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Urs Leuenberger
Title Professor
Institution College of Medicine
Department Medicine
Division Heart and Vascular Institute Imaging
Address 500 University Drive Hershey PA 17033
Telephone 7175316853
Email
Background
PREFERRED TITLE/ROLE:

Physician, Professor of Medicine

EDUCATION:

M.D., University of Bern Medical School, 1977
Residency, Penn State Milton S. Hershey Medical Center
Fellowship, Penn State Milton S. Hershey Medical Center

Publications
1. Gao Z, Novick M, Muller MD, Williams RJ, Spilk S, Leuenberger UA, Sinoway LI. Exercise and diet-induced weight loss attenuates oxidative stress related-coronary vasoconstriction in obese adolescents. Eur J Appl Physiol. 2013 Feb; 113(2):519-28.
  View in: PubMed
 
2. Muller MD, Gao Z, Mast JL, Blaha CA, Drew RC, Leuenberger UA, Sinoway LI. Aging attenuates the coronary blood flow response to cold air breathing and isometric handgrip in healthy humans. Am J Physiol Heart Circ Physiol. 2012 Apr 15; 302(8):H1737-46.
  View in: PubMed
 
3. Muller MD, Gao Z, Drew RC, Herr MD, Leuenberger UA, Sinoway LI. Effect of cold air inhalation and isometric exercise on coronary blood flow and myocardial function in humans. J Appl Physiol. 2011 Dec; 111(6):1694-702.
  View in: PubMed
 
4. Cui J, Leuenberger UA, Gao Z, Sinoway LI. Sympathetic and cardiovascular responses to venous distension in an occluded limb. Am J Physiol Regul Integr Comp Physiol. 2011 Dec; 301(6):R1831-7.
  View in: PubMed
 
5. Gao Z, Spilk S, Momen A, Muller MD, Leuenberger UA, Sinoway LI. Vitamin C prevents hyperoxia-mediated coronary vasoconstriction and impairment of myocardial function in healthy subjects. Eur J Appl Physiol. 2012 Feb; 112(2):483-92.
  View in: PubMed
 
6. Krishnan A, Lucassen EB, Hogeman C, Blaha C, Leuenberger UA. Effects of limb posture on reactive hyperemia. Eur J Appl Physiol. 2011 Jul; 111(7):1415-20.
  View in: PubMed
 
7. Cui J, Leuenberger UA, Blaha C, King NC, Sinoway LI. Effect of P2 receptor blockade with pyridoxine on sympathetic response to exercise pressor reflex in humans. J Physiol. 2011 Feb 1; 589(Pt 3):685-95.
  View in: PubMed
 
8. Momen A, Gao Z, Cohen A, Khan T, Leuenberger UA, Sinoway LI. Coronary vasoconstrictor responses are attenuated in young women as compared with age-matched men. J Physiol. 2010 Oct 15; 588(Pt 20):4007-16.
  View in: PubMed
 
9. Leuenberger UA. The muscle metaboreflex: reining in the heart? J Appl Physiol. 2010 Aug; 109(2):263-4.
  View in: PubMed
 
10. Cui J, Leuenberger UA, Blaha C, Yoder J, Gao Z, Sinoway LI. Local adenosine receptor blockade accentuates the sympathetic responses to fatiguing exercise. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H2130-7.
  View in: PubMed
 
11. Moradkhan R, Spitnale B, McQuillan P, Hogeman C, Gray KS, Leuenberger UA. Hypoxia-induced vasodilation and effects of regional phentolamine in awake patients with sleep apnea. J Appl Physiol. 2010 May; 108(5):1234-40.
  View in: PubMed
 
12. Herr MD, Hogeman CS, Koch DW, Krishnan A, Momen A, Leuenberger UA. A real-time device for converting Doppler ultrasound audio signals into fluid flow velocity. Am J Physiol Heart Circ Physiol. 2010 May; 298(5):H1626-32.
  View in: PubMed
 
13. Momen A, Kozak M, Leuenberger UA, Ettinger S, Blaha C, Mascarenhas V, Lendel V, Herr MD, Sinoway LI. Transthoracic Doppler echocardiography to noninvasively assess coronary vasoconstrictor and dilator responses in humans. Am J Physiol Heart Circ Physiol. 2010 Feb; 298(2):H524-9.
  View in: PubMed
 
