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Victor Ruiz-Velasco
Title Associate Professor
Institution College of Medicine
Department Anesthesiology
Address 500 University Drive Hershey PA 17033
Mailbox: H187
Telephone 7175316076
Fax 7175316221
Email
Background
PREFERRED TITLE/ROLE:

Associate Professor
Associate Vice Chairman for Basic Science Research

SECONDARY APPOINTMENT(S)/ INSTITUTE(S)/ CENTER(S):

Neural and Behavioral Sciences
Pharmacology

EDUCATION:

Ph.D., Tulane University School of Medicine
Postdoctoral Training, University of Nevada at Reno 1995-1997
Postdoctoral Training, Guthrie Research Institute, 1997-2002
Publications
1. Laufenberg LJ, Weller GE, Lang CH, Ruiz-Velasco V. Nociceptin receptor signaling in sympathetic neurons from septic rats. J Surg Res. 2013 Apr 11.
  View in: PubMed
 
2. Yamauchi K, Kim JS, Stone AJ, Ruiz-Velasco V, Kaufman MP. Endoperoxide 4 receptors play a role in evoking the exercise pressor reflex in rats with simulated peripheral artery disease. J Physiol. 2013 Apr 8.
  View in: PubMed
 
3. Stone AJ, Kim JS, Yamauchi K, Ruiz-Velasco V, Kaufman MP. Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels. Neurosci Lett. 2013 May 24; 543:177-82.
  View in: PubMed
 
4. Hassan B, Ruiz-Velasco V. The ?-Opioid Receptor Agonist U-50488 Blocks Ca2+ Channels in a Voltage- and G Protein-Independent Manner in Sensory Neurons. Reg Anesth Pain Med. 2013 Jan; 38(1):21-7.
  View in: PubMed
 
5. Mahmoud S, Yun JK, Ruiz-Velasco V. Gß2 and Gß4 participate in the opioid and adrenergic receptor-mediated Ca2+ channel modulation in rat sympathetic neurons. J Physiol. 2012 Oct 1; 590(Pt 19):4673-89.
  View in: PubMed
 
6. Mahmoud S, Thorsell A, Sommer WH, Heilig M, Holgate JK, Bartlett SE, Ruiz-Velasco V. Pharmacological consequence of the A118G µ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²? channels in humanized mouse sensory neurons. Anesthesiology. 2011 Nov; 115(5):1054-62.
  View in: PubMed
 
7. Bezinover D, Ramamoorthy S, Uemura T, Kadry Z, McQuillan PM, Mets B, Falcucci O, Rannels S, Ruiz-Velasco V, Spiess B, Liang J, Mani H, Lou X, Janicki PK. Use of a third-generation perfluorocarbon for preservation of rat DCD liver grafts. J Surg Res. 2012 Jun 1; 175(1):131-7.
  View in: PubMed
 
8. Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, Hommer D, Heilig M. A genetic determinant of the striatal dopamine response to alcohol in men. Mol Psychiatry. 2011 Aug; 16(8):809-17.
  View in: PubMed
 
9. Mahmoud S, Margas W, Trapella C, Caló G, Ruiz-Velasco V. Modulation of silent and constitutively active nociceptin/orphanin FQ receptors by potent receptor antagonists and Na+ ions in rat sympathetic neurons. Mol Pharmacol. 2010 May; 77(5):804-17.
  View in: PubMed
 
10. Margas W, Mahmoud S, Ruiz-Velasco V. Muscarinic acetylcholine receptor modulation of mu (mu) opioid receptors in adult rat sphenopalatine ganglion neurons. J Neurophysiol. 2010 Jan; 103(1):172-82.
  View in: PubMed
 
11. Kester M, Heakal Y, Fox T, Sharma A, Robertson GP, Morgan TT, Altinoglu EI, Tabakovic A, Parette MR, Rouse SM, Ruiz-Velasco V, Adair JH. Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells. Nano Lett. 2008 Dec; 8(12):4116-21.
  View in: PubMed
 
12. Margas W, Sedeek K, Ruiz-Velasco V. Coupling specificity of NOP opioid receptors to pertussis-toxin-sensitive Galpha proteins in adult rat stellate ganglion neurons using small interference RNA. J Neurophysiol. 2008 Sep; 100(3):1420-32.
  View in: PubMed
 
13. Margas W, Ruiz-Velasco V. Electrophysiological and immunofluorescence characterization of Ca(2+) channels of acutely isolated rat sphenopalatine ganglion neurons. Neurosci Lett. 2007 Jun 4; 419(3):207-12.
  View in: PubMed
 
