent gonadotropin releasing hormone antagonist. J Clin Endocrinol Metab. 1986 Sep; 63(3):792-4.
  View in: PubMed
 
47. Pandey KN, Pavlou SN, Kovacs WJ, Inagami T. Atrial natriuretic factor regulates steroidogenic responsiveness and cyclic nucleotide levels in mouse Leydig cells in vitro. Biochem Biophys Res Commun. 1986 Jul 16; 138(1):399-404.
  View in: PubMed
 
48. Kovacs WJ, Griffin JE, Wilson JD. Androgen resistance in man. Adv Exp Med Biol. 1986; 196:257-67.
  View in: PubMed
 
49. Pandey KN, Kovacs WJ, Inagami T. The inhibition of progesterone secretion and the regulation of cyclic nucleotides by atrial natriuretic factor in gonadotropin responsive murine Leydig tumor cells. Biochem Biophys Res Commun. 1985 Dec 17; 133(2):800-6.
  View in: PubMed
 
50. Wilson JD, Carlson BR, Weaver DD, Kovacs WJ, Griffin JE. Endocrine and genetic characterization of cousins with male pseudohermaphroditism: evidence that the Lubs phenotype can result from a mutation that alters the structure of the androgen receptor. Clin Genet. 1984 Oct; 26(4):363-70.
  View in: PubMed
 
51. Kovacs WJ, Griffin JE, Weaver DD, Carlson BR, Wilson JD. A mutation that causes lability of the androgen receptor under conditions that normally promote transformation to the DNA-binding state. J Clin Invest. 1984 Apr; 73(4):1095-104.
  View in: PubMed
 
52. Kovacs WJ, Griffin JE, Wilson JD. Transformation of human androgen receptors to the deoxyribonucleic acid-binding state. Endocrinology. 1983 Nov; 113(5):1574-81.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Thymus Gland
Androgens
Receptors, Androgen
T-Lymphocytes
Dihydrotestosterone
See all (312) keywords
Co-Authors  
Olsen, Nancy
See all (1) people
Site Index | Privacy and Legal Statements | Copyright Information | The Pennsylvania State University © 2011