14. Momen A, Mascarenhas V, Gahremanpour A, Gao Z, Moradkhan R, Kunselman A, Boehmer JP, Sinoway LI, Leuenberger UA. Coronary blood flow responses to physiological stress in humans. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H854-61.
  View in: PubMed
 
15. Lydakis C, Momen A, Blaha C, Gugoff S, Gray K, Herr M, Leuenberger UA, Sinoway LI. Changes of central haemodynamic parameters during mental stress and acute bouts of static and dynamic exercise. J Hum Hypertens. 2008 May; 22(5):320-8.
  View in: PubMed
 
16. Lydakis C, Momen A, Blaha C, Herr M, Leuenberger UA, Sinoway LI. Changes of elastic properties of central arteries during acute static exercise and lower body negative pressure. Eur J Appl Physiol. 2008 Apr; 102(6):633-41.
  View in: PubMed
 
17. Leuenberger UA, Johnson D, Loomis J, Gray KS, MacLean DA. Venous but not skeletal muscle interstitial nitric oxide is increased during hypobaric hypoxia. Eur J Appl Physiol. 2008 Mar; 102(4):457-61.
  View in: PubMed
 
18. Moradkhan R, McQuillan P, Hogeman C, Leuenberger A, Linton-Frazier L, Leuenberger UA. Metabolic forearm vasodilation is enhanced following Bier block with phentolamine. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2289-95.
  View in: PubMed
 
19. Wilson TE, Sauder CL, Kearney ML, Kuipers NT, Leuenberger UA, Monahan KD, Ray CA. Skin-surface cooling elicits peripheral and visceral vasoconstriction in humans. J Appl Physiol. 2007 Oct; 103(4):1257-62.
  View in: PubMed
 
20. Leuenberger UA, Hogeman CS, Quraishi S, Linton-Frazier L, Gray KS. Short-term intermittent hypoxia enhances sympathetic responses to continuous hypoxia in humans. J Appl Physiol. 2007 Sep; 103(3):835-42.
  View in: PubMed
 
21. Imadojemu VA, Mawji Z, Kunselman A, Gray KS, Hogeman CS, Leuenberger UA. Sympathetic chemoreflex responses in obstructive sleep apnea and effects of continuous positive airway pressure therapy. Chest. 2007 May; 131(5):1406-13.
  View in: PubMed
 
22. Momen A, Gahremanpour A, Mansoor A, Kunselman A, Blaha C, Pae W, Leuenberger UA, Sinoway LI. Vasoconstriction seen in coronary bypass grafts during handgrip in humans. J Appl Physiol. 2007 Feb; 102(2):735-9.
  View in: PubMed
 
23. Monahan KD, Leuenberger UA, Ray CA. Aldosterone impairs baroreflex sensitivity in healthy adults. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H190-7.
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24. Monahan KD, Leuenberger UA, Ray CA. Effect of repetitive hypoxic apnoeas on baroreflex function in humans. J Physiol. 2006 Jul 15; 574(Pt 2):605-13.
  View in: PubMed
 
25. Momen A, Thomas K, Blaha C, Gahremanpour A, Mansoor A, Leuenberger UA, Sinoway LI. Renal vasoconstrictor responses to static exercise during orthostatic stress in humans: effects of the muscle mechano- and the baroreflexes. J Physiol. 2006 Jun 15; 573(Pt 3):819-25.
  View in: PubMed
 
26. Momen A, Handly B, Kunselman A, Leuenberger UA, Sinoway LI. Influence of sex and active muscle mass on renal vascular responses during static exercise. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H121-6.
  View in: PubMed
 
27. Leuenberger UA, Brubaker D, Quraishi S, Hogeman CS, Imadojemu VA, Gray KS. Effects of intermittent hypoxia on sympathetic activity and blood pressure in humans. Auton Neurosci. 2005 Aug 31; 121(1-2):87-93.
  View in: PubMed
 
28. Momen A, Bower D, Leuenberger UA, Boehmer J, Lerner S, Alfrey EJ, Handly B, Sinoway LI. Renal vascular response to static handgrip exercise: sympathetic vs. autoregulatory control. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1770-6.
  View in: PubMed
 
29. Newcomer SC, Leuenberger UA, Hogeman CS, Proctor DN. Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance training. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H308-15.
  View in: PubMed
 
30. Momen A, Bower D, Boehmer J, Kunselman AR, Leuenberger UA, Sinoway LI. Renal blood flow in heart failure patients during exercise. Am J Physiol Heart Circ Physiol. 2004 Dec; 287(6):H2834-9.
  View in: PubMed
 