14. Margas W, Zubkoff I, Schuler HG, Janicki PK, Ruiz-Velasco V. Modulation of Ca2+ channels by heterologously expressed wild-type and mutant human micro-opioid receptors (hMORs) containing the A118G single-nucleotide polymorphism. J Neurophysiol. 2007 Feb; 97(2):1058-67.
  View in: PubMed
 
15. Janicki PK, Schuler G, Francis D, Bohr A, Gordin V, Jarzembowski T, Ruiz-Velasco V, Mets B. A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gene in patients with acute and chronic pain. Anesth Analg. 2006 Oct; 103(4):1011-7.
  View in: PubMed
 
16. Yang Q, Sumner AD, Puhl HL, Ruiz-Velasco V. M(1) and M(2) muscarinic acetylcholine receptor subtypes mediate Ca(2+) channel current inhibition in rat sympathetic stellate ganglion neurons. J Neurophysiol. 2006 Nov; 96(5):2479-87.
  View in: PubMed
 
17. Ruiz-Velasco V, Puhl HL, Fuller BC, Sumner AD. Modulation of Ca2+ channels by opioid receptor-like 1 receptors natively expressed in rat stellate ganglion neurons innervating cardiac muscle. J Pharmacol Exp Ther. 2005 Sep; 314(3):987-94.
  View in: PubMed
 
18. Fuller BC, Sumner AD, Kutzler MA, Ruiz-Velasco V. A novel approach employing ultrasound guidance for percutaneous cardiac muscle injection to retrograde label rat stellate ganglion neurons. Neurosci Lett. 2004 Jun 17; 363(3):252-6.
  View in: PubMed
 
19. Ruiz-Velasco V, Ikeda SR. A splice variant of the G protein beta 3-subunit implicated in disease states does not modulate ion channels. Physiol Genomics. 2003 Apr 16; 13(2):85-95.
  View in: PubMed
 
20. Ruiz-Velasco V, Ikeda SR, Puhl HL. Cloning, tissue distribution, and functional expression of the human G protein beta 4-subunit. Physiol Genomics. 2002 Feb 11; 8(1):41-50.
  View in: PubMed
 
21. Ruiz-Velasco V, Ikeda SR. Functional expression and FRET analysis of green fluorescent proteins fused to G-protein subunits in rat sympathetic neurons. J Physiol. 2001 Dec 15; 537(Pt 3):679-92.
  View in: PubMed
 
22. Kammermeier PJ, Ruiz-Velasco V, Ikeda SR. A voltage-independent calcium current inhibitory pathway activated by muscarinic agonists in rat sympathetic neurons requires both Galpha q/11 and Gbeta gamma. J Neurosci. 2000 Aug 1; 20(15):5623-9.
  View in: PubMed
 
23. Ruiz-Velasco V, Ikeda SR. Multiple G-protein betagamma combinations produce voltage-dependent inhibition of N-type calcium channels in rat superior cervical ganglion neurons. J Neurosci. 2000 Mar 15; 20(6):2183-91.
  View in: PubMed
 
24. Ikeda SR, Jeong SW, Kammermeier PJ, Ruiz-Velasco V, King MM. Heterologous expression of a green fluorescent protein-pertussis toxin S1 subunit fusion construct disrupts calcium channel modulation in rat superior cervical ganglion neurons. Neurosci Lett. 1999 Aug 27; 271(3):163-6.
  View in: PubMed
 
25. Ruiz-Velasco V, Ikeda SR. Heterologous expression and coupling of G protein-gated inwardly rectifying K+ channels in adult rat sympathetic neurons. J Physiol. 1998 Dec 15; 513 ( Pt 3):761-73.
  View in: PubMed
 
26. Ruiz-Velasco V, Zhong J, Hume JR, Keef KD. Modulation of Ca2+ channels by cyclic nucleotide cross activation of opposing protein kinases in rabbit portal vein. Circ Res. 1998 Mar 23; 82(5):557-65.
  View in: PubMed
 
27. Ruiz-Velasco V, Mayer MB, Hymel LJ. Dihydropyridine-sensitive Ca2+ influx modulated by stretch in A7r5 vascular smooth muscle cells. Eur J Pharmacol. 1996 Feb 5; 296(3):327-34.
  View in: PubMed
 
28. Ruiz-Velasco V, Mayer MB, Inscho EW, Hymel LJ. Modulation of dihydropyridine receptors in vascular smooth muscle cells by membrane potential and cell proliferation. Eur J Pharmacol. 1994 Aug 16; 268(3):311-8.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Neurons
Calcium Channels, N-Type
Calcium Channels
Receptors, Opioid, mu
Stellate Ganglion
See all (184) keywords
Co-Authors  
Bezinover, Dmitri
Janicki, Piotr
Mets, Berend
Robertson, Gavin
Yun, Jong
See all (16) people
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