31. Proctor DN, Koch DW, Newcomer SC, Le KU, Smithmyer SL, Leuenberger UA. Leg blood flow and VO2 during peak cycle exercise in younger and older women. Med Sci Sports Exerc. 2004 Apr; 36(4):623-31.
  View in: PubMed
 
32. Momen A, Leuenberger UA, Handly B, Sinoway LI. Effect of aging on renal blood flow velocity during static exercise. Am J Physiol Heart Circ Physiol. 2004 Aug; 287(2):H735-40.
  View in: PubMed
 
33. Newcomer SC, Leuenberger UA, Hogeman CS, Handly BD, Proctor DN. Different vasodilator responses of human arms and legs. J Physiol. 2004 May 1; 556(Pt 3):1001-11.
  View in: PubMed
 
34. Imadojemu VA, Sinoway LI, Leuenberger UA. Vascular dysfunction in sleep apnea: a reversible link to cardiovascular disease? Am J Respir Crit Care Med. 2004 Feb 1; 169(3):328-9.
  View in: PubMed
 
35. Leuenberger UA, Mostoufi-Moab S, Herr M, Gray K, Kunselman A, Sinoway LI. Control of skin sympathetic nerve activity during intermittent static handgrip exercise. Circulation. 2003 Nov 11; 108(19):2329-35.
  View in: PubMed
 
36. Proctor DN, Koch DW, Newcomer SC, Le KU, Leuenberger UA. Impaired leg vasodilation during dynamic exercise in healthy older women. J Appl Physiol. 2003 Nov; 95(5):1963-70.
  View in: PubMed
 
37. Koch DW, Leuenberger UA, Proctor DN. Augmented leg vasoconstriction in dynamically exercising older men during acute sympathetic stimulation. J Physiol. 2003 Aug 15; 551(Pt 1):337-44.
  View in: PubMed
 
38. Momen A, Leuenberger UA, Ray CA, Cha S, Handly B, Sinoway LI. Renal vascular responses to static handgrip: role of muscle mechanoreflex. Am J Physiol Heart Circ Physiol. 2003 Sep; 285(3):H1247-53.
  View in: PubMed
 
39. Proctor DN, Newcomer SC, Koch DW, Le KU, MacLean DA, Leuenberger UA. Leg blood flow during submaximal cycle ergometry is not reduced in healthy older normally active men. J Appl Physiol. 2003 May; 94(5):1859-69.
  View in: PubMed
 
40. Khan MH, Kunselman AR, Leuenberger UA, Davidson WR, Ray CA, Gray KS, Hogeman CS, Sinoway LI. Attenuated sympathetic nerve responses after 24 hours of bed rest. Am J Physiol Heart Circ Physiol. 2002 Jun; 282(6):H2210-5.
  View in: PubMed
 
41. Imadojemu VA, Gleeson K, Quraishi SA, Kunselman AR, Sinoway LI, Leuenberger UA. Impaired vasodilator responses in obstructive sleep apnea are improved with continuous positive airway pressure therapy. Am J Respir Crit Care Med. 2002 Apr 1; 165(7):950-3.
  View in: PubMed
 
42. Imadojemu VA, Gleeson K, Gray KS, Sinoway LI, Leuenberger UA. Obstructive apnea during sleep is associated with peripheral vasoconstriction. Am J Respir Crit Care Med. 2002 Jan 1; 165(1):61-6.
  View in: PubMed
 
43. Leuenberger UA, Hardy JC, Herr MD, Gray KS, Sinoway LI. Hypoxia augments apnea-induced peripheral vasoconstriction in humans. J Appl Physiol. 2001 Apr; 90(4):1516-22.
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44. Mostoufi-Moab S, Herr MD, Silber DH, Gray KS, Leuenberger UA, Sinoway LI. Limb congestion enhances the synchronization of sympathetic outflow with muscle contraction. Am J Physiol Regul Integr Comp Physiol. 2000 Aug; 279(2):R478-83.
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45. Silber DH, Sinoway LI, Leuenberger UA, Amassian VE. Magnetic stimulation of the human motor cortex evokes skin sympathetic nerve activity. J Appl Physiol. 2000 Jan; 88(1):126-34.
  View in: PubMed
 
46. Leuenberger UA, Gray K, Herr MD. Adenosine contributes to hypoxia-induced forearm vasodilation in humans. J Appl Physiol. 1999 Dec; 87(6):2218-24.
  View in: PubMed
 
47. MacLean DA, Sinoway LI, Leuenberger U. Systemic hypoxia elevates skeletal muscle interstitial adenosine levels in humans. Circulation. 1998 Nov 10; 98(19):1990-2.
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48. Kasravi B, Boehmer JP, Leuenberger UA. A noninvasive method for estimating cardiac output using lung to finger circulation time of oxygen. Am J Cardiol. 1998 Oct 1; 82(7):915-7.
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49. Fritsch-Yelle JM, Leuenberger UA, D'Aunno DS, Rossum AC, Brown TE, Wood ML, Josephson ME, Goldberger AL. An episode of ventricular tachycardia during long-duration spaceflight. Am J Cardiol. 1998 Jun 1; 81(11):1391-2.
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50. Silber DH, Sutliff G, Yang QX, Smith MB, Sinoway LI, Leuenberger UA. Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure. J Appl Physiol. 1998 May; 84(5):1551-9.
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51. Sturtz CL, Abt AB, Leuenberger UA, Damiano R. Hamartoma of mature cardiac myocytes: a case report. Mod Pathol. 1998 May; 11(5):496-9.
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52. Shoemaker JK, Hogeman CS, Leuenberger UA, Herr MD, Gray K, Silber DH, Sinoway LI. Sympathetic discharge and vascular resistance after bed rest. J Appl Physiol. 1998 Feb; 84(2):612-7.
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53. Sinoway L, Shenberger J, Leaman G, Zelis R, Gray K, Baily R, Leuenberger U. Forearm training attenuates sympathetic responses to prolonged rhythmic forearm exercise. J Appl Physiol. 1996 Oct; 81(4):1778-84.
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54. Leuenberger U, Gaul L, Noack H, Gubin S, Zelis R. Angiotensin-converting enzyme inhibition and the norepinephrine spillover response to dynamic exercise. J Appl Physiol. 1996 Sep; 81(3):1138-42.
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55. Luck JC, Hoover RJ, Biederman RW, Ettinger SM, Sinoway LI, Leuenberger UA. Observations on carotid sinus hypersensitivity from direct intraneural recordings of sympathetic nerve traffic. Am J Cardiol. 1996 Jun 15; 77(15):1362-5.
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56. Waradekar NV, Sinoway LI, Zwillich CW, Leuenberger UA. Influence of treatment on muscle sympathetic nerve activity in sleep apnea. Am J Respir Crit Care Med. 1996 Apr; 153(4 Pt 1):1333-8.
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57. Haque WA, Boehmer J, Clemson BS, Leuenberger UA, Silber DH, Sinoway LI. Hemodynamic effects of supplemental oxygen administration in congestive heart failure. J Am Coll Cardiol. 1996 Feb; 27(2):353-7.
  View in: PubMed
 
58. Leuenberger U, Jacob E, Sweer L, Waravdekar N, Zwillich C, Sinoway L. Surges of muscle sympathetic nerve activity during obstructive apnea are linked to hypoxemia. J Appl Physiol. 1995 Aug; 79(2):581-8.
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59. Stylos L, Parilak L, Green MH, Leuenberger U, Zelis R. Compartmental analysis of norepinephrine kinetics in congestive heart failure. Am J Cardiol. 1995 Feb 1; 75(4):299-301.
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60. Hardy JC, Gray K, Whisler S, Leuenberger U. Sympathetic and blood pressure responses to voluntary apnea are augmented by hypoxemia. J Appl Physiol. 1994 Nov; 77(5):2360-5.
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61. Sinoway LI, Smith MB, Enders B, Leuenberger U, Dzwonczyk T, Gray K, Whisler S, Moore RL. Role of diprotonated phosphate in evoking muscle reflex responses in cats and humans. Am J Physiol. 1994 Aug; 267(2 Pt 2):H770-8.
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62. Batman BA, Hardy JC, Leuenberger UA, Smith MB, Yang QX, Sinoway LI. Sympathetic nerve activity during prolonged rhythmic forearm exercise. J Appl Physiol. 1994 Mar; 76(3):1077-81.
  View in: PubMed
 
63. Leuenberger U, Sinoway L, Gubin S, Gaul L, Davis D, Zelis R. Effects of exercise intensity and duration on norepinephrine spillover and clearance in humans. J Appl Physiol. 1993 Aug; 75(2):668-74.
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64. Gauch R, Leuenberger U, Müller U. [Determination of water-soluble vitamins B1, B2, B6 and B12 in milk using HPLC]. Z Lebensm Unters Forsch. 1992 Oct; 195(4):312-5.
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65. Leuenberger U, Kenney G, Davis D, Clemson B, Zelis R. Comparison of norepinephrine and isoproterenol clearance in congestive heart failure. Am J Physiol. 1992 Jul; 263(1 Pt 2):H56-60.
  View in: PubMed
 
66. Leuenberger U, Gleeson K, Wroblewski K, Prophet S, Zelis R, Zwillich C, Sinoway L. Norepinephrine clearance is increased during acute hypoxemia in humans. Am J Physiol. 1991 Nov; 261(5 Pt 2):H1659-64.
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67. Zelis R, Sinoway LI, Leuenberger U, Clemson BS, Davis D. Time-constant adaptations in heart failure. Eur Heart J. 1991 Aug; 12 Suppl C:2-7.
  View in: PubMed
 
68. Baily RG, Leuenberger U, Leaman G, Silber D, Sinoway LI. Norepinephrine kinetics and cardiac output during nonhypotensive lower body negative pressure. Am J Physiol. 1991 May; 260(5 Pt 2):H1708-12.
  View in: PubMed
 
69. Gauch R, Leuenberger U, Müller U. [The determination of the herbicide glyphosate and its chief metabolite aminomethylphosphonic acid (AMPA) in drinking water with the aid of HPLC]. Z Lebensm Unters Forsch. 1989 Jan; 188(1):36-8.
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70. Leuenberger U, Gauch R, Müller U, Schällibaum M. [The transition of morantel in cow's milk following administration in the retard form, "Paratect Bolus" (Pfizer)]. Z Lebensm Unters Forsch. 1987 May; 184(5):388-9.
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71. Leuenberger U, Gauch R, Müller U. [Determination of piperazine in hen eggs with HPLC following oral administration]. Z Lebensm Unters Forsch. 1986 Aug; 183(2):90-2.
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72. Gauch R, Leuenberger U, Limacher W, Müller U, Schällibaum M. [Thin-layer chromatographic determination of pyrantel in cow's milk and blood serum after oral administration of Banminth]. Z Lebensm Unters Forsch. 1983; 177(2):117-20.
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73. Goldhirsch A, Joss RA, Leuenberger U, Cavalli F, Ryssel HJ, Brunner KW. An evaluation of tamoxifen dose escalation in advanced breast cancer. Am J Clin Oncol. 1982 Oct; 5(5):501-3.
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74. Goldhirsch A, Leuenberger U, Ryssel HJ, Cavalli F, Sonntag RW, Joss RA, Brunner KW. Combination hormonotherapy with tamoxifen and fluoxymesterone in patients with advanced breast cancer relapsing on hormonotherapy. Oncology. 1982; 39(5):284-6.
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75. Goldhirsch A, Leuenberger U, Cavalli F. [Hormone receptors and breast cancer]. Gynakol Rundsch. 1981; 21(1):18-23.
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76. Gauch R, Leuenberger U, Baumgartner E. Rapid and simple determination of aflatoxin M1 in milk in the low parts per 10(12) range. J Chromatogr. 1979 Oct 31; 178(2):543-9.
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77. Leuenberger U, Gauch R, Baumgartner E. Determination of food preservatives and saccharin by high-performance liquid chromatography. J Chromatogr. 1979 May 21; 173(2):343-8.
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78. Leuenberger U, Gauch R, Baumgartner E. [The quantitative analysis of the mycotoxin patulin in fruit juices by high-pressure liquid or thin-layer chromatography (author's transl)]. J Chromatogr. 1978 Nov 21; 161:303-9.
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79. Salzmann C, Althaus U, Hugentobler B, Leuenberger U, Merki H. [Surgery of mitral valve stenosis: open or closed commissurotomy?]. Schweiz Med Wochenschr. 1976 Nov 6; 106(45):1579-83.
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80. Leuenberger U, Stewart I, King RW. Isolation and identification of beta-citraurol, a C30 carotenoid in citrus. J Org Chem. 1975 Mar 5; 41(5):891-2.
  View in: PubMed
 
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Sympathetic Nervous System
Anoxia
Vasodilation
Sleep Apnea, Obstructive
Blood Pressure
See all (310) keywords
Co-Authors  
Gao, Zhaohui
Kunselman, Allen
Momen, Afsana
Silber, David
Sinoway, Lawrence
See all (24) people
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